fig|216592.1.peg.2545
Escherichia coli 042 (810-1372/1372)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|655817.3.peg.332
Escherichia coli ABU 83972 (809-1371/1371)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|199310.1.peg.333
Escherichia coli CFT073 (809-1371/1371)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|216592.3.peg.4768
Escherichia coli 042 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|585055.6.peg.3317
Escherichia coli 55989 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|585055.6.peg.4683
Escherichia coli 55989 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|585055.8.peg.3321
Escherichia coli 55989 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|585055.8.peg.4688
Escherichia coli 55989 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|6666666.5357.peg.2551
Escherichia coli TY-2482 (469-1031/1031)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|1040638.4.peg.2520
Escherichia coli O104:H4 str. LB226692 (508-1070/1070)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|656440.3.peg.100
Escherichia coli TA206 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|525281.3.peg.2675
Escherichia coli 83972 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|199310.4.peg.328
Escherichia coli CFT073 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|656393.3.peg.873
Escherichia coli H299 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|749528.3.peg.4087
Escherichia coli MS 45-1 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|749546.3.peg.3640
Escherichia coli MS 185-1 (548-1110/1110)
V
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
N
S
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
T
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETTASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHT
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
KDPAQ
-
GQS
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RMI
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
ET
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|1040638.4.peg.1222
Escherichia coli O104:H4 str. LB226692
M
HD
G
G
H
L
T
A
LN
G
L
FS
D
G
H
-----------
-
------
I
QAGK
NG
K
I
T
L
----------
S
G
T
P
VKDTA
N
Q-YA
P
AV-YLTDGYD
L
T
---------
G
D
N
-------------
A
A
L
EITRGAH
A
S
G
D
I
HA
-
SAAST
--
V
TI
G
SDTPAELASAETAASAFAG
----------------------------
S
L
LE
G
YNA
A
FN
G
A
I
T
-
GG
R
A
D
V
S
M
-
H
N
A
L
W
T
L
G
G
D
S
A
IHS
L
TVRN
S
R
I
S
S
EG
-
D---RT
F
R
TLTV
N
K
L
D
A
TG
S
D
F
V
L
R
T
D
LKN
--
A
D
KIN
V
TEKA
T
G
S
D
N
SLN
V
S
F
M
NNPAQ
-
GQA
L
N
I
P
LV
T
AP
AG
T
SA
E
M
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TSGGNTK
W
I
L
D
G
FKAEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMGDLRD
T
NGD
A
G
A
W
A
R
IMS
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
HELD
G
V
DLFTG
VTM
T
Y
TDSSA
DSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
E
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
SL
G
TK
H
YN
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
D
M
DL
S
M
KNRDFS
PL
V
G
-----
RTGV
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RY
M
F
fig|340185.3.peg.3793
Escherichia coli E22 (748-1309/1309)
V
RD
G
G
H
L
T
A
QK
G
L
Y
S
D
G
R
-----------
-
------
V
QIGK
NG
T
L
S
L
----------
S
G
T
P
ENGAD
N
T-WM
P
VLTYMTEGYD
L
T
---------
G
D
N
-------------
A
T
L
DISQQAH
V
S
G
D
V
HA
-
TSSST
--
I
RI
G
SENPGSVSS--SVSPVLAA
----------------------------
G
V
FS
G
YNA
A
YY
G
A
I
T
-
GG
K
G
N
V
S
M
-
N
N
G
L
W
Q
L
T
G
D
S
D
INS
L
TTRN
S
R
V
Q
S
EE
-
K---GA
F
R
TLTV
N
T
L
D
A
TG
S
D
F
V
L
R
T
D
LKG
--
A
D
KIS
I
TEKA
S
G
S
D
N
TLN
V
S
F
M
KNPSP
-
GQS
L
N
I
P
LV
S
AP
AG
T
SG
DI
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TTGGSTK
W
I
L
D
G
FRTEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMG
E
LRD
T
NGD
A
G
A
W
A
R
IMN
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
H
V
LD
G
V
DLFTG
ITM
T
Y
TDSSA
DSDAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
I
DLI
G
KY
I
H
H
N
N
D
Y
TG
--
N
FA
GL
G
TK
H
YG
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
E
M
DL
S
M
KNKDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
M
F
fig|340185.4.peg.3988
Escherichia coli E22 (693-1254/1254)
V
RD
G
G
H
L
T
A
QK
G
L
Y
S
D
G
R
-----------
-
------
V
QIGK
NG
T
L
S
L
----------
S
G
T
P
ENGAD
N
T-WM
P
VLTYMTEGYD
L
T
---------
G
D
N
-------------
A
T
L
DISQQAH
V
S
G
D
V
HA
-
TSSST
--
I
RI
G
SENPGSVSS--SVSPVLAA
----------------------------
G
V
FS
G
YNA
A
YY
G
A
I
T
-
GG
K
G
N
V
S
M
-
N
N
G
L
W
Q
L
T
G
D
S
D
INS
L
TTRN
S
R
V
Q
S
EE
-
K---GA
F
R
TLTV
N
T
L
D
A
TG
S
D
F
V
L
R
T
D
LKG
--
A
D
KIS
I
TEKA
S
G
S
D
N
TLN
V
S
F
M
KNPSP
-
GQS
L
N
I
P
LV
S
AP
AG
T
SG
DI
--
F
K
A
G
T
RVT
GFS
R
VTP
TLHVD
-------
TTGGSTK
W
I
L
D
G
FRTEA
D
KA
-----------------------------
-
-------
AAAK
A
DSFM
N
A
-
G
Y
KN
F
MT
EVNNLNKRMG
E
LRD
T
NGD
A
G
A
W
A
R
IMN
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
H
V
LD
G
V
DLFTG
ITM
T
Y
TDSSA
DSDAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
I
DLI
G
KY
I
H
H
N
N
D
Y
TG
--
N
FA
GL
G
TK
H
YG
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
E
M
DL
S
M
KNKDFS
PL
I
G
-----
RTG
I
EL
GK
T
FSGKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
M
F
fig|431946.3.peg.4176
Escherichia coli SE15 (693-1254/1254)
V
RD
G
G
H
L
T
A
QK
G
L
Y
S
D
G
R
-----------
-
------
V
QIGK
NG
T
L
S
L
----------
S
G
T
P
ENGAD
N
T-WM
P
VLTYMTEGYD
L
T
---------
G
D
N
-------------
A
T
L
NISQQAH
V
S
G
D
V
HA
-
TSSSS
--
I
RI
G
SENPGSVSS--SVSPVLAA
----------------------------
G
L
FS
G
YNA
A
YY
G
A
I
T
-
GG
K
G
N
V
S
M
-
N
N
G
L
W
Q
L
T
G
D
S
D
INS
L
TTRN
S
R
V
Q
S
EE
-
N---GA
F
R
TLTV
K
T
L
D
A
TG
S
D
F
V
L
R
T
D
LKD
--
A
D
KIS
I
TEKA
S
G
S
D
N
TLN
V
S
F
M
KNPSP
-
GQS
L
N
I
P
LV
S
AP
AG
T
SG
DI
--
F
K
A
G
T
RVT
GFS
R
VTP
TLRVD
-------
TTGGSTK
W
I
L
D
G
FRTEA
D
KA
-----------------------------
-
-------
AAAK
A
NSFM
N
A
-
G
Y
KS
F
MT
EVNNLNKRMG
E
LRD
T
NGD
A
G
A
W
A
R
IMN
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
H
A
LD
G
V
DLFTG
VTM
T
Y
TDSSA
DSDAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YG
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
E
M
DL
S
M
KNKDFS
PL
I
G
-----
RTG
I
EL
GK
T
F
R
GKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
M
F
fig|656417.3.peg.5223
Escherichia coli M605 (693-1254/1254)
V
RD
G
G
H
L
T
A
QK
G
L
Y
S
D
G
R
-----------
-
------
V
QIGK
K
G
T
L
S
L
----------
S
G
T
P
ENGAD
N
T-WM
P
VLTYMTEGYD
L
T
---------
G
D
N
-------------
A
T
L
NISQQAH
V
S
G
D
V
HA
-
TSSSS
--
I
RI
G
SENPGSVSS--SVSPVLAA
----------------------------
G
L
FS
G
YNA
A
YY
G
A
I
T
-
GG
K
G
N
V
S
M
-
N
N
G
L
W
Q
L
T
G
D
S
D
INS
L
TTRN
S
R
V
Q
S
EE
-
N---GA
F
R
TLTV
K
T
L
D
A
TG
S
D
F
V
L
R
T
D
LKD
--
A
D
KIS
I
TEKA
S
G
S
D
N
TLN
V
S
F
M
KNPSP
-
GQS
L
N
I
P
LV
S
AP
AG
T
SG
DI
--
F
K
A
G
T
RVT
GFS
R
VTP
TLRVD
-------
TTGGSTK
W
I
L
D
G
FRTEA
D
KA
-----------------------------
-
-------
AAAK
A
NSFM
N
A
-
G
Y
KS
F
MT
EVNNLNKRMG
E
LRD
T
NGD
A
G
A
W
A
R
IMN
G
A
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
V
G
F
DKK
-
H
A
LD
G
V
DLFTG
VTM
T
Y
TDSSA
DSDAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
I
DLI
G
KY
I
H
H
D
N
D
Y
TG
--
N
FA
GL
G
TK
H
YG
T
HS
W
YAGAE
T
GYRYHLT
E
-
DT
---
F
IEPQAELVYG
AVS
G
KT
F
R
W
K
D
G
E
M
DL
S
M
KNKDFS
PL
I
G
-----
RTG
I
EL
GK
T
F
R
GKDW
S
V
T
A
RAGT
SWQ
FDL
LN
