fig|1040638.4.peg.1171
Escherichia coli O104:H4 str. LB226692
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|6666666.5357.peg.3973
Escherichia coli TY-2482
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585055.6.peg.4641
Escherichia coli 55989
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585055.8.peg.4646
Escherichia coli 55989
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|331112.3.peg.4080
Escherichia coli HS
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|331112.6.peg.4254
Escherichia coli HS
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585034.4.peg.4233
Escherichia coli IAI1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585034.5.peg.4228
Escherichia coli IAI1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749537.3.peg.4282
Escherichia coli MS 115-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340184.3.peg.705
Escherichia coli B7A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340184.6.peg.736
Escherichia coli B7A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|679204.3.peg.3954
Escherichia coli MS 145-7
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|409438.11.peg.4605
Escherichia coli SE11
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
S
L
LPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|550672.3.peg.4204
Escherichia coli B088
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|344601.3.peg.1158
Escherichia coli B171
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|344601.5.peg.1222
Escherichia coli B171
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340186.3.peg.1051
Escherichia coli E110019
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340186.5.peg.1092
Escherichia coli E110019
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340185.3.peg.1418
Escherichia coli E22
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340185.4.peg.1501
Escherichia coli E22
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|331111.12.peg.4888
Escherichia coli E24377A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|331111.3.peg.2279
Escherichia coli E24377A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.375.peg.2953
Escherichia coli EC4100B
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|679207.4.peg.3013
Escherichia coli MS 107-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|679205.4.peg.4501
Escherichia coli MS 124-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749545.3.peg.2430
Escherichia coli MS 182-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749532.3.peg.4544
Escherichia coli MS 78-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749533.3.peg.4391
Escherichia coli MS 84-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585395.4.peg.5121
Escherichia coli O103:H2 str. 12009
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585396.4.peg.5200
Escherichia coli O111:H- str. 11128
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|573235.3.peg.5407
Escherichia coli O26:H11 str. 11368
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|566546.3.peg.2184
Escherichia coli W
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|566546.4.peg.4421
Escherichia coli W
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656408.3.peg.4623
Escherichia coli H591
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|679206.4.peg.985
Escherichia coli MS 119-7
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656443.3.peg.5111
Escherichia coli TA271
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
M
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
G
K
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|216592.3.peg.4662
Escherichia coli 042
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|358709.5.peg.1876
Escherichia coli 101-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.371.peg.3643
Escherichia coli 1044A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.373.peg.5760
Escherichia coli 1125A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.372.peg.3415
Escherichia coli 1212A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|344610.3.peg.1402
Escherichia coli 53638
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|344610.7.peg.2003
Escherichia coli 53638
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.374.peg.2750
Escherichia coli 536A
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|481805.3.peg.4191
Escherichia coli ATCC 8739
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|481805.6.peg.4178
Escherichia coli ATCC 8739
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|550676.3.peg.4400
Escherichia coli B185
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|595496.3.peg.4200
Escherichia coli BW2952
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|316401.4.peg.5040
Escherichia coli ETEC H10407
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656379.3.peg.498
Escherichia coli FVEC1302
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656380.3.peg.490
Escherichia coli FVEC1412
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656393.3.peg.242
Escherichia coli H299
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656414.3.peg.4685
Escherichia coli H736
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|83333.1.peg.4037
Escherichia coli K12
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|595495.4.peg.4114
Escherichia coli KO11
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749538.3.peg.1241
Escherichia coli MS 116-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749544.3.peg.108
