fig|340185.3.peg.2302
Escherichia coli E22
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LL
P
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340185.4.peg.2436
Escherichia coli E22
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LL
P
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|1040638.4.peg.1322
Escherichia coli O104:H4 str. LB226692
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|358709.5.peg.3006
Escherichia coli 101-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|344610.3.peg.2258
Escherichia coli 53638
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|344610.7.peg.2286
Escherichia coli 53638
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585055.6.peg.4412
Escherichia coli 55989
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585055.8.peg.4415
Escherichia coli 55989
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|481805.3.peg.4427
Escherichia coli ATCC 8739
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|481805.6.peg.4406
Escherichia coli ATCC 8739
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340184.3.peg.1503
Escherichia coli B7A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340184.6.peg.1582
Escherichia coli B7A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|595496.3.peg.3906
Escherichia coli BW2952
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|536056.3.peg.4339
Escherichia coli DH1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340186.3.peg.1209
Escherichia coli E110019
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340186.5.peg.1250
Escherichia coli E110019
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|331112.3.peg.3860
Escherichia coli HS
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|331112.6.peg.4026
Escherichia coli HS
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585034.4.peg.4003
Escherichia coli IAI1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585034.5.peg.4000
Escherichia coli IAI1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|83333.1.peg.3826
Escherichia coli K12
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656419.3.peg.5011
Escherichia coli M718
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|679204.3.peg.3707
Escherichia coli MS 145-7
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749544.3.peg.551
Escherichia coli MS 175-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749545.3.peg.1078
Escherichia coli MS 182-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749547.3.peg.3770
Escherichia coli MS 187-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749532.3.peg.2947
Escherichia coli MS 78-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656443.3.peg.4864
Escherichia coli TA271
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656444.3.peg.5250
Escherichia coli TA280
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|316407.3.peg.3239
Escherichia coli W3110
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|316385.5.peg.4040
Escherichia coli str. K-12 substr. DH10B
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|316385.7.peg.4125
Escherichia coli str. K-12 substr. DH10B
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|511145.12.peg.4021
Escherichia coli str. K-12 substr. MG1655
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|511145.6.peg.4004
Escherichia coli str. K-12 substr. MG1655
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|413997.3.peg.3983
Escherichia coli B str. REL606
MTVLHSV
-----
DFF
P
S
GN
V
S
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|511693.5.peg.4000
Escherichia coli BL21
MTVLHSV
-----
DFF
P
S
GN
V
S
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|469008.4.peg.4285
Escherichia coli BL21(DE3)
MTVLHSV
-----
DFF
P
S
GN
V
S
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|550672.3.peg.3982
Escherichia coli B088
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|344601.3.peg.1718
Escherichia coli B171
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|344601.5.peg.1797
Escherichia coli B171
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|679207.4.peg.4238
Escherichia coli MS 107-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|679205.4.peg.1902
Escherichia coli MS 124-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749533.3.peg.3969
Escherichia coli MS 84-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|409438.11.peg.4370
Escherichia coli SE11
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.375.peg.76
Escherichia coli EC4100B
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656408.3.peg.4384
Escherichia coli H591
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|595495.4.peg.3502
Escherichia coli KO11
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|679206.4.peg.3513
Escherichia coli MS 119-7
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|566546.3.peg.3907
Escherichia coli W
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|566546.4.peg.4154
Escherichia coli W
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
N
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|316401.4.peg.4737
Escherichia coli ETEC H10407
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
A
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|331111.12.peg.4658
Escherichia coli E24377A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTG
V
T
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|331111.3.peg.2057
Escherichia coli E24377A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VA
E
QF
SLS
L
R
T
L
HR
Q
L
K
