fig|550676.3.peg.4349
Escherichia coli B185
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKAL
D
YEREVLGKFDKTADQ
fig|1040638.4.peg.1124
Escherichia coli O104:H4 str. LB226692
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|6666666.5357.peg.2289
Escherichia coli TY-2482
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|358709.5.peg.1824
Escherichia coli 101-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|670888.3.peg.4665
Escherichia coli 1827-70
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|344610.3.peg.1347
Escherichia coli 53638
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|344610.7.peg.2057
Escherichia coli 53638
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585055.6.peg.4598
Escherichia coli 55989
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585055.8.peg.4603
Escherichia coli 55989
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|511693.5.peg.4185
Escherichia coli BL21
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|469008.4.peg.4105
Escherichia coli BL21(DE3)
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|331111.12.peg.4843
Escherichia coli E24377A
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|331111.3.peg.2232
Escherichia coli E24377A
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.375.peg.3002
Escherichia coli EC4100B
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656408.3.peg.4577
Escherichia coli H591
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|331112.3.peg.4034
Escherichia coli HS
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|331112.6.peg.4211
Escherichia coli HS
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585034.4.peg.4190
Escherichia coli IAI1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585034.5.peg.4185
Escherichia coli IAI1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|679207.4.peg.2967
Escherichia coli MS 107-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749537.3.peg.770
Escherichia coli MS 115-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|679206.4.peg.4413
Escherichia coli MS 119-7
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|679205.4.peg.1285
Escherichia coli MS 124-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749545.3.peg.2382
Escherichia coli MS 182-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749547.3.peg.2688
Escherichia coli MS 187-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749532.3.peg.4615
Escherichia coli MS 78-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749533.3.peg.4314
Escherichia coli MS 84-1
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|573235.3.peg.5364
Escherichia coli O26:H11 str. 11368
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|409438.11.peg.4555
Escherichia coli SE11
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656443.3.peg.5066
Escherichia coli TA271
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|566546.3.peg.2229
Escherichia coli W
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|566546.4.peg.4377
Escherichia coli W
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|216592.1.peg.2376
Escherichia coli 042
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|216592.3.peg.4619
Escherichia coli 042
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.371.peg.3589
Escherichia coli 1044A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.373.peg.5815
Escherichia coli 1125A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.372.peg.3469
Escherichia coli 1212A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|670897.3.peg.1386
Escherichia coli 2362-75
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|362663.8.peg.4344
Escherichia coli 536
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|362663.9.peg.4360
Escherichia coli 536
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.374.peg.2804
Escherichia coli 536A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|525281.3.peg.1800
Escherichia coli 83972
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|655817.3.peg.4816
Escherichia coli ABU 83972
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|481805.3.peg.4245
Escherichia coli ATCC 8739
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|481805.6.peg.4230
Escherichia coli ATCC 8739
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340184.3.peg.3871
Escherichia coli B7A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340184.6.peg.4045
Escherichia coli B7A
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|199310.1.peg.4969
Escherichia coli CFT073
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|199310.4.peg.4759
Escherichia coli CFT073
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|216593.1.peg.3937
Escherichia coli E2348/69
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340197.3.peg.2095
Escherichia coli F11
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340197.5.peg.2207
Escherichia coli F11
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656379.3.peg.455
Escherichia coli FVEC1302
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656380.3.peg.447
Escherichia coli FVEC1412
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656393.3.peg.187
Escherichia coli H299
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656414.3.peg.4630
Escherichia coli H736
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585057.4.peg.4639
Escherichia coli IAI39
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585057.6.peg.4648
Escherichia coli IAI39
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656419.3.peg.5315
Escherichia coli M718
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749538.3.peg.284
Escherichia coli MS 116-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|679204.3.peg.3016
Escherichia coli MS 145-7
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749540.3.peg.1639
Escherichia coli MS 146-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749544.3.peg.3132
Escherichia coli MS 175-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749546.3.peg.5027
Escherichia coli MS 185-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749548.3.peg.393
Escherichia coli MS 196-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749549.3.peg.1611
Escherichia coli MS 198-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749550.3.peg.1416
Escherichia coli MS 200-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749527.3.peg.2938
