fig|1040638.4.peg.1462
Escherichia coli O104:H4 str. LB226692
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|6666666.5357.peg.2529
Escherichia coli TY-2482
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|216592.1.peg.1134
Escherichia coli 042
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|216592.3.peg.4288
Escherichia coli 042
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|358709.5.peg.6
Escherichia coli 101-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.371.peg.2970
Escherichia coli 1044A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.373.peg.896
Escherichia coli 1125A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.372.peg.3854
Escherichia coli 1212A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|670888.3.peg.2467
Escherichia coli 1827-70
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|670897.3.peg.3511
Escherichia coli 2362-75
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|362663.8.peg.3980
Escherichia coli 536
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|344610.3.peg.4902
Escherichia coli 53638
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|344610.7.peg.2436
Escherichia coli 53638
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.374.peg.1943
Escherichia coli 536A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585055.6.peg.4258
Escherichia coli 55989
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585055.8.peg.4261
Escherichia coli 55989
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|525281.3.peg.3250
Escherichia coli 83972
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|655817.3.peg.4426
Escherichia coli ABU 83972
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|405955.13.peg.4207
Escherichia coli APEC O1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|405955.9.peg.3524
Escherichia coli APEC O1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|481805.3.peg.4569
Escherichia coli ATCC 8739
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|481805.6.peg.4549
Escherichia coli ATCC 8739
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|413997.3.peg.3817
Escherichia coli B str. REL606
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|550672.3.peg.3832
Escherichia coli B088
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|344601.3.peg.2359
Escherichia coli B171
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|344601.5.peg.2463
Escherichia coli B171
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|550677.3.peg.4336
Escherichia coli B354
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340184.3.peg.4326
Escherichia coli B7A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340184.6.peg.4533
Escherichia coli B7A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|511693.5.peg.3835
Escherichia coli BL21
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|469008.4.peg.4452
Escherichia coli BL21(DE3)
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|595496.3.peg.3757
Escherichia coli BW2952
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|199310.1.peg.4579
Escherichia coli CFT073
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|199310.4.peg.4391
Escherichia coli CFT073
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|536056.3.peg.4487
Escherichia coli DH1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340186.3.peg.4844
Escherichia coli E110019
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340186.5.peg.5107
Escherichia coli E110019
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340185.3.peg.2231
Escherichia coli E22
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340185.4.peg.2359
Escherichia coli E22
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|216593.1.peg.4564
Escherichia coli E2348/69
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|331111.12.peg.4504
Escherichia coli E24377A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|331111.3.peg.1905
Escherichia coli E24377A
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.375.peg.235
Escherichia coli EC4100B
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585397.7.peg.4437
Escherichia coli ED1a
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585397.9.peg.4434
Escherichia coli ED1a
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|316401.4.peg.4584
Escherichia coli ETEC H10407
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AIAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340197.3.peg.403
Escherichia coli F11
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|340197.5.peg.413
Escherichia coli F11
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656379.3.peg.4607
Escherichia coli FVEC1302
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656380.3.peg.4892
Escherichia coli FVEC1412
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656393.3.peg.4926
Escherichia coli H299
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656408.3.peg.4215
Escherichia coli H591
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656414.3.peg.4283
Escherichia coli H736
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|331112.3.peg.3718
Escherichia coli HS
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|331112.6.peg.3875
Escherichia coli HS
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585034.4.peg.3849
Escherichia coli IAI1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585034.5.peg.3846
Escherichia coli IAI1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|714962.3.peg.4243
Escherichia coli IHE3034
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|83333.1.peg.3688
Escherichia coli K12
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656417.3.peg.4638
Escherichia coli M605
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656419.3.peg.4814
Escherichia coli M718
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|679207.4.peg.6
Escherichia coli MS 107-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749537.3.peg.253
Escherichia coli MS 115-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|679206.4.peg.4292
Escherichia coli MS 119-7
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|679205.4.peg.4069
Escherichia coli MS 124-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|679204.3.peg.2824
Escherichia coli MS 145-7
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749540.3.peg.563
Escherichia coli MS 146-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749545.3.peg.3491
Escherichia coli MS 182-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749546.3.peg.1532
Escherichia coli MS 185-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749547.3.peg.4400
Escherichia coli MS 187-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749548.3.peg.4560
Escherichia coli MS 196-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749549.3.peg.408
