fig|1040638.4.peg.1179
Escherichia coli O104:H4 str. LB226692
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|6666666.5357.peg.4163
Escherichia coli TY-2482
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585055.6.peg.4647
Escherichia coli 55989
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585055.8.peg.4652
Escherichia coli 55989
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|595496.3.peg.4206
Escherichia coli BW2952
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|536056.3.peg.4100
Escherichia coli DH1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340186.3.peg.1056
Escherichia coli E110019
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340186.5.peg.1098
Escherichia coli E110019
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|316401.4.peg.5047
Escherichia coli ETEC H10407
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656414.3.peg.4692
Escherichia coli H736
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|331112.3.peg.4085
Escherichia coli HS
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|331112.6.peg.4260
Escherichia coli HS
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|83333.1.peg.4042
Escherichia coli K12
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|595495.4.peg.4107
Escherichia coli KO11
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|679207.4.peg.3020
Escherichia coli MS 107-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749537.3.peg.4275
Escherichia coli MS 115-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|679206.4.peg.992
Escherichia coli MS 119-7
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749544.3.peg.115
Escherichia coli MS 175-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749548.3.peg.3649
Escherichia coli MS 196-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656443.3.peg.5118
Escherichia coli TA271
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|566546.3.peg.2177
Escherichia coli W
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|566546.4.peg.4428
Escherichia coli W
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|316407.3.peg.3968
Escherichia coli W3110
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|316385.5.peg.4276
Escherichia coli str. K-12 substr. DH10B
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|316385.7.peg.4366
Escherichia coli str. K-12 substr. DH10B
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|511145.12.peg.4262
Escherichia coli str. K-12 substr. MG1655
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|511145.6.peg.4241
Escherichia coli str. K-12 substr. MG1655
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|358709.5.peg.1882
Escherichia coli 101-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|413997.3.peg.4222
Escherichia coli B str. REL606
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|550672.3.peg.4481
Escherichia coli B088
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340184.3.peg.700
Escherichia coli B7A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340184.6.peg.730
Escherichia coli B7A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|511693.5.peg.4243
Escherichia coli BL21
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|469008.4.peg.4047
Escherichia coli BL21(DE3)
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340185.3.peg.1424
Escherichia coli E22
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340185.4.peg.1508
Escherichia coli E22
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|331111.12.peg.4894
Escherichia coli E24377A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|331111.3.peg.2284
Escherichia coli E24377A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|679205.4.peg.4508
Escherichia coli MS 124-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|679204.3.peg.3947
Escherichia coli MS 145-7
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749533.3.peg.4398
Escherichia coli MS 84-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585395.4.peg.5128
Escherichia coli O103:H2 str. 12009
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|562.375.peg.2945
Escherichia coli EC4100B
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749540.3.peg.1320
Escherichia coli MS 146-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
T
FATRFLFS
TPTNMIQESND
fig|749532.3.peg.4537
Escherichia coli MS 78-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656408.3.peg.4630
Escherichia coli H591
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
N
M
GS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749545.3.peg.2437
Escherichia coli MS 182-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
P
LG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|344601.3.peg.1164
Escherichia coli B171
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
H
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|344601.5.peg.1228
Escherichia coli B171
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
H
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|550676.3.peg.4406
Escherichia coli B185
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|562.371.peg.3650
Escherichia coli 1044A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|562.373.peg.5753
Escherichia coli 1125A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|562.372.peg.3408
Escherichia coli 1212A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|344610.3.peg.1407
Escherichia coli 53638
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|344610.7.peg.1997
Escherichia coli 53638
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|562.374.peg.2743
Escherichia coli 536A
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|83334.1.peg.5090
Escherichia coli O157:H7
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|155864.1.peg.5072
Escherichia coli O157:H7 EDL933
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|155864.8.peg.5055
Escherichia coli O157:H7 EDL933
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444449.5.peg.3649
Escherichia coli O157:H7 str. EC4042
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444448.5.peg.2407
Escherichia coli O157:H7 str. EC4045
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444453.5.peg.2044
Escherichia coli O157:H7 str. EC4076
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444452.5.peg.1120
Escherichia coli O157:H7 str. EC4113
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444450.8.peg.5485
Escherichia coli O157:H7 str. EC4115
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444451.5.peg.2148
Escherichia coli O157:H7 str. EC4196
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|444447.5.peg.2573
Escherichia coli O157:H7 str. EC4206
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|478005.5.peg.625
Escherichia coli O157:H7 str. EC4486
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|478006.5.peg.1510
Escherichia coli O157:H7 str. EC4501
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|478007.5.peg.1027
Escherichia coli O157:H7 str. EC508