Escherichia coli MS 21-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749528.3.peg.640
Escherichia coli MS 45-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|749531.3.peg.2343
Escherichia coli MS 69-1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|753642.3.peg.4067
Escherichia coli NC101
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|574521.7.peg.4501
Escherichia coli O127:H6 str. E2348/69
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|83334.1.peg.5036
Escherichia coli O157:H7
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|155864.1.peg.5018
Escherichia coli O157:H7 EDL933
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|155864.8.peg.4998
Escherichia coli O157:H7 EDL933
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444454.5.peg.4138
Escherichia coli O157:H7 str. EC4024
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444449.5.peg.3592
Escherichia coli O157:H7 str. EC4042
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444448.5.peg.2349
Escherichia coli O157:H7 str. EC4045
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444453.5.peg.1986
Escherichia coli O157:H7 str. EC4076
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444452.5.peg.1177
Escherichia coli O157:H7 str. EC4113
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444450.8.peg.5428
Escherichia coli O157:H7 str. EC4115
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444451.5.peg.2090
Escherichia coli O157:H7 str. EC4196
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|444447.5.peg.2515
Escherichia coli O157:H7 str. EC4206
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|478004.5.peg.2039
Escherichia coli O157:H7 str. EC4401
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|478005.5.peg.569
Escherichia coli O157:H7 str. EC4486
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|478006.5.peg.1451
Escherichia coli O157:H7 str. EC4501
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|478007.5.peg.1086
Escherichia coli O157:H7 str. EC508
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|478008.5.peg.100
Escherichia coli O157:H7 str. EC869
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|637388.3.peg.2314
Escherichia coli O157:H7 str. FRIK2000
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|570506.3.peg.1409
Escherichia coli O157:H7 str. FRIK966
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|386585.9.peg.5286
Escherichia coli O157:H7 str. Sakai
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|544404.4.peg.5240
Escherichia coli O157:H7 str. TW14359
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|502346.5.peg.1583
Escherichia coli O157:H7 str. TW14588
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|701177.3.peg.4906
Escherichia coli O55:H7 str. CB9615
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|685038.3.peg.4170
Escherichia coli O83:H1 str. NRG 857C
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|439855.10.peg.4655
Escherichia coli SMS-3-5
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656437.3.peg.4593
Escherichia coli TA143
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656440.3.peg.4654
Escherichia coli TA206
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656444.3.peg.5539
Escherichia coli TA280
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585056.7.peg.4778
Escherichia coli UMN026
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|562.376.peg.1739
Escherichia coli WV_060327
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|656417.3.peg.5154
Escherichia coli M605
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYERE
M
LGKFDKTADQ
fig|431946.3.peg.4111
Escherichia coli SE15
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYERE
M
LGKFDKTADQ
fig|405955.13.peg.4571
Escherichia coli APEC O1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|405955.9.peg.3859
Escherichia coli APEC O1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|714962.3.peg.4609
Escherichia coli IHE3034
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585035.6.peg.4470
Escherichia coli S88
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|869729.3.peg.4421
Escherichia coli UM146
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|364106.7.peg.4545
Escherichia coli UTI89
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|364106.8.peg.4544
Escherichia coli UTI89
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
HHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|550677.3.peg.78
Escherichia coli B354
MKN
L
KF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|344601.3.peg.1103
Escherichia coli B171
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|344601.5.peg.1168
Escherichia coli B171
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340185.3.peg.1365
Escherichia coli E22
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340185.4.peg.1448
Escherichia coli E22
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585395.4.peg.5069
Escherichia coli O103:H2 str. 12009
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585397.7.peg.4790
Escherichia coli ED1a
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
S
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|585397.9.peg.4790
Escherichia coli ED1a
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
S
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|413997.3.peg.4164
Escherichia coli B str. REL606
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|595496.3.peg.4148
Escherichia coli BW2952
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|536056.3.peg.4158
Escherichia coli DH1
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|83333.1.peg.3987
Escherichia coli K12
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|595495.4.peg.3118
Escherichia coli KO11
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|316407.3.peg.3914
Escherichia coli W3110
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|316385.7.peg.4307
Escherichia coli str. K-12 substr. DH10B
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|511145.12.peg.4201
Escherichia coli str. K-12 substr. MG1655
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|511145.6.peg.4183
Escherichia coli str. K-12 substr. MG1655
MKNIKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340186.3.peg.1007
Escherichia coli E110019
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
S
L
V
