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Extended Table of Sources & Properties of TyrA Sequences
Cohesion group & lineagea Click at right of each CG# to view gene neighborhood	Source of TyrA sequence: Bacteria	Acronymb	SEED: fig & peg number	gi numberc	TyrA specificitiesd & fusionse	Core size (aa)	276-Rxxx----R-284f
β                       TyrCG-1	Actinobacillus actinomycetemcomitans	Aact	fig|714.2.peg.737	NAg	AroHI●NADTyrAc	258	RLELAMVGR
lower-Gammaproteobacteria (4 Orders)	Actinobacillus pleuropneumoniae	Aple_1	fig|228399.1.peg.927	32034455 *	AroHI●NADTyrAc	257	RLELAMVGR
16S rRNA - congruent	Actinobacillus succinogenes	Asuc	NA	75429313 *	AroHI●NADTyrAc	260	RLELAMIGR
	Blochmannia floridanush	Bflo	fig|203907.1.peg.169	33519649 *	AroHI●NADTyrAc	260	QLELILIGR
	Citrobacter rodentium	Crod	NA	NA	AroHI●NADTyrAc	256	RLELAMVGR
	Colwellia psychrerythraea	Cpsy_4	fig|167879.3.peg.3829	71281624 *	AroHI●NADTyrAc	256	RLELIMVGR
	Erwinia carotovora	Ecar	fig|218491.3.peg.2590	50122273 *	AroHI●NADTyrAc	257	RLELIMVGR
	Erwinia chrysanthemi	Echr	NA	NA	AroHI●NADTyrAc	257	RLELAMVGR
	Escherichia coli	Ecol	fig|199310.1.peg.3046	26248963 *	AroHI●NADTyrAc	257	RLELAMVGR
	Haemophilus influenzae	Hinf	fig|71421.1.peg.1230	16273204 *	AroHI●NADTyrAc	258	RLELAMVGR
	Haemophilus somnus	Hsom	fig|205914.1.peg.1395	53692322 *	AroHI●NADTyrAc	258	RLELAMVGR
	Idiomarina loihiensis	Iloi	fig|283942.3.peg.1532	56460822 *	AroHI●NADTyrAc	257	RMELMMIGR
	Klebsiella pneumoniae	Kpne	fig|573.2.peg.6446	NA	AroHI●NADTyrAc	257	RLELAMVGR
	Mannheimia haemolytica	Mhae	fig|75985.2.peg.2378	NA	AroHI●NADTyrAc	258	RLELAMVGR
	Mannheimia succiniciproducens	Msuc	fig|221988.1.peg.1037	52307209 *	AroHI●NADTyrAc	258	RLELAMVGR
	Pantoea agglomerans	Pagg	NA	267186	AroHI●NADTyrAc	257	RLELAMVGR
	Pasteurella multocida	Pmul	fig|272843.1.peg.664	15602529 *	AroHI●NADTyrAc	258	RLELAMVGR
	Photobacterium profundum	Ppro_2	fig|298386.1.peg.5258	46914574 *	AroHI●NADTyrAc	257	RLELAMVGR
	Photorhabdus asymbiotica	Pasy	fig|171440.1.peg.2864	NA	AroHI●NADTyrAc	259	RLELIMVGR
	Photorhabdus luminescens	Plum	fig|243265.1.peg.1198	37525230 *	AroHI●NADTyrAc	257	RLELIMVGR
	Proteus mirabilis	Pmir_1	fig|584.1.peg.249	NA	AroHI●NADTyrAc	260	RLELAMIGR
	Salmonella bongori	Sbon	fig|12149.1.peg.2668	NA	AroHI●NADTyrAc	257	RLELAMVGR
	Salmonella enterica	Sent_2	fig|209261.1.peg.2450	29142993 *	AroHI●NADTyrAc	257	RLELAMVGR
	Salmonella typhimurium	Styp_1	fig|99287.1.peg.2578	16765984 *	AroHI●NADTyrAc	257	RLELAMVGR
	Serratia marcescens	Smar	fig|615.1.peg.3937	NA	AroHI●NADTyrAc	257	RLELAMVGR
	Shewanella amazonensis	Sama	fig|326297.3.peg.3526	68547562 *	AroHI●NADTyrAc	254	RLELAMVGR
	Shewanella baltica	Sbal	fig|325240.3.peg.4134	68544265 *	AroHI●NADTyrAc	258	RLELAMVGR
	Shewanella denitrificans	Sden_1	fig|318161.3.peg.1131	91794100 *	AroHI●NADTyrAc	258	RLELAMVGR
	Shewanella frigidimarina	Sfri	fig|318167.3.peg.2662	69952675 *	AroHI●NADTyrAc	258	RLELAMVGR
	Shewanella oneidensis	Sone	fig|211586.1.peg.1265	24372940 *	AroHI●NADTyrAc	258	RLELAMVGR
	Shigella dysenteriae	Sdys	fig|216598.1.peg.4845	82777951 *	AroHI●NADTyrAc	257	RLELAMVGR