Escherichia coli MS 198-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749550.3.peg.2412
Escherichia coli MS 200-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749527.3.peg.88
Escherichia coli MS 21-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749528.3.peg.2812
Escherichia coli MS 45-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749531.3.peg.1866
Escherichia coli MS 69-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749532.3.peg.74
Escherichia coli MS 78-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749533.3.peg.1042
Escherichia coli MS 84-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|753642.3.peg.4169
Escherichia coli NC101
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585395.4.peg.4612
Escherichia coli O103:H2 str. 12009
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585396.4.peg.4747
Escherichia coli O111:H- str. 11128
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|574521.7.peg.4140
Escherichia coli O127:H6 str. E2348/69
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|83334.1.peg.4663
Escherichia coli O157:H7
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444454.5.peg.3781
Escherichia coli O157:H7 str. EC4024
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444449.5.peg.3236
Escherichia coli O157:H7 str. EC4042
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444448.5.peg.1991
Escherichia coli O157:H7 str. EC4045
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444453.5.peg.2132
Escherichia coli O157:H7 str. EC4076
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444452.5.peg.5252
Escherichia coli O157:H7 str. EC4113
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444450.8.peg.5073
Escherichia coli O157:H7 str. EC4115
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444451.5.peg.5305
Escherichia coli O157:H7 str. EC4196
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|444447.5.peg.2155
Escherichia coli O157:H7 str. EC4206
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|478004.5.peg.548
Escherichia coli O157:H7 str. EC4401
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|478005.5.peg.2060
Escherichia coli O157:H7 str. EC4486
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|478007.5.peg.3626
Escherichia coli O157:H7 str. EC508
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|478008.5.peg.1874
Escherichia coli O157:H7 str. EC869
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|637388.3.peg.3012
Escherichia coli O157:H7 str. FRIK2000
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|570506.3.peg.4805
Escherichia coli O157:H7 str. FRIK966
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|386585.9.peg.4898
Escherichia coli O157:H7 str. Sakai
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|544404.4.peg.4883
Escherichia coli O157:H7 str. TW14359
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|502346.5.peg.1924
Escherichia coli O157:H7 str. TW14588
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|573235.3.peg.4972
Escherichia coli O26:H11 str. 11368
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|685038.3.peg.3814
Escherichia coli O83:H1 str. NRG 857C
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585035.6.peg.4104
Escherichia coli S88
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|409438.11.peg.4214
Escherichia coli SE11
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|431946.3.peg.3746
Escherichia coli SE15
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|439855.10.peg.4261
Escherichia coli SMS-3-5
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656437.3.peg.4237
Escherichia coli TA143
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656440.3.peg.4067
Escherichia coli TA206
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656443.3.peg.4698
Escherichia coli TA271
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|656444.3.peg.5093
Escherichia coli TA280
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|869729.3.peg.4062
Escherichia coli UM146
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585056.7.peg.4452
Escherichia coli UMN026
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|364106.7.peg.4210
Escherichia coli UTI89
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|364106.8.peg.4212
Escherichia coli UTI89
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|566546.3.peg.3238
Escherichia coli W
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|316407.3.peg.3373
Escherichia coli W3110
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|562.376.peg.2426
Escherichia coli WV_060327
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|316385.5.peg.3890
Escherichia coli str. K-12 substr. DH10B
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|316385.7.peg.3974
Escherichia coli str. K-12 substr. DH10B
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|511145.12.peg.3875
Escherichia coli str. K-12 substr. MG1655
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|511145.6.peg.3857
Escherichia coli str. K-12 substr. MG1655
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|550676.3.peg.3966
Escherichia coli B185
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
S
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585057.4.peg.4491
Escherichia coli IAI39
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
L
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|585057.6.peg.4501
Escherichia coli IAI39
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
L
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|701177.3.peg.4567
Escherichia coli O55:H7 str. CB9615
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
A
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|155864.1.peg.4697
Escherichia coli O157:H7 EDL933
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
X
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|155864.8.peg.4656
Escherichia coli O157:H7 EDL933
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
X
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
V
Y
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|749538.3.peg.3791
Escherichia coli MS 116-1
MTT
Q
T
V
S
GR
R
YF
T
K
A
WL
M
E
Q
K
S
L
IA
L
L
VL
I
AI
V
S
TLS
--
P
N
F
F
T
I
NNL
F
NIL
Q
Q
T
S
VNA
I
M
A
V
GMT
L
VILT
S
GIDLSVG
SL
L
AL
TG
A
VAA
S
I
V
G
------------
IE
V
N
A
-------------
L
V
AVAA
A
L
A
LGA
A
IG
A
V
T
G
V
I
V
A
KGR
V
QA
FI
A
TL
V
M
M
LL
LRG
V
TMVY
TN
---
G
S
P
---
VNT
G
FTENA
D
L
---
F
G
W
F
G
I
GR
P
LGV
-
P
TPVW
IM
G
I
VFLAAWY
M
LH
H
T
R
L
GR
Y
I
Y
A
L
GGN
EA
A
T
RLSGINV
NKIK
I
I
IY
S
L
C
GLLA
SLA
GI
I
E
V
A
RL
S
SA
QPTA
G
T
GYELDAIAAVV
L
GGTSL
A
GG
K
G
R
I
V
GTL
I
G
A
LI
L
G
F
L
NNGL
N
LLGV
S
S
Y
Y
Q
M
IVK
A
V
V
IL
L
AVL
V
D
NK
KQ
fig|431946.3.peg.533
Escherichia coli SE15 (3-328/355)
Q
KY
M
I
Y
M
Y
L
L
K
A
R
T
F
IA
L
L
LV
I
A
F
F
S
VMV
--
P
N
F
L
T
A
S
NL
L
I
M
T
Q
HV