QQTG
V
T
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|216592.1.peg.4601
Escherichia coli 042
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|216592.3.peg.4439
Escherichia coli 042
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|550677.3.peg.4486
Escherichia coli B354
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.371.peg.1910
Escherichia coli 1044A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.373.peg.2583
Escherichia coli 1125A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.372.peg.3692
Escherichia coli 1212A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.374.peg.3573
Escherichia coli 536A
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|550676.3.peg.4120
Escherichia coli B185
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|83334.1.peg.4806
Escherichia coli O157:H7
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|155864.1.peg.4843
Escherichia coli O157:H7 EDL933
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|155864.8.peg.4808
Escherichia coli O157:H7 EDL933
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444454.5.peg.3932
Escherichia coli O157:H7 str. EC4024
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444449.5.peg.3388
Escherichia coli O157:H7 str. EC4042
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444448.5.peg.2143
Escherichia coli O157:H7 str. EC4045
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444453.5.peg.2284
Escherichia coli O157:H7 str. EC4076
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444452.5.peg.1826
Escherichia coli O157:H7 str. EC4113
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444450.8.peg.5225
Escherichia coli O157:H7 str. EC4115
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444451.5.peg.2873
Escherichia coli O157:H7 str. EC4196
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|444447.5.peg.2308
Escherichia coli O157:H7 str. EC4206
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|478004.5.peg.2358
Escherichia coli O157:H7 str. EC4401
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|478005.5.peg.2208
Escherichia coli O157:H7 str. EC4486
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|478006.5.peg.2203
Escherichia coli O157:H7 str. EC4501
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|478008.5.peg.2030
Escherichia coli O157:H7 str. EC869
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|637388.3.peg.598
Escherichia coli O157:H7 str. FRIK2000
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|570506.3.peg.3190
Escherichia coli O157:H7 str. FRIK966
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|386585.9.peg.5050
Escherichia coli O157:H7 str. Sakai
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|544404.4.peg.5035
Escherichia coli O157:H7 str. TW14359
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|502346.5.peg.1773
Escherichia coli O157:H7 str. TW14588
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|701177.3.peg.4717
Escherichia coli O55:H7 str. CB9615
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YH
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|525281.3.peg.3389
Escherichia coli 83972
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|655817.3.peg.4601
Escherichia coli ABU 83972
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|199310.1.peg.4752
Escherichia coli CFT073
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|199310.4.peg.4557
Escherichia coli CFT073
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749546.3.peg.2614
Escherichia coli MS 185-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749528.3.peg.1057
Escherichia coli MS 45-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656440.3.peg.4448
Escherichia coli TA206
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
YSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|670897.3.peg.4989
Escherichia coli 2362-75
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|362663.8.peg.4145
Escherichia coli 536
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|362663.9.peg.4161
Escherichia coli 536
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|216593.1.peg.4737
Escherichia coli E2348/69
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340197.3.peg.2777
Escherichia coli F11
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|340197.5.peg.2907
Escherichia coli F11
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656417.3.peg.4814
Escherichia coli M605
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749550.3.peg.2786
Escherichia coli MS 200-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|753642.3.peg.1981
Escherichia coli NC101
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|574521.7.peg.4302
Escherichia coli O127:H6 str. E2348/69
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|685038.3.peg.3977
Escherichia coli O83:H1 str. NRG 857C
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|431946.3.peg.3918
Escherichia coli SE15
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656437.3.peg.4395
Escherichia coli TA143
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|562.376.peg.1432
Escherichia coli WV_060327
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749537.3.peg.2711
Escherichia coli MS 115-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAG
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749531.3.peg.3402
Escherichia coli MS 69-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656414.3.peg.4442
Escherichia coli H736
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