Escherichia coli MS 175-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749547.3.peg.2657
Escherichia coli MS 187-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749548.3.peg.3642
Escherichia coli MS 196-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749549.3.peg.1655
Escherichia coli MS 198-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|83334.1.peg.5085
Escherichia coli O157:H7
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|155864.1.peg.5066
Escherichia coli O157:H7 EDL933
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|155864.8.peg.5049
Escherichia coli O157:H7 EDL933
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444454.5.peg.4189
Escherichia coli O157:H7 str. EC4024
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444449.5.peg.3643
Escherichia coli O157:H7 str. EC4042
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444448.5.peg.2400
Escherichia coli O157:H7 str. EC4045
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444453.5.peg.2037
Escherichia coli O157:H7 str. EC4076
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444452.5.peg.1126
Escherichia coli O157:H7 str. EC4113
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444450.8.peg.5479
Escherichia coli O157:H7 str. EC4115
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444451.5.peg.2141
Escherichia coli O157:H7 str. EC4196
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|444447.5.peg.2566
Escherichia coli O157:H7 str. EC4206
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|478004.5.peg.2089
Escherichia coli O157:H7 str. EC4401
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|478005.5.peg.619
Escherichia coli O157:H7 str. EC4486
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|478006.5.peg.1503
Escherichia coli O157:H7 str. EC4501
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|478007.5.peg.1034
Escherichia coli O157:H7 str. EC508
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|478008.5.peg.152
Escherichia coli O157:H7 str. EC869
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|637388.3.peg.2365
Escherichia coli O157:H7 str. FRIK2000
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|570506.3.peg.1358
Escherichia coli O157:H7 str. FRIK966
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|386585.9.peg.5337
Escherichia coli O157:H7 str. Sakai
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|544404.4.peg.5291
Escherichia coli O157:H7 str. TW14359
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|502346.5.peg.1532
Escherichia coli O157:H7 str. TW14588
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|701177.3.peg.4957
Escherichia coli O55:H7 str. CB9615
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656437.3.peg.4635
Escherichia coli TA143
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585056.7.peg.4821
Escherichia coli UMN026
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|316407.3.peg.3962
Escherichia coli W3110
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|316385.5.peg.4270
Escherichia coli str. K-12 substr. DH10B
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|316385.7.peg.4359
Escherichia coli str. K-12 substr. DH10B
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|511145.12.peg.4256
Escherichia coli str. K-12 substr. MG1655
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|511145.6.peg.4235
Escherichia coli str. K-12 substr. MG1655
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|536056.3.peg.4106
Escherichia coli DH1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
ISA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|439855.10.peg.4703
Escherichia coli SMS-3-5
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHA
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|405955.13.peg.4628
Escherichia coli APEC O1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|405955.9.peg.3913
Escherichia coli APEC O1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|714962.3.peg.4667
Escherichia coli IHE3034
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585035.6.peg.4527
Escherichia coli S88
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|869729.3.peg.4479
Escherichia coli UM146
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|364106.7.peg.4601
Escherichia coli UTI89
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|364106.8.peg.4600
Escherichia coli UTI89
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|431946.3.peg.4167
Escherichia coli SE15
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749540.3.peg.1313
Escherichia coli MS 146-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
IMIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|550677.3.peg.120
Escherichia coli B354
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
I
FVQ
IPWDGERSNR
fig|656444.3.peg.5584
Escherichia coli TA280
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VST
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHA
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749531.3.peg.2388
Escherichia coli MS 69-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHA
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656417.3.peg.5212
Escherichia coli M605
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
AQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585057.4.peg.4690
Escherichia coli IAI39
MR
HS
LP
Y
R
I
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PHESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585057.6.peg.4699
Escherichia coli IAI39
MR
HS
LP
Y
R
I
