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E
TKLY
V
PQGV
Q
A
Y
P
T
L
RP
L
I
G
G
-
TL
N
IKH
V
RA
HWD
D
ILRLA
S
SIKQGTV
T
AS
L
MLRKLGSYPRQNGLAVALRELGRIERTLFILDWLQSVELRRRVHAGLNKGEARN
S
LARAVFF
N
R
L
GEIRDRS
F
EQQRYRAS
G
LNLVTAAIVLWNTVYLE
R
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TQG
L
V
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G
KP
VD
G
E
LLQ
F
LSPLGWEHINLTGDY
V
WR
Q
SRR
L
ED
G
K
FRPLR
M
P
G
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P
fig|656419.3.peg.1859
Escherichia coli M718 (185-982/995)
PL
TPA
HR
D
A
LD
H
LL
ESS
D
N-
Q
P
S
R
L
T
WL
L
Q
P
P
G
K
I
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G
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H
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LH
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L
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--
TR
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A
-
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A
ALAELVNAQ
GKR
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L
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AF
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G
S
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GR
YA
G
Q
V
NPKYG
Q
E
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FYTHISDQY
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PF
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T
C
I
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H
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KL
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QS
L
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H
R
L
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P
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L
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LSPLGWEHINLTGDY
I
W
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fig|701177.3.peg.5332
Escherichia coli O55:H7 str. CB9615 (185-984/992)
PL
TSA
HR
E
A
LD
R
LL
ESS
D
N-
Q
P
S
R
L
T
WL
L
Q
P
P
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RL
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V
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RH
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N
N
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ST
L
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L
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K
K
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--
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V
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I
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V
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--
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LL
L
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G
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A
-
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C
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L
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Y
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S
A
ALAELVNAQ
GKR
P
L
A
AF
WGDGTTSSSDGQNFRT
G
N
S
GR
YA
G
Q
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Q
E
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C
Q
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PF
Y
T
C
I
I
S
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V
RDST
H
VLDGLLYHESDL
D
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R
EHYTDTAGFTDHVFALMHLLGF
A
F
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H
D
K
KL
F
I
KGKA
D
Q
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P
AL
HS
L
I
S
P
T
RI
N
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I
EI
HW
R
E
V
LRLATSIKQGTV
T
AS
L
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A
SYP
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QNGLA
K
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M
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R
D
PA
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Q
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M
H
R
L
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K
P
E
N
Q
S
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G
L
T
L
L
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LWNTVY
M
E
R
A
VDA
L
K
RK
G
MK
IN
A
Q
LL
S
H
LSPLGWEHINLTGDY
I
W
KN
NRI
P
TS
G
K
FR
R
LR
-
S
VK
fig|679206.4.peg.4762
Escherichia coli MS 119-7 (181-958/961)
I
A
SR
L
PMS
I
R
E
Q
L
L
A
LL
EET
A
DD
R
V
T
R
F
V
WLRQ
F
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P
GS
NS
SSA
N
RL
L
D
RL
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L
QR
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L
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PA
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L
R
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G
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V
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A
M
L
A
D
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L
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R
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R
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L
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L
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--
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-
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RH
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R
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ACA
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I
G
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P
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LA
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GR
V
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DW
I
L
D
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H
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G
Q
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L
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K
L
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KL
L
SP
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LL
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H
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SPLGWEHINLTG
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fig|749527.3.peg.4071
Escherichia coli MS 21-1 (40-845/849)
Q
R
S
Q
L
E
M
LL
GPT
D
CS
R
L
S
L
L
E
S
L
KK
G
P
V
TISGPAFN
E
A
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W
KT
L
ND
F
G
L
H
AE
N
L
S
T
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K
N