D
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
C
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749540.3.peg.1653
Escherichia coli MS 146-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
D
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
C
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585397.7.peg.4598
Escherichia coli ED1a
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
Y
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
M
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585397.9.peg.4595
Escherichia coli ED1a
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
Y
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
M
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749527.3.peg.3107
Escherichia coli MS 21-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|439855.10.peg.4428
Escherichia coli SMS-3-5
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|405955.13.peg.4372
Escherichia coli APEC O1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|405955.9.peg.3674
Escherichia coli APEC O1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656379.3.peg.5149
Escherichia coli FVEC1302
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656380.3.peg.5041
Escherichia coli FVEC1412
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585057.4.peg.3198
Escherichia coli IAI39
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585057.6.peg.3204
Escherichia coli IAI39
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|714962.3.peg.4405
Escherichia coli IHE3034
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585035.6.peg.4270
Escherichia coli S88
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|585056.7.peg.4603
Escherichia coli UMN026
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|364106.7.peg.4376
Escherichia coli UTI89
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|364106.8.peg.4378
Escherichia coli UTI89
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|656393.3.peg.5095
Escherichia coli H299
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
LF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|869729.3.peg.4240
Escherichia coli UM146
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
A
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749549.3.peg.711
Escherichia coli MS 198-1
MTVLHSV
-----
DFF
P
S
GNAS
VAIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QEQD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EE
K
NV
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
Q
K
TGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|749548.3.peg.2050
Escherichia coli MS 196-1
M
AIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
D
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|670888.3.peg.2317
Escherichia coli 1827-70
M
AIE
P
R
L
PQ
AD
F
P
EH
H
HDF
H
E
I
VIV
EH
G
T
G
I
HV
F
N
G
Q
PY
T
IT
G
G
T
V
CFVR
D
H
D
R
H
L
Y
EH
T
DN
LCL
T
N
V
L
Y
RS
P
D
R
F
Q
F
LAG
L
NQL
LP
--
QELD
GQ
YP
S
HWR
V
N
HSVLQ
Q
V
RQ
L
V
A
Q
M
E
Q
Q
EG
E
ND
L
P
S
--
TAS
RE
I
LF
M
QL
L
LLL
R
K
S
SL
QEN---
L
E
NS
A
SR
-------------
L
N
L
LL
AW
L
E
D
H
FADEVNW
E
A
VAD
QF
SLS
L
R
T
L
HR
Q
L
K
QQTGLT
PQ
R
YL
NR
L
R
L
M
K
AR
H
LL
R
HS
EA
S
V
T
DIA
YR
CGF
S
DSN
H
FS
TL
F
R
RE
F
NW
SP
R
D
I
R
Q
GRDGFLQ
fig|216593.1.peg.4738
Escherichia coli E2348/69 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|358709.5.peg.3005
Escherichia coli 101-1 (30-306/312)
TV
V
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|413997.3.peg.3984
Escherichia coli B str. REL606 (30-306/312)
TV
V
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|511693.5.peg.4001
Escherichia coli BL21 (30-306/312)
TV
V
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|469008.4.peg.4284
Escherichia coli BL21(DE3) (30-306/312)
TV
V
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749547.3.peg.3769
Escherichia coli MS 187-1 (30-306/312)
TV
V
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656444.3.peg.5251
Escherichia coli TA280 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QRA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656379.3.peg.5150
Escherichia coli FVEC1302 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QRA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656380.3.peg.5042
Escherichia coli FVEC1412 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QRA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749549.3.peg.710
Escherichia coli MS 198-1 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QRA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585056.7.peg.4604
Escherichia coli UMN026 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QRA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585397.7.peg.4599
Escherichia coli ED1a (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585397.9.peg.4596
Escherichia coli ED1a (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|574521.7.peg.4303
Escherichia coli O127:H6 str. E2348/69 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|550672.3.peg.3983
Escherichia coli B088 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|199310.1.peg.4753
Escherichia coli CFT073 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656437.3.peg.4396
Escherichia coli TA143 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
I
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|478005.5.peg.2209
Escherichia coli O157:H7 str. EC4486 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|753642.3.peg.1980
Escherichia coli NC101 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|550676.3.peg.4121