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PHESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|670897.3.peg.1442
Escherichia coli 2362-75
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|362663.8.peg.4402
Escherichia coli 536
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|362663.9.peg.4418
Escherichia coli 536
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|525281.3.peg.1743
Escherichia coli 83972
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|655817.3.peg.4875
Escherichia coli ABU 83972
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|199310.1.peg.5022
Escherichia coli CFT073
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|199310.4.peg.4817
Escherichia coli CFT073
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340197.3.peg.3475
Escherichia coli F11
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|340197.5.peg.3642
Escherichia coli F11
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749546.3.peg.1604
Escherichia coli MS 185-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749550.3.peg.4446
Escherichia coli MS 200-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749528.3.peg.3730
Escherichia coli MS 45-1
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|753642.3.peg.4008
Escherichia coli NC101
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|685038.3.peg.4227
Escherichia coli O83:H1 str. NRG 857C
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656440.3.peg.4699
Escherichia coli TA206
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|562.376.peg.1799
Escherichia coli WV_060327
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656419.3.peg.5372
Escherichia coli M718
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALK
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
H
A
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|749527.3.peg.5044
Escherichia coli MS 21-1
MR
HS
LP
Y
R
I
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PHESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MQ
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
NALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VK
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585397.7.peg.4846
Escherichia coli ED1a
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
NALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|585397.9.peg.4846
Escherichia coli ED1a
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
N
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
NALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|216593.1.peg.3878
Escherichia coli E2348/69
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
S
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|574521.7.peg.4553
Escherichia coli O127:H6 str. E2348/69
MR
HS
LP
Y
RM
L
RKRPMKLSTTV
I
L
M
VSA
VLFS
V
LL
VVH
L
I
-
YF
S------
-
--
Q
I
S
DM
TRDGLANK
A
L
A
V
A
R
T
LA
D
S
P
E
IRQG
LQ
K
K
PQESG
I
Q
A
IA
EAV
R
K
R
S
D
LLFI
V
VT
D
MH
S
L
R
Y
S
-------
HP
EAQ
R
IG
Q
P
FK
G
DDI
L
KALN
GE
ENVAINR
G
FL
A
Q
A
L
R
VF
TPI
Y
DE
--------------
N
H
K
Q
IGVVAIGL
E
LS
R
V
TQ
Q
I
N
DS
RWSII
W
SVL
F
----
-
GM
L
V
G
LIG
T
C
I
L
VN
V
----
-
L
K
K
I
L
F
G
L
EP
YE
I
S
T
L
F
E
QR
Q
A
M
L
Q
S
IK
EG
V
V
AVD
DR
G
EV
T
L
IN
DA
A
QE
LL
N
Y
RKSQD
---
D
EK
LS
T
L
SHS
W
-----
S
Q
VV
DVS
E
V
LR
D
GTP
R
R
D
E
E
ITIKDRL
L
--
LI
N
TVPV
RS
NGVII
GAI
ST
FR
D
K
T
E
VRK
L
MQR
L
DGLVN
Y
ADA
LR
ER
SHE
FM
N
K
L
H
V
I
L
GLL
H
LK
S
Y
K
Q
L
-------
E
DY
I
LKT
ANN
Y
Q
EE
I
G
SLL
GK
I
KSPVI
AG
F
L
IS
KI
----------------
N
RA
T
DLG
H
T
L
I
L
---
N
SE
SQLPD
S
--
G
S
ED
Q
V
A
T
L
I
TTL
GNL
I
E
NA
L
EA
-
L
GP
E
P
G
G
E-
I
S
V
---
T
L
H
YRHGW
L
HC
EV
N
D
D
G
P
GI
AP
DKI
D
H
IF
------
D
K
GVST
K
G
---
S
E
R
G
V
GL
A
L
VKQQ
V
ENL
GG
S
I
A
V
ES
E
P
GI
F
T
Q
F
FVQ
IPWDGERSNR
fig|656419.3.peg.899
Escherichia coli M718 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
H
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656393.3.peg.1298
Escherichia coli H299 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749550.3.peg.4826
Escherichia coli MS 200-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
T--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|525281.3.peg.2318
Escherichia coli 83972 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|655817.3.peg.715
Escherichia coli ABU 83972 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|199310.1.peg.683
Escherichia coli CFT073 (35-558/572)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|199310.4.peg.673
Escherichia coli CFT073 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749546.3.peg.3448
Escherichia coli MS 185-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749528.3.peg.4014
Escherichia coli MS 45-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656417.3.peg.744
Escherichia coli M605 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
Y
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|431946.3.peg.580
Escherichia coli SE15 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
Y
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|405955.13.peg.598
Escherichia coli APEC O1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|405955.9.peg.494
Escherichia coli APEC O1 (35-558/572)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|714962.3.peg.646
Escherichia coli IHE3034 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585035.6.peg.655
Escherichia coli S88 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|364106.7.peg.727
Escherichia coli UTI89 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|364106.8.peg.724
Escherichia coli UTI89 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|216592.1.peg.377
