fig|1040638.4.peg.1292
Escherichia coli O104:H4 str. LB226692
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSFL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|6666666.5357.peg.1255
Escherichia coli TY-2482
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSFL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|585055.6.peg.4382
Escherichia coli 55989
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSFL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|585055.8.peg.4385
Escherichia coli 55989
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSFL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|670888.3.peg.2343
Escherichia coli 1827-70
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|550672.3.peg.3953
Escherichia coli B088
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|340186.3.peg.1179
Escherichia coli E110019
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|340186.5.peg.1220
Escherichia coli E110019
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|331112.3.peg.3836
Escherichia coli HS
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|331112.6.peg.4000
Escherichia coli HS
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|679207.4.peg.4207
Escherichia coli MS 107-1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|481805.3.peg.4451
Escherichia coli ATCC 8739
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CI
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|481805.6.peg.4431
Escherichia coli ATCC 8739
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CI
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|749527.3.peg.3137
Escherichia coli MS 21-1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|525281.3.peg.3414
Escherichia coli 83972
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|655817.3.peg.4573
Escherichia coli ABU 83972
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|199310.1.peg.4728
Escherichia coli CFT073
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|199310.4.peg.4533
Escherichia coli CFT073
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|749546.3.peg.757
Escherichia coli MS 185-1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|749528.3.peg.1237
Escherichia coli MS 45-1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|685038.3.peg.3953
Escherichia coli O83:H1 str. NRG 857C
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|656437.3.peg.4366
Escherichia coli TA143
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|656444.3.peg.5222
Escherichia coli TA280
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|362663.8.peg.4122
Escherichia coli 536
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|362663.9.peg.4138
Escherichia coli 536
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|405955.13.peg.4347
Escherichia coli APEC O1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|405955.9.peg.3653
Escherichia coli APEC O1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|340197.3.peg.4014
Escherichia coli F11
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|340197.5.peg.4189
Escherichia coli F11
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|656393.3.peg.5070
Escherichia coli H299
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|714962.3.peg.4381
Escherichia coli IHE3034
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|749550.3.peg.2761
Escherichia coli MS 200-1
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|585035.6.peg.4245
Escherichia coli S88
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|869729.3.peg.4213
Escherichia coli UM146
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|364106.7.peg.4351
Escherichia coli UTI89
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|364106.8.peg.4353
Escherichia coli UTI89
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|562.376.peg.1457
Escherichia coli WV_060327
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|562.375.peg.110
Escherichia coli EC4100B
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
ALL
F
Y
P
D
SD
P
FIG
L
I
A
A
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MA
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|550677.3.peg.4456
Escherichia coli B354
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SA
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
I
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|753642.3.peg.2006
Escherichia coli NC101
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
Y
QE
IG
IW
AP
L
V
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
SV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQST
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASYRYIREQSHEN
fig|670897.3.peg.5021
Escherichia coli 2362-75
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
H
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
PV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASY
C
YIREQSHEN
fig|216593.1.peg.4703
Escherichia coli E2348/69
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
H
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
PV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASY
C
YIREQSHEN
fig|574521.7.peg.4273
Escherichia coli O127:H6 str. E2348/69
MSEKLPAP
R
EG
-
LS
G
K
A
M
RR
V
VM
G
S
FA
G
AL
M
E
W
Y
DF
F
I
F
G
TA
A
GL
VF
APL
F
Y
P
D
SD
P
FIG
L
I
AS
F
ATF
GV
G
FL
T
RP
L
GG
I
VFGHFGD
K
I
GRK
IT
L
I
W
T
L
AIV
G
CS
T
FL
IG
FI
P
T
H
QE
IG
IW
AP
L
I
L
MV
L
R
LI
QG
F
GLGGE
Y
GGAAL
MTI
ESAP
ESR
R
GFL
G
S
LP
Q
T
A
AS
VG
IML
ATG
IFA
L
C
NHFL
T
S
EQF
L
SWGWR
I
PF
WL
S
A
V
M
L
I
V
G
L
FI
R
LH
T
E
E
T
LD
F
Q
K
QKTTN
N
KE
K
PV
P
---
P
LIEL
F
K
K
H
P
------
RNI
L
LALG
A
R
LA
ESVSSN
------------------
I
IN
A
FG
I
V
Y
ISSQ
----
LA
L
S
R
-
DIPLTG
ML
I
A
S
A
I
--------------------------------------
GIFSC
P
LV
G
W
L
S
D
R
I
G
Q
K
SL
Y
L
SGAGFCV
L
F
A
-
FPFF
L
L
L
DSK
S
TL
---
-
I
I
W
CSM
I
LG
YN
L
GPTMMF
A
VQPT
L
FT
R
M
F
G
T
KV
RYTG
LS
F
A
Y
QF
S
A
I
L
-
G
GL
S
P
L
IA
S
S
L
LA-
L
GG
G
KP
------
WY-
-
V
A
L
F
L
F
A
VSVL
S
F
V
CV
W
L
IE
P
T
DE
QETASY
C
YIREQSHEN
fig|656379.3.peg.2508
Escherichia coli FVEC1302 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALFGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656380.3.peg.3425
Escherichia coli FVEC1412 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALFGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585056.7.peg.2500
Escherichia coli UMN026 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALFGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585034.4.peg.2041
Escherichia coli IAI1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
ENK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
D
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585034.5.peg.2036
Escherichia coli IAI1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
ENK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
D
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|550676.3.peg.2297