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|340186.5.peg.1049
Escherichia coli E110019
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
S
L
V
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLGKFDKTADQ
fig|316401.4.peg.4981
Escherichia coli ETEC H10407
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYE
L
EVLGKFDKTADQ
fig|585396.4.peg.5157
Escherichia coli O111:H- str. 11128
MK
S
IKF
-
SLAWQILFA
M
V
LGILLGS
YL
H
YHS
DS
RD
W
L
VVNLLS
P
A
GD
I
F
I
H
LIKMIV
V
P
I
V
I
S
T
L
V
V
GIAG
V
G
D
AKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
ILG
I
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
VT
V
F
R
S
I
S
ET
M
FK
V
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LV
L
LV
H
FAI
L
F
F
ALV
VLG
I
V
A
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
I
E
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
-
S
T
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
L
DMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KKALAYEREVLG
fig|749527.3.peg.1609
Escherichia coli MS 21-1 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GI
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|216592.1.peg.799
Escherichia coli 042 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|344610.3.peg.70
Escherichia coli 53638 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|405955.9.peg.3323
Escherichia coli APEC O1 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|481805.3.peg.196
Escherichia coli ATCC 8739 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|344601.3.peg.2987
Escherichia coli B171 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|340184.3.peg.326
Escherichia coli B7A (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|199310.1.peg.4245
Escherichia coli CFT073 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|340186.3.peg.1660
Escherichia coli E110019 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|340185.3.peg.72
Escherichia coli E22 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|331111.12.peg.4258
Escherichia coli E24377A (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|331111.3.peg.1668
Escherichia coli E24377A (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|562.375.peg.506
Escherichia coli EC4100B (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|340197.3.peg.636
Escherichia coli F11 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|656379.3.peg.4851
Escherichia coli FVEC1302 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|656380.3.peg.4637
Escherichia coli FVEC1412 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|656414.3.peg.4033
Escherichia coli H736 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|331112.3.peg.3498
Escherichia coli HS (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|83333.1.peg.3461
Escherichia coli K12 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|656419.3.peg.4547
Escherichia coli M718 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|83334.1.peg.4380
Escherichia coli O157:H7 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|155864.1.peg.4416
Escherichia coli O157:H7 EDL933 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|155864.8.peg.4364
Escherichia coli O157:H7 EDL933 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|444449.5.peg.2948
Escherichia coli O157:H7 str. EC4042 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|444447.5.peg.1865
Escherichia coli O157:H7 str. EC4206 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|544404.4.peg.4594
Escherichia coli O157:H7 str. TW14359 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|502346.5.peg.2236
Escherichia coli O157:H7 str. TW14588 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|585056.7.peg.4204
Escherichia coli UMN026 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|316407.3.peg.3601
Escherichia coli W3110 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|216593.1.peg.4260
Escherichia coli E2348/69 (1-409/428)
MK
T
SL
F
K
SL
YF
Q
V
L
T
A
I
A
I
GILLG
-
--
H
FYP
E
-
--
-
-
IGEQMK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
I
I
G
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
T
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
FN
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
-
T
S
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KK
fig|550677.3.peg.1220
Escherichia coli B354 (26-449/463)
QWS
L
AKKVLVG
L
VMG
V
F
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|358709.5.peg.3229
Escherichia coli 101-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
E
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|331111.12.peg.2227
Escherichia coli E24377A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
A
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|331111.3.peg.4372
Escherichia coli E24377A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
A
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340184.3.peg.4144
Escherichia coli B7A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340184.6.peg.4342
Escherichia coli B7A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|595495.4.peg.2389
Escherichia coli KO11 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|679204.3.peg.657
Escherichia coli MS 145-7 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|566546.3.peg.912
Escherichia coli W (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|566546.4.peg.1885
Escherichia coli W (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
I
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|405955.13.peg.1819
Escherichia coli APEC O1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|405955.9.peg.1484
Escherichia coli APEC O1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|714962.3.peg.1884
Escherichia coli IHE3034 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585035.6.peg.1771
Escherichia coli S88 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|869729.3.peg.1804
Escherichia coli UM146 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|364106.7.peg.1963
Escherichia coli UTI89 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|364106.8.peg.1966
Escherichia coli UTI89 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585057.4.peg.1387
Escherichia coli IAI39 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585057.6.peg.1387
Escherichia coli IAI39 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|550672.3.peg.2575