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G
M
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FN
I
A
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SP
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K
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M
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V
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F
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L
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D
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L
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L
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D
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I
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L
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L
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I
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L
A
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MV
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Q
Y
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L
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V
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L
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--
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DV
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S
PL
A
S
L
DE
PD
S
L
K
R
L
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TELLLE
INA
H
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ADE
F
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H
A
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R
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D
DL
PV
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S
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A
E
A
C
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I
GL
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R
S
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V
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L
N
W
T
K
A
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L
R
A
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LV
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L
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S
A
DG
MR
F
V
T
P
VR
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N
A
G
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NRKYF
G
N
N
R
G
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T
W
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NFV
SDQY
SG
FH
G
I
V
IPGT
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IF
VL
E
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EQ
E
TG
L
NP
T
E
IM
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AS
D
L
VF
G
L
FW
LLG
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F
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PR
LA
D
A
G
A
S
VF
W
R
MDHD
A
D
Y
G
V
L
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I
A
R
G
-
QS
D
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I
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Q
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MI
R
T
A
G
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L
K
L
G
K
V
Q
AS
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R
S
L
LKSE
R
PS
GL
TQ
A
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E
V
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TL
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L
NYIDDEDY
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ILTQ
LN
R
GE
S
R
H
A
V
ARA
IC
H
G
Q
K
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K
R
Y
T
DG
Q
EDQLG
A
L
G
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N
A
V
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I
Y
MQ
A
A
LDH
LR
AQ
G
ET
LN
D
E
DIA
R
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CHG
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ML
G
H
Y
S
FTL
AEL
V
TK
G
H
L
RPL
KEAS
E
A
fig|749550.3.peg.282
Escherichia coli MS 200-1 (192-997/1001)
Q
R
S
Q
L
E
M
LL
GPT
D
CS
R
L
S
L
L
E
S
L
KK
G
P
V
TISGPAFN
E
A
IER
W
KT
L
ND
F
G
L
H
AE
N
L
S
T
LPA
V
RL
K
N
LAR
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G
M
T
SV
FN
I
A
RM
SP
Q
K
R
M
A
V
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F
V
L
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D
DA
L
D
VL
D
AM
L
AV
IIR
D
A
RK
I
G
Q
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R
S
L
K
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AL
A
LASAC
S
Y
L
L
K
E
ETP
D
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S
Y
I
P
R
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L
A
E
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T
L
V
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S
D
DN
F
H
EE
MV
E
Q
Y
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RR
FL
P
HL
L
NT
V
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L
N
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F
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Q
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D
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I
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SR
--
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I
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--
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A
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NEAV
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L
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DV
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L
T
I
S
PL
A
S
L
DE
PD
S
L
K
R
L
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I
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P
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INA
H
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F
F
H
A
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D
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AVLM
A
E
A
C
N
I
GL
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R
S
N
V
P
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T
RHR
L
N
W
T
K
A
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L
R
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A
R
LV
DF
Q
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P
L
A
QI
WG
G
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S
A
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MR
F
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VR
TI
N
A
G
P
NRKYF
G
N
N
R
G
I
T
W
Y
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SDQY
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FH