A
ITG
L
L
A
I
GMT
L
VILT
G
GIDLSVG
AV
A
G
I
CG
M
VA
G
A
LL
T
------------
NG
L
P
L
WSGNIIFFNVPEV
I
L
CVA-
--
V
F
G
I
L
V
G
L
V
N
G
A
V
I
T
RFG
V
AP
FI
C
TLG
M
M
YV
A
RG
S
ALLF
N
D
---
G
S
TYPN
LNG
M
ETLGN
T
G
---
F
A
T
LG
S
G
T
F
LG
I
-
Y
LPIW
L
M
I
G
FLILGYW
I
TT
KT
P
L
GR
Y
I
Y
A
I
GGN
ES
AARL
A
G
V
P
I
VKVK
V
F
V
Y
A
F
SGL
C
A
AFV
G
L
I
V
A
S
Q
L
Q
T
A
HPMT
G
N
M
F
E
M
DAI
G
A
T
V
L
GGT
A
L
A
GG
R
G
R
V
S
G
SI
I
G
A
F
V
I
V
F
L
A
D
G
M
V
MM
GV
S
D
F
WQ
M
VI
KG
L
V
I
V
T
AV
V
V
D
QF
Q
Q
fig|701177.3.peg.4920
Escherichia coli O55:H7 str. CB9615 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
AV
I
I
I
AVL
I
D
KY
R
fig|550676.3.peg.4364
Escherichia coli B185 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIA
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
AV
I
I
I
AVL
I
D
KY
R
fig|656419.3.peg.5333
Escherichia coli M718 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIA
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
AV
I
I
I
AVL
I
D
KY
R
fig|562.371.peg.3605
Escherichia coli 1044A (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|562.373.peg.5799
Escherichia coli 1125A (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|562.372.peg.3453
Escherichia coli 1212A (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|562.374.peg.2788
Escherichia coli 536A (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|83334.1.peg.5049
Escherichia coli O157:H7 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|155864.1.peg.5030
Escherichia coli O157:H7 EDL933 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|155864.8.peg.5012
Escherichia coli O157:H7 EDL933 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|478006.5.peg.1466
Escherichia coli O157:H7 str. EC4501 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|478007.5.peg.1071
Escherichia coli O157:H7 str. EC508 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|478008.5.peg.114
Escherichia coli O157:H7 str. EC869 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|637388.3.peg.2328
Escherichia coli O157:H7 str. FRIK2000 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|570506.3.peg.1395
Escherichia coli O157:H7 str. FRIK966 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|386585.9.peg.5300
Escherichia coli O157:H7 str. Sakai (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|502346.5.peg.1569
Escherichia coli O157:H7 str. TW14588 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVGGN
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|358709.5.peg.4401
Escherichia coli 101-1 (19-324/327)
K
E
L
L
M
R
L
A
P
L
FS
L
I
I
L
V
L
F
F
S
FSS
--
P
F
F
F
N
T
E
N
I
M
T
I
A
L
Q
T
S
VIG
I
M
A
I
G
V
T
F
VI
I
T
A
GIDLS
L
G
SV
VA
F
SG
V
AVG
I
CA
T
------------
LG
L
P
L
-------------
P
V
CIIA
G
V
L
A
G
G
M
C
G
Y
V
N
G
L
L
V
T
KMT
I
PP
FI
A
TLG
L
M
MS
V
RGI
NMVM
T
D
---
G
R
A
---
I--
-
YFADY
P
M
---
F
K
T
L
A
Q
GR
L
FD
V
L
P
YPVF
Y
L
V
I
VALVGAY
I
LK
KT
V
I
GR
Y
VY
AVG
S
N
EV
AA
H
LSGI
K
V
QRVK
I
F
V
Y
A
F
C
GLL
T
GIA
G
V
IL
A
S
RL
N
S
G
QPTV
G
V
GYEL
E
AIAAVV
I
GGTSL
M
GG
I
G
T
I
G
GT
I
I
G
A
F
I
M
S
V
L
K
NGL
N
L
M
GV
S
Q
F
WQ
M
V
AM
GV
V
VV
A
AV
Y
L
D
TL
R
K
fig|413997.3.peg.2781
Escherichia coli B str. REL606 (19-324/327)
K
E
L
L
M
R
L
A
P
L
FS
L
I
I
L
V
L
F
F
S
FSS
--
P
F
F
F
N
T
E
N
I
M
T
I
A
L
Q
T
S
VIG
I
M
A
I
G
V
T
F
VI
I
T
A
GIDLS
L
G
SV
VA
F
SG
V
AVG
I
CA
T
------------
LG
L
P
L
-------------
P
V
CIIA
G
V
L
A
G
G
M
C
G
Y
V
N
G
L
L
V
T
KMT
I
PP
FI
A
TLG
L
M
MS
V
RGI
NMVM
T
D
---
G
R
A
---
I--
-
YFADY
P
M
---
F
K
T
L
A
Q
GR
L
FD
V
L
P
YPVF
Y
L
V
I
VALVGAY
I
LK
KT
V
I
GR
Y
VY
AVG
S
N
EV
AA
H
LSGI
K
V
QRVK
I
F
V
Y
A
F
C
GLL
T
GIA
G
V
IL
A
S
RL
N
S
G
QPTV
G
V
GYEL
E
AIAAVV
I
GGTSL
M
GG
I
G
T
I
G
GT
I
I
G
A
F
I
M
S
V
L
K
NGL
N
L
M
GV
S
Q
F
WQ
M
V
AM
GV
V
VV
A
AV
Y
L
D
TL
R
K
fig|511693.5.peg.2796
Escherichia coli BL21 (19-324/327)
K
E
L
L
M
R
L
A
P
L
FS
L
I
I
L
V
L
F
F
S
FSS
--
P
F
F
F
N
T
E
N
I
M
T
I
A
L
Q
T
S
VIG
I
M
A
I
G
V
T
F
VI
I
T
A
GIDLS
L
G
SV
VA
F
SG
V
AVG
I
CA
T
------------
LG
L
P
L
-------------
P
V
CIIA
G
V
L
A
G
G
M
C
G
Y
V
N
G
L
L
V
T
KMT
I
PP
FI
A
TLG
L
M
MS
V
RGI
NMVM
T
D
---
G
R
A
---
I--
-
YFADY
P
M
---
F
K
T
L
A
Q
GR
L
FD
V
L
P
YPVF
Y
L
V
I
VALVGAY
I
LK
KT
V
I
GR
Y
VY
AVG
S
N
EV
AA
H
LSGI
K
V
QRVK
I
F
V
Y
A
F
C
GLL
T
GIA
G
V
IL
A
S
RL
N
S
G
QPTV
G
V
GYEL
E
AIAAVV
I
GGTSL
M
GG
I
G
T
I
G
GT
I
I
G
A
F
I
M
S
V
L
K
NGL
N
L
M
GV
S
Q
F
WQ
M
V
AM
GV
V
VV
A
AV
Y
L
D
TL
R
K
fig|469008.4.peg.943
Escherichia coli BL21(DE3) (19-324/327)
K
E
L
L
M
R
L
A
P
L
FS
L
I
I
L
V
L
F
F
S
FSS
--
P
F
F
F
N
T
E
N
I
M
T
I
A
L
Q
T
S
VIG
I
M
A
I
G
V
T
F
VI
I
T
A
GIDLS
L
G
SV
VA
F
SG
V
AVG
I
CA
T
------------
LG
L
P
L
-------------
P
V
CIIA
G
V
L
A
G
G
M
C
G
Y
V
N
G
L
L
V
T
KMT
I
PP
FI
A
TLG
L
M
MS
V
RGI
NMVM
T
D
---
G
R
A
---
I--
-
YFADY
P
M
---
F
K
T
L
A
Q
GR
L
FD
V
L
P
YPVF
Y
L
V
I
VALVGAY
I
LK
KT
V
I
GR
Y
VY
AVG
S
N
EV
AA
H
LSGI
K
V
QRVK
I
F
V
Y
A
F
C
GLL
T
GIA
G
V
IL
A
S
RL
N
S
G
QPTV
G
V
GYEL
E
AIAAVV
I
GGTSL
M
GG
I
G
T
I
G
GT
I
I
G
A
F
I
M
S
V
L
K
NGL
N
L
M
GV
S
Q
F
WQ
M
V
AM
GV
V
VV
A
AV
Y
L
D
TL
R
K
fig|749547.3.peg.3376
Escherichia coli MS 187-1 (19-324/327)
K
E
L
L
M
R
L
A
P
L
FS
L
I
I
L
V
L
F
F
S
FSS
--
P
F
F
F
N
T
E
N
I
M
T
I
A
L
Q
T
S
VIG
I
M
A
I
G
V
T
F
VI
I
T
A
GIDLS
L
G
SV
VA
F
SG
V
AVG
I
CA
T
------------
LG
L
P
L
-------------
P
V
CIIA
G
V
L
A
G
G
M
C
G
Y
V
N
G
L
L
V
T
KMT
I
PP
FI
A
TLG
L
M
MS
V
RGI
NMVM
T
D
---
G
R
A
---
I--
-
YFADY
P
M
---
F
K
T
L
A
Q
GR
L
FD
V
L
P
YPVF
Y
L
V
I
VALVGAY
I
LK
KT
V
I
GR
Y
VY
AVG
S
N
EV
AA
H
LSGI
K
V
QRVK
I
F
V
Y
A
F
C
GLL
T
GIA
G
V
IL
A
S
RL
N
S
G
QPTV
G
V
GYEL
E
AIAAVV
I
GGTSL
M
GG
I
G
T
I
G
GT
I
I
G
A
F
I
M
S
V
L
K
NGL
N
L
M
GV
S
Q
F
WQ
M
V
AM
GV
V
VV
A
AV
Y
L
D
TL
R
K
fig|444454.5.peg.4152
Escherichia coli O157:H7 str. EC4024 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444449.5.peg.3606
Escherichia coli O157:H7 str. EC4042 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444448.5.peg.2363
Escherichia coli O157:H7 str. EC4045 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444453.5.peg.2000
Escherichia coli O157:H7 str. EC4076 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444452.5.peg.1163
Escherichia coli O157:H7 str. EC4113 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444450.8.peg.5442
Escherichia coli O157:H7 str. EC4115 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444451.5.peg.2104
Escherichia coli O157:H7 str. EC4196 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|444447.5.peg.2528
Escherichia coli O157:H7 str. EC4206 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|478004.5.peg.2052
Escherichia coli O157:H7 str. EC4401 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|478005.5.peg.582
Escherichia coli O157:H7 str. EC4486 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|544404.4.peg.5254
Escherichia coli O157:H7 str. TW14359 (1-317/324)
M
T
T
S
A
K
T
S
AK
K
ML
M
S
D
L
M
Q
T
V
G
I
L
PI
