fig|1040638.4.peg.1278
Escherichia coli O104:H4 str. LB226692
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|6666666.5357.peg.659
Escherichia coli TY-2482
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|358709.5.peg.3049
Escherichia coli 101-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585055.6.peg.4368
Escherichia coli 55989
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585055.8.peg.4371
Escherichia coli 55989
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|481805.6.peg.4445
Escherichia coli ATCC 8739
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|344601.5.peg.3170
Escherichia coli B171
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340184.6.peg.1536
Escherichia coli B7A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|331111.12.peg.4611
Escherichia coli E24377A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749537.3.peg.2669
Escherichia coli MS 115-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|679205.4.peg.1858
Escherichia coli MS 124-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749545.3.peg.3780
Escherichia coli MS 182-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749532.3.peg.2900
Escherichia coli MS 78-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585395.4.peg.4505
Escherichia coli O103:H2 str. 12009
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|409438.11.peg.4324
Escherichia coli SE11
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.371.peg.1958
Escherichia coli 1044A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.373.peg.2536
Escherichia coli 1125A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.372.peg.3740
Escherichia coli 1212A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.374.peg.3526
Escherichia coli 536A
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|550676.3.peg.4075
Escherichia coli B185
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|595496.3.peg.3864
Escherichia coli BW2952
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|536056.3.peg.4381
Escherichia coli DH1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340186.5.peg.1205
Escherichia coli E110019
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|316401.4.peg.4694
Escherichia coli ETEC H10407
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656393.3.peg.5056
Escherichia coli H299
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656414.3.peg.4399
Escherichia coli H736
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|595495.4.peg.3550
Escherichia coli KO11
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|679207.4.peg.4193
Escherichia coli MS 107-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749538.3.peg.1625
Escherichia coli MS 116-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|679206.4.peg.3465
Escherichia coli MS 119-7
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749540.3.peg.4711
Escherichia coli MS 146-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749544.3.peg.2951
Escherichia coli MS 175-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749548.3.peg.3629
Escherichia coli MS 196-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749527.3.peg.1927
Escherichia coli MS 21-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749531.3.peg.3360
Escherichia coli MS 69-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444454.5.peg.3885
Escherichia coli O157:H7 str. EC4024
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444449.5.peg.3342
Escherichia coli O157:H7 str. EC4042
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444448.5.peg.2097
Escherichia coli O157:H7 str. EC4045
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444450.8.peg.5179
Escherichia coli O157:H7 str. EC4115
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444451.5.peg.2919
Escherichia coli O157:H7 str. EC4196
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444447.5.peg.2261
Escherichia coli O157:H7 str. EC4206
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|478006.5.peg.2249
Escherichia coli O157:H7 str. EC4501
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|478007.5.peg.2305
Escherichia coli O157:H7 str. EC508
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|478008.5.peg.1982
Escherichia coli O157:H7 str. EC869
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|637388.3.peg.549
Escherichia coli O157:H7 str. FRIK2000
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|544404.4.peg.4989
Escherichia coli O157:H7 str. TW14359
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|502346.5.peg.1819
Escherichia coli O157:H7 str. TW14588
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|573235.3.peg.4859
Escherichia coli O26:H11 str. 11368
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|701177.3.peg.4672
Escherichia coli O55:H7 str. CB9615
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656443.3.peg.4817
Escherichia coli TA271
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656444.3.peg.5208
Escherichia coli TA280
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|566546.3.peg.3955
Escherichia coli W
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|316385.7.peg.4081
Escherichia coli str. K-12 substr. DH10B
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|511145.12.peg.3980
Escherichia coli str. K-12 substr. MG1655
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|511145.6.peg.3962
Escherichia coli str. K-12 substr. MG1655
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585396.4.peg.4856
Escherichia coli O111:H- str. 11128
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DNWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|670888.3.peg.2356
Escherichia coli 1827-70
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
H
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|344610.7.peg.2329
Escherichia coli 53638
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRAL
H
SGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|413997.3.peg.3939
Escherichia coli B str. REL606
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
THLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|511693.5.peg.3957
Escherichia coli BL21
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
THLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|469008.4.peg.4328
Escherichia coli BL21(DE3)
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
THLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|331112.6.peg.3986
Escherichia coli HS
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
H
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749547.3.peg.3653
Escherichia coli MS 187-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
THLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|155864.8.peg.4762
Escherichia coli O157:H7 EDL933
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
XEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656419.3.peg.4961
Escherichia coli M718
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
V
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585057.4.peg.3243
Escherichia coli IAI39
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
ELR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585057.6.peg.3250
Escherichia coli IAI39
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
ELR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585397.7.peg.4560
Escherichia coli ED1a
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585397.9.peg.4557
Escherichia coli ED1a
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340197.5.peg.4175
Escherichia coli F11
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|714962.3.peg.4370
Escherichia coli IHE3034
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749550.3.peg.2746
Escherichia coli MS 200-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|753642.3.peg.2018
Escherichia coli NC101