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
FN
VG
M
NAQ
IK
DN
M
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
M
F
fig|216593.1.peg.985
Escherichia coli E2348/69 (755-1308/1308)
L
EK
GA
K
L
T
A
QG
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
I
L
----------
T
G
T
P
SAQKQ
E
Y-YS
P
VI-STTEGIN
L
-
---------
G
D
K
-------------
A
S
L
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DGD----AE---TDSPLFS
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
E
Q
S
T
V
N
M
-
N
N
A
L
W
Y
S
D
G
N
S
T
IGT
L
KSTG
G
R
V
E
L
GG
-
G---KD
F
A
TL
R
V
K
E
L
N
A
NN
A
T
F
L
M
H
TN
NSQ
--
A
D
QLN
V
TNKL
L
G
S
NN
TVL
V
D
F
L
NKPAS
-
E--
M
N
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTDDATK
W
M
L
T
G
YQTVS
D
AG
-----------------------------
-
-------
ASKT
A
TDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
D
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
Y
TA
--
SFA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
ES
---
W
V
EPQ
M
ELVYG
SVS
G
KS
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
T
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
F
E
G
E
KD
S
RML
MN
VG
M
NA
E
IK
DN
M
RFGLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|574521.7.peg.2961
Escherichia coli O127:H6 str. E2348/69 (755-1308/1308)
L
EK
GA
K
L
T
A
QG
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
I
L
----------
T
G
T
P
SAQKQ
E
Y-YS
P
VI-STTEGIN
L
-
---------
G
D
K
-------------
A
S
L
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DGD----AE---TDSPLFS
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
E
Q
S
T
V
N
M
-
N
N
A
L
W
Y
S
D
G
N
S
T
IGT
L
KSTG
G
R
V
E
L
GG
-
G---KD
F
A
TL
R
V
K
E
L
N
A
NN
A
T
F
L
M
H
TN
NSQ
--
A
D
QLN
V
TNKL
L
G
S
NN
TVL
V
D
F
L
NKPAS
-
E--
M
N
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTDDATK
W
M
L
T
G
YQTVS
D
AG
-----------------------------
-
-------
ASKT
A
TDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
D
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
Y
TA
--
SFA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
ES
---
W
V
EPQ
M
ELVYG
SVS
G
KS
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
T
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
F
E
G
E
KD
S
RML
MN
VG
M
NA
E
IK
DN
M
RFGLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|670897.3.peg.1267
Escherichia coli 2362-75 (356-909/909)
L
EK
GA
K
L
T
A
QG
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
I
L
----------
T
G
T
P
SAQKQ
E
Y-YS
P
VI-STTEGIN
L
-
---------
G
D
K
-------------
A
S
L
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DGD----AE---TDSPLFS
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
E
Q
S
T
V
N
M
-
N
N
A
L
W
Y
S
D
G
N
S
T
IGT
L
KSTG
G
R
V
E
L
GG
-
G---KD
F
A
TL
R
V
K
E
L
N
A
NN
A
T
F
L
M
H
TN
NSQ
--
A
D
QLN
V
TNKL
L
G
S
NN
TVL
V
D
F
L
NKPAS
-
E--
M
N
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTDDATK
W
M
L
T
G
YQTVS
D
AG
-----------------------------
-
-------
ASKT
A
TDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
D
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
Y
TA
--
SFA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
ES
---
W
V
EPQ
M
ELVYG
SVS
G
KS
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
T
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
F
E
G
E
KD
S
RML
MN
VG
M
NA
E
IK
DN
M
RFGLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|585395.4.peg.3978
Escherichia coli O103:H2 str. 12009 (765-1329/1329)
I
HK
G
G
A
L
T
A
QG
G
L
F
T
S
G
S
-----------
-
------
I
DIG-
D
A
S
L
L
L
----------
T
G
T
P
VNSDD
A
A-FL
P
TINMADGGFK
L
M
---------
S
D
S
-------------
S
V
L
KARDQAS
V
V
G
D
I
IS
-
DKQAT
--
I
SF
G
TESGKEGILSEKASRGLAV
----------------------------
G
L
LS
G
FNT
A
YR
G
A
IH
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
S
LRS
L
KNTG
S
M
T
Y
F
TG
-
SAANKA
F
H
TLTV
D
E
L
T
T
NG
T
A
Y
A
MR
T
D
LKN
--
A
D
KLV
V
NQKL
S
G
K
D
N
ILL
V
D
F
L
NKPTG
-
EK-
L
D
I
E
LV
S
AP
GN
S
SK
D
V
--
F
K
G
S
E
QEI
GFS
N
VTP
VITAI
-------
DAGDKTT
W
N
L
T
G
YRMAE
N
PA
-----------------------------
-
-------
ATQS
A
SGLA
S
V
-
G
Y
KS
F
LS
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
H
T
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADAF
K
G
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYR
C
H
V
T
E
-
DT
---
W
IEPQAELVYG
AVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDRDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|562.376.peg.3462
Escherichia coli WV_060327 (604-1157/1157)
L
EK
GA
K
L
T
A
QG
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
I
L
----------
T
G
T
P
SAQKQ
E
Y-YS
P
VI-STTEGIN
L
-
---------
G
D
K
-------------
A
S
L
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DGD----AE---TDSPLFS
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
E
Q
S
T
V
N
M
-
N
N
A
L
W
Y
S
D
G
N
S
T
IGT
L
KSTG
G
R
V
E
L
GG
-
G---KD
F
A
TL
R
V
K
E
L
N
A
NN
A
T
F
L
M
H
TN
NSQ
--
A
D
QLN
V
TNKL
L
G
S
NN
TVL
V
D
F
L
NKPAS
-
E--
M
N
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTDDATK
W
M
L
T
G
YQTVS
D
AG
-----------------------------
-
-------
ASKT
A
TDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
D
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
Y
TA
--
SFA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
ES
---
W
V
EPQ
M
ELVYG
SVS
G
KS
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
T
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
F
E
G
E
KD
S
RML
MN
VG
M
NA
E
IK
DN
M
RFGLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|656393.3.peg.73
Escherichia coli H299 (765-1329/1329)
I
HK
G
G
A
L
T
A
QG
G
L
F
T
S
G
S
-----------
-
------
I
DIG-
D
A
S
L
L
L
----------
T
G
T
P
VNSDD
A
A-FL
P
TINMADGGFK
L
M
---------
S
D
S
-------------
S
V
L
KARDQAS
V
V
G
D
I
IS
-
DKQAT
--
I
SF
G
TESGKEGILSEKASRGLAV
----------------------------
G
L
LS
G
FNT
A
YR
G
A
IH
-
AP
S
A
S
A
T
V
-
N
N
T
W
W
Q
L
T
G
D
S
S
LRS
L
KNTG
S
M
T
Y
F
TG
-
SAANKA
F
H
TLTV
D
E
L
T
T
NG
T
A
Y
A
MR
T
D
LKN
--
A
D
KLV
V
NKKL
S
G
K
D
N
ILL
V
D
F
L
NKPSG
-
EK-
L
D
I
E
LV
S
AP
GN
S
SK
D
V
--
F
K
G
S
E
QAI
GFS
N
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|6666666.5357.peg.192
Escherichia coli TY-2482 (205-758/758)
GA
K
L
T
A
QS
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
T
L
----------
T
G
M
P
SAQKQ
G
Y-YS
P
VI-STTEGIN
L
-
---------
E
D
K
-------------
A
S
F
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DSD----ADAGKTDSPLFS
----------------------------
S
L
MK
G
YNA
V
LR
G
SI
T
-
G
A
Q
S
T
V
N
M
-
I
N
A
L
W
Y
S
D
G
K
S
E
AGA
L
KAKG
S
R
I
E
L
GD
-
G---KH
F
A
TL
Q
V
K
E
L
S
A
DN
T
T
F
L
M
H
TN
NSW
--
A
D
QLN
V
TDKL
S
G
S
NN
SVL
V
D
F
L
NKPAS
-
E--
M
S
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTNDATK
W
V
L
T
G
YQTTA
D
AG
-----------------------------
-
-------
ASKA
A
KDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
G
D
Y
S
D
N
YT
H
V
Q
I
G
V
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
H
TA
--
N
FA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHLT
K
-
ES
---
W
V
EPQ
I
ELVYG
SVS
G
KA
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
A
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
Q
DA
S
GE
KR
F
E
G
E
KD
S
RML
MT
VG
M
NA
E
IK
DN
M
R
L
GLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
V
F
fig|1040638.4.peg.124
Escherichia coli O104:H4 str. LB226692 (192-745/745)
GA
K
L
T
A
QS
G
I
FS
T
G
A
-----------
-
------
V
DVKE
N
A
S
L
T
L