L
I
LI
V
A
V
F
G
FIT
--
P
N
F
F
T
E
S
NL
L
NI
T
R
QAS
INI
V
L
A
A
GMT
F
I
ILT
G
GIDLSVG
SI
LG
-
TT
A
VAA
M
V
V
S
------------
LS
PE
F
------------
A
M
L
SIPA
A
L
M
LG
L
L
L
G
L
F
N
G
A
L
V
A
FAG
L
PP
FI
V
TLG
T
Y
TA
LRG
A
AYLL
A
D
---
G
T
T
---
V--
-
INSNI
N
-
---
F
E
W
I
G
N
NY
L
GP
V
-
P
WLVV
I
A
L
A
VIVVCWF
I
LR
R
T
T
L
G
V
H
I
Y
AVG
S
N
MQ
AARL
T
GI
K
V
WLVL
L
F
V
Y
G
M
SGLL
S
GLG
GI
M
S
A
S
RL
Y
SA
NGNL
G
M
GYELDAIAAV
I
L
GGTS
F
V
GG
I
G
T
I
T
GTL
V
G
A
LI
I
A
T
L
NNG
M
T
L
M
GV
S
Y
F
WQ
L
VI
KG
A
M
I
I
I
AVL
I
D
KY
R
fig|585057.4.peg.3878
Escherichia coli IAI39 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
VY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|585057.6.peg.3887
Escherichia coli IAI39 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
VY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|749527.3.peg.2175
Escherichia coli MS 21-1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
VY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|362663.8.peg.3373
Escherichia coli 536 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|362663.9.peg.3384
Escherichia coli 536 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|340197.3.peg.3957
Escherichia coli F11 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|340197.5.peg.4133
Escherichia coli F11 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|656417.3.peg.4090
Escherichia coli M605 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
VP
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|585396.4.peg.4219
Escherichia coli O111:H- str. 11128 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|685038.3.peg.3291
Escherichia coli O83:H1 str. NRG 857C (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|525281.3.peg.3775
Escherichia coli 83972 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|655817.3.peg.3831
Escherichia coli ABU 83972 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|199310.1.peg.3924
Escherichia coli CFT073 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|199310.4.peg.3780
Escherichia coli CFT073 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|585397.7.peg.3913
Escherichia coli ED1a (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|585397.9.peg.3910
Escherichia coli ED1a (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|749528.3.peg.4214
Escherichia coli MS 45-1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|753642.3.peg.4711
Escherichia coli NC101 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|562.376.peg.1642
Escherichia coli WV_060327 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|431946.3.peg.3218
Escherichia coli SE15 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|656440.3.peg.3488
Escherichia coli TA206 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
GG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|405955.13.peg.3670
Escherichia coli APEC O1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|405955.9.peg.3064
Escherichia coli APEC O1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|714962.3.peg.3708
Escherichia coli IHE3034 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|573235.3.peg.4461
Escherichia coli O26:H11 str. 11368 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
R
R
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|585035.6.peg.3570
Escherichia coli S88 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|869729.3.peg.23
Escherichia coli UM146 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|364106.7.peg.3643
Escherichia coli UTI89 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|364106.8.peg.3644
Escherichia coli UTI89 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
T
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|749550.3.peg.1315
Escherichia coli MS 200-1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
I
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
V
V
T
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|656419.3.peg.3317
Escherichia coli M718 (17-320/332)
K
Q
F
V
S
R
YI
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.371.peg.5417
Escherichia coli 1044A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.373.peg.3743
Escherichia coli 1125A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.372.peg.1966
Escherichia coli 1212A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.374.peg.3169
Escherichia coli 536A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|83334.1.peg.3412
Escherichia coli O157:H7 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|155864.1.peg.3410
Escherichia coli O157:H7 EDL933 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|155864.8.peg.3324
Escherichia coli O157:H7 EDL933 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444454.5.peg.2436
Escherichia coli O157:H7 str. EC4024 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444449.5.peg.1902
Escherichia coli O157:H7 str. EC4042 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444448.5.peg.656
Escherichia coli O157:H7 str. EC4045 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444453.5.peg.137
Escherichia coli O157:H7 str. EC4076 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444452.5.peg.1454
Escherichia coli O157:H7 str. EC4113 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444450.8.peg.3745
Escherichia coli O157:H7 str. EC4115 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444451.5.peg.1224
Escherichia coli O157:H7 str. EC4196 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|444447.5.peg.798
Escherichia coli O157:H7 str. EC4206 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|478004.5.peg.4412
Escherichia coli O157:H7 str. EC4401 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|478006.5.peg.1666
Escherichia coli O157:H7 str. EC4501 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|478007.5.peg.1710
Escherichia coli O157:H7 str. EC508 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|478008.5.peg.3102
Escherichia coli O157:H7 str. EC869 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|637388.3.peg.45
Escherichia coli O157:H7 str. FRIK2000 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|570506.3.peg.5288
Escherichia coli O157:H7 str. FRIK966 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|386585.9.peg.3565
Escherichia coli O157:H7 str. Sakai (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|544404.4.peg.3548
Escherichia coli O157:H7 str. TW14359 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|502346.5.peg.3867
Escherichia coli O157:H7 str. TW14588 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
H
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749545.3.peg.4811
Escherichia coli MS 182-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
SIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749532.3.peg.4451