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585035.6.peg.4233
Escherichia coli S88
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|431946.3.peg.3870
Escherichia coli SE15
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656437.3.peg.4352
Escherichia coli TA143
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|364106.7.peg.4339
Escherichia coli UTI89
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|364106.8.peg.4341
Escherichia coli UTI89
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|216592.3.peg.4397
Escherichia coli 042
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656379.3.peg.5101
Escherichia coli FVEC1302
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656380.3.peg.4998
Escherichia coli FVEC1412
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749549.3.peg.1148
Escherichia coli MS 198-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585056.7.peg.4559
Escherichia coli UMN026
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|216592.1.peg.4646
Escherichia coli 042 (18-489/489)
V
TFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
SE
L
FESTVAESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|362663.8.peg.4108
Escherichia coli 536
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
D
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|362663.9.peg.4124
Escherichia coli 536
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
D
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|670897.3.peg.5033
Escherichia coli 2362-75
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLT
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|405955.9.peg.3643
Escherichia coli APEC O1 (18-489/489)
V
TFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|216593.1.peg.4691
Escherichia coli E2348/69 (18-489/489)
V
TFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLT
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|525281.3.peg.3428
Escherichia coli 83972
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|655817.3.peg.4559
Escherichia coli ABU 83972
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|199310.4.peg.4519
Escherichia coli CFT073
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749528.3.peg.1251
Escherichia coli MS 45-1
MTFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|481805.3.peg.4465
Escherichia coli ATCC 8739
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|344601.3.peg.3036
Escherichia coli B171
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340184.3.peg.1457
Escherichia coli B7A
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340185.3.peg.2346
Escherichia coli E22
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340185.4.peg.2483
Escherichia coli E22
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|331111.3.peg.2012
Escherichia coli E24377A
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|679204.3.peg.4869
Escherichia coli MS 145-7
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749533.3.peg.3926
Escherichia coli MS 84-1
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|550677.3.peg.4442
Escherichia coli B354
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340186.3.peg.1165
Escherichia coli E110019
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656408.3.peg.4337
Escherichia coli H591
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|83333.1.peg.3788
Escherichia coli K12
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|83334.1.peg.4764
Escherichia coli O157:H7
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444453.5.peg.2238
Escherichia coli O157:H7 str. EC4076
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|444452.5.peg.1873
Escherichia coli O157:H7 str. EC4113
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|478004.5.peg.2312
Escherichia coli O157:H7 str. EC4401
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|570506.3.peg.3142
Escherichia coli O157:H7 str. FRIK966
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|386585.9.peg.5004
Escherichia coli O157:H7 str. Sakai
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|439855.10.peg.4383
Escherichia coli SMS-3-5
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|566546.4.peg.4111
Escherichia coli W
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|316407.3.peg.3276
Escherichia coli W3110
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|199310.1.peg.4715
Escherichia coli CFT073 (18-489/489)
V
TFMQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|344610.3.peg.2299
Escherichia coli 53638
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRAL
H
SGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|331112.3.peg.3822
Escherichia coli HS
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNIQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
H
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|155864.1.peg.4801
Escherichia coli O157:H7 EDL933
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
XEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|749546.3.peg.743
Escherichia coli MS 185-1
MTFMQRGI
VW
G
VDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
LE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585034.4.peg.3957
Escherichia coli IAI1
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AS
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|585034.5.peg.3954
Escherichia coli IAI1
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AS
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|685038.3.peg.3937
Escherichia coli O83:H1 str. NRG 857C
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.376.peg.1471
Escherichia coli WV_060327
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|405955.13.peg.4335
Escherichia coli APEC O1
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|340197.3.peg.4000
Escherichia coli F11
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656417.3.peg.4771
Escherichia coli M605
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|869729.3.peg.4201
Escherichia coli UM146
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESNVPESTSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|656440.3.peg.4408
Escherichia coli TA206
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
EP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|562.375.peg.124
Escherichia coli EC4100B (1-455/461)
MQRGI
VW
VVDDD
SSIRW
V
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
fig|478005.5.peg.2163
Escherichia coli O157:H7 str. EC4486
M
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLA
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESTSQ
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|574521.7.peg.4261
Escherichia coli O127:H6 str. E2348/69
M
L
ERA
L
AGA
G
LTCTT
F
E
N
G
AEV
L
EALASKTP
D
VL
L
S
DIRM
P
G
MDG
L
AL
LK
Q
IK
QRH
P
ML
PVIIMTAH
SD
L
DA
AV
S
A
Y
Q
Q
GAFDYL
P
KP
F
D
I
D
E
A
VAL
VE
R
A
I
S
---
HYQ
E
QQQP
--
RNVQLNG
P
T
TD--
-
---
-
I
I
G
E
A
PAM
QD
V
FRIIGR
L
S
R
S
SI
SVLINGESGTGKEL
V
A
H
A
L
H
RH
S
P
RA
KA
PFI
A
LN
M
AA
I
P
K
D
L
I
ESELFGHEKGAFTGA
NTI
R
Q
GRF
EQ
ADGGTLFLDEIGDMP
LD
V
Q
T
RLLR
V
L
ADG
Q
F
Y
RVG
G
Y
AP
V
K
VDVRIIAATH
QN
L
EQR
V
QE
G
K
FREDL
FH
RLNV
I
R
V
H
LP
P
LRERREDIP
R
LA
R
HFLQ
V
AA
R
E
LGVEAKLLH
P
E
TE
AA
L
TRLT
WPGNVRQL
E
N
TC
R
WL
T
V
-
M
A
A
G
QE
V
LIQD
LP
GE
L
FESTVAESPSH
M
Q-
P
DSWATLL
AQWADRALRSGHQNLLS
E
AQP
E
L
E
RTL
L
TTA
L
R
H
T
Q
G
H
K
Q
E
AAR
L
LG
WG
R
N
TL
TR
KL
K
ELGME
fig|362663.8.peg.2283
Escherichia coli 536 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|362663.9.peg.2287
Escherichia coli 536 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|525281.3.peg.4029
Escherichia coli 83972 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|655817.3.peg.2672
Escherichia coli ABU 83972 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|405955.13.peg.2442
Escherichia coli APEC O1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|405955.9.peg.1995