Escherichia coli B185 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
I
TA
LL
MK
fig|362663.8.peg.1979
Escherichia coli 536 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|362663.9.peg.1984
Escherichia coli 536 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|525281.3.peg.502
Escherichia coli 83972 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|655817.3.peg.2358
Escherichia coli ABU 83972 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|550677.3.peg.1512
Escherichia coli B354 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|199310.1.peg.2378
Escherichia coli CFT073 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|199310.4.peg.2294
Escherichia coli CFT073 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340197.3.peg.4211
Escherichia coli F11 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340197.5.peg.4395
Escherichia coli F11 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656414.3.peg.2336
Escherichia coli H736 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|714962.3.peg.2199
Escherichia coli IHE3034 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656417.3.peg.2602
Escherichia coli M605 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749546.3.peg.526
Escherichia coli MS 185-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749550.3.peg.4163
Escherichia coli MS 200-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749527.3.peg.5509
Escherichia coli MS 21-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749528.3.peg.907
Escherichia coli MS 45-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|753642.3.peg.2323
Escherichia coli NC101 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|431946.3.peg.1918
Escherichia coli SE15 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656440.3.peg.1945
Escherichia coli TA206 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|869729.3.peg.1528
Escherichia coli UM146 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|364106.7.peg.2228
Escherichia coli UTI89 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|364106.8.peg.2229
Escherichia coli UTI89 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|1040638.4.peg.3529
Escherichia coli O104:H4 str. LB226692 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|6666666.5357.peg.2831
Escherichia coli TY-2482 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|344610.3.peg.4448
Escherichia coli 53638 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|344610.7.peg.4521
Escherichia coli 53638 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585055.6.peg.2252
Escherichia coli 55989 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585055.8.peg.2257
Escherichia coli 55989 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|405955.13.peg.2140
Escherichia coli APEC O1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|405955.9.peg.1747
Escherichia coli APEC O1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340186.3.peg.4162
Escherichia coli E110019 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340186.5.peg.4376
Escherichia coli E110019 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|679205.4.peg.2705
Escherichia coli MS 124-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749544.3.peg.2206
Escherichia coli MS 175-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749548.3.peg.882
Escherichia coli MS 196-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749531.3.peg.504
Escherichia coli MS 69-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749533.3.peg.146
Escherichia coli MS 84-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|685038.3.peg.2007
Escherichia coli O83:H1 str. NRG 857C (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585035.6.peg.2034
Escherichia coli S88 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|550672.3.peg.1719
Escherichia coli B088 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|409438.11.peg.2417
Escherichia coli SE11 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|670888.3.peg.4343
Escherichia coli 1827-70 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
M
YL
L
A
GCLI
S
A
I
TA
LL
MK
fig|331112.3.peg.1974
Escherichia coli HS (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
CM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|331112.6.peg.2058
Escherichia coli HS (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
CM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|670897.3.peg.2856
Escherichia coli 2362-75 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749538.3.peg.4607
Escherichia coli MS 116-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
G
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.376.peg.1003
Escherichia coli WV_060327 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340184.3.peg.4529
Escherichia coli B7A (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340184.6.peg.4747
Escherichia coli B7A (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340185.3.peg.5045
Escherichia coli E22 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|340185.4.peg.5344
Escherichia coli E22 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|595495.4.peg.4136
Escherichia coli KO11 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749532.3.peg.2340
Escherichia coli MS 78-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585395.4.peg.2552
Escherichia coli O103:H2 str. 12009 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|439855.10.peg.1307
Escherichia coli SMS-3-5 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|566546.3.peg.2582
Escherichia coli W (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|566546.4.peg.2140
Escherichia coli W (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|358709.5.peg.4888
Escherichia coli 101-1 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
M
YL
L
A
GCLI
S
A
I
TA
LL
MK
fig|481805.3.peg.1784
Escherichia coli ATCC 8739 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|481805.6.peg.1779
Escherichia coli ATCC 8739 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656393.3.peg.2968
Escherichia coli H299 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|656408.3.peg.2152
Escherichia coli H591 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|216592.1.peg.5529
Escherichia coli 042 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
V
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGM
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
I
TA
LL
MK
fig|216592.3.peg.2314
Escherichia coli 042 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
V
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGM
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
I
TA
LL
MK
fig|749545.3.peg.191
Escherichia coli MS 182-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
V
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGM
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
I
TA
LL
MK
fig|331111.12.peg.2546