Escherichia coli B088 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585034.4.peg.1766
Escherichia coli IAI1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585034.5.peg.1761
Escherichia coli IAI1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|679205.4.peg.2494
Escherichia coli MS 124-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749533.3.peg.2689
Escherichia coli MS 84-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585396.4.peg.2324
Escherichia coli O111:H- str. 11128 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|573235.3.peg.2541
Escherichia coli O26:H11 str. 11368 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.373.peg.5487
Escherichia coli 1125A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.372.peg.4817
Escherichia coli 1212A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|670888.3.peg.230
Escherichia coli 1827-70 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.374.peg.4295
Escherichia coli 536A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|481805.3.peg.2052
Escherichia coli ATCC 8739 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|481805.6.peg.2048
Escherichia coli ATCC 8739 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|413997.3.peg.1776
Escherichia coli B str. REL606 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|550676.3.peg.2040
Escherichia coli B185 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|511693.5.peg.1804
Escherichia coli BL21 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|469008.4.peg.1974
Escherichia coli BL21(DE3) (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749537.3.peg.1464
Escherichia coli MS 115-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749547.3.peg.2955
Escherichia coli MS 187-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444454.5.peg.1182
Escherichia coli O157:H7 str. EC4024 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444449.5.peg.670
Escherichia coli O157:H7 str. EC4042 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444448.5.peg.4974
Escherichia coli O157:H7 str. EC4045 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444453.5.peg.3528
Escherichia coli O157:H7 str. EC4076 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444452.5.peg.2459
Escherichia coli O157:H7 str. EC4113 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444450.8.peg.2485
Escherichia coli O157:H7 str. EC4115 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444451.5.peg.2597
Escherichia coli O157:H7 str. EC4196 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|444447.5.peg.5014
Escherichia coli O157:H7 str. EC4206 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|478004.5.peg.3433
Escherichia coli O157:H7 str. EC4401 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|478005.5.peg.4286
Escherichia coli O157:H7 str. EC4486 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|478007.5.peg.2782
Escherichia coli O157:H7 str. EC508 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|478008.5.peg.3325
Escherichia coli O157:H7 str. EC869 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|637388.3.peg.4863
Escherichia coli O157:H7 str. FRIK2000 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|570506.3.peg.3942
Escherichia coli O157:H7 str. FRIK966 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|544404.4.peg.2347
Escherichia coli O157:H7 str. TW14359 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|701177.3.peg.2177
Escherichia coli O55:H7 str. CB9615 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585397.7.peg.1956
Escherichia coli ED1a (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585397.9.peg.1951
Escherichia coli ED1a (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|670897.3.peg.2612
Escherichia coli 2362-75 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|362663.8.peg.1693
Escherichia coli 536 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|362663.9.peg.1697
Escherichia coli 536 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|525281.3.peg.772
Escherichia coli 83972 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|655817.3.peg.2079
Escherichia coli ABU 83972 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|199310.1.peg.2065
Escherichia coli CFT073 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|199310.4.peg.1994
Escherichia coli CFT073 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340197.3.peg.1814
Escherichia coli F11 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340197.5.peg.1911
Escherichia coli F11 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656417.3.peg.2234
Escherichia coli M605 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749546.3.peg.4480
Escherichia coli MS 185-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749550.3.peg.3136
Escherichia coli MS 200-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749528.3.peg.4802
Escherichia coli MS 45-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|753642.3.peg.3232
Escherichia coli NC101 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|685038.3.peg.1746
Escherichia coli O83:H1 str. NRG 857C (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|431946.3.peg.1651
Escherichia coli SE15 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656440.3.peg.1648
Escherichia coli TA206 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.376.peg.2387
Escherichia coli WV_060327 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|216592.1.peg.1268
Escherichia coli 042 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|216592.3.peg.1969
Escherichia coli 042 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656379.3.peg.2201
Escherichia coli FVEC1302 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656380.3.peg.3165
Escherichia coli FVEC1412 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656393.3.peg.2526
Escherichia coli H299 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749549.3.peg.2493
Escherichia coli MS 198-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749527.3.peg.3474
Escherichia coli MS 21-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749531.3.peg.349
Escherichia coli MS 69-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|439855.10.peg.1621
Escherichia coli SMS-3-5 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656437.3.peg.1956
Escherichia coli TA143 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656444.3.peg.2638