Escherichia coli APEC O1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|199310.1.peg.2692
Escherichia coli CFT073 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|199310.4.peg.2600
Escherichia coli CFT073 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585397.7.peg.2689
Escherichia coli ED1a (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585397.9.peg.2686
Escherichia coli ED1a (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|340197.3.peg.286
Escherichia coli F11 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|340197.5.peg.294
Escherichia coli F11 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|714962.3.peg.2502
Escherichia coli IHE3034 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749546.3.peg.2650
Escherichia coli MS 185-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749550.3.peg.1712
Escherichia coli MS 200-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749527.3.peg.1735
Escherichia coli MS 21-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749528.3.peg.2769
Escherichia coli MS 45-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749531.3.peg.2733
Escherichia coli MS 69-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|753642.3.peg.2865
Escherichia coli NC101 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|685038.3.peg.2284
Escherichia coli O83:H1 str. NRG 857C (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585035.6.peg.2348
Escherichia coli S88 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656440.3.peg.2209
Escherichia coli TA206 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|869729.3.peg.1208
Escherichia coli UM146 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|364106.7.peg.2529
Escherichia coli UTI89 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|364106.8.peg.2529
Escherichia coli UTI89 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585057.4.peg.2455
Escherichia coli IAI39 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SNE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585057.6.peg.2458
Escherichia coli IAI39 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SNE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656419.3.peg.2984
Escherichia coli M718 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SNE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656417.3.peg.2898
Escherichia coli M605 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
R
V
IAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|431946.3.peg.2195
Escherichia coli SE15 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
R
V
IAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656379.3.peg.2756
Escherichia coli FVEC1302 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KCI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656380.3.peg.2315
Escherichia coli FVEC1412 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KCI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749549.3.peg.1806
Escherichia coli MS 198-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KCI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|585056.7.peg.2738
Escherichia coli UMN026 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KCI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|216592.1.peg.3030
Escherichia coli 042 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|216592.3.peg.2573
Escherichia coli 042 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|216593.1.peg.2517
Escherichia coli E2348/69 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
SRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SP
T
M
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656437.3.peg.2495
Escherichia coli TA143 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|550677.3.peg.1768
Escherichia coli B354 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETYC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SNE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
S-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|670888.3.peg.4058
Escherichia coli 1827-70 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|344610.3.peg.1670
Escherichia coli 53638 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|344610.7.peg.4175
Escherichia coli 53638 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|413997.3.peg.2243
Escherichia coli B str. REL606 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|511693.5.peg.2255
Escherichia coli BL21 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|469008.4.peg.1480
Escherichia coli BL21(DE3) (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|595496.3.peg.2191
Escherichia coli BW2952 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|536056.3.peg.1511
Escherichia coli DH1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|562.375.peg.3209
Escherichia coli EC4100B (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|316401.4.peg.2695
Escherichia coli ETEC H10407 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656414.3.peg.2598
Escherichia coli H736 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|331112.3.peg.2217
Escherichia coli HS (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|331112.6.peg.2314
Escherichia coli HS (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|83333.1.peg.2195
Escherichia coli K12 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749538.3.peg.2287
Escherichia coli MS 116-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|679205.4.peg.4956
Escherichia coli MS 124-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749540.3.peg.4025
Escherichia coli MS 146-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749547.3.peg.3522
Escherichia coli MS 187-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749548.3.peg.2144
Escherichia coli MS 196-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|749533.3.peg.1658
Escherichia coli MS 84-1 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|316407.3.peg.2155
Escherichia coli W3110 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|316385.5.peg.2345
Escherichia coli str. K-12 substr. DH10B (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|316385.7.peg.2399
Escherichia coli str. K-12 substr. DH10B (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|511145.12.peg.2309
Escherichia coli str. K-12 substr. MG1655 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|511145.6.peg.2293
Escherichia coli str. K-12 substr. MG1655 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|574521.7.peg.2421
Escherichia coli O127:H6 str. E2348/69 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SP
T
M
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|439855.10.peg.2537
Escherichia coli SMS-3-5 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
T
L
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|481805.3.peg.1531
Escherichia coli ATCC 8739 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTS
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|481805.6.peg.1525
Escherichia coli ATCC 8739 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTS
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEVK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656393.3.peg.3255
Escherichia coli H299 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SNE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GAFDY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SPAM
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
L
S
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|670897.3.peg.3201
Escherichia coli 2362-75 (1-457/461)
MTAINR
IL
I
VDD
E
DNVRR
M
L
STA
F
ALQ
G
FETHC
A
NN
G
RTA
L
HLFADIHP
D
V
VL
M
DIRM
P
EMDGI
KA
LKE
M
R
SHE
T
RT
PVI
L
MTA
Y
AE
V
ET
AV
E
A
L
R
C
GA
L
DY
V
I
KP
F
D
L
D
E
L
NLI
V
Q
R
AL
Q
LQS
MKK
E
IRHL
--
HQ-----
-
A
LSTS
W
QWG
H
I
L
T
N
SP
T
M
MD
I
CKDTAK
I
A
L
S
QA
SVLI
S