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|478008.5.peg.158
Escherichia coli O157:H7 str. EC869
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|637388.3.peg.2371
Escherichia coli O157:H7 str. FRIK2000
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|570506.3.peg.1352
Escherichia coli O157:H7 str. FRIK966
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|386585.9.peg.5343
Escherichia coli O157:H7 str. Sakai
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|544404.4.peg.5297
Escherichia coli O157:H7 str. TW14359
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|502346.5.peg.1525
Escherichia coli O157:H7 str. TW14588
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|701177.3.peg.4963
Escherichia coli O55:H7 str. CB9615
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|670888.3.peg.4603
Escherichia coli 1827-70
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|481805.3.peg.4185
Escherichia coli ATCC 8739
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|481805.6.peg.4172
Escherichia coli ATCC 8739
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656419.3.peg.5379
Escherichia coli M718
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
L
T
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|656444.3.peg.5591
Escherichia coli TA280
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
R
Y
LFS
TPTNMIQESND
fig|670897.3.peg.1448
Escherichia coli 2362-75
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|362663.8.peg.4409
Escherichia coli 536
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|362663.9.peg.4425
Escherichia coli 536
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|525281.3.peg.1737
Escherichia coli 83972
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|655817.3.peg.4882
Escherichia coli ABU 83972
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|405955.13.peg.4635
Escherichia coli APEC O1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|405955.9.peg.3917
Escherichia coli APEC O1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|199310.1.peg.5030
Escherichia coli CFT073
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|199310.4.peg.4824
Escherichia coli CFT073
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|216593.1.peg.3872
Escherichia coli E2348/69
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585397.7.peg.4852
Escherichia coli ED1a
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585397.9.peg.4852
Escherichia coli ED1a
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340197.3.peg.3481
Escherichia coli F11
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|340197.5.peg.3649
Escherichia coli F11
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656393.3.peg.248
Escherichia coli H299
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|714962.3.peg.4673
Escherichia coli IHE3034
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656417.3.peg.5229
Escherichia coli M605
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749546.3.peg.1597
Escherichia coli MS 185-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749550.3.peg.4453
Escherichia coli MS 200-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749528.3.peg.3723
Escherichia coli MS 45-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|574521.7.peg.4559
Escherichia coli O127:H6 str. E2348/69
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585035.6.peg.4533
Escherichia coli S88
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|431946.3.peg.4182
Escherichia coli SE15
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656440.3.peg.4706
Escherichia coli TA206
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|869729.3.peg.4486
Escherichia coli UM146
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|364106.7.peg.4607
Escherichia coli UTI89
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|364106.8.peg.4606
Escherichia coli UTI89
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|562.376.peg.1806
Escherichia coli WV_060327
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|656437.3.peg.4642
Escherichia coli TA143
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|585034.4.peg.4239
Escherichia coli IAI1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|585034.5.peg.4234
Escherichia coli IAI1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|573235.3.peg.5414
Escherichia coli O26:H11 str. 11368
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|409438.11.peg.4612
Escherichia coli SE11
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|216592.1.peg.2437
Escherichia coli 042
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|216592.3.peg.4668
Escherichia coli 042
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|550677.3.peg.127
Escherichia coli B354
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|656379.3.peg.505
Escherichia coli FVEC1302
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|656380.3.peg.497
Escherichia coli FVEC1412
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|749549.3.peg.1662
Escherichia coli MS 198-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|585056.7.peg.4828
Escherichia coli UMN026
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FA
A
RFLFS
TPTNMIQESND
fig|439855.10.peg.4709
Escherichia coli SMS-3-5
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
TW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|749527.3.peg.5051
Escherichia coli MS 21-1
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
M
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|753642.3.peg.4001
Escherichia coli NC101
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
A
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|685038.3.peg.4234
Escherichia coli O83:H1 str. NRG 857C
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
A
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNMIQESND
fig|444454.5.peg.4195
Escherichia coli O157:H7 str. EC4024
MK
TP
SQPRA
I
Y
Y
I
V
A
I
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
H
QLG
F
D
D
NH
A
IS
LFSA
Y
A
S
LVY
VT
PI
L
GGWL
A
D
R
LLG
NR
TA
V
I
A
GAL
LMTL
G
H
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
C
G
Y
GLFK
S
N
I
S
C
LL
G
E
L
Y
DEN
D
H
R
R
DGGF
S
L
L
Y
AA
G
NIGS
IA
A
P
IA
C
-
VA
A
QW
YGW
H
V
G
F
A
L
AGG
G
M
F
I
G
LL
I
F
LS
G
H
RHF
QS
T
R
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
DWS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LM
F
VGT
LFW
V
L
A
Q
Q
GGSTISL
F
ID
R
F
V
N
R
QA
FN
IE
V
P
T
AL
FQ
S
V
N
AIA
VML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
G
L
L
LMA
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
A
ELFI
D
P
VA
I
A
Q
I
T
R
L
KM---S
G
VL
T
G
I
YM
L
A
T
G
A
V
AN
W
L
A
G
V
VA
---
---
QQ
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
L
A
FATRFLFS
TPTNM
V
QESND
fig|656440.3.peg.562
Escherichia coli TA206 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
M
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|595495.4.peg.4368
Escherichia coli KO11 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|566546.3.peg.5016