Escherichia coli 042 (35-558/572)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|216592.3.peg.683
Escherichia coli 042 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|670897.3.peg.784
Escherichia coli 2362-75 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|362663.8.peg.654
Escherichia coli 536 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|362663.9.peg.654
Escherichia coli 536 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|550677.3.peg.1039
Escherichia coli B354 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|216593.1.peg.2999
Escherichia coli E2348/69 (35-558/572)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585397.7.peg.618
Escherichia coli ED1a (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585397.9.peg.620
Escherichia coli ED1a (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340197.3.peg.2458
Escherichia coli F11 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340197.5.peg.2576
Escherichia coli F11 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656379.3.peg.1402
Escherichia coli FVEC1302 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656380.3.peg.1230
Escherichia coli FVEC1412 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585057.4.peg.634
Escherichia coli IAI39 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585057.6.peg.632
Escherichia coli IAI39 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749549.3.peg.4885
Escherichia coli MS 198-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749527.3.peg.4182
Escherichia coli MS 21-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749531.3.peg.4083
Escherichia coli MS 69-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|753642.3.peg.1035
Escherichia coli NC101 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|574521.7.peg.559
Escherichia coli O127:H6 str. E2348/69 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|685038.3.peg.565
Escherichia coli O83:H1 str. NRG 857C (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|439855.10.peg.808
Escherichia coli SMS-3-5 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656437.3.peg.698
Escherichia coli TA143 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656440.3.peg.479
Escherichia coli TA206 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585056.7.peg.910
Escherichia coli UMN026 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.376.peg.1991
Escherichia coli WV_060327 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|670888.3.peg.1189
Escherichia coli 1827-70 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGK
T
I
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|331112.3.peg.627
Escherichia coli HS (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGK
T
I
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|331112.6.peg.655
Escherichia coli HS (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGK
T
I
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|481805.3.peg.3244
Escherichia coli ATCC 8739 (35-558/572)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|481805.6.peg.3231
Escherichia coli ATCC 8739 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749537.3.peg.4039
Escherichia coli MS 115-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KS
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.371.peg.2880
Escherichia coli 1044A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.373.peg.3114
Escherichia coli 1125A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.372.peg.1610
Escherichia coli 1212A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.374.peg.5368
Escherichia coli 536A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|83334.1.peg.734
Escherichia coli O157:H7 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|155864.1.peg.654
Escherichia coli O157:H7 EDL933 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|155864.8.peg.671
Escherichia coli O157:H7 EDL933 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444454.5.peg.5146
Escherichia coli O157:H7 str. EC4024 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444449.5.peg.5482
Escherichia coli O157:H7 str. EC4042 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444448.5.peg.3356
Escherichia coli O157:H7 str. EC4045 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444453.5.peg.698
Escherichia coli O157:H7 str. EC4076 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444452.5.peg.829
Escherichia coli O157:H7 str. EC4113 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444450.8.peg.816
Escherichia coli O157:H7 str. EC4115 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444451.5.peg.2318
Escherichia coli O157:H7 str. EC4196 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|444447.5.peg.3531
Escherichia coli O157:H7 str. EC4206 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|478004.5.peg.1524
Escherichia coli O157:H7 str. EC4401 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|478006.5.peg.786
Escherichia coli O157:H7 str. EC4501 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|478007.5.peg.1015
Escherichia coli O157:H7 str. EC508 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|478008.5.peg.1758
Escherichia coli O157:H7 str. EC869 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|637388.3.peg.1153
Escherichia coli O157:H7 str. FRIK2000 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|570506.3.peg.3690
Escherichia coli O157:H7 str. FRIK966 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|386585.9.peg.769