GESGTGKEL
I
A
R
AIH
YN
S
R
RA
KG
PFI
K
V
NCAALPE
S
LLESELFGHEKGAFTGA
QTL
R
Q
G
L
F
ER
A
N
E
GTL
L
LDEIG
E
MP
LV
LQ
A
K
LLR
I
LQERE
F
E
R
I
G
G
H
QT
I
K
VD
I
RIIAAT
N
RDL
QAM
V
KE
G
T
FREDL
F
YRLNV
I
H
L
I
LP
P
LR
D
RREDI
S
LLA
N
HFLQ
K
FS
S
E
NQRDIIDID
P
M
AM
SL
L
TAWS
WPGN
I
R
E
L
S
N
VI
E
RA
VV
-
M
N
SG
PI
I
FSED
LP
PQ
I
RQPVCNAGEAK
T
A-
P
VGERNLK
-----------------
E
EIK
R
V
E
KRI
I
MEV
LE
Q
Q
E
GN
R
T
R
T
A
L
M
LG
IS
R
R
A
L
MY
KL
Q
E
Y
G
ID
fig|656393.3.peg.5203
Escherichia coli H299 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
P
V
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
TV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|670897.3.peg.1052
Escherichia coli 2362-75 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFS
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
PVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|216593.1.peg.4033
Escherichia coli E2348/69 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFS
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
PVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|574521.7.peg.4411
Escherichia coli O127:H6 str. E2348/69 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFS
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
PVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749537.3.peg.2900
Escherichia coli MS 115-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
CGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|362663.8.peg.4248
Escherichia coli 536 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|362663.9.peg.4264
Escherichia coli 536 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|199310.1.peg.4859
Escherichia coli CFT073 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|199310.4.peg.4661
Escherichia coli CFT073 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340197.3.peg.4427
Escherichia coli F11 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340197.5.peg.4626
Escherichia coli F11 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749550.3.peg.2685
Escherichia coli MS 200-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|753642.3.peg.31
Escherichia coli NC101 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|550677.3.peg.4581
Escherichia coli B354 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|525281.3.peg.4719
Escherichia coli 83972 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
ST
R
K
TL
LA
KL
fig|655817.3.peg.4711
Escherichia coli ABU 83972 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
ST
R
K
TL
LA
KL
fig|358709.5.peg.4552
Escherichia coli 101-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|481805.3.peg.4326
Escherichia coli ATCC 8739 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|481805.6.peg.4308
Escherichia coli ATCC 8739 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|413997.3.peg.4080
Escherichia coli B str. REL606 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|511693.5.peg.4100
Escherichia coli BL21 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|469008.4.peg.4187
Escherichia coli BL21(DE3) (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|316401.4.peg.4840
Escherichia coli ETEC H10407 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749547.3.peg.1130
Escherichia coli MS 187-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|1040638.4.peg.1034
Escherichia coli O104:H4 str. LB226692 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|6666666.5357.peg.3452
Escherichia coli TY-2482 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585055.6.peg.4515
Escherichia coli 55989 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585055.8.peg.4519
Escherichia coli 55989 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340186.3.peg.921
Escherichia coli E110019 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340186.5.peg.963
Escherichia coli E110019 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656444.3.peg.5391
Escherichia coli TA280 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.376.peg.123
Escherichia coli WV_060327 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFS
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340184.3.peg.3756
Escherichia coli B7A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340184.6.peg.3920
Escherichia coli B7A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656379.3.peg.5247
Escherichia coli FVEC1302 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656380.3.peg.5139
Escherichia coli FVEC1412 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656408.3.peg.4492
Escherichia coli H591 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|595495.4.peg.4755
Escherichia coli KO11 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|679206.4.peg.4365
Escherichia coli MS 119-7 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|679205.4.peg.712
Escherichia coli MS 124-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|679204.3.peg.4766
Escherichia coli MS 145-7 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749549.3.peg.1690
Escherichia coli MS 198-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749533.3.peg.5021
Escherichia coli MS 84-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656437.3.peg.4498
Escherichia coli TA143 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585056.7.peg.4698
Escherichia coli UMN026 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|566546.3.peg.4736
Escherichia coli W (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|566546.4.peg.4297
Escherichia coli W (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749531.3.peg.1088
Escherichia coli MS 69-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVVL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
D
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
LI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|685038.3.peg.4078
Escherichia coli O83:H1 str. NRG 857C (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656440.3.peg.4556
Escherichia coli TA206 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|431946.3.peg.4016
Escherichia coli SE15 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|344610.3.peg.1268
Escherichia coli 53638 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|344610.7.peg.2142
Escherichia coli 53638 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|701177.3.peg.4821
Escherichia coli O55:H7 str. CB9615 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|670888.3.peg.4749
Escherichia coli 1827-70 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|595496.3.peg.4003
Escherichia coli BW2952 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|536056.3.peg.4241
Escherichia coli DH1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656414.3.peg.4544
Escherichia coli H736 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|83333.1.peg.3917
Escherichia coli K12 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749538.3.peg.941
Escherichia coli MS 116-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749540.3.peg.2247
Escherichia coli MS 146-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749544.3.peg.675
Escherichia coli MS 175-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749548.3.peg.1722
Escherichia coli MS 196-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|316407.3.peg.3150
Escherichia coli W3110 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|316385.5.peg.4136
Escherichia coli str. K-12 substr. DH10B (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|316385.7.peg.4222
Escherichia coli str. K-12 substr. DH10B (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|511145.12.peg.4119
Escherichia coli str. K-12 substr. MG1655 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|511145.6.peg.4101
Escherichia coli str. K-12 substr. MG1655 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QI