G
I
V
IPGT
LRDS
IF
VL
E
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L
NP
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ASEL
VF
G
L
FW
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F
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PR
LA
D
A
G
A
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W
R
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A
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G
V
L
ND
I
A
R
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R
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A
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L
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A
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fig|749532.3.peg.4064
Escherichia coli MS 78-1 (192-997/1001)
Q
R
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Q
L
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M
LL
GPT
D
CS
R
L
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L
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fig|749537.3.peg.628
Escherichia coli MS 115-1 (52-846/858)
Q
L
A
G
LL
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L
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V
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fig|6666666.5357.peg.4170
Escherichia coli TY-2482 (40-845/849)
Q
R
S
Q
L
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M
LL
GPT
D
CS
R
L
S
L
L
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fig|358709.5.peg.4699
Escherichia coli 101-1 (192-997/1001)
Q
R
S
Q
L
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M
LL
GPT
D
CS
R
L
S
L
L
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L
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L
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A
fig|679207.4.peg.3406
Escherichia coli MS 107-1 (192-997/1001)
Q
R
S
Q
L
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M
LL
GPT
D
CS
R
L
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L
L
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G
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S
VF
W
R
MDHD
A
D
Y
G
V
L
ND
I
A
R
G
-
QS
D
PRK
I
VL
Q
WDE
MI
R
T
A
G
S
L
K
L
G
K
V
Q
V
S
V
LV
R
S
L
LKSE
R
PS
GL
TQ
A
II
E
V
GRI
NK
TL
YL
L
NYIDDEDY
RRR
ILTQ
LN
R
GE
S
R
H
A
V
ARA
IC
H
G
Q
K
GEIR
K
R
Y
T
DG
Q
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T
L
G
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N
A
V
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I
Y
MQ
A
A
LDH
LR
AQ
G
ET
LN
D
E
DIA
R
LSPL
CHG
HIN
ML
G
H
Y
S
FTL
AEL
V
TK
G
H
L
RPL
KEAS
E
A
fig|749538.3.peg.325
Escherichia coli MS 116-1 (192-997/1001)
Q
R
S
Q
L
E
M
LL
GPT
D
CS
R
L
S
L
L
E
S
L
KK
G
P
V
TISGPAFN
E
A
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KT
L
ND
F
G
L
H
AE
N
L
S
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K
N
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G
M
T
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FN
I
A
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L
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A
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I
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L
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L
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Y
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P
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L
A
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Y
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L
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L
N
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--
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S
L
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T
D
PQ
E
AI
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L
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Q
LD
S
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Y
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V
--
A
A
R
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L
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DV
SG
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L
T
I
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PL
A
S
L
DE
PD
S
L
K
R
L
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I
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P
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INA
H
TGF
ADE
F
F
H
A
S
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R
V
D
DL
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SI
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AVLM
A
E
A
C
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R
S
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L
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W
T
K
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L
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G
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A
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F
V
T
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TI
N
A
G
P
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G
N
N
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G
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SG
FH
G
I
V
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IF
VL
E
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EQ
E
TG
L
NP
T
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IM
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VF
G
L
FW
LLG
YQ
F
S
PR
LA
D
A
G
A
S
VF
W
R
MDHD
A
D
Y
G
V
L
ND
I
A
R
G
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QS
D
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I
VL
Q
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MI
R
T
A
G
S
L
K
L
G
K
V
Q
V
S
V
LV
R
S
L
LKSE
R
PS
GL
TQ
A
II
E
V
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NK
TL
YL
L
NYIDDEDY
RRR
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LN
R
GE
S
R
H
A
V
ARA
IC
H
G
Q
K
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K
R
Y
T
DG
Q
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T
L
G
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N
A
V
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Y
MQ
A
A
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LR
AQ
G
ET
LN
D
E
DIA
R
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CHG
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ML
G
H
Y
S
FTL
AEL
V
TK
G
H
L
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KEAS
E
A
fig|749544.3.peg.2986
Escherichia coli MS 175-1 (192-997/1001)
Q
R
S
Q
L
E
M
LL
GPT
D
CS
R
L
S
L
L
E
S
L
KK
G