Escherichia coli B185 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656393.3.peg.5096
Escherichia coli H299 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|550677.3.peg.4487
Escherichia coli B354 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.376.peg.1431
Escherichia coli WV_060327 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQ
T
VA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|525281.3.peg.3388
Escherichia coli 83972 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|655817.3.peg.4602
Escherichia coli ABU 83972 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|344601.3.peg.1717
Escherichia coli B171 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|199310.4.peg.4558
Escherichia coli CFT073 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340185.3.peg.2301
Escherichia coli E22 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340185.4.peg.2435
Escherichia coli E22 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|331111.12.peg.4659
Escherichia coli E24377A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|331111.3.peg.2058
Escherichia coli E24377A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340197.3.peg.2778
Escherichia coli F11 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749537.3.peg.2712
Escherichia coli MS 115-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|679205.4.peg.1903
Escherichia coli MS 124-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749545.3.peg.1077
Escherichia coli MS 182-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749546.3.peg.2613
Escherichia coli MS 185-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749550.3.peg.2787
Escherichia coli MS 200-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749528.3.peg.1058
Escherichia coli MS 45-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749532.3.peg.2948
Escherichia coli MS 78-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749533.3.peg.3970
Escherichia coli MS 84-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585395.4.peg.4839
Escherichia coli O103:H2 str. 12009 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|685038.3.peg.3978
Escherichia coli O83:H1 str. NRG 857C (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|409438.11.peg.4371
Escherichia coli SE11 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|431946.3.peg.3919
Escherichia coli SE15 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|670897.3.peg.4988
Escherichia coli 2362-75 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
N
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
D
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.371.peg.1909
Escherichia coli 1044A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.373.peg.2584
Escherichia coli 1125A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.372.peg.3691
Escherichia coli 1212A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.374.peg.3574
Escherichia coli 536A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585055.6.peg.4413
Escherichia coli 55989 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585055.8.peg.4416
Escherichia coli 55989 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340184.3.peg.1504
Escherichia coli B7A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340184.6.peg.1583
Escherichia coli B7A (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656408.3.peg.4385
Escherichia coli H591 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656417.3.peg.4815
Escherichia coli M605 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656419.3.peg.5012
Escherichia coli M718 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|679207.4.peg.4239
Escherichia coli MS 107-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|679204.3.peg.3708
Escherichia coli MS 145-7 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749531.3.peg.3403
Escherichia coli MS 69-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|83334.1.peg.4807
Escherichia coli O157:H7 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|155864.1.peg.4844
Escherichia coli O157:H7 EDL933 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|155864.8.peg.4809
Escherichia coli O157:H7 EDL933 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444454.5.peg.3933
Escherichia coli O157:H7 str. EC4024 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444453.5.peg.2285
Escherichia coli O157:H7 str. EC4076 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444452.5.peg.1825
Escherichia coli O157:H7 str. EC4113 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444450.8.peg.5226
Escherichia coli O157:H7 str. EC4115 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444451.5.peg.2872
Escherichia coli O157:H7 str. EC4196 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444447.5.peg.2309
Escherichia coli O157:H7 str. EC4206 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|478004.5.peg.2359
Escherichia coli O157:H7 str. EC4401 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|478006.5.peg.2202
Escherichia coli O157:H7 str. EC4501 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|478007.5.peg.2258
Escherichia coli O157:H7 str. EC508 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|478008.5.peg.2031
Escherichia coli O157:H7 str. EC869 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|637388.3.peg.599
Escherichia coli O157:H7 str. FRIK2000 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|570506.3.peg.3191