Escherichia coli W (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|566546.4.peg.763
Escherichia coli W (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|525281.3.peg.2240
Escherichia coli 83972 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|655817.3.peg.795
Escherichia coli ABU 83972 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|405955.13.peg.675
Escherichia coli APEC O1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|405955.9.peg.560
Escherichia coli APEC O1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|199310.1.peg.761
Escherichia coli CFT073 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|199310.4.peg.752
Escherichia coli CFT073 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|714962.3.peg.723
Escherichia coli IHE3034 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|656417.3.peg.835
Escherichia coli M605 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749546.3.peg.167
Escherichia coli MS 185-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749528.3.peg.3933
Escherichia coli MS 45-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|753642.3.peg.952
Escherichia coli NC101 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|685038.3.peg.640
Escherichia coli O83:H1 str. NRG 857C (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585035.6.peg.734
Escherichia coli S88 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|431946.3.peg.667
Escherichia coli SE15 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|869729.3.peg.3001
Escherichia coli UM146 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|364106.7.peg.804
Escherichia coli UTI89 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|364106.8.peg.803
Escherichia coli UTI89 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|562.376.peg.1917
Escherichia coli WV_060327 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585057.4.peg.708
Escherichia coli IAI39 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
SH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585057.6.peg.705
Escherichia coli IAI39 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
SH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|670897.3.peg.859
Escherichia coli 2362-75 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|216593.1.peg.2919
Escherichia coli E2348/69 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585397.7.peg.686
Escherichia coli ED1a (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585397.9.peg.688
Escherichia coli ED1a (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|574521.7.peg.636
Escherichia coli O127:H6 str. E2348/69 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|439855.10.peg.885
Escherichia coli SMS-3-5 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
SH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|481805.3.peg.3158
Escherichia coli ATCC 8739 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|481805.6.peg.3143
Escherichia coli ATCC 8739 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DI
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|562.371.peg.574
Escherichia coli 1044A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|562.373.peg.3024
Escherichia coli 1125A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|562.372.peg.1702
Escherichia coli 1212A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|562.374.peg.5275
Escherichia coli 536A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|83334.1.peg.805
Escherichia coli O157:H7 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444454.5.peg.5227
Escherichia coli O157:H7 str. EC4024 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444449.5.peg.5563
Escherichia coli O157:H7 str. EC4042 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444448.5.peg.3438
Escherichia coli O157:H7 str. EC4045 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444453.5.peg.781
Escherichia coli O157:H7 str. EC4076 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444452.5.peg.3565
Escherichia coli O157:H7 str. EC4113 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444450.8.peg.897
Escherichia coli O157:H7 str. EC4115 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444451.5.peg.4509
Escherichia coli O157:H7 str. EC4196 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|444447.5.peg.3618
Escherichia coli O157:H7 str. EC4206 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|478004.5.peg.3842
Escherichia coli O157:H7 str. EC4401 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|478005.5.peg.1285
Escherichia coli O157:H7 str. EC4486 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|478006.5.peg.4334
Escherichia coli O157:H7 str. EC4501 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|478007.5.peg.4001
Escherichia coli O157:H7 str. EC508 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|478008.5.peg.2127
Escherichia coli O157:H7 str. EC869 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|637388.3.peg.1486
Escherichia coli O157:H7 str. FRIK2000 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|386585.9.peg.850
Escherichia coli O157:H7 str. Sakai (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|544404.4.peg.762
Escherichia coli O157:H7 str. TW14359 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|502346.5.peg.457
Escherichia coli O157:H7 str. TW14588 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|656414.3.peg.890
Escherichia coli H736 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
CE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749540.3.peg.3806
Escherichia coli MS 146-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
CE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|216592.1.peg.456
Escherichia coli 042 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|216592.3.peg.760
Escherichia coli 042 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|358709.5.peg.3974
Escherichia coli 101-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|670888.3.peg.1270
Escherichia coli 1827-70 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|413997.3.peg.711
Escherichia coli B str. REL606 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|550677.3.peg.1114
Escherichia coli B354 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|511693.5.peg.708
Escherichia coli BL21 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|469008.4.peg.3048
Escherichia coli BL21(DE3) (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|749547.3.peg.1746
Escherichia coli MS 187-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|749527.3.peg.2592
Escherichia coli MS 21-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|656437.3.peg.780
Escherichia coli TA143 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|656444.3.peg.1244
Escherichia coli TA280 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|155864.1.peg.732
Escherichia coli O157:H7 EDL933 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPX
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|155864.8.peg.754