Escherichia coli E24377A (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
F
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|331111.3.peg.9
Escherichia coli E24377A (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
F
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|216593.1.peg.2823
Escherichia coli E2348/69 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
T
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|574521.7.peg.2150
Escherichia coli O127:H6 str. E2348/69 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
T
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SIMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.371.peg.327
Escherichia coli 1044A (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.373.peg.4732
Escherichia coli 1125A (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.372.peg.298
Escherichia coli 1212A (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.374.peg.719
Escherichia coli 536A (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|83334.1.peg.2789
Escherichia coli O157:H7 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444454.5.peg.1555
Escherichia coli O157:H7 str. EC4024 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444449.5.peg.1049
Escherichia coli O157:H7 str. EC4042 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444448.5.peg.5336
Escherichia coli O157:H7 str. EC4045 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444453.5.peg.5313
Escherichia coli O157:H7 str. EC4076 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444452.5.peg.5402
Escherichia coli O157:H7 str. EC4113 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444450.8.peg.2843
Escherichia coli O157:H7 str. EC4115 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|444451.5.peg.5411
Escherichia coli O157:H7 str. EC4196 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|478004.5.peg.5497
Escherichia coli O157:H7 str. EC4401 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|478005.5.peg.4100
Escherichia coli O157:H7 str. EC4486 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|478006.5.peg.5226
Escherichia coli O157:H7 str. EC4501 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|478007.5.peg.5196
Escherichia coli O157:H7 str. EC508 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|478008.5.peg.4483
Escherichia coli O157:H7 str. EC869 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|637388.3.peg.3590
Escherichia coli O157:H7 str. FRIK2000 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|570506.3.peg.516
Escherichia coli O157:H7 str. FRIK966 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|386585.9.peg.2910
Escherichia coli O157:H7 str. Sakai (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|544404.4.peg.2706
Escherichia coli O157:H7 str. TW14359 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|502346.5.peg.4608
Escherichia coli O157:H7 str. TW14588 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|701177.3.peg.2505
Escherichia coli O55:H7 str. CB9615 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|316401.4.peg.2395
Escherichia coli ETEC H10407 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SW
S
WR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|562.375.peg.2192
Escherichia coli EC4100B (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
V
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585057.4.peg.1118
Escherichia coli IAI39 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
IA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585057.6.peg.1114
Escherichia coli IAI39 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
IA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|344601.3.peg.4683
Escherichia coli B171 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AV
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
Q
A
GCLI
S
A
M
TA
LL
MK
fig|344601.5.peg.4945
Escherichia coli B171 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AV
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
Q
A
GCLI
S
A
M
TA
LL
MK
fig|413997.3.peg.1986
Escherichia coli B str. REL606 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|511693.5.peg.2017
Escherichia coli BL21 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|469008.4.peg.1713
Escherichia coli BL21(DE3) (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|595496.3.peg.1949
Escherichia coli BW2952 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|536056.3.peg.1764
Escherichia coli DH1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585397.7.peg.2314
Escherichia coli ED1a (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|585397.9.peg.2311
Escherichia coli ED1a (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|83333.1.peg.1958
Escherichia coli K12 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|679207.4.peg.3549
Escherichia coli MS 107-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|749547.3.peg.3317
Escherichia coli MS 187-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|316407.3.peg.1921
Escherichia coli W3110 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|316385.5.peg.2097
Escherichia coli str. K-12 substr. DH10B (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|316385.7.peg.2146
Escherichia coli str. K-12 substr. DH10B (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|511145.12.peg.2059
Escherichia coli str. K-12 substr. MG1655 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|511145.6.peg.2042
Escherichia coli str. K-12 substr. MG1655 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|155864.1.peg.2798
Escherichia coli O157:H7 EDL933 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
X
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
X
G
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|155864.8.peg.2678
Escherichia coli O157:H7 EDL933 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQYNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
X
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
X
G
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|679206.4.peg.2023
Escherichia coli MS 119-7 (21-433/438)
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
R
L
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
ENK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGALIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|573235.3.peg.2926
Escherichia coli O26:H11 str. 11368 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
V
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
V
QF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHNQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
R
L
A
D
R
FGRR
RV
Y
I
TGALIGM
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
I
TA
LL
MK
fig|749540.3.peg.2012
Escherichia coli MS 146-1 (10-433/438)
PDEGTLSL
S
R
A
RRA
AL
G
S
FA
G
AV
V
D
W
Y
DF
L
LY
G
IT
A
AL
VF
NRE
FFPQ
VS
P
AMG
TL
A
A
F
ATF
GV
G
FL
F
RP
L
GG