Escherichia coli O157:H7 str. Sakai (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|544404.4.peg.681
Escherichia coli O157:H7 str. TW14359 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|502346.5.peg.539
Escherichia coli O157:H7 str. TW14588 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISE
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|1040638.4.peg.5313
Escherichia coli O104:H4 str. LB226692 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|358709.5.peg.1928
Escherichia coli 101-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585055.6.peg.623
Escherichia coli 55989 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585055.8.peg.624
Escherichia coli 55989 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|550672.3.peg.191
Escherichia coli B088 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|344601.3.peg.2250
Escherichia coli B171 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|344601.5.peg.2352
Escherichia coli B171 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|550676.3.peg.87
Escherichia coli B185 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340184.3.peg.2419
Escherichia coli B7A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340184.6.peg.2539
Escherichia coli B7A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340185.3.peg.1716
Escherichia coli E22 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340185.4.peg.1809
Escherichia coli E22 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|331111.12.peg.948
Escherichia coli E24377A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|331111.3.peg.3170
Escherichia coli E24377A (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|562.375.peg.1535
Escherichia coli EC4100B (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656408.3.peg.557
Escherichia coli H591 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585034.4.peg.598
Escherichia coli IAI1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585034.5.peg.597
Escherichia coli IAI1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|595495.4.peg.1992
Escherichia coli KO11 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|679207.4.peg.2838
Escherichia coli MS 107-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|679206.4.peg.2846
Escherichia coli MS 119-7 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|679205.4.peg.627
Escherichia coli MS 124-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|679204.3.peg.2644
Escherichia coli MS 145-7 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749545.3.peg.5013
Escherichia coli MS 182-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749547.3.peg.3616
Escherichia coli MS 187-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749532.3.peg.3695
Escherichia coli MS 78-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749533.3.peg.5431
Escherichia coli MS 84-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585396.4.peg.675
Escherichia coli O111:H- str. 11128 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|573235.3.peg.702
Escherichia coli O26:H11 str. 11368 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|701177.3.peg.781
Escherichia coli O55:H7 str. CB9615 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|409438.11.peg.811
Escherichia coli SE11 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|566546.3.peg.2827
Escherichia coli W (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|566546.4.peg.679
Escherichia coli W (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656443.3.peg.879
Escherichia coli TA271 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
MRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656444.3.peg.1160
Escherichia coli TA280 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
G
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|869729.3.peg.3082
Escherichia coli UM146 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
T
M
N
Q
AK
I
I
A
S
N
D
S
IISA
VK
T
R
DYKR-
L
A
TIA
DKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKP
G
ALEK
GE
SYFITGK
G
SI
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
V
IVPGS
QL
SQLP
P
G
--
L
D
RT
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|344610.3.peg.1609
Escherichia coli 53638 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|344610.7.peg.1069
Escherichia coli 53638 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|595496.3.peg.545
Escherichia coli BW2952 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|536056.3.peg.3178
Escherichia coli DH1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316401.4.peg.744
Escherichia coli ETEC H10407 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|656414.3.peg.798
Escherichia coli H736 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|83333.1.peg.620
Escherichia coli K12 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749538.3.peg.4230
Escherichia coli MS 116-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749540.3.peg.616
Escherichia coli MS 146-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|749548.3.peg.4510
Escherichia coli MS 196-1 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316407.3.peg.602
Escherichia coli W3110 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316385.5.peg.576
Escherichia coli str. K-12 substr. DH10B (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316385.5.peg.687
Escherichia coli str. K-12 substr. DH10B (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316385.7.peg.584
Escherichia coli str. K-12 substr. DH10B (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|316385.7.peg.695