Escherichia coli O157:H7 EDL933 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPX
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|344610.3.peg.4396
Escherichia coli 53638 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|344610.7.peg.977
Escherichia coli 53638 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|595496.3.peg.635
Escherichia coli BW2952 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|536056.3.peg.3088
Escherichia coli DH1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|316401.4.peg.836
Escherichia coli ETEC H10407 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|331112.3.peg.703
Escherichia coli HS (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|331112.6.peg.734
Escherichia coli HS (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|83333.1.peg.701
Escherichia coli K12 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749538.3.peg.662
Escherichia coli MS 116-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749544.3.peg.3259
Escherichia coli MS 175-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749548.3.peg.3235
Escherichia coli MS 196-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|316407.3.peg.683
Escherichia coli W3110 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|316385.7.peg.784
Escherichia coli str. K-12 substr. DH10B (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|511145.12.peg.739
Escherichia coli str. K-12 substr. MG1655 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|511145.6.peg.730
Escherichia coli str. K-12 substr. MG1655 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|656393.3.peg.1394
Escherichia coli H299 (3-476/493)
K
YA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|1040638.4.peg.5056
Escherichia coli O104:H4 str. LB226692 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|6666666.5357.peg.2124
Escherichia coli TY-2482 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585055.6.peg.705
Escherichia coli 55989 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585055.8.peg.707
Escherichia coli 55989 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|550676.3.peg.165
Escherichia coli B185 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|656408.3.peg.651
Escherichia coli H591 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585034.4.peg.679
Escherichia coli IAI1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585034.5.peg.678
Escherichia coli IAI1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|679207.4.peg.1363
Escherichia coli MS 107-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749537.3.peg.2048
Escherichia coli MS 115-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|679206.4.peg.2782
Escherichia coli MS 119-7 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749532.3.peg.2581
Escherichia coli MS 78-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585396.4.peg.757
Escherichia coli O111:H- str. 11128 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|573235.3.peg.784
Escherichia coli O26:H11 str. 11368 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|409438.11.peg.894
Escherichia coli SE11 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749531.3.peg.1857
Escherichia coli MS 69-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LY
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|570506.3.peg.431
Escherichia coli O157:H7 str. FRIK966 (3-476/493)
K
HA
SQPR
S
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|701177.3.peg.861
Escherichia coli O55:H7 str. CB9615 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
M
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|656379.3.peg.1483
Escherichia coli FVEC1302 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|656380.3.peg.1311
Escherichia coli FVEC1412 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|585056.7.peg.991
Escherichia coli UMN026 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|344601.3.peg.3398
Escherichia coli B171 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|344601.5.peg.3555
Escherichia coli B171 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|340185.3.peg.3897
Escherichia coli E22 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|340185.4.peg.4107
Escherichia coli E22 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|562.375.peg.1448
Escherichia coli EC4100B (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|585395.4.peg.743
Escherichia coli O103:H2 str. 12009 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749545.3.peg.3921
Escherichia coli MS 182-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
G
A
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|656443.3.peg.972
Escherichia coli TA271 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KX
X
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749549.3.peg.4472
Escherichia coli MS 198-1 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
G
A
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|362663.8.peg.734
Escherichia coli 536 (3-476/493)
K
HA
SQP
L
A
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|362663.9.peg.734
Escherichia coli 536 (3-476/493)
K
HA
SQP
L
A
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|340197.3.peg.4195
Escherichia coli F11 (3-476/493)
K
HA
SQP
L
A
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|340197.5.peg.4378
Escherichia coli F11 (3-476/493)
K
HA
SQP
L
A
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|749550.3.peg.4744
Escherichia coli MS 200-1 (3-476/493)
K
HA
SQP
L
A
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
SD
NH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|331111.12.peg.1030
Escherichia coli E24377A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
G
R
S
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|331111.3.peg.3249
Escherichia coli E24377A (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YE
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
RHF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
G
R
S
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
I
fig|656419.3.peg.982
Escherichia coli M718 (3-476/493)
K
HA
SQPRA
I
Y
Y
VV
A
L
QI
WE
Y
F
SF
YGM
RA
LL
IL
YL
T
N
QL
K
Y
N
D
TH
A
YK
LFSA
Y
C
S
LVY
VT
PI
L
GG
F
L
A
D
K
V
LG
NR
MA
V
MLGAL
LM
AIG
H
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
C
G
Y
GLFK
S
N
V
S
C
LL
G
E
L
Y
EPT
DPR
R
DGGF
S
L
M
Y
AA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
G
M
I
A
G
L
V
I
F
LC
G
N
C
HF
TH
T
R
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
E
WS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
TF
FSM
LFW
A
FA
Q
Q
GGS
S
ISLYID
R
F
V
N
R
DM
F
G
YT
V
P
T
AM
FQ
S
I
N
A
F
A
VML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
G
L
G
LM
S
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
A
ELFI
D
P
VA
M
SQ
I
T
R
I
EIPGVT
G
VL
T
G
I
YM
L
L
S
G
A
I
AN
Y
L
A
G
VI
A
---
---
D
Q
T
S
Q
ASF
DASGAIN
Y
S
I
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
I
fig|562.373.peg.5385
Escherichia coli 1125A (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444454.5.peg.5621