Escherichia coli MS 78-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
SIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|431946.3.peg.2495
Escherichia coli SE15 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749537.3.peg.4127
Escherichia coli MS 115-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNS
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|216592.3.peg.2879
Escherichia coli 042 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|550676.3.peg.1750
Escherichia coli B185 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656379.3.peg.3181
Escherichia coli FVEC1302 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656380.3.peg.2630
Escherichia coli FVEC1412 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656393.3.peg.3560
Escherichia coli H299 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585034.4.peg.2570
Escherichia coli IAI1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585034.5.peg.2569
Escherichia coli IAI1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749549.3.peg.2365
Escherichia coli MS 198-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749531.3.peg.3834
Escherichia coli MS 69-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|701177.3.peg.3109
Escherichia coli O55:H7 str. CB9615 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|409438.11.peg.3002
Escherichia coli SE11 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656437.3.peg.2877
Escherichia coli TA143 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656444.3.peg.3547
Escherichia coli TA280 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585056.7.peg.3053
Escherichia coli UMN026 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|670888.3.peg.3742
Escherichia coli 1827-70 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|481805.3.peg.1210
Escherichia coli ATCC 8739 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|481805.6.peg.1208
Escherichia coli ATCC 8739 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|344610.3.peg.497
Escherichia coli 53638 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|344610.7.peg.3779
Escherichia coli 53638 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656408.3.peg.2839
Escherichia coli H591 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|331112.3.peg.2533
Escherichia coli HS (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|331112.6.peg.2643
Escherichia coli HS (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|679206.4.peg.562
Escherichia coli MS 119-7 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749533.3.peg.2235
Escherichia coli MS 84-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656443.3.peg.3307
Escherichia coli TA271 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|670897.3.peg.1169
Escherichia coli 2362-75 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|362663.8.peg.2580
Escherichia coli 536 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|362663.9.peg.2585
Escherichia coli 536 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|405955.13.peg.2826
Escherichia coli APEC O1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|405955.9.peg.2333
Escherichia coli APEC O1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585397.7.peg.2984
Escherichia coli ED1a (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585397.9.peg.2981
Escherichia coli ED1a (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340197.3.peg.2737
Escherichia coli F11 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340197.5.peg.2865
Escherichia coli F11 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585057.4.peg.2854
Escherichia coli IAI39 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585057.6.peg.2858
Escherichia coli IAI39 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|714962.3.peg.2936
Escherichia coli IHE3034 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656417.3.peg.3260
Escherichia coli M605 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749550.3.peg.419
Escherichia coli MS 200-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585035.6.peg.2686
Escherichia coli S88 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|439855.10.peg.2860
Escherichia coli SMS-3-5 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656440.3.peg.2591
Escherichia coli TA206 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|869729.3.peg.855
Escherichia coli UM146 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|364106.7.peg.2867
Escherichia coli UTI89 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|364106.8.peg.2866
Escherichia coli UTI89 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.376.peg.4457
Escherichia coli WV_060327 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|525281.3.peg.4319
Escherichia coli 83972 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|655817.3.peg.2968
Escherichia coli ABU 83972 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|199310.1.peg.2993
Escherichia coli CFT073 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|199310.4.peg.2894
Escherichia coli CFT073 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|753642.3.peg.2567
Escherichia coli NC101 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|685038.3.peg.2573
Escherichia coli O83:H1 str. NRG 857C (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|550677.3.peg.2430
Escherichia coli B354 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340186.3.peg.1500
Escherichia coli E110019 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340186.5.peg.1548
Escherichia coli E110019 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|595495.4.peg.3321
Escherichia coli KO11 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585396.4.peg.3375
Escherichia coli O111:H- str. 11128 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|573235.3.peg.3663
Escherichia coli O26:H11 str. 11368 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|566546.3.peg.3863
Escherichia coli W (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|566546.4.peg.2745
Escherichia coli W (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|358709.5.peg.2162
Escherichia coli 101-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|413997.3.peg.2556
Escherichia coli B str. REL606 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|511693.5.peg.2570
Escherichia coli BL21 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|469008.4.peg.1166
Escherichia coli BL21(DE3) (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|595496.3.peg.2529
Escherichia coli BW2952 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|536056.3.peg.1180
Escherichia coli DH1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|331111.12.peg.3110
Escherichia coli E24377A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|331111.3.peg.560