----------
T
G
M
P
SAQKQ
G
Y-YS
P
VI-STTEGIN
L
-
---------
E
D
K
-------------
A
S
F
SVKNMGY
L
S
SD
I
HA
G
TTAAT
--
I
NL
G
DSD----ADAGKTDSPLFS
----------------------------
S
L
MK
G
YNA
V
LR
G
SI
T
-
G
A
Q
S
T
V
N
M
-
I
N
A
L
W
Y
S
D
G
K
S
E
AGA
L
KAKG
S
R
I
E
L
GD
-
G---KH
F
A
TL
Q
V
K
E
L
S
A
DN
T
T
F
L
M
H
TN
NSW
--
A
D
QLN
V
TDKL
S
G
S
NN
SVL
V
D
F
L
NKPAS
-
E--
M
S
V
T
L
I
T
AP
KG
S
DE
K
T
--
F
T
A
G
T
QQI
GFS
N
VTP
VISTE
-------
KTNDATK
W
V
L
T
G
YQTTA
D
AG
-----------------------------
-
-------
ASKA
A
KDFM
A
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
T
Q
GD
A
G
V
W
A
R
IMN
G
T
GSA
D
----------
G
D
Y
S
D
N
YT
H
V
Q
I
G
V
D
R
K
-
HELD
G
V
DLFTG
ALL
T
Y
TDS
N
A
SSHAF
SG
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
F
DLI
G
KY
L
H
H
D
N
Q
H
TA
--
N
FA
SL
G
TK
D
YS
S
HS
W
YAGAE
V
GYRYHLT
K
-
ES
---
W
V
EPQ
I
ELVYG
SVS
G
KA
F
S
W
E
D
R
GM
A
L
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
G
R
A
FSG
D
DW
K
I
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
Q
DA
S
GE
KR
F
E
G
E
KD
S
RML
MT
VG
M
NA
E
IK
DN
M
R
L
GLE
L
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RY
V
F
fig|749531.3.peg.1025
Escherichia coli MS 69-1 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|199310.1.peg.3537
Escherichia coli CFT073 (742-1299/1299)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|199310.4.peg.3407
Escherichia coli CFT073 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|656379.3.peg.4405
Escherichia coli FVEC1302 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|656380.3.peg.4320
Escherichia coli FVEC1412 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|749549.3.peg.23
Escherichia coli MS 198-1 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|585056.7.peg.3545
Escherichia coli UMN026 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
N
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IIS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|340184.3.peg.4473
Escherichia coli B7A (817-1366/1366)
L
T
A
QS
G
I
FS
T
G
V
-----------
-
------
V
DLKG
N
A
S
L
T
L
----------
T
G
I
P
SAEKH
S
Y-YS
P
VV-SIIEGIN
L
-
---------
G
S
Q
-------------
S
S
L
TVENMGY
L
N
SD
I
MA
-
ENEAM
--
V
NL
G
DSG----AETGKTDSPLFI
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
A
K
S
I
V
N
M
-
N
NS
L
W
C
I
T
G
N
S
T
TGM
L
NARN
S
R
V
E
V
GN
-
G---KN
F
A
N
L
Q
V
K
E
L
V
A
DN
S
T
F
L
M
H
TN
NSQ
--
A
D
HLN
V
TDKL
S
G
S
R
N
TIL
V
N
F
L
NNPAN
-
G--
M
N
V
T
L
I
T
AP
KG
S
NE
KM
--
F
Q
A
G
T
QQI
GFS
N
VTP
VISAE
-------
KTDSSTK
W
V
L
T
G
YQTVS
D
VR
-----------------------------
-
-------
TSKI
A
TDFM
A
S
-
G
Y
KS
F
LR
EVNNLNKRMGDLRD
T
Q
GD
T
G
V
W
G
R
IMN
G
R
GSA
N
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
N
-
HELD
N
MDLFTG
VLL
T
Y
TDS
D
A
SSHVF
R
G
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
F
DLI
G
KY
L
H
D
D
N
Q
Y
TA
--
D
FA
SL
G
AK
N
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
EA
---
W
V
EPQ
I
ELVYG
AVS
G
KS
F
K
W
E
D
R
GM
E
L
G
M
KDRDYN
PL
I
G
-----
R
S
GV
DM
GK
V
FSG
G
DW
K
I
T
A
RAG
L
GYQ
FDL
LT
N
G
E
TV
L
R
D
I
S
GE
KR
FN
G
E
KD
S
RML
VS
VG
L
NA
E
IK
N
N
M
RFGLE
L
D
K
SAFGKYN
V
D
N
A
I
NAN
I
RY
Y
F
fig|340184.6.peg.4686
Escherichia coli B7A (817-1366/1366)
L
T
A
QS
G
I
FS
T
G
V
-----------
-
------
V
DLKG
N
A
S
L
T
L
----------
T
G
I
P
SAEKH
S
Y-YS
P
VV-SIIEGIN
L
-
---------
G
S
Q
-------------
S
S
L
TVENMGY
L
N
SD
I
MA
-
ENEAM
--
V
NL
G
DSG----AETGKTDSPLFI
----------------------------
S
L
MK
G
YNA
V
LS
GN
I
T
-
G
A
K
S
I
V
N
M
-
N
NS
L
W
C
I
T
G
N
S
T
TGM
L
NARN
S
R
V
E
V
GN
-
G---KN
F
A
N
L
Q
V
K
E
L
V
A
DN
S
T
F
L
M
H
TN
NSQ
--
A
D
HLN
V
TDKL
S
G
S
R
N
TIL
V
N
F
L
NNPAN
-
G--
M
N
V
T
L
I
T
AP
KG
S
NE
KM
--
F
Q
A
G
T
QQI
GFS
N
VTP
VISAE
-------
KTDSSTK
W
V
L
T
G
YQTVS
D
VR
-----------------------------
-
-------
TSKI
A
TDFM
A
S
-
G
Y
KS
F
LR
EVNNLNKRMGDLRD
T
Q
GD
T
G
V
W
G
R
IMN
G
R
GSA
N
----------
GG
Y
S
D
N
YT
H
V
Q
I
G
A
D
R
N
-
HELD
N
MDLFTG
VLL
T
Y
TDS
D
A
SSHVF
R
G
K
TKS
V
G
G
G
L
YAS
A
L
F
N
SGAY
F
DLI
G
KY
L
H
D
D
N
Q
Y
TA
--
D
FA
SL
G
AK
N
YS
S
HS
W
YAGAE
V
GYRYHL
S
E
-
EA
---
W
V
EPQ
I
ELVYG
AVS
G
KS
F
K
W
E
D
R
GM
E
L
G
M
KDRDYN
PL
I
G
-----
R
S
GV
DM
GK
V
FSG
G
DW
K
I
T
A
RAG
L
GYQ
FDL
LT
N
G
E
TV
L
R
D
I
S
GE
KR
FN
G
E
KD
S
RML
VS
VG
L
NA
E
IK
N
N
M
RFGLE
L
D
K
SAFGKYN
V
D
N
A
I
NAN
I
RY
Y
F
fig|525281.3.peg.3272
Escherichia coli 83972 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
D
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|655817.3.peg.3424
Escherichia coli ABU 83972 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
D
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|749528.3.peg.4271
Escherichia coli MS 45-1 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
D
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|749548.3.peg.1831
Escherichia coli MS 196-1 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
T
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
D
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
K
F
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|585396.4.peg.5723
Escherichia coli O111:H- str. 11128 (710-1263/1263)
L
T
A
NM
W
L
M
N
S
G
T
-----------
-
------
I
NVGE
N
A
E
L
N
I
----------
Q
G
Y
P
IADK-
-
--FI
P
SIH-DLGNVK
M
T
---------
A
S
N
-------------
A
T
L
TAGNYAM
F
S
G
E
L
TA
-
DNATA
VR
V
NL
G
SETSTLSEFNPNPE--LTD
----------------------------
L
M
FD
K
YNT
S
WT
G
K
IS
-
A
L
K
G
D
A
S
M
-
V
N
T
V
W
R
M
T
G
D
S
G
LNT
L
KTSK
S
L
T
V
F
SS
-
D---NK
F
S
TLTV
N
D
L
T
T
SD
S
T
F
V
L
R
S
D
STG
--
S
D
KVV
V
KNKL
E
G
K
NN
NLL
V
D
YV
ANDGK
-
HNS
L
N
F
E
LV
S
AP
KG
T
AA
D
V
--
F
N
S
Q
T
QNV
GFS
D
VTP
VIEQK
-------
DSGEKTT
W
T
L
K
G
FNAVA
N
QQ
-----------------------------
-
-------
SAEK
A
ENFM
S
A
-
G
Y
KN
F
LA
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|749527.3.peg.5203
Escherichia coli MS 21-1 (738-1295/1295)
GA
K
V
I
A
QN
S
M
F
T
T
K
G
-----------
-
------
I
DI--
S
G
E
L
T
M
----------
M
G
I
P
--EQN
S
KTVT
P
GLHYAADGFR
L
S
---------
G
G
N
-------------
A
N
F
IARNMAS
V
T
G
N
I
YA
-
DDAAT
--
I
TL
G
QPETETPTISSAYQA-WAE
----------------------------
T
L
LY
G
FDT
A
YR
G
A
I
T
-
AP
K
A
T
V
S
M
-
N
N
A
I
W
H
L
N
S
Q
S
S
INR
L
ETKD
S
M
V
R
F
TG
-
D--NGK
F
T
TLTV
D
N
L
T
I
DD
S
A
F
V
L
RA
N
LAQ
--
A
D
QLV
V
NKSL
S
G
K
NN
LLL
V
D
FI
EKNGN
-
SNG
L
N
I
D
LV
S
AP
KG
T
AV
D
V
--
F
K
A
T
T
RSI
GFS
D
VTP
VIEQK
-------
NDTDKAT
W
T
L
I
G
YKSVA
N
AD
-----------------------------
-
-------
AAKK
A
TLLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
S
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
K
F
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
L
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|216592.1.peg.5179
Escherichia coli 042 (741-1299/1299)
I
HK
GA
N
V
T
A
SS
S
L
F
T
T
S
N
-----------
-
------
I
KS--
G
G
D
L
T
L
----------
T
G
A
T
--EST
G
E-IT
P
SMFYAAGGYE
L
T
---------
E
D
G
-------------
A
N
F
TAKNQAS
V
T
G
D
I
KS
-
EKAAK
--
L
SF
G
SADKDNS--ATRYSQ-FAL
----------------------------
A
M
LD
G
FDT
S
YQ
G
SI
K
-
A
A
Q
S
S
L
AM
-
N
N
A
L
W
K
V
T
G
N
S
E
LKK
L
NSTG
S
M
V
L
F
NG
-
G--KNI
F
N
TLTV
D
E
L
T
T
SN
S
A
F
V
MR
TN
TQQ
--
A
D
QLI
V
KNKL
E
G
A
NN
LLL
V
D
FI
EKKGN
D
KNG
L
N
I
D
LV
K
AP
EN
T
SK
D
V
--
F
K
T
E
T
QTI
GFS
D
VTP
EIKQQ
-------
EKDGKSV
W
T
L
T
G
YKTVA
N
AD
-----------------------------
-
-------
AAKK
A
TSLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|216592.3.peg.5129