Escherichia coli O157:H7 str. EC4024 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444449.5.peg.567
Escherichia coli O157:H7 str. EC4042 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444448.5.peg.4875
Escherichia coli O157:H7 str. EC4045 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444453.5.peg.4739
Escherichia coli O157:H7 str. EC4076 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444452.5.peg.3487
Escherichia coli O157:H7 str. EC4113 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444450.8.peg.2386
Escherichia coli O157:H7 str. EC4115 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444451.5.peg.3406
Escherichia coli O157:H7 str. EC4196 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|444447.5.peg.5113
Escherichia coli O157:H7 str. EC4206 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|478004.5.peg.4098
Escherichia coli O157:H7 str. EC4401 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|478007.5.peg.3551
Escherichia coli O157:H7 str. EC508 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|544404.4.peg.2249
Escherichia coli O157:H7 str. TW14359 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|1040638.4.peg.3685
Escherichia coli O104:H4 str. LB226692 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AN
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|6666666.5357.peg.4693
Escherichia coli TY-2482 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AN
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585055.6.peg.1829
Escherichia coli 55989 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AN
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585055.8.peg.1833
Escherichia coli 55989 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AN
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|331112.3.peg.1610
Escherichia coli HS (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
T
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|331112.6.peg.1677
Escherichia coli HS (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
T
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|216592.3.peg.1873
Escherichia coli 042 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|358709.5.peg.1149
Escherichia coli 101-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|670888.3.peg.128
Escherichia coli 1827-70 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|344610.3.peg.3151
Escherichia coli 53638 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|344610.7.peg.5282
Escherichia coli 53638 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|481805.3.peg.2152
Escherichia coli ATCC 8739 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|481805.6.peg.2145
Escherichia coli ATCC 8739 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|413997.3.peg.1678
Escherichia coli B str. REL606 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|511693.5.peg.1704
Escherichia coli BL21 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|469008.4.peg.2071
Escherichia coli BL21(DE3) (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|595496.3.peg.1594
Escherichia coli BW2952 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|536056.3.peg.2120
Escherichia coli DH1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|316401.4.peg.1917
Escherichia coli ETEC H10407 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656379.3.peg.2103
Escherichia coli FVEC1302 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656380.3.peg.3069
Escherichia coli FVEC1412 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656393.3.peg.2425
Escherichia coli H299 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656414.3.peg.1945
Escherichia coli H736 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|83333.1.peg.1620
Escherichia coli K12 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749538.3.peg.4303
Escherichia coli MS 116-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|679205.4.peg.1669
Escherichia coli MS 124-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749540.3.peg.4275
Escherichia coli MS 146-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749547.3.peg.3060
Escherichia coli MS 187-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749548.3.peg.3436
Escherichia coli MS 196-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749527.3.peg.3580
Escherichia coli MS 21-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749531.3.peg.4874
Escherichia coli MS 69-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|749533.3.peg.2422
Escherichia coli MS 84-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656437.3.peg.1847
Escherichia coli TA143 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|585056.7.peg.2108
Escherichia coli UMN026 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|316407.3.peg.1592
Escherichia coli W3110 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|316385.7.peg.1791
Escherichia coli str. K-12 substr. DH10B (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|511145.12.peg.1705
Escherichia coli str. K-12 substr. MG1655 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|511145.6.peg.1689
Escherichia coli str. K-12 substr. MG1655 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|344601.3.peg.379
Escherichia coli B171 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|344601.5.peg.377
Escherichia coli B171 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340184.3.peg.968
Escherichia coli B7A (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340184.6.peg.1003
Escherichia coli B7A (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340186.3.peg.3461
Escherichia coli E110019 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340186.5.peg.3614
Escherichia coli E110019 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340185.3.peg.3320
Escherichia coli E22 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|340185.4.peg.3496
Escherichia coli E22 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|331111.12.peg.2129
Escherichia coli E24377A (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|331111.3.peg.4271
Escherichia coli E24377A (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|562.375.peg.1738
Escherichia coli EC4100B (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|656408.3.peg.1779
Escherichia coli H591 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585034.4.peg.1668
Escherichia coli IAI1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585034.5.peg.1663
Escherichia coli IAI1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|679207.4.peg.4249
Escherichia coli MS 107-1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|749537.3.peg.1708
Escherichia coli MS 115-1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|679206.4.peg.1264
Escherichia coli MS 119-7 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|679204.3.peg.552
Escherichia coli MS 145-7 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|749545.3.peg.2662