P
V
TISGPAFN
E
A
IER
W
KT
L
ND
F
G
L
H
AE
N
L
S
T
LPA
V
RL
K
N
LAR
YA
G
M
T
SV
FN
I
A
RM
SP
Q
K
R
M
A
V
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F
V
L
A
WE
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D
DA
L
D
VL
D
AM
L
AV
IIR
D
A
RK
I
G
Q
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R
S
L
K
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KS
AL
A
LASAC
S
Y
L
L
K
E
ETP
D
E
S
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VF
S
Y
I
P
R
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L
A
E
II
T
L
V
RE
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ARP
S
D
DN
F
H
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MV
E
Q
Y
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RR
FL
P
HL
L
NT
V
K
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VT
T
L
N
A
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L
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F
S
S
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R
Q
FF
D
DAPT
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I
I
SR
--
S
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R
LV
INKE
KH
I
T
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Y
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LC
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L
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V
T
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L
LQ
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A
D
W
Q
A
N
R
IKVY
R
S
L
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T
D
PQ
E
AI
KS
L
GH
Q
LD
S
R
Y
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V
--
A
A
R
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L
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T
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PL
A
S
L
DE
PD
S
L
K
R
L
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I
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P
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TELLLE
INA
H
TGF
ADE
F
F
H
A
S
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R
V
D
DL
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S
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A
E
A
C
N
I
GL
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R
S
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V
P
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T
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L
N
W
T
K
A
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L
R
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DF
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P
L
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QI
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G
G
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S
A
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MR
F
V
T
P
VR
TI
N
A
G
P
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G
N
N
R
G
I
T
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SG
FH
G
I
V
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IF
VL
E
GLL
EQ
E
TG
L
NP
T
E
IM
TDTAG
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VF
G
L
FW
LLG
YQ
F
S
PR
LA
D
A
G
A
S
VF
W
R
MDHD
A
D
Y
G
V
L
ND
I
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R
G
-
QS
D
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I
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Q
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MI
R
T
A
G
S
L
K
L
G
K
V
Q
V
S
V
LV
R
S
L
LKSE
R
PS
GL
TQ
A
II
E
V
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NK
TL
YL
L
NYIDDEDY
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LN
R
GE
S
R
H
A
V
ARA
IC
H
G
Q
K
GEIR
K
R
Y
T
DG
Q
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T
L
G
LVT
N
A
V
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MQ
A
A
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LR
AQ
G
ET
LN
D
E
DIA
R
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CHG
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ML
G
H
Y
S
FTL
AEL
V
TK
G
H
L
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A
fig|478005.5.peg.5473
Escherichia coli O157:H7 str. EC4486 (245-1050/1054)
Q
R
S
Q
L
E
M
LL
GPT
D
CS
R
L
S
L
L
E
S
L
KK
G
P
V
TISGPAFN
E
A
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W
KT
L
ND
F
G
L
H
AE
N
L
S
T
LPA
V
RL
K
N
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YA
G
M
T
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FN
I
A
RM
SP
Q
K
R
M
A
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F
V
L
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D
DA
L
D
VL
D
AM
L
AV
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D
A
RK
I
G
Q
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R
S
L
K
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AL
A
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Y
L
L
K
E
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S
Y
I
P
R
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L
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L
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H
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MV
E
Q
Y
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L
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VT
T
L
N
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FF
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A
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N
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R
S
L
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T
D
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E
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L
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--
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L
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PL
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L
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L
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INA
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A
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R
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IF
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EQ
E
TG
L
NP
T
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VF
G
L
FW
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F
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PR
LA
D
A
G
A
S
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W
R
MDHD
A
D
Y
G
V
L
ND
I
A
R
G
-
QS
D
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I
VL
Q
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MI