V
I
FGHFGDR
L
GRK
RM
L
M
L
T
V
WMM
G
IA
T
AL
IG
IL
P
S
F
ST
IG
WW
API
L
L
VT
L
R
AI
QG
F
A
A
GGEWGGAAL
LSV
ESAP
KNK
K
AFY
SS
GV
Q
V
G
YG
VG
LLL
S
TG
LVS
L
I
SMMT
T
D
EQF
L
SWGWR
I
PF
LF
SIV
L
V
L
G
ALWVR
NG
M
E
ES
AE
FE
Q
QQHYQ
A
AA
K
KR
I
---
P
VIEA
L
L
RH
P
------
GAF
L
KIIA
L
R
L
C
ELLTMY
------------------
I
VT
A
FA
L
N
Y
STQN
----
MG
L
P
R
-
ELFLNI
G
L
L
V
G
G
L
--------------------------------------
SCLTI
P
CF
A
W
L
A
D
R
FGRR
RV
Y
I
TGTLIGT
L
S
A
-
FPFF
M
AL
EAQ
S
IF
---
W
I
VF
FSI
ML
A
-N
I
AHDMVV
C
VQQP
M
FT
E
M
F
G
A
SY
RY
S
GAG
V
G
Y
Q
V
A
S
V
V
GG
GF
T
P
F
IAA
A
L
IT-
Y
FA
G
N-
------
WHS
-
V
A
IYL
L
A
GCLI
S
A
M
TA
LL
MK
fig|679207.4.peg.3976
Escherichia coli MS 107-1 (32-452/464)
RA
TV
S
C
WL
G
TT
M
E
Y
A
DF
A
LY
G
LA
A
GI
I
F
GDV
FFP
E
AT
P
VMA
L
L
S
S
F
A
A
Y
SV
G
F
I
A
RP
I
G
A
L
L
FG
WI
GD
K
H
GRK
IV
M
V
I
T
I
GLM
G
MS
T
ML
IG
LI
P
S
Y
AQ
IG
VW
API
C
L
VI
L
R
FS
QG
L
G
A
G
A
E
LS
G
GT
V
MLG
E
Y
AP
VKR
R
GLV
SS
VI
G
L
G
SN
S
G
TLL
A
S
L
VWL
IV
LQMD
K
D
D
-
L
L
SWGWR
I
PF
LC
SI
L
I
AA
A
AL
L
I
R
RH
I
R
E
T
PV
FE
R
QKALL
Q
AE
R
EK
V
IREE
KAQQ
Q
H
DS
R
SFWKRT
RAF
W
TMVG
L
R
I
G
ENGPSY
------------------
L
AQ
G
FI
I
G
Y
VAKV
----
LM
V
D
K
-
SVPTAA
V
L
I
A
S
V
L
--------------------------------------
GFAII
P
LA
G
W
L
S
D
R
FGRR
II
Y
R
WFCLLLI
L
Y
A
-
FP
A
F
M
L
L
DSR
E
PW
---
-
I
V
I
PTI
I
T
G
MG
L
ASLGIF
G
VQAA
W
GV
E
L
F
G
V
TN
RYT
KMA
F
A
KE
L
G
S
I
L
S
G
GT
AP
L
IA
S
A
L
LSY
Y
GH
-
--
------
WWP
-
I
A
IY
F
A
F
MAAI
G
L
V
TT
FF
AP
ET
fig|749531.3.peg.469
Escherichia coli MS 69-1 (32-452/464)
RA
TV
S
C
WL
G
TT
M
E
Y
A
DF
A
LY
G
LA
A
GI
I
F
GDV
FFP
E
AT
P
VMA
L
L
S
S
F
A
A
Y
SV
G
F
I
A
RP
I
G
A
L
L
FG
WI
GD
K
H
GRK
IV
M
V
I
T
I
GLM
G
MS
T
ML
IG
LI
P
S
Y
AQ
IG
VW
API
C
L
VI
L
R
FS
QG
L
G
A
G
A
E
LS
G
GT
V
MLG
E
Y
AP
VKR
R
GLV
SS
VI
G
L
G
SN
S
G
TLL
A
S
L
VWL
IV
LQMD
K
D
D
-
L
L
SWGWR
I
PF
LC
SI
L
I
AA
A
AL
L
I
R
RH
I
R
E
T
PV
FE
R
QKALL
Q
AE
R
EK
V
IREE
KAQQ
Q
H
DS
R
SFWKRT
RAF
W
TMVG
L
R
I
G
ENGPSY
------------------
L
AQ
G
FI
I
G
Y
VAKV
----
LM
V
D
K
-
SVPTAA
V
L
I
A
S
V
L
--------------------------------------
GFAII
P
LA
G
W
L
S
D
R
FGRR
II
Y
R
WFCLLLI
L
Y
A
-
FP
A
F
M
L
L
DSR
E
PW
---
-
I
V
I
PTI
I
T
G
MG
L
ASLGIF
G
VQAA
W
GV
E
L
F
G
V
TN
RYT
KMA
F
A
KE
L
G
S
I
L
S
G
GT
AP
L
IA
S
A
L
LSY
Y
GH
-
--
------
WWP
-
I
A
IY
F
A
F
MAAI
G
L
V
TT
FF
AP
ET
fig|749532.3.peg.2744
Escherichia coli MS 78-1 (32-452/464)
RA
TV
S
C
WL
G
TT
M
E
Y
A
DF
A
LY
G
LA
A
GI
I
F
GDV
FFP
E
AT
P
VMA
L
L
S
S
F
A
A
Y
SV
G
F
I
A
RP
I
G
A
L
L
FG
WI
GD
K
H
GRK
IV
M
V
I
T
I
GLM
G
MS
T
ML
IG
LI
P
S
Y
AQ
IG
VW
API
C
L
VI
L
R
FS
QG
L
G
A
G
A
E
LS
G
GT
V
MLG
E
Y
AP
VKR
R
GLV
SS
VI
G
L
G
SN
S
G
TLL
A
S
L
VWL
IV
LQMD
K
D
D
-
L
L
SWGWR
I
PF
LC
SI
L
I
AA
A
AL
L
I
R
RH
I
R
E
T
PV
FE
R
QKALL
Q
AE
R
EK
V
IREE
KAQQ
Q
H
DS
R
SFWKRT
RAF
W
TMVG
L
R
I
G
ENGPSY
------------------
L
AQ
G
FI
I
G
Y
VAKV
----
LM
V
D
K
-
SVPTAA
V
L
I
A
S
V
L
--------------------------------------
GFAII
P
LA
G
W
L
S
D
R
FGRR
II
Y
R
WFCLLLI
L
Y
A
-
FP
A
F
M
L
L
DSR
E
PW
---
-
I
V
I
PTI
I
T
G
MG
L
ASLGIF
G
VQAA
W
GV
E
L
F
G
V
TN
RYT
KMA
F
A
KE
L
G
S
I
L
S
G
GT
AP
L
IA
S
A
L
LSY
Y
GH
-
--
------
WWP
-
I
A
IY
F
A
F
MAAI
G
L
V
TT
FF
AP
ET
fig|439855.10.peg.1267
Escherichia coli SMS-3-5 (32-452/464)
RA
TV
S
C
WL
G
TT
M
E
Y
A
DF
A
LY
G
LA
A
GI
I
F
GDV
FFP
E
AT
P
VMA
L
L
S
S
F
A
A
Y
SV
G
F
I
A
RP
I
G
A
L
L
FG
WI
GD
K
H
GRK
IV
M
V
I
T
I
GLM
G
MS
T
ML
IG
LI
P
S
Y
AQ
IG
VW
API
C
L
VI
L
R
FS
QG
L
G
A
G
A
E
LS
G
GT
V
MLG
E
Y
AP
VKR
R
GLV
SS
VI
G
L
G
SN
S
G
TLL
A
S
L
VWL
IV
LQMD
K
D
D
-
L
L
SWGWR
I
PF
LC
SI
L
I
AA
A
AL
L
I
R
RH
I
R
E
T
PV
FE
R
QKALL
Q
AE
R
EK
V
IREE
KAQQ
Q
H
DS
R
SFWKRT
RAF
W
TMVG
L
R
I
G
ENGPSY
------------------
L
AQ
G
FI
I
G
Y
VAKV
----
LM
V
D
K
-
SVPTAA
V
L
I
A
S
V
L
--------------------------------------
GFAII
P
LA
G
W
L
S
D
R
FGRR
II
Y
R
WFCLLLI
L
Y
A
-
FP
A
F
M
L
L
DSR
E
PW
---
-
I
V
I
PTI
I
T
G
MG
L
ASLGIF
G
VQAA
W
GV
E
L
F
G
V
TN
RYT
KMA
F
A
KE
L
G
S
I
L
S
G
GT
AP
L
IA
S
A
L
LSY
Y
GH
-
--
------
WWP
-
I
A
IY
F
A
F
MAAI
G
L
V
TT
FF
AP
ET
fig|405955.13.peg.4526
Escherichia coli APEC O1 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|405955.9.peg.3818
Escherichia coli APEC O1 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|714962.3.peg.4564
Escherichia coli IHE3034 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|656417.3.peg.5110
Escherichia coli M605 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|585035.6.peg.4424
Escherichia coli S88 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|869729.3.peg.4375
Escherichia coli UM146 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|364106.7.peg.4500
Escherichia coli UTI89 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|364106.8.peg.4499
Escherichia coli UTI89 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
I
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|525281.3.peg.1846
Escherichia coli 83972 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|655817.3.peg.4768
Escherichia coli ABU 83972 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|199310.1.peg.4917
Escherichia coli CFT073 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|199310.4.peg.4714
Escherichia coli CFT073 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|749546.3.peg.1008
Escherichia coli MS 185-1 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|749528.3.peg.4426
Escherichia coli MS 45-1 (1-431/466)
MQPSQP
A
EK
AN
V
S
S
A
D
L
RRA
AW
TC
SL
G
SA
L
E
Y
Y
DF
A
LY
S
LA
S
AI
I
F
GPL
FFP
N
QE
P
GMA
L
I
AS
F
G
T
Y
FL
G
F
A
V
RP
V
GG
I
L
FG
SL
GDR
L
GRK
FV
L
L
A
T
V
LLM
G
IA
S
TL
IG
VL
P
T
Y
ET
A
G
IW
API
M
L
IA
L
R
LL
QG
L
G
A
G
A
E
QA
GAA
V
LMT
E
Y
AP
DGK
R
GYY
AA
LP
F
L
G
IQ
I
G
TFM
A
S
A
VYF
I
L
LHNV
T
N
L
-
A
E
T
W
W
WR
L
PF
LS
S
V
V
I
I
A
V
A
IYI
R
LH
L
K
ES
PS
F
A
K
LEA--
-
--
R
QQ
V
TES
P
LRNL
L
K
TS
R
------
RNV
F
VGIG
L
R
LA
ENGGSS
------------------
I
YQ
A
LA
I
S
Y
IVGV
----
VG
L
D
K
-
SVGTLC
L
M
S
A
V
V
V
--------------------------------------
GAIMV
P
IA
G
W
L
T
D
R
FGR
V
LV
Y
R
SLAIFQL
L
I
T
-
FP
V
W
W
S
F
SHG
N
VP
---
-
V
TI
VSL
S
L
A
LG
I
GAWGMF
G
AQGA
F
LP
E
L
F
G
A
RH
RY
I
G
VAL
A
RE
V
S
A
V
I
A
G
GI
AP
L
V
GS
A
I
ISW
V
IH
T
ND
PSGIAA
WMP
-
I
A
IYL
S
L
LTVG
T
I
I
AT
fig|670897.3.peg.3828
Escherichia coli 2362-75 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|216593.1.peg.4255
Escherichia coli E2348/69 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|574521.7.peg.3852
Escherichia coli O127:H6 str. E2348/69 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|573235.3.peg.4729
Escherichia coli O26:H11 str. 11368 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
Q
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585396.4.peg.4486
Escherichia coli O111:H- str. 11128 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGS
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|362663.8.peg.3656
Escherichia coli 536 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|362663.9.peg.3669