Escherichia coli 042 (737-1295/1295)
I
HK
GA
N
V
T
A
SS
S
L
F
T
T
S
N
-----------
-
------
I
KS--
G
G
D
L
T
L
----------
T
G
A
T
--EST
G
E-IT
P
SMFYAAGGYE
L
T
---------
E
D
G
-------------
A
N
F
TAKNQAS
V
T
G
D
I
KS
-
EKAAK
--
L
SF
G
SADKDNS--ATRYSQ-FAL
----------------------------
A
M
LD
G
FDT
S
YQ
G
SI
K
-
A
A
Q
S
S
L
AM
-
N
N
A
L
W
K
V
T
G
N
S
E
LKK
L
NSTG
S
M
V
L
F
NG
-
G--KNI
F
N
TLTV
D
E
L
T
T
SN
S
A
F
V
MR
TN
TQQ
--
A
D
QLI
V
KNKL
E
G
A
NN
LLL
V
D
FI
EKKGN
D
KNG
L
N
I
D
LV
K
AP
EN
T
SK
D
V
--
F
K
T
E
T
QTI
GFS
D
VTP
EIKQQ
-------
EKDGKSV
W
T
L
T
G
YKTVA
N
AD
-----------------------------
-
-------
AAKK
A
TSLM
S
G
-
G
Y
KA
F
LA
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
G
----------
GGF
S
D
N
YT
H
V
Q
V
G
A
D
N
K
-
HELD
G
L
DLFTG
VTM
T
Y
TDS
H
A
GSDAF
SG
E
TKS
V
G
A
G
L
YAS
A
MF
E
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
S
HS
W
YAGAE
V
GYRYH
V
T
D
-
SA
---
W
IEPQAELVYG
AVS
G
KQ
F
S
W
K
D
Q
GMN
L
T
M
KDKDFN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
FA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
G
RML
MN
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
A
I
NAN
F
RYSF
fig|562.371.peg.2017
Escherichia coli 1044A (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|562.372.peg.393
Escherichia coli 1212A (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|562.374.peg.1886
Escherichia coli 536A (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|83334.1.peg.82
Escherichia coli O157:H7 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|155864.8.peg.5610
Escherichia coli O157:H7 EDL933 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444454.5.peg.647
Escherichia coli O157:H7 str. EC4024 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444449.5.peg.5680
Escherichia coli O157:H7 str. EC4042 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444448.5.peg.5650
Escherichia coli O157:H7 str. EC4045 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444453.5.peg.4375
Escherichia coli O157:H7 str. EC4076 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444452.5.peg.3624
Escherichia coli O157:H7 str. EC4113 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444450.8.peg.77
Escherichia coli O157:H7 str. EC4115 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444451.5.peg.4166
Escherichia coli O157:H7 str. EC4196 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|444447.5.peg.5731
Escherichia coli O157:H7 str. EC4206 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478004.5.peg.4010
Escherichia coli O157:H7 str. EC4401 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478005.5.peg.3232
Escherichia coli O157:H7 str. EC4486 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478006.5.peg.3456
Escherichia coli O157:H7 str. EC4501 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478007.5.peg.3850
Escherichia coli O157:H7 str. EC508 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478007.5.peg.5210
Escherichia coli O157:H7 str. EC508 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|478008.5.peg.4927
Escherichia coli O157:H7 str. EC869 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|637388.3.peg.3563
Escherichia coli O157:H7 str. FRIK2000 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|570506.3.peg.2737
Escherichia coli O157:H7 str. FRIK966 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|386585.9.peg.90
Escherichia coli O157:H7 str. Sakai (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|544404.4.peg.5649
Escherichia coli O157:H7 str. TW14359 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|502346.5.peg.5699
Escherichia coli O157:H7 str. TW14588 (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
VN
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|562.373.peg.839
Escherichia coli 1125A (738-1300/1300)
I
EN
GA
D
V
T
T
QS
G
M
FS
T
S
D
-----------
-
------
I
SI--
S
G
N
L
S
M
----------
T
G
N
P
--DKD
N
K-FE
P
SIYLNDASYL
L
T
---------
D
D
S
-------------
A
R
L
VAKNKAS
V
V
G
D
I
HS
-
TKSAS
--
I
MF
G
HDESDLSQLSDRTSKGLAL
----------------------------
G
L
LG
G
FDV
S
YR
G
S
V
H
-
AP
S
A
S
A
T
M
-
N
N
T
W
W
Q
L
T
G
D
S
A
LKT
L
KSTN
S
M
V
Y
F
TD
-
SANNKK
F
H
TLTV
D
E
L
A
T
SN
S
A
Y
A
MR
TN
LSE
--
S
D
KLE
V
KKHL
S
G
E
NN
ILL
V
D
F
L
QKPTP
-
EKQ
L
N
I
E
LV
S
AP
KD
T
NE
N
V
--
F
K
A
S
K
QTI
GFS
D
VTP
VITTR
-------
ETDDKIT
W
S
L
T
G
YNTVA
N
KE
-----------------------------
-
-------
ATRN
A
AALF
S
V
-
D
Y
KA
F
LN
EVNNLNKRMGDLRD
I
NG
E
A
G
A
W
A
R
IMS
G
T
GSA
S
----------
GGF
S
D
N
YT
H
V
Q
V
G
V
DKK
-
HELD
G
L
DLFTG
FTV
T
H
TDSSA
SADVF
SG
K
TKS
V
G
A
G
L
YAS
A
MF
D
SGAY
I
DLI
G
KY
V
H
H
D
N
E
Y
TA
--
T
FA
GL
G
TR
D
YS
T
HS
W
YAGAE
A
GYRYH
V
T
E
-
DA
---
W
IEPQAELVYG
SVS
G
KQ
F
A
W
K
D
Q
GM
HL
S
M
KDKDYN
PL
I
G
-----
RTGV
DV
GK
S
FSGKDW
K
V
T
A
RAG
L
GYQ
FDL
LA
N
G
E
TV
L
R
DA
S
GE
KR
IKG
E
KD
S
RML
MS
VG
L
NA
E
IR
DN
V
RFGLE
F
E
K
SAFGKYN
V
D
N
AVNAN
F
RYSF
fig|331111.12.peg.299
Escherichia coli E24377A (810-1366/1366)
L
EK
GA
K
L
T
A
QS
G
I
F
T
N
N
T
-----------
-
------
M
EIKE
N
A
S
L
T
L
----------
T
G
I
P
SVGKP
G
Y-YS
P
VI-STTEGIH
L
-
---------
G
E
R
-------------
A
S
L
SVKNMGY
L
S
S
N
I
IA
E
DSAAI
--
I
NL
G
DSN----ATIGKTDSPLFN
----------------------------
T
L
MR
G
YNA
V
LQ
GN
I
M
-
G
P
Q
S
S
V
N
M
-
N
N
A
L
W
H
S
D
R
N
S
E
IKE
L
KAND
S
Q
I
E
L
GG
-
R---GH
F
A
K
L
R
V
K
E
L
I
A
SN
S
V
F
L
V
HV
N
NGQ
--
A
D
QLN
V
TGKL
Q
G
S
NN
TIL
V
N
F
F
NKAAN
-
G--
T
N
V
T
L
I
T
AP
KG
S
DE
NT
--
F
K
A
G
T
QQI
GFS
N
I
TP
EIRTE
-------
NTDTATK
W
V
L
T
G
YQSVA
D
AR
-----------------------------
-
-------
ASKI
A
TDFM
D
S
-
G
Y
KS
F
LT
EVNNLNKRMGDLRD
S
Q
GD
A
G
G
W
A
R
IMN
G
T
GS
G
E
----------
S
G
Y
R
D
N
YT
H
V
Q
I
G
A
D
R
K
-
HEL
N
G
LN
LFTG
ALL
T
Y
TDS
N
A
SSQAF
SG
K
TKS
L
G
G
G
V
YAS
G
L
F
E
SGAY
F
DLI
G
KY
L
H
H
D
N
R
Y
TL
--
N
FA
SL
G
ER
S
YT
T
HS
L
YAGAE
I
GYRYH
M
S
E
-
NT
---
W
V
EPQ
M
ELVYG
SVS
G
KS
F
N
W
K
D
Q
GM
Q
L
S
M
KDKDYH
PL
I
G
-----
RTGV
DV
G
R
V
FSG
DT
W
K
V
T
A
RAG
L
SYQ
FDL
LA
N
G
E
TV
L
Q
DA
S
G
K
KH
F
KG
E
KD
S
RML
MN
VG
T
N
V
E
VK
DN
M
RFGLE
L
E
K
SAFG
R
YN
I
D
N
S
I
NAN
F
RY
Y
F
fig|199310.1.peg.374
Escherichia coli CFT073 (817-1376/1376)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|749528.3.peg.1421
Escherichia coli MS 45-1 (817-1376/1376)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|753642.3.peg.1353
Escherichia coli NC101 (817-1376/1376)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|869729.3.peg.3412
Escherichia coli UM146 (817-1376/1376)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|405955.9.peg.235
Escherichia coli APEC O1 (817-1376/1376)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|405955.9.peg.4271
Escherichia coli APEC O1 (818-1377/1377)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
I
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSP
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSN
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
ILSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SADLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
D
V
I
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
S
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|656419.3.peg.1851
Escherichia coli M718 (818-1377/1377)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
I
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSP
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSN
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
ILSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SADLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
D
V
I
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
S
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|340197.3.peg.1397
Escherichia coli F11 (817-1376/1376)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|656440.3.peg.153
Escherichia coli TA206 (817-1376/1376)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|749546.3.peg.33
Escherichia coli MS 185-1 (181-740/740)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
R
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KNPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|655817.3.peg.394
Escherichia coli ABU 83972 (529-1088/1088)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|656393.3.peg.911
Escherichia coli H299 (529-1088/1088)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|405955.13.peg.5093
Escherichia coli APEC O1 (746-1305/1305)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
I
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSP
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSN
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
ILSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SADLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
D
V
I
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
S
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|364106.7.peg.411
Escherichia coli UTI89 (181-740/740)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|364106.8.peg.409
Escherichia coli UTI89 (181-740/740)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|656417.3.peg.411
Escherichia coli M605 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSP
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|525281.3.peg.2621
Escherichia coli 83972 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|405955.13.peg.282
Escherichia coli APEC O1 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|199310.4.peg.364
Escherichia coli CFT073 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|685038.3.peg.266
Escherichia coli O83:H1 str. NRG 857C (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|585035.6.peg.274
Escherichia coli S88 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|714962.3.peg.271
Escherichia coli IHE3034 (475-1034/1034)
L
NK
GA
N
V
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
G
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|362663.8.peg.342
Escherichia coli 536 (475-1034/1034)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|362663.9.peg.341
Escherichia coli 536 (475-1034/1034)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|340197.5.peg.1477
Escherichia coli F11 (475-1034/1034)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|749550.3.peg.957
Escherichia coli MS 200-1 (475-1034/1034)
L
NK
GA
N
A
L
A
SQ
S
F
V
S
D
G
P
-----------
-
------
V
NIS-
D
A
T
L
S
L
----------
N
S
R
P
--DEV
S
HTLL
P
VYDYA-GSWN
L
K
---------
G
D
D
-------------
A
R
L
NVGPYSM
L
S
G
N
I
NV
-
QDKGT
--
V
TL
G
GEGELSPDLTLQNQ--MLY
----------------------------
S
L
FN
G
YRN
T
WS
G
SL
N
-
AP
D
A
T
V
S
M
-
T
D
T
Q
W
S
M
N
G
N
S
T
AGN
M
KLNR
T
I
V
G
F
NG
-
G--TSS
F
T
TLT
T
D
N
L
D
A
VQ
S
A
F
V
MR
T
D
LNK
--
A
D
KLV
I
NKSA
T
G
H
D
N
SIW
V
N
F
L
KKPSD
-
KDT
L
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
R
A
S
T
RVV
GFS
D
VTP
TLSVR
-------
KEDGKKE
W
V
L
D
G
YQVAR
N
DG
-----------------------------
-
-------
QGKA
A
ATFM
H
I
-
S
Y
NN
F
IT
EVNNLNKRMGDLRD
I
NG
E
A
G
T
W
V
R
LLN
GSGSA
D
----------
GGF
T
D
H
YT
L
L
Q
M
G
A
D
R
K
-
HEL
G
S
MDLFTG
VMA
T
Y
TD
T
D
A
SAGLY
SG
K
TKS
W
G
G
G
F
YAS
G
L
F
R
SGAY
F
DLI
A
KY
I
H
N
E
N
K
Y
DL
--
N
FA
GA
G
KQ
N
FR
S
HS
L
YAGAE
V
GYRYHLT
D
-
TT
---
F
V
EPQAELV
W
G
RLQ
G
QT
F
N
W
N
D
S
GM
DV
S
M
RRNSVN
PL
V
G
-----
RTGV
VS
GK
T
FSGKDW
S
LT
A
RAG
L
HYE
FDL
TD
S
A
D
VH
L
K
DA
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VG
L
NA
R
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
A
I
NAN
I
RYSF
fig|550672.3.peg.4213
Escherichia coli B088 (745-1281/1281)
L
AD
GA
N
L
T
A
TS
G
L
I
S
D
G
E
-----------
-
------
V
TAGA
GS
T
L
S
M
----------
L
-
-
S
-----
-
--GQ
-
---YTAGRWS
F
I
---------
G
Q
G
-------------
S
T
L
NVGAGSI
M
A
G
N
I
QA
-
NDAAS
--
L
SF
G
VTNQADQNL-F--------
----------------------------
-
-
--
-
--T
A
YG
GN
LS
-
AP
L
A
R
V
M
M
-
T
N
T
L
W
R
A
E
G
Q
S
V
VKS
L
ELKG
A
Q
V
S
F
SN
-
V---GA
A
G
A
LTV
D
T
L
T
A
NN
S
M
F
I
I
N
TN
GKT
--
A
D
MVT
V
NQSL
NG
K
NN
SLV
V
V
PT
VSAAR
-
EAT
S
S
L
P
LV
N
AP
KA
T
ES
D
V
FM
L
N
P
I
T
QRT
GF
H
T
Y
TP
QLSMV
-------
ETENSKQ
W
R
L
E
G
FDVQQ
D
KA
-----------------------------
-
-------
AIQA
G
KSVM
D
V
-
G
Y
KS
F
LT
E
M
NNLN
Y
RMGDLR
N
T
H
GD
T
G
T
W
A
R
IYS
G
T
GSA
D
----------
A
G
Y
S
N
S
W
T
H
L
Q
I
G
A
D
R
K
-
QSF
N
G
G
DLFTG
VTA
T
F
T
N
S
NS
HGTGW
SG
Q
TKS
V
G
I
G
L
YAS
T
MF
D
SG
L
Y
V
D
V
I
G
KY
V
H
H
D
N
H
Y
SA
--
T
EV
SM
S
EQ
D
YS
S
R
S
W
Y
L
G
T
E
T
G
W
R
F
S
L
P
G
-
EA
---
F
IEPQ
T
ELVYG
AVS
G
NR
F
A
W
Q
S
E
G
Y
D
I
S
M
QRKQEN
PL
I
G
-----
RTGV
EI
GK
T
F
T
G
G
D
Y
K
LT
A
L
AG
V
HYQ
Y
DL
FN
P
E
K
TV
V
R
D
L
A
GE
TF
I
R
N
G
KD
S
R
V
N
FN
L
GVNA
E
IK
E
N
T
R
IS
L
D
V
E
R
SA
S
G
H
Y
D
I
D
K
A
I
NAN
V
RYSF
fig|656440.3.peg.3872
Escherichia coli TA206 (738-1255/1255)
L
SD
N
A
Q
L
T
S
TA
G
L
Q
S
D
G
T
-----------
-
------
I
EFGN
G
A
K
L
S
L
----------
L
G
E
S
-----
-
--SS
T
FTPFSATAWN
L
K
---------
G
T
G
-------------
S
T
L
NIGSGTN
V
N
G
D
I
NA
-
WSDTN
--
I
NF
G
NSGK-QSTSSG--------
----------------------------
-
-
--
-
--I
L
YT
G
DI
Y
-
AP
E
A
N
V
SI
-
D
N
T
S
W
T
L
N
K
T
S
W
LGN
L
TLK-
-
-
-
-
-
--
-
------
-
-
-----
-
-
-
-
-N
S
Q
L
I
M
S
T
D
GKT
--
S
S
AIK
V
VDTF
S
G
E
NN
ILY
V
K
PT
RSLSE
-
MSV
S
N
I
P
L
I
T
A
-
KN
V
TN
NTRA
F
K
T
V
T
QQT
GF
H
S
M
TP
KIEVV
-------
NVDGTTQ
W
C
L
K
G
FDVQS
D
ST
-----------------------------
-
-------
ALKE
G
QRLM
N
T
-
N
I
KN
F
LT
EVNNLN
R
RMGDLRD
T
K
G
E
T
G
A
W
A
R
LMN
S
SGS
G
Y
----------
GGF
S
D
R
H
V
H
L
Q
V
G
A
D
R
K
-
H
HF
E
G
G
DLFTG
VMM
T
V
TDS
K
A
SAESY
Q
G
K
T
R
S
V
G
G
G
L
YAS
T
L
F
D
SG
V
Y
V
D
V
I
G
KY
V
H
H
S
N
D
Y
LL
--
QTM
GL
K
AD
D
-T
AHS
W
Y
L
G
T
E
T
G
W
RY
QWK
P
-
DV
---
F
IEPQAELVYG
TLS
G
NT
F
N
W
Q
Y
N
GM
DV
S
M
ERKKAK
PL
I
G
-----
RTGV
EF
GK
T
LD
G
R
DW
Q
V
T
A
K
AG
L
SYQ
FDL
RN
T
G
A
TT
Y
R
D
F
A
GE
ST
V
YN
G
KD
G
RML
AN
I
G
ID
T
R
IK
DN
T
R
I
GL
T
V
E
K
SAFGKYN
V
D
N
A
I
NAN
I
RY
T
F
fig|439855.10.peg.4063
Escherichia coli SMS-3-5 (503-1020/1020)
L
SD
N
A
Q
L
T
S
TA
G
L
Q
S
D
G
T
-----------
-
------
I
EFGN
G
A
K
L
S
L
----------
L
G
E
S
-----
-
--SS
T
FTPFSATAWN
L
K
---------
G
T
G
-------------
S
S
L
NIGSGTN
V
N
G
D
I
NA
-
WSDTN
--
I
NF
G
NSGK-QSTSSG--------
----------------------------
-
-
--
-
--I
L
YT
G
DI
Y
-
AP
E
A
N
V
SI
-
D
N
T
S
W
T
L
N
K
T
S
L
LGN
L
TLK-
-
-
-
-
-
--
-
------
-
-
-----
-
-
-
-
-N
S
Q
L
I
M
S
T
D
GKT
--
S
S
GIK
V
VDTF
S
G
E
NN
ILY
V
K
PT
RSLSE
-
MSV
S
N
I
P
L
I
T
A
-
KN
V
TN
NTRV
F
K
T
V
T
QQT
GF
H
S
M
TP
KIEVV
-------
NVDGTTQ
W
R
L
K
G
FDVQS
D
ST
-----------------------------
-
-------
ALKE
G
QRLM
N
T
-
N
I
KN
F
LT
EVNNLN
R
RMGDLRD
T
K
G
E
T
G
A
W
A
R
LMN
S
SGS
G
Y
----------
GGF
S
D
R
H
V
H
L
Q
V
G
A
D
R
K
-
H
HF
E
G
G
DLFTG
VMM
T
V
TDS
K
A
SAESY
Q
G
K
T
R
S
V
G
G
G
L
YAS
T
L
F
D
SG
V
Y
V
D
V
I
G