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|550676.3.peg.4263
Escherichia coli B185 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AG
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585057.4.peg.4531
Escherichia coli IAI39 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
T
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585057.6.peg.4541
Escherichia coli IAI39 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
T
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|216592.1.peg.2287
Escherichia coli 042 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
KA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
A
LR
Q
RREDIPLLA
D
Y
FLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
SI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|216592.3.peg.4536
Escherichia coli 042 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
KA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
A
LR
Q
RREDIPLLA
D
Y
FLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
SI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|405955.13.peg.4474
Escherichia coli APEC O1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
I
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QST
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|405955.9.peg.3771
Escherichia coli APEC O1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
I
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QST
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|714962.3.peg.4511
Escherichia coli IHE3034 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
I
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QST
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585035.6.peg.4373
Escherichia coli S88 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
I
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QST
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|439855.10.peg.4571
Escherichia coli SMS-3-5 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
T
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656417.3.peg.4920
Escherichia coli M605 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
V
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585396.4.peg.5003
Escherichia coli O111:H- str. 11128 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNC
V
AL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656419.3.peg.5120
Escherichia coli M718 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
EAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
I
DVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AG
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|331111.12.peg.4760
Escherichia coli E24377A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
V
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|331111.3.peg.2151
Escherichia coli E24377A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
V
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749545.3.peg.3722
Escherichia coli MS 182-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
V
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|749532.3.peg.724
Escherichia coli MS 78-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLL
V
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|573235.3.peg.5269
Escherichia coli O26:H11 str. 11368 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNC
V
AL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
S
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RS
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
C
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585397.7.peg.4698
Escherichia coli ED1a (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEK
R
AFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585397.9.peg.4697
Escherichia coli ED1a (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
TLN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSVDAET
PA
VSAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEK
R
AFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
N
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LVQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|550672.3.peg.4081
Escherichia coli B088 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|344601.3.peg.4309
Escherichia coli B171 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|344601.5.peg.4539
Escherichia coli B171 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340185.3.peg.4790
Escherichia coli E22 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|340185.4.peg.5060
Escherichia coli E22 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585034.4.peg.4105
Escherichia coli IAI1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585034.5.peg.4101
Escherichia coli IAI1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|679207.4.peg.4740
Escherichia coli MS 107-1 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|585395.4.peg.4981
Escherichia coli O103:H2 str. 12009 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.371.peg.391
Escherichia coli 1044A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.373.peg.152
Escherichia coli 1125A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|83334.1.peg.4903
Escherichia coli O157:H7 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|155864.1.peg.4944
Escherichia coli O157:H7 EDL933 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444454.5.peg.4035
Escherichia coli O157:H7 str. EC4024 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444449.5.peg.3491
Escherichia coli O157:H7 str. EC4042 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444448.5.peg.2247
Escherichia coli O157:H7 str. EC4045 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444453.5.peg.1885
Escherichia coli O157:H7 str. EC4076 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444452.5.peg.4909
Escherichia coli O157:H7 str. EC4113 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444450.8.peg.5328
Escherichia coli O157:H7 str. EC4115 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444451.5.peg.4829
Escherichia coli O157:H7 str. EC4196 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|444447.5.peg.2413
Escherichia coli O157:H7 str. EC4206 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|478004.5.peg.5162
Escherichia coli O157:H7 str. EC4401 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|478005.5.peg.5072
Escherichia coli O157:H7 str. EC4486 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|478006.5.peg.4874
Escherichia coli O157:H7 str. EC4501 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|478007.5.peg.1189
Escherichia coli O157:H7 str. EC508 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|478008.5.peg.5382
Escherichia coli O157:H7 str. EC869 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|637388.3.peg.4362
Escherichia coli O157:H7 str. FRIK2000 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|570506.3.peg.2909
Escherichia coli O157:H7 str. FRIK966 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|386585.9.peg.5153
Escherichia coli O157:H7 str. Sakai (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|544404.4.peg.5138
Escherichia coli O157:H7 str. TW14359 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|502346.5.peg.1666
Escherichia coli O157:H7 str. TW14588 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.375.peg.3584
Escherichia coli EC4100B (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
I
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|656443.3.peg.4975
Escherichia coli TA271 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AG
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|155864.8.peg.4915
Escherichia coli O157:H7 EDL933 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
X
S
PM
M
L
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|409438.11.peg.4472
Escherichia coli SE11 (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