Escherichia coli 536 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|525281.3.peg.2974
Escherichia coli 83972 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|655817.3.peg.4137
Escherichia coli ABU 83972 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|199310.1.peg.4239
Escherichia coli CFT073 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|199310.4.peg.4071
Escherichia coli CFT073 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340197.3.peg.642
Escherichia coli F11 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340197.5.peg.665
Escherichia coli F11 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656393.3.peg.4601
Escherichia coli H299 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585057.4.peg.4159
Escherichia coli IAI39 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585057.6.peg.4167
Escherichia coli IAI39 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656417.3.peg.4396
Escherichia coli M605 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749546.3.peg.653
Escherichia coli MS 185-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749550.3.peg.811
Escherichia coli MS 200-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749528.3.peg.20
Escherichia coli MS 45-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|439855.10.peg.3972
Escherichia coli SMS-3-5 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656440.3.peg.3790
Escherichia coli TA206 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.376.peg.2718
Escherichia coli WV_060327 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|344601.3.peg.2982
Escherichia coli B171 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|344601.5.peg.3106
Escherichia coli B171 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340185.3.peg.77
Escherichia coli E22 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340185.4.peg.85
Escherichia coli E22 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|331111.12.peg.4252
Escherichia coli E24377A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|331111.3.peg.1663
Escherichia coli E24377A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|595495.4.peg.3912
Escherichia coli KO11 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|679205.4.peg.5204
Escherichia coli MS 124-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749545.3.peg.580
Escherichia coli MS 182-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749532.3.peg.1537
Escherichia coli MS 78-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749533.3.peg.5226
Escherichia coli MS 84-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585395.4.peg.4445
Escherichia coli O103:H2 str. 12009 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|409438.11.peg.3966
Escherichia coli SE11 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|566546.3.peg.4229
Escherichia coli W (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|566546.4.peg.3743
Escherichia coli W (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QAN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|431946.3.peg.3494
Escherichia coli SE15 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
T
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.371.peg.3287
Escherichia coli 1044A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.373.peg.1700
Escherichia coli 1125A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.372.peg.4168
Escherichia coli 1212A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.374.peg.5147
Escherichia coli 536A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|83334.1.peg.4374
Escherichia coli O157:H7 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|155864.1.peg.4411
Escherichia coli O157:H7 EDL933 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|155864.8.peg.4359
Escherichia coli O157:H7 EDL933 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444454.5.peg.3489
Escherichia coli O157:H7 str. EC4024 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444449.5.peg.2943
Escherichia coli O157:H7 str. EC4042 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444448.5.peg.1697
Escherichia coli O157:H7 str. EC4045 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444453.5.peg.1228
Escherichia coli O157:H7 str. EC4076 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444452.5.peg.114
Escherichia coli O157:H7 str. EC4113 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444450.8.peg.4778
Escherichia coli O157:H7 str. EC4115 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444451.5.peg.288
Escherichia coli O157:H7 str. EC4196 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|444447.5.peg.1860
Escherichia coli O157:H7 str. EC4206 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|478004.5.peg.254
Escherichia coli O157:H7 str. EC4401 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|478006.5.peg.219
Escherichia coli O157:H7 str. EC4501 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|478007.5.peg.227
Escherichia coli O157:H7 str. EC508 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|478008.5.peg.748
Escherichia coli O157:H7 str. EC869 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|637388.3.peg.1940
Escherichia coli O157:H7 str. FRIK2000 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|570506.3.peg.81
Escherichia coli O157:H7 str. FRIK966 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|386585.9.peg.4602
Escherichia coli O157:H7 str. Sakai (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|544404.4.peg.4589
Escherichia coli O157:H7 str. TW14359 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|502346.5.peg.2241
Escherichia coli O157:H7 str. TW14588 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
S
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|358709.5.peg.286
Escherichia coli 101-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAT
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|511693.5.peg.3553
Escherichia coli BL21 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAT
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|469008.4.peg.228
Escherichia coli BL21(DE3) (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAT
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749547.3.peg.352
Escherichia coli MS 187-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAT
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|413997.3.peg.3536
Escherichia coli B str. REL606 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
VT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAT
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|1040638.4.peg.2155
Escherichia coli O104:H4 str. LB226692 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|6666666.5357.peg.616
Escherichia coli TY-2482 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|216592.1.peg.791
Escherichia coli 042 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|216592.3.peg.3967