KY
V
H
H
S
N
D
Y
LL
--
QTM
GL
K
AD
D
-T
AHS
W
Y
L
GAE
T
G
W
RY
QWK
P
-
DV
---
F
IEPQAELVYG
TLS
G
NT
F
N
W
Q
Y
N
GM
DV
S
M
ERKKAK
PL
I
G
-----
RTGV
EF
GK
T
LD
G
R
DW
Q
V
T
A
K
AG
L
SYQ
FDL
RN
T
G
A
TT
Y
R
D
F
A
GE
ST
V
YN
G
KD
G
RML
AN
I
G
ID
T
R
IK
DN
T
R
I
GL
T
V
E
K
SAFGKYN
V
D
N
A
I
NAN
I
RY
T
F
fig|340185.3.peg.3806
Escherichia coli E22 (753-1290/1290)
L
AD
GA
K
L
T
V
TS
G
L
A
S
D
R
G
-----------
-
------
V
TAGA
GS
T
L
S
L
----------
L
-
-
S
-----
-
--GQ
-
---YAAERWS
L
A
---------
G
Q
G
-------------
T
T
L
NVAAGAT
L
A
G
N
I
QA
-
DNVAS
--
I
NF
G
VTDQIGSVIRV--------
----------------------------
-
-
--
-
--T
G
YR
GN
I
N
-
AP
L
A
D
V
T
M
-
T
N
I
G
W
Q
A
D
S
G
S
T
VKS
L
DLKG
S
Q
V
S
F
NQ
-
T---GG
P
G
S
LTV
D
D
F
V
A
SN
S
Q
F
I
V
N
T
D
GKT
--
A
D
TVT
V
KQSL
T
G
K
NN
VLT
V
V
PT
ALPVN
-
NEV
S
S
V
P
LV
T
AP
KS
T
SA
D
V
LT
L
N
P
V
T
QHA
GF
H
T
F
TP
QVGIV
-------
ESEDSKQ
W
L
L
E
G
FDVQQ
D
KA
-----------------------------
-
-------
LLQS
G
KSFM
D
M
-
E
Y
KN
F
LT
E
M
NNLN
Y
RMGDLR
N
T
L
G
E
S
G
T
W
A
R
IFS
G
T
GSA
E
----------
A
G
Y
S
D
S
W
T
H
L
Q
I
G
A
D
R
K
-
H
TF
D
G
A
DLFTG
VTA
T
F
T
N
S
N
R
HGDGW
SG
Q
TKS
T
G
V
G
V
Y
T
S
V
MF
D
SG
L
Y
V
D
A
I
G
KY
V
R
H
D
N
H
Y
SV
--
S
EM
GM
P
EQ
D
YN
S
HS
W
Y
L
GAE
T
G
W
R
F
F
L
P
G
-
ET
---
F
I
Q
PQ
T
ELVYG
KAS
G
NQ
F
A
W
Q
S
A
G
S
D
I
R
M
QRDQMK
PL
I
G
-----
RTGV
ES
GK
T
F
R
GKDW
E
L
M
T
V
AG
V
HYQ
Y
DL
FN
P
S
K
TV
V
H
D
F
A
G
D
TY
I
R
N
G
KD
N
R
V
N
FS
L
GVN
T
R
IK
E
N
T
R
IS
L
N
I
E
R
SAFG
H
Y
D
I
D
K
A
I
NAN
I
RYSF
fig|340185.4.peg.4006
Escherichia coli E22 (707-1244/1244)
L
AD
GA
K
L
T
V
TS
G
L
A
S
D
R
G
-----------
-
------
V
TAGA
GS
T
L
S
L
----------
L
-
-
S
-----
-
--GQ
-
---YAAERWS
L
A
---------
G
Q
G
-------------
T
T
L
NVAAGAT
L
A
G
N
I
QA
-
DNVAS
--
I
NF
G
VTDQIGSVIRV--------
----------------------------
-
-
--
-
--T
G
YR
GN
I
N
-
AP
L
A
D
V
T
M
-
T
N
I
G
W
Q
A
D
S
G
S
T
VKS
L
DLKG
S
Q
V
S
F
NQ
-
T---GG
P
G
S
LTV
D
D
F
V
A
SN
S
Q
F
I
V
N
T
D
GKT
--
A
D
TVT
V
KQSL
T
G
K
NN
VLT
V
V
PT
ALPVN
-
NEV
S
S
V
P
LV
T
AP
KS
T
SA
D
V
LT
L
N
P
V
T
QHA
GF
H
T
F
TP
QVGIV
-------
ESEDSKQ
W
L
L
E
G
FDVQQ
D
KA
-----------------------------
-
-------
LLQS
G
KSFM
D
M
-
E
Y
KN
F
LT
E
M
NNLN
Y
RMGDLR
N
T
L
G
E
S
G
T
W
A
R
IFS
G
T
GSA
E
----------
A
G
Y
S
D
S
W
T
H
L
Q
I
G
A
D
R
K
-
H
TF
D
G
A
DLFTG
VTA
T
F
T
N
S
N
R
HGDGW
SG
Q
TKS
T
G
V
G
V
Y
T
S
V
MF
D
SG
L
Y
V
D
A
I
G
KY
V
R
H
D
N
H
Y
SV
--
S
EM
GM
P
EQ
D
YN
S
HS
W
Y
L
GAE
T
G
W
R
F
F
L
P
G
-
ET
---
F
I
Q
PQ
T
ELVYG
KAS
G
NQ
F
A
W
Q
S
A
G
S
D
I
R
M
QRDQMK
PL
I
G
-----
RTGV
ES
GK
T
F
R
GKDW
E
L
M
T
V
AG
V
HYQ
Y
DL
FN
P
S
K
TV
V
H
D
F
A
G
D
TY
I
R
N
G
KD
N
R
V
N
FS
L
GVN
T
R
IK
E
N
T
R
IS
L
N
I
E
R
SAFG
H
Y
D
I
D
K
A
I
NAN
I
RYSF
fig|656417.3.peg.5218
Escherichia coli M605 (749-1283/1283)
E
GA
K
L
T
A
TA
G
L
L
S
D
G
T
-----------
-
------
V
SSNA
G
A
S
L
S
L
----------
L
-
-
S
-----
-
--DQ
P
GTMYSAQSWE
L
S
---------
G
Q
D
-------------
T
S
L
NVGAGGI
I
T
G
D
I
NA
-
NDAAS
--
I
SF
G
TTDINQS------------
----------------------------
-
-
--
-
--T
N
YY
GN
I
N
-
AP
L
A
S
V
T
M
-
K
D
T
A
W
Q
V
N
K
Q
S
V
AKS
L
TLNG
S
T
L
S
F
NR
-
F---G-
Q
G
G
LT
S
D
T
L
E
A
TN
S
S
F
I
I
N
AD
GKA
--
A
D
TVT
V
NQAL
T
G
G
NN
TLV
V
I
PT
TNSVK
-
QGG
D
P
V
S
LV
T
AP
KN
T
QS
N
I
FT
L
N
P
V
S
INA
GF
H
S
F
TP
QLDVL
-------
ETDVNKQ
W
R
L
E
G
FYIQP
D
KA
-----------------------------
-
-------
ALRT
G
KSFM
D
L
-
G
Y
KN
F
IT
E
I
NNLN
D
RMGDLR
H
T
H
G
E
T
G
A
W
A
R
LNS
GSGSA
T
----------
D
GF
T
G
S
YT
H
L
Q
I
G
A
D
R
K
-
H
I
IE
G
G
E
LFTG
VTA
T
F
T
S
S
N
N
RGTGW
SG
R
TKS
T
G
I
G
V
YAS
A
MF
D
SG
L
Y
V
D
T
I
G
KY
V
R
H
D
N
H
Y
SS
--
S
AL
GM
P
EQ
D
YG
S
HS
W
Y
L
GAE
A
G
W
R
F
S
L
P
D
-
ET
---
YI
Q
PQ
T
EL
I
YG
TVS
E
NQ
F
A
W
Q
F
N
G
GE
I
Y
M
QRKQMQ
PL
I
G
-----
RTG
I
EF
GK
T
F
R
GKDW
E
M
T
A
LT
G
I
NYQ
Y
DL
FK
P
T
V
TA
F
K
D
L
A
G
D
TY
I
N
N
G
KD
S
R
VV
FN
VGVN
T
K
IK
E
N
T
R
IS
L
N
V
E
R
S
E
FG
S
YN
I
D
K
L
I
NAN
I
RY
T
F
fig|431946.3.peg.4172
Escherichia coli SE15 (744-1278/1278)
E
GA
K
L
T
A
TA
G
L
L
S
D
G
T
-----------
-
------
V
SSNA
G
A
S
L
S
L
----------
L
-
-
S
-----
-
--DQ
P
GTMYSAQSWE
L
S
---------
G
Q
D
-------------
T
S
L
NVGAGGI
I
T
G
D
I
NA
-
NDAAS
--
I
SF
G
TTDINQS------------
----------------------------
-
-
--
-
--T
N
YY
GN
I
N
-
AP
L
A
S
V
T
M
-
K
D
T
A
W
Q
V
N
K
Q
S
V
AKS
L
TLNG
S
T
L
S
F
NR
-
F---G-
Q
G
G
LT
S
D
T
L
E
A
TN
S
S
F
I
I
N
AD
GKA
--
A
D
TVT
V
NQAL
T
G
G
NN
TLV
V
I
PT
TNSVK
-
QGG
D
P
V
S
LV
T
AP
KN
T
QS
N
I
FT
L
N
P
V
S
INA
GF
H
S
F
TP
QLDVL
-------
ETDVNKQ
W
R
L
E
G
FYIQP
D
KA
-----------------------------
-
-------
ALRT
G
KSFM
D
L
-
G
Y
KN
F
IT
E
I
NNLN
D
RMGDLR
H
T
H
G
E
T
G
A
W
A
R
LNS
GSGSA
T
----------
D
GF
T
G
S
YT
H
L
Q
I
G
A
D
R
K
-
H
I
IE
G
G
E
LFTG
VTA
T
F
T
S
S
N
N
RGTGW
SG
R
TKS
T
G
I
G
V
YAS
A
MF
D
SG
L
Y
V
D
T
I
G
KY
V
R
H
D
N
H
Y
SS
--
S
AL
GM
P
EQ
D
YG
S
HS
W
Y
L
GAE
A
G
W
R
F
S
L
P
D
-
ET
---
YI
Q
PQ
T
EL
I
YG
TVS
E
NQ
F
A
W
Q
F
N
G
GE
I
Y
M
QRKQMQ
PL
I
G
-----
RTG
I
EF
GK
T
F
R
GKDW
E
M
T
A
LT
G
I
NYQ
Y
DL
FK
P
T
V
TA
F
K
D
L
A
G
D
TY
I
N
N
G
KD
S
R
VV
FN
VGVN
T
K
IK
E
N
T
R
IS
L
N
V
E
R
S
E
FG
S
YN
I
D
K
L
I
NAN
I
RY
T
F
fig|340185.3.peg.3776
Escherichia coli E22 (589-1204/1204)
N
G
D
-----------
-
------
I
NVQN
G
G
T
L
L
L
----------
S
G
N
P
VQHAG
N
V---
-
---FIEGDWN
K
T
QFNLNNINV
A
S
G
-------------
S
S
L
HVSEYAE
L
N
G
N
I
NA
-
GEGAF
--
V
SL
G
YTEGVTQRCKLDNNTGKTS
CSHMTPENVVDSKASRVIATGDVTLNGG
S
L
MH
V
GNA
S
LT
G
G
IS
G
AP
D
S
H
L
I
L
S
S
D
A
M
I
N
L
D
K
N
S
S
VGR
L
VSEG
G
K
V
S
M
LS
-
S--EWS
P
K
KF
T
I
E
E
S
Y
T
SN
L
A
L
N
M
GV
N
IKD
NV
G
D
KIE
I
LNLA
Q
G
A
NN
SLD
L
S
N
L
YGQSG
-
ELA
Y
D
L
T
I
A
S
AP
SG
T
SH
D
F
--
F
S
F
A
S
FDR
GF
T
V
Y
TP
NTQVT
-------
EQDGKVL
W
Q
L
K
G
KNPAP
P
ES
EK
P
V
P
PESEKPV
P
PETEK
P
V
P
P
-------
-
-
ETETPG
ATQP
G
NGLF
D
G
K
D
N
KK
L
LK
D
A
R
N
M
FASRQY
L
--
I
S
NS
S
D
R
W
E
M
IID
D
A
TRN
D
NVWAMNTFRT
GG
Y
-
D
G
F
T
A
K
Q
H
G
L
D
LGI
H
K
AQ
D
S
D
Y
F
W
G
AGI
G
F
HKGDT
SNSLF
RD
D
Y
K
M
F
S
G
N
L
Y
LG
K
D
F
E
SG
L
F
V
N
AA
V
G
Y
K
H
L
SE
N
F
KV
KGEL
N
DL
S
GK
-
VN
T
N
I
V
T
AGA
R
V
GYR
M
H
SD
E
L
QA
---
S
V
S
P
-------
SVS
V
NS
-
S
W
M
E
G
G
-K
I
H
A
KERQVD
LHS
G
WAASV
K
A
GV
LA
D
K
S
F
ENS--
K
V
T
G
--
G
I
YRN
F
S
V
KD
M
P
G
VT
L
S
D
S
W
KS
RS
Y
E
A
K
KD
D
HFT
AT
I
GV
EG
K
IT
E
K
M
NAN
L
K
L
T
S
HF
G
G
D
F
K
T
D
T
IGTL
G
L
K
Y
E
F
fig|340185.4.peg.3970
Escherichia coli E22 (589-1204/1204)
N
G
D
-----------
-
------
I
NVQN
G
G
T
L
L
L
----------
S
G
N
P
VQHAG
N
V---
-
---FIEGDWN
K
T
QFNLNNINV
A
S
G
-------------
S
S
L
HVSEYAE
L
N
G
N
I
NA
-
GEGAF
--
V
SL
G
YTEGVTQRCKLDNNTGKTS
CSHMTPENVVDSKASRVIATGDVTLNGG
S
L
MH
V
GNA
S
LT
G
G
IS
G
AP
D
S
H
L
I
L
S
S
D
A
M
I
N
L
D
K
N
S
S
VGR
L
VSEG
G
K
V
S
M
LS
-
S--EWS
P
K
KF
T
I
E
E
S
Y
T
SN
L
A
L
N
M
GV
N
IKD
NV
G
D
KIE
I
LNLA
Q
G
A
NN
SLD
L
S
N
L
YGQSG
-
ELA
Y
D
L
T
I
A
S
AP
SG
T
SH
D
F
--
F
S
F
A
S
FDR
GF
T
V
Y
TP
NTQVT
-------
EQDGKVL
W
Q
L
K
G
KNPAP
P
ES
EK
P
V
P
PESEKPV
P
PETEK
P
V
P
P
-------
-
-
ETETPG
ATQP
G
NGLF
D
G
K
D
N
KK
L
LK
D
A
R
N
M
FASRQY
L
--
I
S
NS
S
D
R
W
E
M
IID
D
A
TRN
D
NVWAMNTFRT
GG
Y
-
D
G
F
T
A
K
Q
H
G
L
D
LGI
H
K
AQ
D
S
D
Y
F
W
G
AGI
G
F
HKGDT
SNSLF
RD
D
Y
K
M
F
S
G
N
L
Y
LG
K
D
F
E
SG
L
F
V
N
AA
V
G
Y
K
H
L
SE
N
F
KV
KGEL
N
DL
S
GK
-
VN
T
N
I
V
T
AGA
R
V
GYR
M
H
SD
E
L
QA
---
S
V
S
P
-------
SVS
V
NS
-
S
W
M
E
G
G
-K
I
H
A
KERQVD
LHS
G
WAASV
K
A
GV
LA
D
K
S
F
ENS--
K
V
T
G
--
G
I
YRN
F
S
V
KD
M
P
G
VT
L
S
D
S
W
KS
RS
Y
E
A
K
KD
D
HFT
AT
I
GV
EG
K