Escherichia coli str. K-12 substr. DH10B (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|511145.12.peg.649
Escherichia coli str. K-12 substr. MG1655 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|511145.6.peg.640
Escherichia coli str. K-12 substr. MG1655 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
V
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|585395.4.peg.658
Escherichia coli O103:H2 str. 12009 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
L
N
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|413997.3.peg.620
Escherichia coli B str. REL606 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
I
E
VD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|469008.4.peg.3139
Escherichia coli BL21(DE3) (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
GI
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
I
E
VD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340186.3.peg.2274
Escherichia coli E110019 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
A
I
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|340186.5.peg.2347
Escherichia coli E110019 (15-538/552)
RLA
F
P
L
R
-
-
----------
I
F
LL
I--
LV
FSI
FV
IAA
L
A
Q
YF
TASFEDY
L
TL
H
V
R
DM
--------
A
M
N
Q
AK
I
I
A
S
N
D
S
VISA
VK
T
R
DYKR-
L
A
TIA
NKL
Q
R
D
TD
FDYV
V
IG
D
RH
S
I
RL
Y
-------
HP
NPE
KIG
Y
P
MQ
F
TKQ
G
ALEK
GE
SYFITGK
G
SM
G
M
AMR
AK
TPI
F
D
D
--------------
D
G
K
V
IGVV
S
IG
Y
L
V
S
K
I
--
-
-
-
DS
-----
W
RAE
F
LLPM
A
G
V
F
V
V
L
L
A
I
L
ML
LS
W
FLAA
H
I
R
R
Q
M
M
G
M
EP
KQ
IA
R
V
V
RQ
Q
EA
L
F
S
S
VY
EG
L
IAVD
PH
G
YI
T
A
IN
RN
A
RK
M
L
G
-
-----
---
-
--
LS
S
P
GRQ
W
LGKPI
A
EVV
RPA
D
F
FT
E
QID
E
K
R
Q
D
VVANFNG
L
SV
IA
N
REAI
RS
GDDLL
GAI
IS
FR
S
K
D
E
IST
L
NAQ
L
TQIKQ
Y
VES
LR
TL
R
HE
HL
N
W
M
S
T
L
N
GLL
Q
M
K
E
Y
D
R
V
-------
L
AM
V
QGE
SQA
Q
Q
QL
I
D
SL
R
EA
F
ADRQV
AGLL
FG
K
V
----------------
Q
RA
R
E
LGL
K
M
I
IVPGS
QL
SQLP
P
G
--
L
D
ST
E
F
A
A
I
V
---
GNLL
D
NA
F
EA
S
L
RS
D
E
GN
KI
V
E
L
---
F
LS
DEGDD
V
VI
EV
A
D
Q
G
C
G
V
PE
SLR
D
K
IF
------
E
Q
GVSTR
A
DEP
GE
H
GIGL
Y
L
IASY
V
TRC
GG
V
IT
L
E
D
N
D
PC
GT
L
F
SIY
IP
fig|595495.4.peg.2607
Escherichia coli KO11 (6-521/556)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
L
E
fig|749527.3.peg.1224
Escherichia coli MS 21-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
K
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|6666666.5357.peg.3826
Escherichia coli TY-2482 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|216592.1.peg.3570
Escherichia coli 042 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|216592.3.peg.3116
Escherichia coli 042 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|358709.5.peg.4420
Escherichia coli 101-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.371.peg.5837
Escherichia coli 1044A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.373.peg.4294
Escherichia coli 1125A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.372.peg.2225
Escherichia coli 1212A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|670888.3.peg.3525
Escherichia coli 1827-70 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|670897.3.peg.671
Escherichia coli 2362-75 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|362663.8.peg.2802
Escherichia coli 536 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|362663.9.peg.2808
Escherichia coli 536 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|344610.3.peg.4068
Escherichia coli 53638 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|344610.7.peg.3485
Escherichia coli 53638 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.374.peg.3898
Escherichia coli 536A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|525281.3.peg.4518
Escherichia coli 83972 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|655817.3.peg.3176
Escherichia coli ABU 83972 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|481805.3.peg.982
Escherichia coli ATCC 8739 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|481805.6.peg.980
Escherichia coli ATCC 8739 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|413997.3.peg.2759
Escherichia coli B str. REL606 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|344601.3.peg.754
Escherichia coli B171 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|344601.5.peg.781
Escherichia coli B171 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|550676.3.peg.2716
Escherichia coli B185 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|550677.3.peg.3317
Escherichia coli B354 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340184.3.peg.3663
Escherichia coli B7A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340184.6.peg.3827
Escherichia coli B7A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|511693.5.peg.2774
Escherichia coli BL21 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|469008.4.peg.965
Escherichia coli BL21(DE3) (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|595496.3.peg.2768
Escherichia coli BW2952 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|199310.1.peg.3270
Escherichia coli CFT073 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|199310.4.peg.3154
Escherichia coli CFT073 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|536056.3.peg.943
Escherichia coli DH1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340186.3.peg.4339
Escherichia coli E110019 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340186.5.peg.4561
Escherichia coli E110019 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340185.3.peg.3528