Escherichia coli 042 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|670888.3.peg.2717
Escherichia coli 1827-70 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|344610.3.peg.75
Escherichia coli 53638 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|344610.7.peg.2698
Escherichia coli 53638 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585055.6.peg.3998
Escherichia coli 55989 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585055.8.peg.4000
Escherichia coli 55989 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|481805.3.peg.201
Escherichia coli ATCC 8739 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|481805.6.peg.208
Escherichia coli ATCC 8739 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|550676.3.peg.3704
Escherichia coli B185 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|550677.3.peg.4088
Escherichia coli B354 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340184.3.peg.331
Escherichia coli B7A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340184.6.peg.345
Escherichia coli B7A (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|595496.3.peg.3513
Escherichia coli BW2952 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|536056.3.peg.196
Escherichia coli DH1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340186.3.peg.1655
Escherichia coli E110019 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|340186.5.peg.1707
Escherichia coli E110019 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|562.375.peg.4886
Escherichia coli EC4100B (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|316401.4.peg.4276
Escherichia coli ETEC H10407 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656379.3.peg.4845
Escherichia coli FVEC1302 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656380.3.peg.4631
Escherichia coli FVEC1412 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656408.3.peg.3958
Escherichia coli H591 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656414.3.peg.4026
Escherichia coli H736 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|331112.3.peg.3493
Escherichia coli HS (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|331112.6.peg.3635
Escherichia coli HS (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585034.4.peg.3594
Escherichia coli IAI1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585034.5.peg.3592
Escherichia coli IAI1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|83333.1.peg.3456
Escherichia coli K12 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656419.3.peg.4541
Escherichia coli M718 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|679207.4.peg.276
Escherichia coli MS 107-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749537.3.peg.584
Escherichia coli MS 115-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749538.3.peg.3968
Escherichia coli MS 116-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|679206.4.peg.1857
Escherichia coli MS 119-7 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|679204.3.peg.3287
Escherichia coli MS 145-7 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749540.3.peg.2543
Escherichia coli MS 146-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749544.3.peg.880
Escherichia coli MS 175-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749548.3.peg.3906
Escherichia coli MS 196-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749549.3.peg.1462
Escherichia coli MS 198-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749527.3.peg.1615
Escherichia coli MS 21-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|749531.3.peg.4381
Escherichia coli MS 69-1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|701177.3.peg.4279
Escherichia coli O55:H7 str. CB9615 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656443.3.peg.4437
Escherichia coli TA271 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656444.3.peg.4826
Escherichia coli TA280 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585056.7.peg.4198
Escherichia coli UMN026 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|316407.3.peg.3606
Escherichia coli W3110 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|316385.7.peg.3733
Escherichia coli str. K-12 substr. DH10B (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|511145.12.peg.3632
Escherichia coli str. K-12 substr. MG1655 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|511145.6.peg.3614
Escherichia coli str. K-12 substr. MG1655 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|656437.3.peg.3968
Escherichia coli TA143 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
I
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
GVM-V
P
VA
G
L
L
A
D
A
FGRR
KS
M
V
IITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PI
---
-
LVF
AFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
A
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|405955.13.peg.3967
Escherichia coli APEC O1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|405955.9.peg.3318
Escherichia coli APEC O1 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585397.7.peg.4192
Escherichia coli ED1a (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585397.9.peg.4189
Escherichia coli ED1a (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|714962.3.peg.3999
Escherichia coli IHE3034 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|753642.3.peg.4412
Escherichia coli NC101 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|685038.3.peg.3574
Escherichia coli O83:H1 str. NRG 857C (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|585035.6.peg.3861
Escherichia coli S88 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|869729.3.peg.3807
Escherichia coli UM146 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|364106.7.peg.3967
Escherichia coli UTI89 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|364106.8.peg.3968
Escherichia coli UTI89 (22-438/440)
KV
LV
AS
LI
G
TA
I
E
F
FDF
Y
I
YA
TA
A
VI
VF
PHI
FFPQ
GD
P
TAA
TLQ
S
L
ATF
AI
AF
V
A
RP
I
G
S
A
VFGHFGDR
V
GRK
AT
LV
A
SL
LTM
G
IS
T
VV
IG
LL
P
G
Y
AT
IG
IF
AP
L
L
L
AL
AR
FG
QG
L
GLGGEWGGAAL
LAT
E
N
AP
PRK
R
ALY
G
S
FP
Q
L
G
AP
I
G
FFF
A
N
G
TFL
LL
SWLL
T
D
EQF
M
SWGWR
V
PF
IF
S
A
V
L
VI
I
G
L
Y
VR
VS
L
H
ES
PV
FEK
VA--K
A
KK
Q
VK
I
---
P
LGTL
L
T
K
H
V
------
RVT
V
LGTF
I
M
LA
TYTLFY
------------------
I
MT
V
YS
M
T
F
STAA
APVG
LG
L
P
R
N
EVLWML
M
M
A
V
I
G
F
--------------------------------------
AVM-V
P
LA
G
L
L
A
D
A
FGRR
KS
M
V
VITTLII
L
F
A
L
F
A
F
N
P
L
L
GSG
N
PA
---
-
LVF
VFL
L
LG
LS
L
M-GLTF
G
PMGA
L
LP
E
L
F
P
T
EV
RYTGA
S
F
S
YNV
S
S
I
LG
A
SV
AP
Y
IAA
W
L
QTN
Y
GL
G
A-
------
---
-
V
G
L
YL
A
A
MAGL
T
L
I
AL
LL
TH
ETRHQ
fig|550676.3.peg.3374
Escherichia coli B185 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
M
F
G
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|550677.3.peg.3779
Escherichia coli B354 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656379.3.peg.3963