Escherichia coli E24377A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|316401.4.peg.3077
Escherichia coli ETEC H10407 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|656414.3.peg.2918
Escherichia coli H736 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|83333.1.peg.2516
Escherichia coli K12 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749538.3.peg.4852
Escherichia coli MS 116-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749540.3.peg.4583
Escherichia coli MS 146-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749547.3.peg.2406
Escherichia coli MS 187-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|316407.3.peg.2468
Escherichia coli W3110 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|316385.7.peg.2741
Escherichia coli str. K-12 substr. DH10B (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|511145.12.peg.2647
Escherichia coli str. K-12 substr. MG1655 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|511145.6.peg.2633
Escherichia coli str. K-12 substr. MG1655 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|1040638.4.peg.2974
Escherichia coli O104:H4 str. LB226692 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|6666666.5357.peg.2614
Escherichia coli TY-2482 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585055.6.peg.2868
Escherichia coli 55989 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585055.8.peg.2872
Escherichia coli 55989 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|344601.3.peg.1667
Escherichia coli B171 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|344601.5.peg.1741
Escherichia coli B171 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340185.3.peg.2405
Escherichia coli E22 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340185.4.peg.2545
Escherichia coli E22 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|562.375.peg.3535
Escherichia coli EC4100B (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|679207.4.peg.2659
Escherichia coli MS 107-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|679204.3.peg.1544
Escherichia coli MS 145-7 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|585395.4.peg.3213
Escherichia coli O103:H2 str. 12009 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749546.3.peg.1163
Escherichia coli MS 185-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FD
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFS
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PINEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
M
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
G
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|340184.3.peg.3984
Escherichia coli B7A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
G
F
II
V
V
AVL
A
N
fig|340184.6.peg.4166
Escherichia coli B7A (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
V
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
FAVGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
G
F
II
V
V
AVL
A
N
fig|679205.4.peg.1431
Escherichia coli MS 124-1 (11-320/332)
G
K
S
V
SL
K
Q
F
V
S
R
H
I
N
E
I
G
L
L
VV
I
A
I
L
Y
LV
F
S
LNA
--
P
G
F
I
S
L
NN
Q
M
N
V
L
R
D
A
A
TIG
I
A
A
W
A
MT
L
I
I
I
S
G
E
ID
V
SVG
PM
VA
F
VS
V
CL
A
F
LL
Q
------------
FE
VP
L
-------------
A
I
ACLL
VL
L
LGA
L
M
G
T
L
A
G
V
L
R
G
VFN
V
PS
F
V
A
TLG
L
W
SA
LRG
M
GLFM
TN
---
A
L
P
---
V--
-
PIDEN
E
V
---
L
D
WLG
-
G
Q
F
LGV
-
P
VSAL
IM
I
V
LFALFVF
I
SR
KT
A
FGR
S
V
XX
VGGN
AT
AA
Q
L
C
GINV
RRVR
I
L
I
F
T
LSGLLA
AVT
GIL
L
A
A
RL
G
S
G
NAGA
A
N
G
L
E
F
D
V
IAAVVVGGT
A
LSGG
R
G
S
L
F
GTL
L
GVL
V
I
T
L
I
G
NGL
V
LLG
I
N
S
F
F
Q
Q
V
V
R
GVII
V
V
AVL
A
N
fig|749546.3.peg.1833
Escherichia coli MS 185-1 (20-325/329)
F
K
K
V
F
R
Q
Y
G
G
I
L
SG
M
V
VL
I
I
L
F
S
FIN
--
D
S
F
F
T
A
NN
I
T
NI
I
L
Q
V
S
IIA
I
T
A
Y
GMT
Y
V
L
L
L
G
D
IDLSVG
ST
I
AL
IG
TF
AA
L
GA
S
------------
WG
I
P
F
-------------
V
L
LVPL
S
I
I
AA
L
A
L
G
M
I
N
G
G
L
T
A
IAG
I
PS
FI
V
T
V
A
T
M
GI
F
RGI
AYIV
T
D
---
G
M
P
---
I--
-
MIKD-
D
A
---
F
L
A
LG
N
G
E
F
L
YI
-
P
IPIW
I
L
I
I
LLLINHF
I
LT
KT
T
FGR
K
I
Y
IT
GGN
KE
AA
IY
SGINV
TRLK
I
K
VF
M
I
T
A
V
LA
GIS
G
MIL
A
S
RL
Y
S
G
QPNS
A
L
S
YELDAIAA
A
V
L
GGTSL
N
GG
Y
G
T
V
G
GT
V
I
G
A
L
T
I
G
V
INNG
M
N
L
M
N
V
P
Y
F
Y
Q
M
V
VKG
L
V
IL
V
AV
Y
F
D
VR
N
K
fig|444454.5.peg.541
Escherichia coli O157:H7 str. EC4024 (6-310/334)
L
K
H
R
E
A
L
LG
A
V
I
V
L
M
V
V
A
IGS
RV
P
S
F
I
A
P
G
NL
V
E
M
F
N
D
T
A
ILI
V
L
A
L
G
QM
M
V
L
LT
K
GIDLS
M
A
AN
L
AL
TG
MI
V
A
L
I
N
F
----------
HY
PD
VP
V
-------------
W
A
LLIL
A
S
A
LG
L
L
M
G
A
I
N
G
L
L
V
W
KLG
I
PA
I
V
V
TLG
T
M
SI
Y
RG
M
IFLL
S
G
---
-
-
-
---
--G
G
WVNSN
Q
M
GAD
F
L
G
L
P
R
AS
V
LG
L
-
P
VLSW
C
A
I
A
ALLLVGY
F
LR
Y
S
R
T
GR
A
L
Y
TA
GGN
AT
AA
YY
T
GIN
A
GKMQ
F
I
S
F
C
LSGLLA
GFC
G
Y
L
WI
S
R
F
A
V
A
YVDV
A
N
G
F
EL
Q
V
V
AA
C
V
I
GG
I
S
TM
GG
T
G
R
V
L
G
C
L
F
G
A
L
F
L
G
V
INN
A
L
P
VI
GV
S
P
F
WQ
M
A
I
S
G
T
V
I
V
I
AVL
L
N
ER
fig|6666666.5357.peg.496
Escherichia coli TY-2482 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
F
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|670897.3.peg.3122
Escherichia coli 2362-75 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|405955.13.peg.2366
Escherichia coli APEC O1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|405955.9.peg.1928
Escherichia coli APEC O1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|216593.1.peg.2601
Escherichia coli E2348/69 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585397.7.peg.2598
Escherichia coli ED1a (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585397.9.peg.2595
Escherichia coli ED1a (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585057.4.peg.2378
Escherichia coli IAI39 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585057.6.peg.2380
Escherichia coli IAI39 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|714962.3.peg.2425
Escherichia coli IHE3034 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656417.3.peg.2818
Escherichia coli M605 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585035.6.peg.2273
Escherichia coli S88 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|439855.10.peg.2462
Escherichia coli SMS-3-5 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656440.3.peg.2133
Escherichia coli TA206 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|869729.3.peg.1284
Escherichia coli UM146 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|364106.7.peg.2452
Escherichia coli UTI89 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|364106.8.peg.2453
Escherichia coli UTI89 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|362663.8.peg.2203
Escherichia coli 536 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|362663.9.peg.2207
Escherichia coli 536 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|525281.3.peg.3951
Escherichia coli 83972 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|655817.3.peg.2593