T
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
H
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|331112.3.peg.3953
Escherichia coli HS (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
H
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AG
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|331112.6.peg.4124
Escherichia coli HS (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVREQVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HSIDAET
PA
VTAS
-
QFG
-
M
VG
K
S
S
AM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
Q
V
RLLR
A
I
QEREV
Q
RVGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
H
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AG
T
PI
P
LGQSQDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.372.peg.3581
Escherichia coli 1212A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
C
VGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|562.374.peg.3684
Escherichia coli 536A (8-439/441)
ILVVDDD
ISHCT
I
L
QAL
L
RGW
G
YNVAL
A
N
SG
RQA
L
EQVRERVF
DLVL
C
D
V
RM
A
EMDGI
AT
LKEIK
ALN
P
AI
PV
L
IMTA
Y
SS
V
ET
AV
E
A
L
K
T
GA
L
DYL
I
KP
L
D
F
D
N
L
QAT
L
E
K
AL
A
---
---
-
--HT
--
HIIDAET
PA
VTAS
-
QFG
-
M
VG
K
SPAM
QH
L
LSEIAL
VA
P
S
EA
T
VLI
H
G
D
SGTGKEL
V
A
R
AIH
AS
S
A
R
S
EK
P
LV
T
LNCAAL
N
E
S
LLESELFGHEKGAFTGA
DKR
REGRF
VE
ADGGTLFLDEIGD
IS
PM
M
L
V
RLLR
A
I
QEREV
Q
C
VGSN
QT
I
S
VDVR
L
IAATHRDL
AAE
V
NA
G
R
FR
Q
DLYYRLNVV
A
I
E
V
P
S
LR
Q
RREDIPLLA
G
HFLQ
R
F
A
E
R
NRKAVKGFT
P
Q
AM
DL
L
IHYD
WPGN
I
R
E
L
E
N
AV
E
RA
VV
-
L
L
T
G
EY
I
SERE
LP
LA
I
---------AS
T
PI
P
LAQSLDI
-----------------
Q
PLV
E
V
E
KEV
I
LAA
LE
K
T
G
GN
K
T
E
AAR
Q
LG
IT
R
K
TL
LA
KL
fig|362663.8.peg.2588
Escherichia coli 536 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
KL
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|362663.9.peg.2593
Escherichia coli 536 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
KL
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340197.3.peg.2729
Escherichia coli F11 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
KL
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340197.5.peg.2856
Escherichia coli F11 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
KL
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749550.3.peg.410
Escherichia coli MS 200-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
KL
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340184.3.peg.3078
Escherichia coli B7A (10-432/459)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340184.6.peg.3213
Escherichia coli B7A (10-432/459)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656440.3.peg.2601
Escherichia coli TA206 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|1040638.4.peg.2984
Escherichia coli O104:H4 str. LB226692 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|6666666.5357.peg.2622
Escherichia coli TY-2482 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|216592.3.peg.2887
Escherichia coli 042 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|670897.3.peg.1177
Escherichia coli 2362-75 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585055.6.peg.2876
Escherichia coli 55989 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585055.8.peg.2880
Escherichia coli 55989 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|344601.3.peg.1676
Escherichia coli B171 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|344601.5.peg.1749
Escherichia coli B171 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|550677.3.peg.2438
Escherichia coli B354 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340184.3.peg.4710
Escherichia coli B7A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340185.3.peg.2413
Escherichia coli E22 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340185.4.peg.2553
Escherichia coli E22 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|331111.12.peg.3118
Escherichia coli E24377A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|331111.3.peg.568
Escherichia coli E24377A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.375.peg.3544
Escherichia coli EC4100B (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|316401.4.peg.3088
Escherichia coli ETEC H10407 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656379.3.peg.3189
Escherichia coli FVEC1302 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656380.3.peg.2638
Escherichia coli FVEC1412 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656393.3.peg.3569
Escherichia coli H299 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656408.3.peg.2848
Escherichia coli H591 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|331112.3.peg.2542
Escherichia coli HS (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|331112.6.peg.2654
Escherichia coli HS (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585034.4.peg.2578
Escherichia coli IAI1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585034.5.peg.2577
Escherichia coli IAI1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|595495.4.peg.3312
Escherichia coli KO11 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656417.3.peg.3269
Escherichia coli M605 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|679207.4.peg.2650
Escherichia coli MS 107-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|679206.4.peg.552
Escherichia coli MS 119-7 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|679204.3.peg.1535
Escherichia coli MS 145-7 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749545.3.peg.4802
Escherichia coli MS 182-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749549.3.peg.2355
Escherichia coli MS 198-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749527.3.peg.664
Escherichia coli MS 21-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749532.3.peg.4442
Escherichia coli MS 78-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585395.4.peg.3221
Escherichia coli O103:H2 str. 12009 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585396.4.peg.3385
Escherichia coli O111:H- str. 11128 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|573235.3.peg.3672
Escherichia coli O26:H11 str. 11368 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|685038.3.peg.2581
Escherichia coli O83:H1 str. NRG 857C (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|409438.11.peg.3010
Escherichia coli SE11 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|431946.3.peg.2503
Escherichia coli SE15 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|439855.10.peg.2868
Escherichia coli SMS-3-5 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656437.3.peg.2887
Escherichia coli TA143 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656443.3.peg.3316
Escherichia coli TA271 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656444.3.peg.3558
Escherichia coli TA280 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585056.7.peg.3061
Escherichia coli UMN026 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|566546.3.peg.3854
Escherichia coli W (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|566546.4.peg.2753
Escherichia coli W (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.376.peg.4466
Escherichia coli WV_060327 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|216592.1.peg.5343
Escherichia coli 042 (23-445/457)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|216593.1.peg.159
Escherichia coli E2348/69 (23-445/457)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|550672.3.peg.2287
Escherichia coli B088 (1-423/435)
M
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749531.3.peg.3843
Escherichia coli MS 69-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
ISE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585397.7.peg.2993
Escherichia coli ED1a (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
I
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585397.9.peg.2990