Escherichia coli MS 182-1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|749532.3.peg.1488
Escherichia coli MS 78-1 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585395.4.peg.1857
Escherichia coli O103:H2 str. 12009 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|585396.4.peg.2185
Escherichia coli O111:H- str. 11128 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|573235.3.peg.2399
Escherichia coli O26:H11 str. 11368 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|656443.3.peg.2288
Escherichia coli TA271 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|566546.3.peg.1016
Escherichia coli W (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|566546.4.peg.1789
Escherichia coli W (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|409438.11.peg.1903
Escherichia coli SE11 (19-478/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVI
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
T
fig|562.371.peg.4483
Escherichia coli 1044A (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|562.372.peg.4716
Escherichia coli 1212A (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|562.374.peg.4396
Escherichia coli 536A (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|550676.3.peg.1939
Escherichia coli B185 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|550677.3.peg.3019
Escherichia coli B354 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|585057.4.peg.1489
Escherichia coli IAI39 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|585057.6.peg.1488
Escherichia coli IAI39 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|83334.1.peg.2369
Escherichia coli O157:H7 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|155864.1.peg.2378
Escherichia coli O157:H7 EDL933 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|155864.8.peg.2220
Escherichia coli O157:H7 EDL933 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|478006.5.peg.4037
Escherichia coli O157:H7 str. EC4501 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|478008.5.peg.4546
Escherichia coli O157:H7 str. EC869 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|637388.3.peg.5007
Escherichia coli O157:H7 str. FRIK2000 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|570506.3.peg.4226
Escherichia coli O157:H7 str. FRIK966 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|386585.9.peg.2452
Escherichia coli O157:H7 str. Sakai (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|502346.5.peg.5062
Escherichia coli O157:H7 str. TW14588 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|701177.3.peg.2026
Escherichia coli O55:H7 str. CB9615 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656444.3.peg.2530
Escherichia coli TA280 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|216592.1.peg.2240
Escherichia coli 042 (1-464/487)
M
N
AF
K
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|656417.3.peg.2129
Escherichia coli M605 (19-483/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
K
L
Y
fig|670897.3.peg.2283
Escherichia coli 2362-75 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|362663.8.peg.1593
Escherichia coli 536 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|362663.9.peg.1597
Escherichia coli 536 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|525281.3.peg.872
Escherichia coli 83972 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|655817.3.peg.1972
Escherichia coli ABU 83972 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|405955.13.peg.1717
Escherichia coli APEC O1 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|405955.9.peg.1401
Escherichia coli APEC O1 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|199310.1.peg.1964
Escherichia coli CFT073 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|199310.4.peg.1893
Escherichia coli CFT073 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|585397.7.peg.1852
Escherichia coli ED1a (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|585397.9.peg.1847
Escherichia coli ED1a (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|340197.3.peg.3563
Escherichia coli F11 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|340197.5.peg.3725
Escherichia coli F11 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|714962.3.peg.1785
Escherichia coli IHE3034 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|656419.3.peg.2342
Escherichia coli M718 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|749546.3.peg.4589
Escherichia coli MS 185-1 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|749550.3.peg.3243
Escherichia coli MS 200-1 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|749528.3.peg.4909
Escherichia coli MS 45-1 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|753642.3.peg.1527
Escherichia coli NC101 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|685038.3.peg.1651
Escherichia coli O83:H1 str. NRG 857C (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|585035.6.peg.1672
Escherichia coli S88 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|431946.3.peg.1553
Escherichia coli SE15 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|869729.3.peg.1909
Escherichia coli UM146 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|364106.7.peg.1864
Escherichia coli UTI89 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|364106.8.peg.1867
Escherichia coli UTI89 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|562.376.peg.2919
Escherichia coli WV_060327 (19-480/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|216593.1.peg.406
Escherichia coli E2348/69 (1-467/487)
M
N
AF
K
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
TI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
T
AP
fig|749549.3.peg.5246
Escherichia coli MS 198-1 (19-477/500)
QP
K
AFY
L
IF
S
IELWERFGYYG
L
QG
I
M
AVYLV
K
QLG
M
S
E
AD
S
IT
LFS
S
F
S
ALVYGL
VA
IGGWLGD
K
V
LGTK
RV
IMLGA
I
VLAIGY
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
VGNGLFKAN
P
SSLLS
T
CY
EKN
DPRLDG
A
FT
M
Y
YMS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
G
A
F
A
L
SVV
GL
L
I
T
IV
N
F
A-
-
-
---
-F
C
Q
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
WL
L
HN
Q
EVA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LML
EAI
I
F
F
V
LY
S
QMPTSLNFFAIRNV
E
H
SI
LG
LA
V
E
P
EQ
Y
QALNPFW
I
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
MP
T
KFA
I
GM
V
MCS
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
GEL
M
IS
G
LGLAM
V
A
Q
L
VPQRLM
GFI
M
G
S
WFL
-
T
T
A
G
AN
L
I
GGYVA
GMM
AVPDN
V
TD
PL-
-------
M
SL
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
fig|1040638.4.peg.2121
Escherichia coli O104:H4 str. LB226692 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|6666666.5357.peg.4125
Escherichia coli TY-2482 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|358709.5.peg.320
Escherichia coli 101-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585055.6.peg.3966
Escherichia coli 55989 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585055.8.peg.3968
Escherichia coli 55989 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|413997.3.peg.3505