Escherichia coli ABU 83972 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|199310.1.peg.2613
Escherichia coli CFT073 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|199310.4.peg.2522
Escherichia coli CFT073 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340197.3.peg.207
Escherichia coli F11 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340197.5.peg.215
Escherichia coli F11 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749546.3.peg.2927
Escherichia coli MS 185-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749550.3.peg.1793
Escherichia coli MS 200-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
G
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749528.3.peg.2544
Escherichia coli MS 45-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|753642.3.peg.2944
Escherichia coli NC101 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|685038.3.peg.2206
Escherichia coli O83:H1 str. NRG 857C (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|431946.3.peg.2120
Escherichia coli SE15 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|1040638.4.peg.3222
Escherichia coli O104:H4 str. LB226692 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|216592.1.peg.2939
Escherichia coli 042 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|216592.3.peg.2485
Escherichia coli 042 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|358709.5.peg.591
Escherichia coli 101-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|670888.3.peg.4136
Escherichia coli 1827-70 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|344610.3.peg.1780
Escherichia coli 53638 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|344610.7.peg.4286
Escherichia coli 53638 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585055.6.peg.2431
Escherichia coli 55989 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585055.8.peg.2438
Escherichia coli 55989 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|481805.3.peg.1609
Escherichia coli ATCC 8739 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|481805.6.peg.1603
Escherichia coli ATCC 8739 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|413997.3.peg.2166
Escherichia coli B str. REL606 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|344601.3.peg.1380
Escherichia coli B171 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|344601.5.peg.1455
Escherichia coli B171 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|550676.3.peg.2444
Escherichia coli B185 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|550677.3.peg.1693
Escherichia coli B354 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340184.3.peg.461
Escherichia coli B7A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340184.6.peg.481
Escherichia coli B7A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|511693.5.peg.2174
Escherichia coli BL21 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|469008.4.peg.1559
Escherichia coli BL21(DE3) (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|595496.3.peg.2121
Escherichia coli BW2952 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|536056.3.peg.1589
Escherichia coli DH1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340186.3.peg.4294
Escherichia coli E110019 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340186.5.peg.4514
Escherichia coli E110019 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340185.3.peg.578
Escherichia coli E22 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|340185.4.peg.619
Escherichia coli E22 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|331111.12.peg.2727
Escherichia coli E24377A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|331111.3.peg.186
Escherichia coli E24377A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.375.peg.3128
Escherichia coli EC4100B (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|316401.4.peg.2613
Escherichia coli ETEC H10407 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656379.3.peg.2680
Escherichia coli FVEC1302 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656380.3.peg.2238
Escherichia coli FVEC1412 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656393.3.peg.3176
Escherichia coli H299 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656408.3.peg.2391
Escherichia coli H591 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656414.3.peg.2515
Escherichia coli H736 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|331112.3.peg.2140
Escherichia coli HS (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|331112.6.peg.2236
Escherichia coli HS (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585034.4.peg.2195
Escherichia coli IAI1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585034.5.peg.2191
Escherichia coli IAI1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|83333.1.peg.2123
Escherichia coli K12 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|595495.4.peg.292
Escherichia coli KO11 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656419.3.peg.2902
Escherichia coli M718 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|679207.4.peg.4100
Escherichia coli MS 107-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749538.3.peg.3291
Escherichia coli MS 116-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|679206.4.peg.2368
Escherichia coli MS 119-7 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|679205.4.peg.4944
Escherichia coli MS 124-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|679204.3.peg.177
Escherichia coli MS 145-7 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749540.3.peg.796
Escherichia coli MS 146-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749544.3.peg.1612
Escherichia coli MS 175-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749545.3.peg.4052
Escherichia coli MS 182-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749548.3.peg.2225
Escherichia coli MS 196-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749549.3.peg.1886
Escherichia coli MS 198-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749527.3.peg.137
Escherichia coli MS 21-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749531.3.peg.2000
Escherichia coli MS 69-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749532.3.peg.3427
Escherichia coli MS 78-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|749533.3.peg.364
Escherichia coli MS 84-1 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585395.4.peg.2743
Escherichia coli O103:H2 str. 12009 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585396.4.peg.2959
Escherichia coli O111:H- str. 11128 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|573235.3.peg.3127
Escherichia coli O26:H11 str. 11368 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|409438.11.peg.2568
Escherichia coli SE11 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656437.3.peg.2415