Escherichia coli ED1a (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
I
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|714962.3.peg.2944
Escherichia coli IHE3034 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQV
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|364106.7.peg.2875
Escherichia coli UTI89 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AS
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|364106.8.peg.2874
Escherichia coli UTI89 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AS
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|525281.3.peg.4328
Escherichia coli 83972 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|655817.3.peg.2977
Escherichia coli ABU 83972 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|405955.13.peg.2834
Escherichia coli APEC O1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|550676.3.peg.1760
Escherichia coli B185 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
K
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|199310.4.peg.2902
Escherichia coli CFT073 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749546.3.peg.1173
Escherichia coli MS 185-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749528.3.peg.2436
Escherichia coli MS 45-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|753642.3.peg.2558
Escherichia coli NC101 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585035.6.peg.2694
Escherichia coli S88 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|869729.3.peg.846
Escherichia coli UM146 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|405955.9.peg.2341
Escherichia coli APEC O1 (23-445/457)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|199310.1.peg.3001
Escherichia coli CFT073 (23-445/457)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
TR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585057.4.peg.2862
Escherichia coli IAI39 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|585057.6.peg.2867
Escherichia coli IAI39 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
VEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
I
DVRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|358709.5.peg.2153
Escherichia coli 101-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.371.peg.5426
Escherichia coli 1044A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.373.peg.3752
Escherichia coli 1125A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.372.peg.1975
Escherichia coli 1212A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|670888.3.peg.3732
Escherichia coli 1827-70 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|344610.3.peg.507
Escherichia coli 53638 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|344610.7.peg.3768
Escherichia coli 53638 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|562.374.peg.3178
Escherichia coli 536A (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|481805.3.peg.1201
Escherichia coli ATCC 8739 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|481805.6.peg.1199
Escherichia coli ATCC 8739 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|413997.3.peg.2565
Escherichia coli B str. REL606 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|511693.5.peg.2579
Escherichia coli BL21 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|469008.4.peg.1157
Escherichia coli BL21(DE3) (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|595496.3.peg.2538
Escherichia coli BW2952 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|536056.3.peg.1171
Escherichia coli DH1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340186.3.peg.1492
Escherichia coli E110019 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|340186.5.peg.1540
Escherichia coli E110019 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656414.3.peg.2928
Escherichia coli H736 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|83333.1.peg.2524
Escherichia coli K12 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|656419.3.peg.3326
Escherichia coli M718 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749538.3.peg.4842
Escherichia coli MS 116-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|679205.4.peg.1443
Escherichia coli MS 124-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749540.3.peg.4595
Escherichia coli MS 146-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749547.3.peg.2416
Escherichia coli MS 187-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749548.3.peg.1304
Escherichia coli MS 196-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749533.3.peg.2225
Escherichia coli MS 84-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|83334.1.peg.3420
Escherichia coli O157:H7 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|155864.1.peg.3418
Escherichia coli O157:H7 EDL933 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|155864.8.peg.3333
Escherichia coli O157:H7 EDL933 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444454.5.peg.2445
Escherichia coli O157:H7 str. EC4024 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444449.5.peg.1911
Escherichia coli O157:H7 str. EC4042 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444448.5.peg.665
Escherichia coli O157:H7 str. EC4045 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444453.5.peg.145
Escherichia coli O157:H7 str. EC4076 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444452.5.peg.1445
Escherichia coli O157:H7 str. EC4113 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444450.8.peg.3754
Escherichia coli O157:H7 str. EC4115 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444451.5.peg.1215
Escherichia coli O157:H7 str. EC4196 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|444447.5.peg.806
Escherichia coli O157:H7 str. EC4206 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|478004.5.peg.4403
Escherichia coli O157:H7 str. EC4401 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|478005.5.peg.2638
Escherichia coli O157:H7 str. EC4486 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|478006.5.peg.1675
Escherichia coli O157:H7 str. EC4501 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|478007.5.peg.1719
Escherichia coli O157:H7 str. EC508 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|478008.5.peg.3115
Escherichia coli O157:H7 str. EC869 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|637388.3.peg.36
Escherichia coli O157:H7 str. FRIK2000 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|570506.3.peg.5296
Escherichia coli O157:H7 str. FRIK966 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|386585.9.peg.3574
Escherichia coli O157:H7 str. Sakai (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|544404.4.peg.3557
Escherichia coli O157:H7 str. TW14359 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|502346.5.peg.3858
Escherichia coli O157:H7 str. TW14588 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|701177.3.peg.3117
Escherichia coli O55:H7 str. CB9615 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|316407.3.peg.2476
Escherichia coli W3110 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|316385.7.peg.2750
Escherichia coli str. K-12 substr. DH10B (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|511145.12.peg.2656
Escherichia coli str. K-12 substr. MG1655 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|511145.6.peg.2642
Escherichia coli str. K-12 substr. MG1655 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
EI
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
SP
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|749537.3.peg.4137
Escherichia coli MS 115-1 (10-432/444)
L
VDDD
PGLLK
LL
GLR
L
TSE
G
YSVVT
AESG
AEG
L
RVLNREKV
DLV
I
S
D
L
RM
D
EMDG
M
QL
FA
V
I
Q
KVQ
P
GM
PVII
L
TAH
GS
I
PD
AV
A
A
T
Q
Q
G
V
F
SF
L
T
KP
V
D
K
D
A
L
YQA
ID
D
AL
E
---
---
-
----
--
----QSA