Escherichia coli FVEC1302 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656380.3.peg.3882
Escherichia coli FVEC1412 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656419.3.peg.4203
Escherichia coli M718 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749549.3.peg.2099
Escherichia coli MS 198-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749531.3.peg.2641
Escherichia coli MS 69-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656437.3.peg.3646
Escherichia coli TA143 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656444.3.peg.4483
Escherichia coli TA280 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585056.7.peg.3880
Escherichia coli UMN026 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|216592.3.peg.3646
Escherichia coli 042 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|155864.1.peg.4100
Escherichia coli O157:H7 EDL933 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|216592.1.peg.4151
Escherichia coli 042 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|344610.3.peg.4138
Escherichia coli 53638 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|481805.3.peg.509
Escherichia coli ATCC 8739 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|344601.3.peg.3452
Escherichia coli B171 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340184.3.peg.3290
Escherichia coli B7A (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340186.3.peg.3517
Escherichia coli E110019 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340185.3.peg.3735
Escherichia coli E22 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|595496.3.peg.3204
Escherichia coli BW2952 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|536056.3.peg.504
Escherichia coli DH1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|83333.1.peg.3168
Escherichia coli K12 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|316407.3.peg.3102
Escherichia coli W3110 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|316385.7.peg.3424
Escherichia coli str. K-12 substr. DH10B (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|511145.12.peg.3320
Escherichia coli str. K-12 substr. MG1655 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|511145.6.peg.3305
Escherichia coli str. K-12 substr. MG1655 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
A
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|1040638.4.peg.1808
Escherichia coli O104:H4 str. LB226692 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|6666666.5357.peg.891
Escherichia coli TY-2482 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|358709.5.peg.3908
Escherichia coli 101-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|670888.3.peg.3023
Escherichia coli 1827-70 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|344610.7.peg.3014
Escherichia coli 53638 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585055.6.peg.3674
Escherichia coli 55989 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585055.8.peg.3677
Escherichia coli 55989 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|481805.6.peg.510
Escherichia coli ATCC 8739 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|413997.3.peg.3229
Escherichia coli B str. REL606 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|344601.5.peg.3610
Escherichia coli B171 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340184.6.peg.3434
Escherichia coli B7A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|511693.5.peg.3240
Escherichia coli BL21 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|469008.4.peg.536
Escherichia coli BL21(DE3) (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340186.5.peg.3671
Escherichia coli E110019 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340185.4.peg.3928
Escherichia coli E22 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656414.3.peg.3702
Escherichia coli H736 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585034.4.peg.3305
Escherichia coli IAI1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585034.5.peg.3303
Escherichia coli IAI1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|595495.4.peg.696
Escherichia coli KO11 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|679207.4.peg.2515
Escherichia coli MS 107-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749537.3.peg.2604
Escherichia coli MS 115-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749538.3.peg.3536
Escherichia coli MS 116-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|679204.3.peg.956
Escherichia coli MS 145-7 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749540.3.peg.1510
Escherichia coli MS 146-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749545.3.peg.3859
Escherichia coli MS 182-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749547.3.peg.2155
Escherichia coli MS 187-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749548.3.peg.4350
Escherichia coli MS 196-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749532.3.peg.1270
Escherichia coli MS 78-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585395.4.peg.4145
Escherichia coli O103:H2 str. 12009 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585396.4.peg.4184
Escherichia coli O111:H- str. 11128 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|573235.3.peg.4426
Escherichia coli O26:H11 str. 11368 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|566546.3.peg.3133
Escherichia coli W (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|566546.4.peg.3454
Escherichia coli W (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|562.371.peg.2532
Escherichia coli 1044A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|562.373.peg.2005
Escherichia coli 1125A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|562.372.peg.2727
Escherichia coli 1212A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|562.374.peg.4804
Escherichia coli 536A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656408.3.peg.3645
Escherichia coli H591 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|679206.4.peg.4135
Escherichia coli MS 119-7 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|83334.1.peg.4071
Escherichia coli O157:H7 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|155864.8.peg.4032
Escherichia coli O157:H7 EDL933 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444454.5.peg.3154
Escherichia coli O157:H7 str. EC4024 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444449.5.peg.2612
Escherichia coli O157:H7 str. EC4042 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444448.5.peg.1365
Escherichia coli O157:H7 str. EC4045 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444453.5.peg.2788
Escherichia coli O157:H7 str. EC4076 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444452.5.peg.4526
Escherichia coli O157:H7 str. EC4113 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444450.8.peg.4448