Escherichia coli TA143 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656443.3.peg.2851
Escherichia coli TA271 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|585056.7.peg.2661
Escherichia coli UMN026 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|566546.3.peg.1486
Escherichia coli W (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|566546.4.peg.2327
Escherichia coli W (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|316407.3.peg.2081
Escherichia coli W3110 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|316385.7.peg.2319
Escherichia coli str. K-12 substr. DH10B (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|511145.12.peg.2231
Escherichia coli str. K-12 substr. MG1655 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|511145.6.peg.2215
Escherichia coli str. K-12 substr. MG1655 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.371.peg.5003
Escherichia coli 1044A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.373.peg.3892
Escherichia coli 1125A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.372.peg.5626
Escherichia coli 1212A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.374.peg.3292
Escherichia coli 536A (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|83334.1.peg.3034
Escherichia coli O157:H7 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444454.5.peg.1958
Escherichia coli O157:H7 str. EC4024 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444449.5.peg.1419
Escherichia coli O157:H7 str. EC4042 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444448.5.peg.181
Escherichia coli O157:H7 str. EC4045 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444453.5.peg.1528
Escherichia coli O157:H7 str. EC4076 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444452.5.peg.3468
Escherichia coli O157:H7 str. EC4113 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444450.8.peg.3271
Escherichia coli O157:H7 str. EC4115 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444451.5.peg.855
Escherichia coli O157:H7 str. EC4196 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|444447.5.peg.313
Escherichia coli O157:H7 str. EC4206 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|478004.5.peg.4354
Escherichia coli O157:H7 str. EC4401 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|478006.5.peg.4171
Escherichia coli O157:H7 str. EC4501 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|478007.5.peg.3795
Escherichia coli O157:H7 str. EC508 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|478008.5.peg.4074
Escherichia coli O157:H7 str. EC869 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|637388.3.peg.438
Escherichia coli O157:H7 str. FRIK2000 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|570506.3.peg.4894
Escherichia coli O157:H7 str. FRIK966 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|386585.9.peg.3166
Escherichia coli O157:H7 str. Sakai (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|544404.4.peg.3074
Escherichia coli O157:H7 str. TW14359 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|502346.5.peg.4349
Escherichia coli O157:H7 str. TW14588 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|701177.3.peg.2711
Escherichia coli O55:H7 str. CB9615 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|562.376.peg.4067
Escherichia coli WV_060327 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQD
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
V
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
I
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVVFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
IN
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|155864.1.peg.3039
Escherichia coli O157:H7 EDL933 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
I
X
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|155864.8.peg.2924
Escherichia coli O157:H7 EDL933 (12-331/336)
Y
L
K
E
G
G
I
Y
VV
L
L
VL
L
AI
I
I
FQA
--
P
T
F
L
S
L
L
NL
S
NIL
T
Q
S
S
VRI
I
I
A
L
G
VA
G
L
I
V
T
Q
G
T
DLS
A
G
RQ
V
G
L
AA
VVAA
T
LL
Q
SMDNANKVFPEM
AT
M
P
I
-------------
A
L
VILI
V
C
A
I
GA
V
IG
L
I
N
G
L
I
I
A
YLN
V
TP
FI
T
TLG
T
M
II
VY
GI
NSLY
YDFVG
A
S
P
ISG
FDS
G
FSTFA
Q
G
---
F
V
A
LG
S
F
R
L
SYI
-
-
--TF
YA
L
I
AVAFVWV
L
WN
KT
R
FG
K
N
IFA
I
GGN
PE
AA
K
V
SG
V
NV
GLNL
L
M
IY
A
LSG
VFY
AFG
G
M
LEA
G
R
I
G
SA
TNNL
G
F
M
YELDAIAA
C
VVGG
V
S
F
SGG
V
G
T
V
I
G
VV
T
GV
I
I
F
T
V
I
X
Y
GL
T
Y
I
GVN
P
YWQ
Y
I
I
KG
A
II
I
F
AV
A
L
D
SL
K
fig|656408.3.peg.1678
Escherichia coli H591 (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
E
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|679206.4.peg.3272
Escherichia coli MS 119-7 (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
E
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|656443.3.peg.1867
Escherichia coli TA271 (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
E
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|340184.3.peg.42
Escherichia coli B7A (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
Q
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|340184.6.peg.47
Escherichia coli B7A (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
Q
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|562.375.peg.3847
Escherichia coli EC4100B (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
Q
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|679204.3.peg.3855
Escherichia coli MS 145-7 (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
Q
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
fig|409438.11.peg.1744
Escherichia coli SE11 (10-306/342)
E
I
T
A
L
LA
V
V
L
L
F
VF
P
G
FLD
--
R
Q
Y
L
S
V
QT
L
T
M
V
Y
S
S
A
Q
ILI
L
L
A
M
G
A
T
L
V
M
LT
R
N
ID
V
SVG
SI
T
G
M
CA
V
L
L
G
M
LL
N
------------
AG
YS
L
-------------
P
V
ACVA
T
L
L
LG
L
L
A
G
F
F
N
G
V
L
V
A
WLK
I
PA
I
V
A
TLG
T
L
GL
Y
RGI
MLLW
T
G
---
G
K
W
I
E
G
LPA
E
-----
-
-
---
L
K
Q
L
S
A
PL
L
F
GV
-
S
AIGW
L
T
I
I
LVAFMAW
L
LA
KT
A
FGR
S
F
Y
A
T
G
D
N
LQ
G
AR
QL
G
V
RT
EAIR
I
V
A
F
S
L
N
G
C
M
A
ALA
GI
V
F
A
S
Q
I
G
FI
PNQT
G
T
G
L
E
M
K
AIAA
C
V
L
GG
I
SL
L
GG
S
G
A
I
I
G
A
V
L
G
A
WF
L
T
Q
I
DS
V
L
V
LL
R
I
P
A
W
W
N
D
F
I
A
G
L
V
L
L
A
V
LV
F
D
GR
Consen1
Primary consensus
MmTt
k
s
kyF
k
wl
e
g
l
l
vL
ai
s
--
P
F
s
nNl
Nil
qas
I
A
gmt
vIlt
giDlSvG
val
vvaA
ll
------------
vp
-------------
l
vl
lGa
iG
i
G
i
a
v
Fi
TLg
m
lrGi
tn
---
a
P
---
g
d
---
f
wlG
gr
lgv
-
p
im
i
i
kT
fGr
ifAvGGN
AarlsGiNV
i
iy
lsGlla
Gilea
Rl
Sa
g
gyElDaIAAvVvGGtslsGG
G
i
Gtl
Gvli
t
innGl
llGvn
ywQ
ivkgviIl
AVl
d
kq
Consen2
Secondary consensus
t
s
t
v
rq
s
y
k
y
i
i
lv
i
t
l
q
vi
d
a
ava
s
et
v
a
lgf
acl
v
smdnankvfpem
n
ac
i
l
l
g
i
v
v
w
vy
ydfvgg
isg
-
l
af
f
syi
-
ya
v
h
l
k
vy
t
vc
v
l
vf
ic
vfy
milv
i
g
a
ml
f
v
c
l
vaf
vv
aiv
g
lgy
m
y
is
f
viraav
a
n
k
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character