PA
TDER
W
REA
-
IV
T
R
S
Q
L
M
LR
L
LEQARL
VA
Q
S
DV
SVLING
Q
SGTGKE
I
F
A
Q
AIH
NA
S
P
R
N
SK
PFI
A
I
NC
G
ALPE
Q
LLESELFGH
AR
GAFTGA
VSN
REG
L
F
QA
A
E
GGTLFLDEIGDMP
AP
LQ
V
K
LLR
V
LQER
K
V
R
P
L
GSN
RD
I
D
IN
VRII
S
ATHRDL
PKA
M
AR
G
E
FREDLYYRLNVV
S
L
K
I
P
A
L
A
ER
T
EDIPLLA
N
H
L
L
R
Q
AA
E
R
HKPFVRAFS
T
D
AM
KR
L
MTAS
WPGNVRQL
V
N
VI
E
QC
V
A
-
L
T
S
S
PV
I
SDAL
VE
QA
L
EG-------EN
T
AL
P
----TFV
-----------------
E
ARN
Q
F
E
LNY
L
RKL
L
Q
I
T
K
GN
V
T
H
AAR
M
A
G
RN
R
-
T
E
FY
KL
L
fig|431946.3.peg.4083
Escherichia coli SE15 (5-438/452)
FSEIT
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|340197.3.peg.2065
Escherichia coli F11 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
SLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
Y
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|749550.3.peg.1448
Escherichia coli MS 200-1 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
SLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
Y
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|670897.3.peg.1358
Escherichia coli 2362-75 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|525281.3.peg.1829
Escherichia coli 83972 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|655817.3.peg.4785
Escherichia coli ABU 83972 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|405955.9.peg.3833
Escherichia coli APEC O1 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|199310.1.peg.4935
Escherichia coli CFT073 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|199310.4.peg.4731
Escherichia coli CFT073 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|216593.1.peg.3962
Escherichia coli E2348/69 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|585397.7.peg.4761
Escherichia coli ED1a (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|585397.9.peg.4761
Escherichia coli ED1a (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|749546.3.peg.1025
Escherichia coli MS 185-1 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|749528.3.peg.4443
Escherichia coli MS 45-1 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|753642.3.peg.4101
Escherichia coli NC101 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|574521.7.peg.4476
Escherichia coli O127:H6 str. E2348/69 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|685038.3.peg.4141
Escherichia coli O83:H1 str. NRG 857C (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|656440.3.peg.4621
Escherichia coli TA206 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|869729.3.peg.4391
Escherichia coli UM146 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|562.376.peg.1707
Escherichia coli WV_060327 (10-438/452)
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
PVI
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|656417.3.peg.5127
Escherichia coli M605 (5-438/452)
FSEIT
I
V
Y
IE
D
S
DDVRF
AC
EQT
L
TLA
G
YRVIS
CCDA
EHS
I
PLIQSQAN
I
II
L
T
D
V
R
L
P
G
I
S
G
L
EL
L
SY
I
N
EMD
S
KI
P
F
I
L
I
T
G
H
GD
V
EM
AV
D
A
M
R
N
GAFD
F
I
E
KP
S
S
S
D
K
L
LSI
I
A
R
A
V
E
KRR
LVL
E
NQQL
LA
NLQQENG
P
V
----
-
---
-
LI
G
R
SP
Q
M
QQ
L
RKMILN
VA
D
T
GA
D
VLI
Y
GE
T
G
C
GKE
V
V
A
R
M
L
H
HW
S
T
R
R
QG
Q
F
V
A
LNCA
G
LPE
T
L
F
ESE
I
FGHE
A
GAFTGA
VKK
R
I
G
K
I
EH
A
N
GGTLFLDEI
EG
MP
SG
M
Q
V
K
LLR
V
LQER
T
I
E
R
L
G
A
N
QL
I
P
V
N
C
R
V
IAAT
KE
DL
LRR
S
EE
H
L
FR
L
DLYYRLNVV
S
L
N
I
P
P
LR
Q
RREDIP
E
L
F
Y
W
F
AS
Q
AA
Q
K
YNRPLPDIS
P
M
L
L
AW
L
QSQS
WPGNVR
E
L
K
H
NA
E
RF
V
L
G
L
L
T
-
--
-
----
--
--
-
---------HH
Q
PV
P
MTQQEES
--------------
G
L
TA
CID
A
F
E
KKL
I
EDM
L
R
Q
T
E
G
Q
V
S
L
T
AR
L
L
Q
LP
R
K
TL
YD
KL
N
K
fig|344610.3.peg.5042
Escherichia coli 53638 (11-411/418)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QI
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
A
L
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
V
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
A
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|344610.7.peg.233
Escherichia coli 53638 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QI
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
A
L
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
V
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
A
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|405955.13.peg.3320
Escherichia coli APEC O1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|405955.9.peg.2750
Escherichia coli APEC O1 (11-411/418)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|199310.1.peg.5095
Escherichia coli CFT073 (11-411/418)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|199310.4.peg.4880
Escherichia coli CFT073 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|585035.6.peg.3218
Escherichia coli S88 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|753642.3.peg.109
Escherichia coli NC101 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
TWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QI
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
FI
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
V
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PT
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|679207.4.peg.1597
Escherichia coli MS 107-1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
Y
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|362663.8.peg.3005
Escherichia coli 536 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|362663.9.peg.3014
Escherichia coli 536 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|340197.3.peg.1931
Escherichia coli F11 (11-411/418)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|340197.5.peg.2041
Escherichia coli F11 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|656393.3.peg.342
Escherichia coli H299 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
MF
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|679205.4.peg.3135
Escherichia coli MS 124-1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
MF
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|749545.3.peg.2033
Escherichia coli MS 182-1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
MF
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|749533.3.peg.3749
Escherichia coli MS 84-1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QL
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
MF
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
fig|749550.3.peg.153
Escherichia coli MS 200-1 (8-408/415)
IL
LI
DDD
ADVLD
AY
TQL
L
EQS
G
YRVFA
C
NN
P
FEA
Q
AWIQPDWP
G
I
VL
S
D
V
C
M
P
G
CS
GI
DL
M
MLFH
QDD
Q
QI
P
I
LL
I
T
G
H
GD
V
PM
AV
D
A
V
K
K
GA
W
D
F
L
Q
KP
V
D
P
G
K
L
LSL
VE
E
AL
R
QRQ
SII
A
RRQY
CQ
QTLQVE-
-
-
----
-
---
-
LI
G
R
S
EW
I
NQ
Y
RRRLQQ
L
S
E
T
DI
A
V
W
L
Y
G
AP
GTG
R
MT
G
A
R
Y
L
H
QF
G
R
N
A
QG
E
F
V
Y
RELT--
P
D
N
AP
Q
LND
F
----------
---
----I
AL
A
Q
GGTL
V
L
SHPEH
L
T
RE
Q
Q
Y
H
L
VQ
-
LQ
S
Q
E
H
R
P
F---
--
-
-
---
R
L
I
GIGDTS
L
VEL
A
AS
N
H
IIA
E
LYY
CFA
M
T
Q
I
A
CL
P
L
T
Q
R
P
D
DI
EP
L
F
R
H
Y
L
C
K
A
C
Q
R
LNHPVPEVG
K
E
M
L
KE
M
MRRM
WP
N
NVR
E
L
A
N
AA
E
LF
T
V
G
I
L
P-
--
-
----
--
--
L
AETANPLMHVG
T
PA
P
LD-----
-----------------
R
RVE
D
A
E
RQI
I
TEA
L
N
I
H
Q
G
R
I
N
E
V
A
E
Y
L
Q
IP
R
K
K
L
YL
RM
K
KY
G
L
Consen1
Primary consensus
MTfmqrgiilvVDDd
lL
l
G
aesG
L
Dlvl
DiRM
eMDGi
lkeik
p
PViimTAh
v
AV
A
q
Gafdyl
KP
D
D
l
ve
Al
---
-
--
pa
-
-
ivg
sPaM
l
va
S
sVLInGeSGTGKEl
A
AiH
S
Ra
Pfi
lNcaAlpe
LlESELFGHekGAFTGA
ReGrF
AdgGTLfLDEIGdmp
lQ
rLLR
lqerev
rvGsn
i
vdvRiIaAThrdL
v
G
FReDLyyRLNVv
l
lP
LreRrEDIplLA
HfLq
aa
r
p
am
L
WPGNvRqL
N
e
vv
-
l
sg
i
lp
l
t
P
-----------------
e
e
E
l
Le
t
Gn
t
aAr
lG
R
tl
KL
elGme
Consen2
Secondary consensus
mtainrvw
e
f
fnn
vli
g
faqm
t
lll
y
vlsfv
a
i
lqs
e
-
t
w
hm
t
a
l
s
t
i
l
lv
mg
ink
i
ar
q
l
e
l
eis
k
iadg
f
p
g
v
ini
l
s
nqn
m
q
fh
i
a
t
sr
l
r
fs
e
t
te
i
e
r
ta
m
s
v
ve
i
m
aqwadralrsghqnllsq
i
q
h
q
t
l
a
ae
ky
id
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character