Escherichia coli TA280 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585056.7.peg.2204
Escherichia coli UMN026 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.371.peg.4585
Escherichia coli 1044A (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|83334.1.peg.2461
Escherichia coli O157:H7 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|155864.1.peg.2470
Escherichia coli O157:H7 EDL933 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|155864.8.peg.2318
Escherichia coli O157:H7 EDL933 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|478006.5.peg.2663
Escherichia coli O157:H7 str. EC4501 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|386585.9.peg.2549
Escherichia coli O157:H7 str. Sakai (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|502346.5.peg.4965
Escherichia coli O157:H7 str. TW14588 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656419.3.peg.2444
Escherichia coli M718 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
T
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|1040638.4.peg.3792
Escherichia coli O104:H4 str. LB226692 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|6666666.5357.peg.859
Escherichia coli TY-2482 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585055.6.peg.1926
Escherichia coli 55989 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585055.8.peg.1929
Escherichia coli 55989 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|562.375.peg.1842
Escherichia coli EC4100B (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656408.3.peg.1888
Escherichia coli H591 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|679206.4.peg.1161
Escherichia coli MS 119-7 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749545.3.peg.2828
Escherichia coli MS 182-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749532.3.peg.2216
Escherichia coli MS 78-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|409438.11.peg.2045
Escherichia coli SE11 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656443.3.peg.2402
Escherichia coli TA271 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|344601.3.peg.2845
Escherichia coli B171 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|344601.5.peg.2964
Escherichia coli B171 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340186.3.peg.2135
Escherichia coli E110019 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340186.5.peg.2202
Escherichia coli E110019 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340185.3.peg.4157
Escherichia coli E22 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|340185.4.peg.4384
Escherichia coli E22 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|679207.4.peg.3322
Escherichia coli MS 107-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|585395.4.peg.2014
Escherichia coli O103:H2 str. 12009 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|344610.3.peg.2415
Escherichia coli 53638 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|344610.7.peg.5383
Escherichia coli 53638 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|595496.3.peg.1690
Escherichia coli BW2952 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|536056.3.peg.2024
Escherichia coli DH1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|316401.4.peg.2021
Escherichia coli ETEC H10407 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|656414.3.peg.2050
Escherichia coli H736 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|331112.3.peg.1703
Escherichia coli HS (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|331112.6.peg.1771
Escherichia coli HS (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|83333.1.peg.1712
Escherichia coli K12 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749538.3.peg.4333
Escherichia coli MS 116-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749548.3.peg.2515
Escherichia coli MS 196-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|316407.3.peg.1684
Escherichia coli W3110 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|316385.5.peg.1843
Escherichia coli str. K-12 substr. DH10B (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|316385.7.peg.1888
Escherichia coli str. K-12 substr. DH10B (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|511145.12.peg.1800
Escherichia coli str. K-12 substr. MG1655 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|511145.6.peg.1785
Escherichia coli str. K-12 substr. MG1655 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|749540.3.peg.4145
Escherichia coli MS 146-1 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LA
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TG
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|216593.1.peg.553
Escherichia coli E2348/69 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
D
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
fig|574521.7.peg.1899
Escherichia coli O127:H6 str. E2348/69 (43-449/463)
F
G
LAL
HTIY
GS
DS
Q
VLK
DS
VQ
W
-
----FN
I
V
G
N
G
Y
V
Q
L
LQ
MIV
M
PLVF
A
S
I
L
S
AV
A
R
L
H
NA
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
GV
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
VV
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
LT
A
I
D
T
L
Q
SW
V
M
KL
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
VV
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
VE
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
AM
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
D
-
LPV
T
LV
AL
L
I
S
V
EP
L
IDM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
KQ
T
D
K
Consen1
Primary consensus
MKnikF
-
SLawQiLfalalgillGs
h
ds
w
-
p
Gdgfv
LikMIv
Plvf
tiv
giAgl
nakqlGriga
ti
yfe
ttiA
ilGv
v
Nvf
--------
QpGAg
--
vd
a
L
a
s
Y
-----
a
q
sd
gi
ils
iP
n
a
a
gn
---
il
vv
FavlfG
al
L
---
a
kge
v
vi
s
s
vfkl
mvMrlaP
Gvfalma
tva
g
l
Lg
lvv
y
llf
VlG
la
G
S
k
iR
v
eL
a
t
SSes
lPr
ve
-
kme
lG
p
Si
sfv
ptGysfnldG
-
a
lY
amaAvfiAq
gi
-
ldi
itLv
l
vsSkG
AGV
G
f
vllatL
avG
-
lPv
glAli
gvdr
idmaRtalNvvGn
A
v
akW
kq
D
KKALAYEREVLGKFDKTADQ
Consen2
Secondary consensus
sl
k
yf
v
tg
vihtiy
-
q
e
-
-
l
i
niyi
lq
i
ii
s
l
av
r
msav
ktsf
al
tll
slv
l
lvgltaeglv
g
-
mn
-
e
s
t
a
qsttev
k
ks
sv
vmd
v
s
g
t
aeptsmi
i
safl
ga
lkd
g
hrq
af
t
q
mg
li
qyt
algait
vig
n
i
a
fi
h
ifi
h
l
i
f
v
v
s
aa
i
l
daqtr
y
r
v
gla
sf
atigqn
c
i
il
imv
p
ns
pmsp
ai
l
v
lt
a
t
aaaiv
sm
hi
l
lv
fl
siep
seg
alt
ls
s
l
sq
h
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character