Escherichia coli E22 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340185.4.peg.3711
Escherichia coli E22 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|216593.1.peg.1246
Escherichia coli E2348/69 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|331111.12.peg.3370
Escherichia coli E24377A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|331111.3.peg.807
Escherichia coli E24377A (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.375.peg.1125
Escherichia coli EC4100B (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|316401.4.peg.3371
Escherichia coli ETEC H10407 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340197.3.peg.1282
Escherichia coli F11 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|340197.5.peg.1348
Escherichia coli F11 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656379.3.peg.4153
Escherichia coli FVEC1302 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656380.3.peg.4070
Escherichia coli FVEC1412 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656393.3.peg.3783
Escherichia coli H299 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656408.3.peg.3075
Escherichia coli H591 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|331112.3.peg.2741
Escherichia coli HS (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|331112.6.peg.2864
Escherichia coli HS (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|585034.4.peg.2847
Escherichia coli IAI1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|585034.5.peg.2844
Escherichia coli IAI1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|83333.1.peg.2742
Escherichia coli K12 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656419.3.peg.3610
Escherichia coli M718 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|679207.4.peg.802
Escherichia coli MS 107-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749537.3.peg.3821
Escherichia coli MS 115-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749538.3.peg.3690
Escherichia coli MS 116-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|679206.4.peg.362
Escherichia coli MS 119-7 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|679205.4.peg.3035
Escherichia coli MS 124-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|679204.3.peg.2389
Escherichia coli MS 145-7 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749545.3.peg.1380
Escherichia coli MS 182-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749546.3.peg.3129
Escherichia coli MS 185-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749547.3.peg.3356
Escherichia coli MS 187-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749548.3.peg.2884
Escherichia coli MS 196-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749549.3.peg.2198
Escherichia coli MS 198-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749550.3.peg.746
Escherichia coli MS 200-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749528.3.peg.1144
Escherichia coli MS 45-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749531.3.peg.5251
Escherichia coli MS 69-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749532.3.peg.735
Escherichia coli MS 78-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749533.3.peg.4119
Escherichia coli MS 84-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|753642.3.peg.367
Escherichia coli NC101 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|585395.4.peg.3486
Escherichia coli O103:H2 str. 12009 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|585396.4.peg.3632
Escherichia coli O111:H- str. 11128 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|574521.7.peg.3100
Escherichia coli O127:H6 str. E2348/69 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|83334.1.peg.3634
Escherichia coli O157:H7 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|155864.1.peg.3648
Escherichia coli O157:H7 EDL933 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|155864.8.peg.3566
Escherichia coli O157:H7 EDL933 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444454.5.peg.2686
Escherichia coli O157:H7 str. EC4024 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444449.5.peg.2147
Escherichia coli O157:H7 str. EC4042 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444448.5.peg.902
Escherichia coli O157:H7 str. EC4045 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444453.5.peg.383
Escherichia coli O157:H7 str. EC4076 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444452.5.peg.3906
Escherichia coli O157:H7 str. EC4113 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444450.8.peg.3989
Escherichia coli O157:H7 str. EC4115 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444451.5.peg.5026
Escherichia coli O157:H7 str. EC4196 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|444447.5.peg.1051
Escherichia coli O157:H7 str. EC4206 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|478004.5.peg.5057
Escherichia coli O157:H7 str. EC4401 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|478005.5.peg.940
Escherichia coli O157:H7 str. EC4486 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|478006.5.peg.4800
Escherichia coli O157:H7 str. EC4501 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|478007.5.peg.5107
Escherichia coli O157:H7 str. EC508 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|478008.5.peg.3250
Escherichia coli O157:H7 str. EC869 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|637388.3.peg.3189
Escherichia coli O157:H7 str. FRIK2000 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|570506.3.peg.2532