Escherichia coli O157:H7 str. EC4115 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444451.5.peg.4739
Escherichia coli O157:H7 str. EC4196 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|444447.5.peg.1523
Escherichia coli O157:H7 str. EC4206 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|478004.5.peg.1049
Escherichia coli O157:H7 str. EC4401 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|478006.5.peg.4127
Escherichia coli O157:H7 str. EC4501 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|478007.5.peg.3587
Escherichia coli O157:H7 str. EC508 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|478008.5.peg.1422
Escherichia coli O157:H7 str. EC869 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|637388.3.peg.5311
Escherichia coli O157:H7 str. FRIK2000 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|570506.3.peg.916
Escherichia coli O157:H7 str. FRIK966 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|386585.9.peg.4277
Escherichia coli O157:H7 str. Sakai (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|544404.4.peg.4258
Escherichia coli O157:H7 str. TW14359 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|502346.5.peg.3152
Escherichia coli O157:H7 str. TW14588 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|701177.3.peg.3959
Escherichia coli O55:H7 str. CB9615 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CT
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|316401.4.peg.3956
Escherichia coli ETEC H10407 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DR
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656393.3.peg.4271
Escherichia coli H299 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|562.375.peg.877
Escherichia coli EC4100B (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATVLW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340197.3.peg.4533
Escherichia coli F11 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|216593.1.peg.4920
Escherichia coli E2348/69 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|331111.3.peg.1376
Escherichia coli E24377A (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|362663.8.peg.3339
Escherichia coli 536 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|362663.9.peg.3350
Escherichia coli 536 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585397.7.peg.3878
Escherichia coli ED1a (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585397.9.peg.3876
Escherichia coli ED1a (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|340197.5.peg.4742
Escherichia coli F11 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749550.3.peg.1348
Escherichia coli MS 200-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|753642.3.peg.4745
Escherichia coli NC101 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|685038.3.peg.3258
Escherichia coli O83:H1 str. NRG 857C (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656440.3.peg.3453
Escherichia coli TA206 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|670897.3.peg.4108
Escherichia coli 2362-75 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|331111.12.peg.3960
Escherichia coli E24377A (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585057.4.peg.3839
Escherichia coli IAI39 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585057.6.peg.3848
Escherichia coli IAI39 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|679205.4.peg.2804
Escherichia coli MS 124-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749527.3.peg.2865
Escherichia coli MS 21-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|749533.3.peg.2362
Escherichia coli MS 84-1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|409438.11.peg.3673
Escherichia coli SE11 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|439855.10.peg.3674
Escherichia coli SMS-3-5 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|405955.9.peg.3032
Escherichia coli APEC O1 (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|405955.13.peg.3636
Escherichia coli APEC O1 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|714962.3.peg.3674
Escherichia coli IHE3034 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|585035.6.peg.3536
Escherichia coli S88 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|869729.3.peg.58
Escherichia coli UM146 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|364106.7.peg.3609
Escherichia coli UTI89 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|364106.8.peg.3610
Escherichia coli UTI89 (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHGGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAY
D
PHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
L
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|331112.3.peg.3194
Escherichia coli HS (26-476/506)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
AV
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|331112.6.peg.3331
Escherichia coli HS (16-466/496)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
R
LA
M
V
T
S
I
VLF
S
AG
T
LA
C
G
FA
P
G
Y
--
--
--
--
I
T
M
FI
AR
LV
I
G
M
G
M
A
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
AV
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
fig|656443.3.peg.4118
Escherichia coli TA271 (16-436/466)
R
A
Q
W
RA
FS
A
A
WL
G
YL
LD
G
FDF
V
L
I
A
LV
L
TE
V
-
---
---
Q
GE
F
GLT
T
V
QA
A
SLI
SA
AF
I
S
R
W
F
GG
L
M
L
G
AM
GDR
Y
GR
-
--
--
-
--
---
-
--
-
--
--
--
-
-
-
--
--
--
--
-
-
-
--
-
R
LV
I
G
M
G
M
P
GE
Y
G
SS
A
T
YVI
ES
W
P
KHL
R
NKA
S
G
FL
I
S
G
FS
VG
AVV
A
A
Q
VYS
L
V
----
-
-
--
V
P
V
WGWR
A
L
F
FI
G
I
L
P
I
I
F
ALW
L
R
KN
I
P
E
A
ED
W
KE
KHAGK
A
PV
R
TM
V
---
-
--DI
L
Y
R
G
-
------
EHR
I
ANIV
M
T
LA
AATALW
FCFAGNLQNAAIVAVLGLL
CA
A
IF
I
S
F
MVQS
----
--
T
G
K
-
RWPTGV
ML
M
V
V
V
L
FAFLYSWPIQALLPTYLKTDLAYNPHTVANVLFFSGFG
AAVGC
C
VG
G
F
L
G
D
W
L
G
T
R
KA
YV
CSLLASQ
L
L
I
-
I
P
V
F
-
A
I
GGA
N
VW
VLG
L
L
L
F
FQQ
MLG
QG
I
A-----
G
ILPK
L
IG
G
Y
F
D
T
DQ
R
A
A
G
L
GF
T
YNV
G
A
-
LGG
AL
AP
I
I
G
A
L
I
AQR
L
DL
G
TA
LASLSF
SLT
F
V
V
I
L
L
I
G
LDMP
S
R
V
QR
W
L
RP
E
A
Consen1
Primary consensus
MseklpaPdEGtLSl
a
rra
as
G
ld
fDF
lya
a
Vf
ffpq
p
tlqa
atf
aFl
Rp
Gg
vfGhfGDr
GRk
lv
sl
g
T
iG
P
y
ig
api
l
aR
qG
glgGEwGgaAl
EsaP
r
ss
q
G
vG
atg
Ll
t
eqf
sWGWR
pF
siv
vi
aLwvR
l
Es
fek
a
k
i
---
p
l
rh
------
l
l
La
------------------
i
a
i
f
----
l
r
-
ml
v
g
--------------------------------------
p
g
L
D
fGrr
yv
L
a
-
fpff
al
n
---
lvf
mLg
i
g
l
e
F
t
RytGagf
Ynv
s
lgg
aP
Iaa
l
y
G
------
-
V
iyL
a
s
v
lL
etrhQETASYRYIREQSHEN
Consen2
Secondary consensus
mqpsqp
r
-
g
r
wkv
ga
e
y
iig
l
-
---
d
f
l
as
sli
g
w
s
l
am
k
r
m
t
s
c
f
--
--
l
m
l
i
a
a
y
ss
t
nw
k
gg
i
i
s
q
-
--
v
v
l
gal
l
g
w
n
v
-
f
kg
c
fcfagnlqnaaivavlgll
v
y
apvg
t
kn
gm
a
v
faflyswpiqallptylktdlaynphtvanvlffsgfg
c
a
l
tk
m
iliavn
li
s
vlg
i
w
a
l
c
m
g
a
a
lsv
qf
a
v
-
a
t
gs
i
l
laslsf
f
ll
g
t
w
pade
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character