Escherichia coli O157:H7 str. FRIK966 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|386585.9.peg.5051
Escherichia coli O157:H7 str. Sakai (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|544404.4.peg.5036
Escherichia coli O157:H7 str. TW14359 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|502346.5.peg.1772
Escherichia coli O157:H7 str. TW14588 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|701177.3.peg.4718
Escherichia coli O55:H7 str. CB9615 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|481805.3.peg.4426
Escherichia coli ATCC 8739 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|316385.5.peg.4041
Escherichia coli str. K-12 substr. DH10B (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|216592.1.peg.4600
Escherichia coli 042 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
N
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|405955.9.peg.3675
Escherichia coli APEC O1 (37-313/319)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|362663.8.peg.4146
Escherichia coli 536 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|362663.9.peg.4162
Escherichia coli 536 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|344601.5.peg.1796
Escherichia coli B171 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340197.5.peg.2908
Escherichia coli F11 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656440.3.peg.4449
Escherichia coli TA206 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
S
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|637912.3.peg.2446
Escherichia coli OP50 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
G
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|405955.13.peg.4373
Escherichia coli APEC O1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|714962.3.peg.4406
Escherichia coli IHE3034 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|869729.3.peg.4241
Escherichia coli UM146 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|364106.7.peg.4377
Escherichia coli UTI89 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|364106.8.peg.4379
Escherichia coli UTI89 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|670888.3.peg.2316
Escherichia coli 1827-70 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|481805.6.peg.4405
Escherichia coli ATCC 8739 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|595496.3.peg.3907
Escherichia coli BW2952 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|536056.3.peg.4338
Escherichia coli DH1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|316401.4.peg.4738
Escherichia coli ETEC H10407 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656414.3.peg.4443
Escherichia coli H736 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|331112.3.peg.3861
Escherichia coli HS (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|331112.6.peg.4027
Escherichia coli HS (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|83333.1.peg.3827
Escherichia coli K12 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749544.3.peg.552
Escherichia coli MS 175-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|316407.3.peg.3238
Escherichia coli W3110 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|316385.7.peg.4126
Escherichia coli str. K-12 substr. DH10B (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|511145.12.peg.4022
Escherichia coli str. K-12 substr. MG1655 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|511145.6.peg.4005
Escherichia coli str. K-12 substr. MG1655 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|216592.3.peg.4440
Escherichia coli 042 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
N
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444449.5.peg.3389
Escherichia coli O157:H7 str. EC4042 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|444448.5.peg.2144
Escherichia coli O157:H7 str. EC4045 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|6666666.5357.peg.1164
Escherichia coli TY-2482 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|562.375.peg.75
Escherichia coli EC4100B (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585034.4.peg.4004
Escherichia coli IAI1 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585034.5.peg.4001
Escherichia coli IAI1 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|679206.4.peg.3514
Escherichia coli MS 119-7 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|656443.3.peg.4865
Escherichia coli TA271 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749538.3.peg.793
Escherichia coli MS 116-1 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749540.3.peg.1654
Escherichia coli MS 146-1 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749548.3.peg.2051
Escherichia coli MS 196-1 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
NASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585396.4.peg.4903
Escherichia coli O111:H- str. 11128 (41-306/312)
DFFASDQQAVA
VA
D
R
Y
PQ
HV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
A
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|573235.3.peg.4808
Escherichia coli O26:H11 str. 11368 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
HV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
A
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585057.4.peg.3197
Escherichia coli IAI39 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMV
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
H
T
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|585057.6.peg.3203
Escherichia coli IAI39 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMV
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
H
T
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|595495.4.peg.3501
Escherichia coli KO11 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELL
I
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|566546.3.peg.3906
Escherichia coli W (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELL
I
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|566546.4.peg.4155
Escherichia coli W (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QARQ
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELL
I
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|439855.10.peg.4429
Escherichia coli SMS-3-5 (11-276/282)
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
S
L
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340186.3.peg.1210
Escherichia coli E110019 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QA
W
Q
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|340186.5.peg.1251
Escherichia coli E110019 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SVGMA
QA
W
Q
V
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
LL
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
LA
A
S
LKSPFAL
D
K
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|749527.3.peg.3106
Escherichia coli MS 21-1 (30-306/312)
TV
A
H
QLKLLKD
DFFASDQQAVA
VA
D
R
Y
PQ
DV
F
A
EH
T
HDF
C
E
L
VIV
WR
G
N
G
L
HV
L
N
D
R
PY
R
IT
R
G
D
L
FYIH
A
D
D
K
H
S
Y
AS
V
ND
L
V
L
Q
N
I
IY
-C
P
E
RL
K
L
NLD
W
QGA
I
P
GF
SASA
GQ
--
P
HWR
L
G
SMGMA
QARQ
I
I
G
Q
L
E
H
E
SS
Q
HV
P
F
A
--
NEM
A
ELLF
G
QL
V
M
S
L
N
R
H
RY
TSDSLP
P
T
S
S
E
TL
-------------
L
D
K
L
I
TR
L
V
A
S
LKSPFAL
D
E
FC
D
EA
S
C
S
E
R
V
L
RQ
QF
R
QQTG
M
T
IN
QYL
RQ
V
R
V
C
HA
Q
Y
LL
Q
HS
RL
L
I
S
DI
S
TE
CGF
E
DSN
Y
FS
VV
F
T
RE
T
GM
T
P
S
Q
W
R
H
fig|362663.8.peg.4395
Escherichia coli 536 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|362663.9.peg.4411
Escherichia coli 536 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340197.3.peg.3468
Escherichia coli F11 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340197.5.peg.3635
Escherichia coli F11 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749550.3.peg.4438
Escherichia coli MS 200-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749531.3.peg.2381
Escherichia coli MS 69-1 (30-291/302)
IE
F
R
S
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
S
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|1040638.4.peg.1164
Escherichia coli O104:H4 str. LB226692 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|6666666.5357.peg.3966
Escherichia coli TY-2482 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|216592.1.peg.2421
Escherichia coli 042 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|216592.3.peg.4655
Escherichia coli 042 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|358709.5.peg.1869
Escherichia coli 101-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|670888.3.peg.4618
Escherichia coli 1827-70 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|670897.3.peg.1435
Escherichia coli 2362-75 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|344610.3.peg.1395
Escherichia coli 53638 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|344610.7.peg.2010
Escherichia coli 53638 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585055.6.peg.4634
Escherichia coli 55989 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585055.8.peg.4639
Escherichia coli 55989 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|525281.3.peg.1750
Escherichia coli 83972 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|655817.3.peg.4867
Escherichia coli ABU 83972 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|481805.3.peg.4198
Escherichia coli ATCC 8739 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|481805.6.peg.4185
Escherichia coli ATCC 8739 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|413997.3.peg.4208
Escherichia coli B str. REL606 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|550672.3.peg.4197
Escherichia coli B088 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|550677.3.peg.114
Escherichia coli B354 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340184.3.peg.714
Escherichia coli B7A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340184.6.peg.746
Escherichia coli B7A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|511693.5.peg.4229
Escherichia coli BL21 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|469008.4.peg.4061
Escherichia coli BL21(DE3) (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|595496.3.peg.4193
Escherichia coli BW2952 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|199310.1.peg.5016
Escherichia coli CFT073 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|199310.4.peg.4809
Escherichia coli CFT073 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|536056.3.peg.4113
Escherichia coli DH1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340186.3.peg.1044
Escherichia coli E110019 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340186.5.peg.1085
Escherichia coli E110019 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|216593.1.peg.3886
Escherichia coli E2348/69 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|331111.12.peg.4880
Escherichia coli E24377A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|331111.3.peg.2271
Escherichia coli E24377A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.375.peg.2960
Escherichia coli EC4100B (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|316401.4.peg.5030