Escherichia coli B str. REL606 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340184.3.peg.362
Escherichia coli B7A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340184.6.peg.378
Escherichia coli B7A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|511693.5.peg.3521
Escherichia coli BL21 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|469008.4.peg.259
Escherichia coli BL21(DE3) (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340186.3.peg.1625
Escherichia coli E110019 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340186.5.peg.1675
Escherichia coli E110019 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|331111.12.peg.4218
Escherichia coli E24377A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|331111.3.peg.1632
Escherichia coli E24377A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.375.peg.4851
Escherichia coli EC4100B (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656408.3.peg.3921
Escherichia coli H591 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|595495.4.peg.1409
Escherichia coli KO11 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|679206.4.peg.2470
Escherichia coli MS 119-7 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|679204.3.peg.4585
Escherichia coli MS 145-7 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749547.3.peg.1970
Escherichia coli MS 187-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749533.3.peg.5088
Escherichia coli MS 84-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585396.4.peg.4453
Escherichia coli O111:H- str. 11128 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|573235.3.peg.4697
Escherichia coli O26:H11 str. 11368 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656443.3.peg.4399
Escherichia coli TA271 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|566546.3.peg.1972
Escherichia coli W (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|566546.4.peg.3713
Escherichia coli W (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585057.4.peg.4117
Escherichia coli IAI39 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585057.6.peg.4125
Escherichia coli IAI39 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|439855.10.peg.3931
Escherichia coli SMS-3-5 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|670897.3.peg.3864
Escherichia coli 2362-75 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|216593.1.peg.4216
Escherichia coli E2348/69 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|550677.3.peg.4046
Escherichia coli B354 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656379.3.peg.4798
Escherichia coli FVEC1302 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656380.3.peg.4587
Escherichia coli FVEC1412 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656393.3.peg.4554
Escherichia coli H299 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749549.3.peg.2748
Escherichia coli MS 198-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749527.3.peg.2682
Escherichia coli MS 21-1 (7-486/490)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749531.3.peg.1599
Escherichia coli MS 69-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585056.7.peg.4155
Escherichia coli UMN026 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656419.3.peg.4496
Escherichia coli M718 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|670888.3.peg.2748
Escherichia coli 1827-70 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|344610.3.peg.107
Escherichia coli 53638 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|344610.7.peg.2733
Escherichia coli 53638 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|481805.3.peg.229
Escherichia coli ATCC 8739 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|481805.6.peg.238
Escherichia coli ATCC 8739 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|344601.3.peg.1334
Escherichia coli B171 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|344601.5.peg.1404
Escherichia coli B171 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|550676.3.peg.3653
Escherichia coli B185 (7-486/490)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|595496.3.peg.3479
Escherichia coli BW2952 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|536056.3.peg.228
Escherichia coli DH1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340185.3.peg.107
Escherichia coli E22 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340185.4.peg.118
Escherichia coli E22 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656414.3.peg.3989
Escherichia coli H736 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|331112.3.peg.3465
Escherichia coli HS (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|331112.6.peg.3604
Escherichia coli HS (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585034.4.peg.3563
Escherichia coli IAI1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585034.5.peg.3561
Escherichia coli IAI1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|83333.1.peg.3429
Escherichia coli K12 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749538.3.peg.4026
Escherichia coli MS 116-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749540.3.peg.1978
Escherichia coli MS 146-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749544.3.peg.3000
Escherichia coli MS 175-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749545.3.peg.4601
Escherichia coli MS 182-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749548.3.peg.3939
Escherichia coli MS 196-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749532.3.peg.3866
Escherichia coli MS 78-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585395.4.peg.4412
Escherichia coli O103:H2 str. 12009 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|409438.11.peg.3933
Escherichia coli SE11 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|316407.3.peg.3633
Escherichia coli W3110 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|316385.7.peg.3699
Escherichia coli str. K-12 substr. DH10B (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|511145.12.peg.3598
Escherichia coli str. K-12 substr. MG1655 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|511145.6.peg.3581
Escherichia coli str. K-12 substr. MG1655 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|216592.1.peg.746
Escherichia coli 042 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|216592.3.peg.3924
Escherichia coli 042 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656437.3.peg.3920
Escherichia coli TA143 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656444.3.peg.4769
Escherichia coli TA280 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LI
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|362663.8.peg.3618
Escherichia coli 536 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|362663.9.peg.3630
Escherichia coli 536 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|525281.3.peg.2938
Escherichia coli 83972 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|655817.3.peg.4097