Escherichia coli O157:H7 str. FRIK966 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|386585.9.peg.3810
Escherichia coli O157:H7 str. Sakai (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|544404.4.peg.3793
Escherichia coli O157:H7 str. TW14359 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|502346.5.peg.3616
Escherichia coli O157:H7 str. TW14588 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|573235.3.peg.3943
Escherichia coli O26:H11 str. 11368 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|701177.3.peg.3457
Escherichia coli O55:H7 str. CB9615 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|409438.11.peg.3217
Escherichia coli SE11 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|439855.10.peg.3082
Escherichia coli SMS-3-5 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656437.3.peg.3115
Escherichia coli TA143 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656443.3.peg.3546
Escherichia coli TA271 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656444.3.peg.3892
Escherichia coli TA280 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|585056.7.peg.3294
Escherichia coli UMN026 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|566546.3.peg.2914
Escherichia coli W (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|566546.4.peg.2963
Escherichia coli W (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|316407.3.peg.2688
Escherichia coli W3110 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|316385.7.peg.2982
Escherichia coli str. K-12 substr. DH10B (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|511145.12.peg.2886
Escherichia coli str. K-12 substr. MG1655 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|511145.6.peg.2869
Escherichia coli str. K-12 substr. MG1655 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|656414.3.peg.3218
Escherichia coli H736 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
AM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|749540.3.peg.1820
Escherichia coli MS 146-1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
AM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
Q
P
NR
G
S
T
F
WFH
I
NL
D
fig|405955.13.peg.3095
Escherichia coli APEC O1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|405955.9.peg.2562
Escherichia coli APEC O1 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|585397.7.peg.3246
Escherichia coli ED1a (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|585397.9.peg.3242
Escherichia coli ED1a (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|714962.3.peg.3197
Escherichia coli IHE3034 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|656417.3.peg.3536
Escherichia coli M605 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|685038.3.peg.2780
Escherichia coli O83:H1 str. NRG 857C (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|585035.6.peg.2995
Escherichia coli S88 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|431946.3.peg.2698
Escherichia coli SE15 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|656440.3.peg.2805
Escherichia coli TA206 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|869729.3.peg.568
Escherichia coli UM146 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|364106.7.peg.3134
Escherichia coli UTI89 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|364106.8.peg.3134
Escherichia coli UTI89 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
fig|562.376.peg.3605
Escherichia coli WV_060327 (6-519/918)
L
R
A
RM
M
----------
I
L
I
L
APT
VL
IG
L
LL
SI-
-
-
-
F
F
VVHRYND
L
QR
Q
L
E
D
A
--------
G
A
S
I
I
E
P
LA
V
S
T
E
YGMS
LQ
N
R
ESIGQ
L
I
S
VL
H--
RR
H
S
D
IVRA
I
SV
Y
DE
N
N
RL
F
VTSNFHLD
P
SSM
Q
L
G
S
N
VP
F
PRQ
L
TVTR
D
-
-------
-
--
G
D
I
M
I
LR
TPI
I
S
E
SYSPDESPSSDAKN
S
Q
N
M
L
G
YI
A
LE
L
D
L
K
S
V
RL
Q
Q
-
--
-----
Y
KEI
F
ISSV
-
-
M
M
L
F
C
IGI
A
L
I
FG
W
----
R
L
M
R
D
V
T
G
P
IR
NM
V
N
TV
D
R
I
R
R
G
Q
L
D
S
RV
EG
F
M
LGE
LD
M
LK
N
G
IN
SM
A
MS
L
A
A
Y
HEEMQ
HNI
D
QA
T
S
D
L
RET
L
-----
-
E
QM
EIQ
N
V
EL
D
LAK
K
R
A
QE
AA-----
-
--
--
-
----
--
-----
---
--
-
R
I
K
S
E
F--
-
---
-
-----
-
---
L
A
NM
SHE
LR
T
P
L
N
G
V
I
G
FT
R
L
T
L
K
T
E
L
TPTQRDH
L
NT
I
ERS
ANN
L
L
AI
I
N
DV
L
D-
F
SKLEA
GK
L
I
LE
S
I
PFPLRSTLDEVVTLLA
H
SS
H
D
K
GL
E
L
T
L
---
N
IK
S
DV
PD
N
VI
GD
PL
R
L
Q
Q
II
---
T
NL
V
G
NA
I
KF
-
-
-T
E
N
GN
ID
I
L
V
EKR
A
LS
NTKVQ
I
EV
QI
R
D
T
G
I
GIPE
RDQ
S
R
L
F
QAFRQA
D
A
SI
S
R
R
H
---
G
G
T
G
L
GL
V
I
TQKL
V
NEM
GG
D
I
S
F
H
S
L
P
NR
G
S
T
F
WFH
I
NL
D
Consen1
Primary consensus
MRlalp
Rm
----------
i
ll
vlfsill
l
-
yF
l
qv
Dm
--------
a
n
ak
lA
s
e
lq
r
l
tia
rr
tD
v
d
s
Rl
-------
hP
kiG
p
f
l
ge
g
g
amr
TPI
de
--------------
d
k
iGvvaigl
ls
v
q
-
ds
-----
w
F
-
gm
v
liGi
ml
w
----
l
r
m
G
ep
iatv
rqrea
l
S
EG
iavd
g
t
IN
A
ll
y
---
d
lS
l
w
-----
evv
dv
d
er
qe
l
--
n
rs
gai
fR
K
E
l
l
y
Lr
sHE
n
ls
l
Gll
lk
y
rl
-------
l
i
ann
q
I
sll
f
agll
ki
----------------
ra
dlGl
l
l
---
n
SqlPd
--
gd
e
a
ii
---
gNLl
NA
ea
-
l
e
Gn
i
v
---
Ls
v
ev
D
G
Gipe
d
iF
------
d
gvStr
---
ge
GiGL
l
V
GG
It
es
p
gt
F
IpwDGERSNR
Consen2
Secondary consensus
hsfr
-
rkrpmklsttv
im
lvig
fv
-
qf
-
h
atrdglankg
i
i
n
s
vk
k
i
vl
qk
i
y
n
y
vtsnfhld
l
n
g
g
d
-
-
a
ili
sdsyspdespssdakn
n
l
yisley
vk
i
-
n
--
rwsiiy
a
-
v
l
cl
t
i
vflaa
i
k
ir
v
rl
eiq
g
f
lge
m
n
ma
-
hni
-
t
p
llgkpi
qqm
f
e
k
ed
-
sv
-
--
---
-
-
-
-
a
r
t
m
ft
mt
k
vtptqrdhe
v
sqa
l
dvr
i
gkfi
svpfplrstldevvtlla
ss
ek
h
m
ivpgs
dv
p
vils
q
lvttlt
kfs
-
d
g
v
lekr
h
qi
vap
s
l
qafrqae
si
rk
depsg
i
hd
d
fs
nl
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character