IT
E
K
M
NAN
L
K
L
T
S
HF
G
G
D
F
K
T
D
T
IGTL
G
L
K
Y
E
F
fig|656379.3.peg.3292
Escherichia coli FVEC1302 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
N
D
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
T
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656380.3.peg.2135
Escherichia coli FVEC1412 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
N
D
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
T
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749549.3.peg.874
Escherichia coli MS 198-1 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
N
D
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
T
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585056.7.peg.1696
Escherichia coli UMN026 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
N
D
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
T
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|358709.5.peg.1530
Escherichia coli 101-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|413997.3.peg.1241
Escherichia coli B str. REL606 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|469008.4.peg.2494
Escherichia coli BL21(DE3) (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749547.3.peg.596
Escherichia coli MS 187-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|670888.3.peg.1882
Escherichia coli 1827-70 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
S
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749540.3.peg.4436
Escherichia coli MS 146-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|216592.1.peg.1626
Escherichia coli 042 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHSG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITA
D
NS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|216592.3.peg.1304
Escherichia coli 042 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHSG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITA
D
NS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|595496.3.peg.1130
Escherichia coli BW2952 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|536056.3.peg.2577
Escherichia coli DH1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|316401.4.peg.1510
Escherichia coli ETEC H10407 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|83333.1.peg.1188
Escherichia coli K12 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749544.3.peg.1401
Escherichia coli MS 175-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749548.3.peg.4961
Escherichia coli MS 196-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|316407.3.peg.1163
Escherichia coli W3110 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|316385.5.peg.1256
Escherichia coli str. K-12 substr. DH10B (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|316385.7.peg.1282
Escherichia coli str. K-12 substr. DH10B (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|511145.12.peg.1249
Escherichia coli str. K-12 substr. MG1655 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|511145.6.peg.1238
Escherichia coli str. K-12 substr. MG1655 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656414.3.peg.1433
Escherichia coli H736 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
I
S
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|331112.3.peg.1219
Escherichia coli HS (333-955/955)
N
S
I
FS
G
G
S
YGASAQTAT
S
V
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|331112.6.peg.1274
Escherichia coli HS (333-955/955)
N
S
I
FS
G
G
S
YGASAQTAT
S
V
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749545.3.peg.110
Escherichia coli MS 182-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
H
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749532.3.peg.1901
Escherichia coli MS 78-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
H
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749538.3.peg.4718
Escherichia coli MS 116-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYA
T
S
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656437.3.peg.1344
Escherichia coli TA143 (333-961/961)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTP
A
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|511693.5.peg.1272
Escherichia coli BL21 (254-876/876)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749537.3.peg.3852
Escherichia coli MS 115-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
I
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MT
M
K
-
V
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|481805.3.peg.2601
Escherichia coli ATCC 8739 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEP
K
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|481805.6.peg.2588
Escherichia coli ATCC 8739 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEP
K
TQ
L
T
Y
S
HQN
E
MT
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585055.6.peg.1329
Escherichia coli 55989 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585055.8.peg.1328
Escherichia coli 55989 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|344601.3.peg.17
Escherichia coli B171 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|344601.5.peg.17
Escherichia coli B171 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|562.375.peg.4097
Escherichia coli EC4100B (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|1040638.4.peg.4517
Escherichia coli O104:H4 str. LB226692 (94-716/716)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585034.4.peg.1213
Escherichia coli IAI1 (94-716/716)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585034.5.peg.1209
Escherichia coli IAI1 (94-716/716)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|550676.3.peg.683
Escherichia coli B185 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
V
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAG
K
S
Q
L
N
I
YVK
T
GAI
H
EF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|679207.4.peg.1902
Escherichia coli MS 107-1 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|6666666.5357.peg.1682
Escherichia coli TY-2482 (333-954/954)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
S-G
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|679204.3.peg.1436
Escherichia coli MS 145-7 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|344610.3.peg.4280
Escherichia coli 53638 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAG
K
S
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|344610.7.peg.4874
Escherichia coli 53638 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAG
K
S
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|409438.11.peg.1387
Escherichia coli SE11 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|340186.3.peg.4389
Escherichia coli E110019 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
L
P
G
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|340186.5.peg.4614
Escherichia coli E110019 (333-955/955)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPE
------
P
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
L
P
G
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|749531.3.peg.41
Escherichia coli MS 69-1 (333-961/961)
N
S
I
FS
S
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
A
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SISL
E
A
G
Q
R
L
N
L
S
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656408.3.peg.1271