Escherichia coli ABU 83972 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|405955.13.peg.3929
Escherichia coli APEC O1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|405955.9.peg.3289
Escherichia coli APEC O1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|199310.1.peg.4200
Escherichia coli CFT073 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|199310.4.peg.4034
Escherichia coli CFT073 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585397.7.peg.4154
Escherichia coli ED1a (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585397.9.peg.4150
Escherichia coli ED1a (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|316401.4.peg.4242
Escherichia coli ETEC H10407 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340197.3.peg.675
Escherichia coli F11 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|340197.5.peg.703
Escherichia coli F11 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|714962.3.peg.3961
Escherichia coli IHE3034 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656417.3.peg.4354
Escherichia coli M605 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749528.3.peg.3026
Escherichia coli MS 45-1 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|701177.3.peg.4241
Escherichia coli O55:H7 str. CB9615 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|685038.3.peg.3539
Escherichia coli O83:H1 str. NRG 857C (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|585035.6.peg.3824
Escherichia coli S88 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|431946.3.peg.3457
Escherichia coli SE15 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|656440.3.peg.3748
Escherichia coli TA206 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|869729.3.peg.3766
Escherichia coli UM146 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|364106.7.peg.3929
Escherichia coli UTI89 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|364106.8.peg.3930
Escherichia coli UTI89 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|753642.3.peg.4452
Escherichia coli NC101 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
M
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|679207.4.peg.311
Escherichia coli MS 107-1 (1-480/483)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
T
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.371.peg.3332
Escherichia coli 1044A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.373.peg.1745
Escherichia coli 1125A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.372.peg.4214
Escherichia coli 1212A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.374.peg.5102
Escherichia coli 536A (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|83334.1.peg.4338
Escherichia coli O157:H7 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|155864.1.peg.4375
Escherichia coli O157:H7 EDL933 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444454.5.peg.3448
Escherichia coli O157:H7 str. EC4024 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444449.5.peg.2904
Escherichia coli O157:H7 str. EC4042 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444448.5.peg.1657
Escherichia coli O157:H7 str. EC4045 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444453.5.peg.1188
Escherichia coli O157:H7 str. EC4076 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444452.5.peg.154
Escherichia coli O157:H7 str. EC4113 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444450.8.peg.4738
Escherichia coli O157:H7 str. EC4115 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444451.5.peg.328
Escherichia coli O157:H7 str. EC4196 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|444447.5.peg.1819
Escherichia coli O157:H7 str. EC4206 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|478004.5.peg.214
Escherichia coli O157:H7 str. EC4401 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|478006.5.peg.178
Escherichia coli O157:H7 str. EC4501 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|478007.5.peg.186
Escherichia coli O157:H7 str. EC508 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|478008.5.peg.707
Escherichia coli O157:H7 str. EC869 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|637388.3.peg.1899
Escherichia coli O157:H7 str. FRIK2000 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|570506.3.peg.121
Escherichia coli O157:H7 str. FRIK966 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|386585.9.peg.4562
Escherichia coli O157:H7 str. Sakai (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|544404.4.peg.4549
Escherichia coli O157:H7 str. TW14359 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|502346.5.peg.2281
Escherichia coli O157:H7 str. TW14588 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|562.376.peg.2760
Escherichia coli WV_060327 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
QD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
M
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|155864.8.peg.4320
Escherichia coli O157:H7 EDL933 (7-486/489)
M
G
ML
Q
QPR
P
F
F
M
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
T
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
X
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749537.3.peg.414
Escherichia coli MS 115-1 (2-469/472)
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
fig|749546.3.peg.3968
Escherichia coli MS 185-1 (2-469/472)
IF
F
V
ELWERFGYYG
V
QG
V
LAV
FF
V
K
QLG
F
S
Q
EQ
A
FV
T
F
G
AF
A
ALVYGL
IS
IGG
Y
V
GD
H
LLGTK
RT
I
V
LGALVLAIGY
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
VGNGLFKAN
P
A
SLLS
K
CY
PPK
DPRLDG
A
FTL
F
YMS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
GL
I
I
A
LL
V
Y
I-
-
-
---
-A
CR
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
WL
M
HN
V
EVA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LML
EAV
V
F
Y
I
LY
A
QMPTSLNFFAI
N
NV
H
H
EI
LG
FS
I
N
P
VS
FQALNPFWV
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
MP
M
KF
T
L
GM
F
MCS
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
GELFIS
A
LGLAMIA
A
L
VPQHLM
GFI
L
G
M
WFL
-
T
Q
A
A
A
F
L
LGGYVA
TFT
AVPDN
I
TD
PL-
-------
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
M
V
PWLKRMIATP
Consen1
Primary consensus
Mk
sQPrafy
if
ielWErFgyYGmqgllavylv
QLg
sd
a
lFsaf
aLVYgl
iGGwlgD
lLGtk
imlGAlvlaiGy
v
g
s
lyl
la
I
vGnGLFKaN
ssLLs
cY
DpRlDGgFtl
Yms
NiGS
a
ia
p
a
ygw
v
f
L
Gl
i
ll
f
-
---
cr
K
g
F
p
w
Ll
l
vv
i
v
wl
hn
eva
L
v
i
r
k
-
R
m
af
Lml
lFw
ly
QmptslnffairnV
h
lg
v
p
fQalNpfwvml
sp
LA
i
l
mp
KFa
Gm
mcs
gF
-
l
a
a
G
S
mv
y
qs
gELfIs
lglamia
l
Gfi
G
wfL
t
A
An
lgGyvA
avpdn
td
-------
sl
vY
vF
qig
tl
a
lmll
apwlkrmiaTPTNMiQESND
Consen2
Secondary consensus
g
q
kpif
vv
qi
y
sf
ra
milfft
k
s
t
gsy
s
vt
l
va
v
nr
v
a
ilmtl
h
a
d
f
mg
c
y
s
ac
g
l
h
r
a
sm
aa
v
s
sl
g
q
fsy
m
y
m
a
iv
y
g
rhf
tq
l
l
v
i
pa
f
e
-
--
dws
i
v
k
a
n
l
iv
tf
fa
ggstislyidnf
r
fn
i
t
y
s
aiai
i
gv
v
w
t
l
lma
a
aa
m
s
i
l
mg
a
m
d
va
sqvt
i
vl
ym
s
f
ia
vi
---
qq
s
dasgain
i
a
f
kmt
aa
v
v
vfatrflfs
v
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character