R
T
A
G
S
L
K
L
G
K
V
Q
V
S
V
LV
R
S
L
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R
PS
GL
TQ
A
II
E
V
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NK
TL
YL
L
NYIDDEDY
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ILTQ
LN
R
GE
S
R
H
A
V
ARA
IC
H
G
Q
K
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K
R
Y
T
DG
Q
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T
L
G
LVT
N
A
V
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I
Y
MQ
A
A
LDH
LR
AQ
G
ET
LN
D
E
DIA
R
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CHG
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ML
G
H
Y
S
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AEL
V
TK
G
H
L
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KEAS
E
A
fig|316385.7.peg.1387
Escherichia coli str. K-12 substr. DH10B (176-969/979)
E
LL
VIP
E
GQ
R
V
S
A
L
E
Q
L
KK
G
P
V
T
V
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AL
ER
Y
IR
L
RS
L
E
FS
RL
N
F
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G
LPA
I
Q
L
R
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G
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L
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D
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L
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QA
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LA
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L
L
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TELLLE
I
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H
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A
H
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L
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A
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N
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L
R
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IF
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L
NP
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D
I
I
F
G
L
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F
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D
A
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A
VF
W
R
VNKS
A
N
Y
G
V
L
DK
L
A
R
G
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D
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A
ES
Q
WDE
M
M
R
T
A
G
S
L
K
L
GT
I
H
AS
E
L
I
R
S
L
LKS
S
R
PS
GLA
Q
A
I
M
E
V
GR
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TL
YL
L
NYIDDEDY
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ILTQ
LN
R
GE
G
R
H
A
V
ARA
IC
Y
G
Q
R
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K
R
Y
R
E
G
Q
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A
L
G
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N
A
V
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L
Y
M
E
E
A
LSW
M
R
RN
G
EE
I
I
D
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M
HG
HIN
ML
G
H
Y
T
FTL
PED
I
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G
E
L
R
A
L
fig|316385.5.peg.1352
Escherichia coli str. K-12 substr. DH10B (199-992/1002)
E
LL
VIP
E
GQ
R
V
S
A
L
E
Q
L
KK
G
P
V
T
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SGPAFN
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AL
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Y
IR
L
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L
E
FS
RL
N
F
S
G
LPA
I
Q
L
R
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G
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SV
KY
I
A
RM
PQ
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K
L
A
V
L
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D
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D
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L
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L
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L
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NR
L
A
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N
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F
H
DE
MV
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Q
Y
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R
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L
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L
H
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A
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I
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L
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A
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L
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L
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DF
Q
STL
E
L
A
GR
WG
G
G
EVA
S
A
DG
MR
F
V
T
P
V
K
TI
N
S
G
S
NRKYF
GS
G
R
G
I
T
W
Y
NFV
SDQY
SG
FH
G
I
VV
PGT
LRDS
IF
VL
E
GLL
EQQTG
L
NP
V
E
IM
TDTAG
S
S
D
I
I
F
G
L
FW
LLG
YQ
F
S
PR
LA
D
A
G
E
A
VF
W
R
VNKS
A
N
Y
G
V
L
DK
L
A
R
G
-
YA
D
LSK
A
ES
Q
WDE
M
M
R
T
A
G
S
L
K
L
GT
I
H
AS
E
L
I
R
S
L
LKS
S
R
PS
GLA
Q
A
I
M
E
V
GR
VNK
TL
YL
L
NYIDDEDY
RRR
ILTQ
LN
R
GE
G
R
H
A
V
ARA
IC
Y
G
Q
R
GEIR
K
R
Y
R
E
G
Q
EDQLG
A
L
G
LVT
N
A
V
VLWNT
L
Y
M
E
E
A
LSW
M
R
RN
G
EE
I
I
D
E
DIA
R
LSPL
M
HG
HIN
ML
G
H
Y
T
FTL
PED
I
LK
G
E
L
R
A
L
Consen1
Primary consensus
laepL
hR
rLd
LL
d
k
t
L
wLrq
P
kpnsrhmlEhiERl
w
l
Lp
i
r
vhq
RL
klARegGq
tp
lakf
qrR
A
LvA
a
e
atvtDeiiDlhDril
lfn
Akn
hQqqfq
sgKain
vr
ygrig
aLida
g
d
iea
mpw
f
esvt
a
lArP
dfdfl
igE
YatlRRyaP
L
lklraAPAa
vL
A
L
n
d
rk
aDAPt
fI
--
WkkLV
g
-
IdRryYelC
LseLknsLRsgDiwv
gSrqfkDf
Lvp
ekf
s
k
l
Lava
D
qyl
r
lLd
ql
VnrmAa
dlpda
i
-
sG
----
LkItpLda
-
vPd
a
aL
t
lLPhvkiTELLlEvde
TGFtrhF
H
k
a
D
--
ll
ttilAdAiNlGLtkmaes
-
PgtTyakLaW
qawh
RdETy
tAlAeLVnaQ
pfA
WGdGttsSsDGqnFrT
sk
stG
inpkyGs
pGrtfYthiSDQYapFht
VvnvglRDStyVLdGLLyhesdLri
EhyTDTAGftdhVFaLmhLLGfrFaPRirDlG
tklyi
A
Y
aL
mi
g
-
n
i
hWDEilRlAtSiKqGtV
aS
mlRkLgsypRqnGLavAlrElGRierTLfiLdwlqsvelRRRvhagLNkGEaRnAlARAvff
r
GEIRdRs
eqQryras
LnLVTaAiVLWNTvYle
A
Lr
G
vdd
llq
LSPLgweHINltGdY
wrs
i
G
fRpLr
-
plqpA
Consen2
Secondary consensus
mtds
q
e
e
r
s
s
kk
tisgpafn
al
w
l
f
h
n
s
lpa
ni
ya
m
sv
itrm
ak
t
v
a
tlal
da
vl
ami
iir
rk
g
kkrl
tl
dld
al
lasac
y
l
e
d
s
vf
sr
l
aii
v
i
q
ndnph
mv
grv
fl
v
fss
g
t
f
s
k
d
e
i
r
kh
t
ag
tf
e
qda
rr
vyl
n
nrwg
p
lq
a
w
r
r
ghp
ai
l
q
e
y
--
a
r
neav
l
e
pkpr
t
sc
a
de
p
l
r
i
p
dl
m
ina
ade
s
r
dl
si
avlm
e
c
i
epli
an
al
rhr
kqny
a
i
n
r
df
al
g
eva
a
mr
v
vr
n
nrkyf
n
r
iqw
nfv
sg
sg
ipgtv
if
e
eqqtg
np
im
asel
g
fw
yq
s
la
a
vf
r
v
a
st
d
v
q
mi
t
g
l
l
k
v
lv
s
lkse
ps
tq
ii
v
vnk
yl
nyiddedy
iltq
r
s
h
v
ic
q
k
y
dg
edqlg
g
n
v
mq
k
dia
chg
ml
h
ftl
l
a
keas
a
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character