Escherichia coli H591 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|679206.4.peg.801
Escherichia coli MS 119-7 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|595495.4.peg.1742
Escherichia coli KO11 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656443.3.peg.1528
Escherichia coli TA271 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|566546.3.peg.306
Escherichia coli W (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|566546.4.peg.1289
Escherichia coli W (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|585396.4.peg.1591
Escherichia coli O111:H- str. 11128 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|573235.3.peg.1742
Escherichia coli O26:H11 str. 11368 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|340184.3.peg.3621
Escherichia coli B7A (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
T
A
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|340184.6.peg.3785
Escherichia coli B7A (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
T
A
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|562.373.peg.2844
Escherichia coli 1125A (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|478007.5.peg.4699
Escherichia coli O157:H7 str. EC508 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|701177.3.peg.1460
Escherichia coli O55:H7 str. CB9615 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|550677.3.peg.2657
Escherichia coli B354 (333-955/955)
N
S
I
FS
S
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
V
T
M
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTIP
E
PT
PNPEPTPAPAQPPIVNPDPTP
N
------
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
S
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
Y
I
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
Q
N
G
F
Y
S
DL
V
I
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SIS
Q
E
A
G
Q
R
FN
L
S
P
-
TG
YGF
Y
L
EPQ
TQ
L
T
Y
S
HQN
E
MV
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|656444.3.peg.1912
Escherichia coli TA280 (333-961/961)
N
S
I
FS
S
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
TSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
A
PTPKPTT
TADA
G
GNYL
N
V
-
S
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
SG
F
Y
S
DL
V
V
I
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
M
SI
A
L
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
V
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|331111.12.peg.1638
Escherichia coli E24377A (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNATN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|331111.3.peg.3810
Escherichia coli E24377A (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
V
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
A
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNATN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
D
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQ
S
NLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|478008.5.peg.2916
Escherichia coli O157:H7 str. EC869 (254-882/882)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|637388.3.peg.2046
Escherichia coli O157:H7 str. FRIK2000 (254-882/882)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|570506.3.peg.3094
Escherichia coli O157:H7 str. FRIK966 (254-882/882)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
GSTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTPNP
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TS
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
I
YVK
T
GAI
REF
SG
D
T
E
YQ
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|679205.4.peg.4040
Escherichia coli MS 124-1 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHSG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
N
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
ASTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTP
T
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
R
D
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|749533.3.peg.4591
Escherichia coli MS 84-1 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHSG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
GG
K
L
D
VAM
-
N
NS
V
W
N
V
T
N
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
ASTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTP
T
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
R
D
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAGNS
Q
L
N
M
YVK
T
GAI
REF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
H
F
SF
fig|656419.3.peg.1537
Escherichia coli M718 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
D
G
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
ASTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTP
T
P
T
PTPKPTT
TADA
G
GNYL
N
V
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
E
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
LD
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAG
K
S
Q
L
N
I
YVK
T
GAI
H
EF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
KQ
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
fig|550672.3.peg.1503
Escherichia coli B088 (333-961/961)
N
S
I
FS
G
G
S
YGASAQTATAV
I
NMQNTD
I
TVDR
NG
S
LAL
GLWALSGGRI
T
G
D
S
LAITG
A
AGAR
G
IYAMTNSQID
L
T
SDLVIDMST
P
D
Q
MAIATQHDDGYAAS
R
I
NASGRML
I
N
GS
V
LS
-
-KGGL
--
I
NL
D
MHPG---------------
----------------------------
S
V
WT
G
--S
S
LS
D
NVN
-
D
G
K
L
D
VAM
-
N
NS
V
W
N
V
T
S
N
SN
LDT
L
ALSH
S
T
V
D
F
AS
H
ASTAGT
F
T
TL
N
VE
N
L
-
S
GN
S
T
F
I
MRAD
---
--
-
-
---
V
VGEG
NG
V
NN
KGD
L
L
N
I
SGSSA
G
NHV
L
A
I
R
NQ
G
SE
AT
T
GN
EV
--
L
T
V
V
K
TTD
G
AA
S
FSA
SSQVE
LGGYLYD
VRKNGTN
W
E
L
Y
A
SGTVP
E
PT
PNPEPTPAPAQPPIVNPDPTPEPDPTP
T
P
T
PTPKPTT
TADA
G
GNYL
N
I
-
G
Y
LL
N
YV
E
NRT
L
MQ
RMGDLR
N
Q
SK
D
G
N
I
W
L
R
SYG
GS
LDS
F
-----
ASGKLS
GF
D
M
G
Y
S
G
IQ
F
G
G
DK
R
-
-
LS
D
V
M
P
L
YV
G
LYI
G
S
T
H
A
S
P
DYSGG
D
G
T
AR
S
D
Y
M
G
M
YAS
Y
M
A
H
N
G
F
Y
S
DL
V
V
K
A
S
R
Q
KN
S
F
HV
R
D
S
QN
NG
V
NA
N
GT
A
NG
L
SISL
E
A
G
Q
R
FN
LT
P
-
TG
YGF
YIEPQ
TQ
L
T
Y
S
HQN
E
MA
M
K
-
A
S
N
G
L
NI
H
L
--NHYE
S
LLG
-----
R
ASM
IL
G
Y
D
ITAG
K
S
Q
L
N
M
YVK
T
GAI
H
EF
SG
D
T
E
YL
L
N
NS
R
EK
YS
F
KG
N
GW
N
N
--
-G
VGV
S
AQ
YN
T
Q
H
T
F
Y
LE
A
D
Y
TQGNLFD
-
Q
K
Q
VN
GG
Y
R
F
SF
Consen1
Primary consensus
l
Ga
v
a
s
fS
g
-----------
------
i
ng
Lal
----------
g
p
a
p
L
---------
d
-------------
a
l
i
Gsi
-
--
i
g
----------------------------
l
G
s
gnvn
-
gg
a
vaM
-
ns
W
v
s
Sn
l
s
v
f
-
F
TLtve
L
s
S
f
mRad
--
d
v
nG
nN
v
fi
-
L
I
lv
ap
T
ev
--
f
a
k
Gfs
vtp
-------
W
L
g
e
-----------------------------
-------
a
n
-
Y
f
EvnnLnkRMGDLRd
ngd
g
W
R
Gsgsa
----------
gGf
d
Yt
iQ
G
Dkk
-
held
mdLftG
t
Tdssa
sG
tkS
g
G
YAS
mf
sGaY
DLi
Ky
h
kN
y
--
sfa
g
n
ahs
yagaE
GyRyhlt
-
---
yiEPQaeLvyg
g
f
w
d
gmni
m
pLlG
-----
Rtgv
Gk
fsgkdw
lt
ragt
fdl
d
e
L
da
ge
ikG
kd
rml
VGvnAq
dn
rfgLE
e
safgkyn
d
avNan
RysF
Consen2
Secondary consensus
g
l
t
g
v
s
ygasaqtatav
nmqntdv
a
mglwalsggri
s
s
g
sdlvidmst
g
maiatqhddgyaas
i
v
v
d
v
d
t
ap
l
a
d
g
m
t
i
s
h
nt
y
l
tn
-
i
d
l
n
g
nq
se
l
v
t
aa
fsa
lggylyd
a
pnpeptpapaqppivnpdptpepdptpnp
ptpkptt
g
n
nrt
mq
n
ske
n
lds
asgkls
y
m
s
rr
-
lsg
p
yv
g
h
p
d
ar
y
la
n
f
v
a
r
f
ld
qn
v
ng
sisl
q
fnvs
ygf
v
tq
tws
e
m
-
s
dl
l
s
asm
y
itagns
vn
yvkl
ref
d
ns
ek
fn
gw
n
--
s
kq
tly
d
tqgnlfd
q
qi
gg
fm
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character