Escherichia coli ETEC H10407 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656379.3.peg.491
Escherichia coli FVEC1302 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656380.3.peg.483
Escherichia coli FVEC1412 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656393.3.peg.234
Escherichia coli H299 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656408.3.peg.4615
Escherichia coli H591 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656414.3.peg.4678
Escherichia coli H736 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|331112.3.peg.4073
Escherichia coli HS (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|331112.6.peg.4247
Escherichia coli HS (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585034.4.peg.4226
Escherichia coli IAI1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585034.5.peg.4221
Escherichia coli IAI1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585057.4.peg.4682
Escherichia coli IAI39 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585057.6.peg.4691
Escherichia coli IAI39 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|83333.1.peg.4030
Escherichia coli K12 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|595495.4.peg.4121
Escherichia coli KO11 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656419.3.peg.5365
Escherichia coli M718 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|679207.4.peg.3006
Escherichia coli MS 107-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749537.3.peg.4289
Escherichia coli MS 115-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749538.3.peg.1248
Escherichia coli MS 116-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|679206.4.peg.978
Escherichia coli MS 119-7 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|679205.4.peg.4494
Escherichia coli MS 124-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|679204.3.peg.3961
Escherichia coli MS 145-7 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749540.3.peg.1306
Escherichia coli MS 146-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749544.3.peg.101
Escherichia coli MS 175-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749545.3.peg.2422
Escherichia coli MS 182-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749546.3.peg.1612
Escherichia coli MS 185-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749547.3.peg.2664
Escherichia coli MS 187-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749548.3.peg.12
Escherichia coli MS 196-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749549.3.peg.1648
Escherichia coli MS 198-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749527.3.peg.5037
Escherichia coli MS 21-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749528.3.peg.3739
Escherichia coli MS 45-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749532.3.peg.4577
Escherichia coli MS 78-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|749533.3.peg.4384
Escherichia coli MS 84-1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585396.4.peg.5193
Escherichia coli O111:H- str. 11128 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|574521.7.peg.4547
Escherichia coli O127:H6 str. E2348/69 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|637912.3.peg.2502
Escherichia coli OP50 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|409438.11.peg.4598
Escherichia coli SE11 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|431946.3.peg.4160
Escherichia coli SE15 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|439855.10.peg.4696
Escherichia coli SMS-3-5 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656437.3.peg.4628
Escherichia coli TA143 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656440.3.peg.4691
Escherichia coli TA206 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656443.3.peg.5104
Escherichia coli TA271 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|656444.3.peg.5577
Escherichia coli TA280 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585056.7.peg.4814
Escherichia coli UMN026 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|566546.3.peg.2191
Escherichia coli W (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|566546.4.peg.4414
Escherichia coli W (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|316407.3.peg.3955
Escherichia coli W3110 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.376.peg.1791
Escherichia coli WV_060327 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|316385.5.peg.4263
Escherichia coli str. K-12 substr. DH10B (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|316385.7.peg.4352
Escherichia coli str. K-12 substr. DH10B (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|511145.12.peg.4249
Escherichia coli str. K-12 substr. MG1655 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|511145.6.peg.4228
Escherichia coli str. K-12 substr. MG1655 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|573235.3.peg.5400
Escherichia coli O26:H11 str. 11368 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
K
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|550676.3.peg.4393
Escherichia coli B185 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
S
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|344601.3.peg.1151
Escherichia coli B171 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
A
HKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|344601.5.peg.1215
Escherichia coli B171 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
A
HKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340185.3.peg.1411
Escherichia coli E22 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
A
HKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|340185.4.peg.1494
Escherichia coli E22 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
A
HKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585395.4.peg.5114
Escherichia coli O103:H2 str. 12009 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
A
HKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.371.peg.3636
Escherichia coli 1044A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.373.peg.5767
Escherichia coli 1125A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.372.peg.3422
Escherichia coli 1212A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|562.374.peg.2757
Escherichia coli 536A (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|83334.1.peg.5078
Escherichia coli O157:H7 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444454.5.peg.4182
Escherichia coli O157:H7 str. EC4024 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444449.5.peg.3636
Escherichia coli O157:H7 str. EC4042 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444448.5.peg.2393
Escherichia coli O157:H7 str. EC4045 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444453.5.peg.2030
Escherichia coli O157:H7 str. EC4076 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444452.5.peg.1133
Escherichia coli O157:H7 str. EC4113 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444450.8.peg.5472
Escherichia coli O157:H7 str. EC4115 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444451.5.peg.2134
Escherichia coli O157:H7 str. EC4196 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|444447.5.peg.2559
Escherichia coli O157:H7 str. EC4206 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|478004.5.peg.2082
Escherichia coli O157:H7 str. EC4401 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|478005.5.peg.612
Escherichia coli O157:H7 str. EC4486 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|478006.5.peg.1496
Escherichia coli O157:H7 str. EC4501 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|478007.5.peg.1041
Escherichia coli O157:H7 str. EC508 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|478008.5.peg.145
Escherichia coli O157:H7 str. EC869 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|637388.3.peg.2358
Escherichia coli O157:H7 str. FRIK2000 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|570506.3.peg.1365
Escherichia coli O157:H7 str. FRIK966 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|386585.9.peg.5330
Escherichia coli O157:H7 str. Sakai (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|544404.4.peg.5284
Escherichia coli O157:H7 str. TW14359 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|502346.5.peg.1539
Escherichia coli O157:H7 str. TW14588 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|701177.3.peg.4950
Escherichia coli O55:H7 str. CB9615 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|155864.1.peg.5059
Escherichia coli O157:H7 EDL933 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
X
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|155864.8.peg.5042
Escherichia coli O157:H7 EDL933 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
I
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
PN
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
X
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|405955.13.peg.4621
Escherichia coli APEC O1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|405955.9.peg.3907
Escherichia coli APEC O1 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585397.7.peg.4839
Escherichia coli ED1a (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585397.9.peg.4839
Escherichia coli ED1a (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|714962.3.peg.4660
Escherichia coli IHE3034 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|753642.3.peg.4016
Escherichia coli NC101 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|685038.3.peg.4220
Escherichia coli O83:H1 str. NRG 857C (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|585035.6.peg.4520
Escherichia coli S88 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|869729.3.peg.4471
Escherichia coli UM146 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|364106.7.peg.4594
Escherichia coli UTI89 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
fig|364106.8.peg.4593
Escherichia coli UTI89 (30-291/302)
IE
F
R
A
P
H
IM
P
T
S
H
W
H
GQ
V
EV
NVP
FD
G
D
V
E
YL
I
N
N
E
KV
N
I
N
Q
G
H
I
TLFW
A
C
T
P
H
Q
L
TD
T
GT
-
C
Q
S
M
A
I
F
NL
P
M
H
L
F
L
SWP
L
DKD
L
I
--
----
--
--
N
H
VT
H
G
MVIKS
L
A
T
Q
Q
L
S
P
F
E
V
R
RW
Q
QE
L
N
S
Q
N
EQI
R
Q
L
AI
D
EI
G
L
M
L
K
R
F
SL
SGWEPI
L
V
N
K
T
SR
THKNSVSRHAQFYV
S
Q
M
L
GF
I
A
E
N
YDQALTI
N
D
VA
E
HV
K
L
N
A
N
Y
A
MG
I
FQ
RVMQ
LT
MK
QY
I
TA
MRI
N
H
V
R
A
LL
S
DT
DK
SI
L
DIA
LT
A
GF
R
S
S
S
R
F
Y
ST
F
G
KY
V
GMSP
Q
Q
Y
R
K
Consen1
Primary consensus
MTVlHsv
-----
DFFaSdqqaVAie
R
Pq
f
eH
Hdf
Evviv
G
g
hv
N
epy
It
G
i
a
d
H
y
t
lcl
n
iy
P
rl
l
l
lp
--
gq
--
Hwr
g
qarQ
l
q
E
r
q
l
s
--
rellf
ql
llL
r
sl
l
ns
sr
-------------
ls
ll
la
n
d
vad
sls
r
l
qfqqqtglT
qYl
mRi
har
LL
hs
si
DIa
cGF
dSn
Fs
F
re
gmsP
q
R
GRDGFLQ
Consen2
Secondary consensus
a
qlkllkd
p
gnas
va
h
p
s
gq
nvp
v
yl
kv
n
d
t
l
v
-
vq
m
lf
hf
f
w
iigf
--
yp
vt
n
lvt
p
e
p
apn
aqiai
ei
mm
k
ry
p
sk
tlthknsvsrhaqfyv
mi
ie
n
fce
kcn
n
a
il
rvmqm
r
i
kvq
dt
lv
s
a
s
s
y
ky
nwt
d
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character