	Shigella flexneri	Sfle	fig|198214.1.peg.2489	24113939 *	AroHI●NADTyrAc	257	RLELAMVGR
	Shigella sonnei	Sson	fig|216599.1.peg.1580	74313184 *	AroHI●NADTyrAc	257	RLELAMVGR
	Vibrio cholerae	Vcho	fig|243277.1.peg.686	15640715 *	AroHI●NADTyrAc	257	RLELAMVGR
	Vibrio fischeri	Vfis	fig|312309.3.peg.604	59711161 *	AroHI●NADTyrAc	257	RLELLMVGR
	Vibrio parahaemolyticus	Vpar_2	fig|223926.1.peg.547	28897321 *	AroHI●NADTyrAc	257	RLELAMVGR
	Vibrio vulnificus	Vvul	fig|216895.1.peg.466	27360075 *	AroHI●NADTyrAc	257	RLELAMVGR
	Yersinia enterocolitica	Yent	fig|630.2.peg.825	NA	AroHI●NADTyrAc	257	RLELAMVGR
	Yersinia pestis	Ypes	fig|214092.1.peg.3269	16123440 *	AroHI●NADTyrAc	257	RLELAMVGR
	Yersinia pseudotuberculosis	Ypse	fig|273123.1.peg.967	51595192 *	AroHI●NADTyrAc	257	RLELAMVGR
--------------------------	-----------------------------------	-----------	-----------------------	----------	--------------------	-----------	-----------
Xenolog Intruders	Nostoc sp.i	2NOST_1	fig|103690.1.peg.729	17129763 *	jAroHI●NADTyrAc	260	RQEIEIIKR
Cyanobacteria	Nostoc punctiformei	2Npun_1	fig|63737.1.peg.2248	23128268 *	jAroHI●NADTyrAc	260	RQEIDIVKR
α                       TyrCG-2	Azotobacter vinelandii	Avin_1	fig|354.1.peg.1510	67158240 *	NADTyrAc●AroF	280	RDFT----R
upper-Gamma_1proteobacteria (Pseudomonadaceae Family)	Pseudomonas aeruginosa	Paer_1	fig|208964.1.peg.3164	15598360 *	NADTyrAc●AroF	280	RDFT----R
16S rRNA - congruent	Pseudomonas fluorescens	Pflu	fig|205922.3.peg.3160	77460295 *	NADTyrAc●AroF	280	RDFT----R
	Pseudomonas putida	Pput	fig|160488.1.peg.1756	26988501 *	NADTyrAc●AroF	280	RDFT----R
	Pseudomonas stutzeri	Pstu	NA	29727034	NADTyrAc●AroF	280	RDFT----R
	Pseudomonas syringae pv. syringae	Psyr_2	fig|205918.4.peg.4081	66046873 *	NADTyrAc●AroFj	280	RDFT----R
	Pseudomonas syringae pv. tomato	Psyr_3	fig|223283.1.peg.1711	28868954 *	NADTyrAc●AroFj	280	RDFT----R
α                       TyrCG-3	Acinetobacter sp.	ACIN	fig|62977.3.peg.2127	50085330 *	NADPTyrAc●AroF	281	RDFS----R
upper-Gamma_2proteobacteria (Moraxellaceae Family)	Psychrobacter cryohalolentis	Pcry	fig|335284.3.peg.415	93006034 *	NADTyrAc●AroF	286	RDFT----R
16S rRNA - congruent	Psychrobacter sp. (P. arcticus)	PSYC	fig|259536.4.peg.787	71038727 *	NADTyrAc●AroF	285	RDFT----R
β                       TyrCG-4	Stenotrophomonas maltophilia	Smal_2	fig|40324.1.peg.2028	NA	NADTyrAc●ACT	268	ELDTAIISR
upper-Gamma_3proteobacteria (Xanthomonadaceae Family)	Xanthomonas axonopodis	Xaxo	fig|190486.1.peg.1502	21242276 *	NADTyrAc●ACT	268	ELDTAVIAR
16S rRNA - congruent	Xanthomonas campestris	Xcam	fig|190485.1.peg.1454	21230932 *	NADTyrAc●ACT	268	ELDTAVIAR
	Xanthomonas oryzae	Xory	fig|291331.3.peg.4549	58581657 *	NADTyrAc●ACT	268	ELDTAVIAR
	Xylella fastidiosa	Xfas	fig|160492.1.peg.2324	15838929 *	NADTyrAc●ACT	268	ELDTAVIAR
α                       TyrCG-5	Alkalilimnicola ehrlichei	Aehr	fig|187272.6.peg.896	114320089 *	NADPTyrAc	281	RDFT----R
upper-Gamma_4proteobacteria (Chromatiales Order)	Halorhodospira halophila	Hhal_3	NA	88950354 *	NADPTyrAc	283	RDFT----R
16S rRNA - congruent	Nitrococcus mobilis	Nmob	fig|314278.3.peg.2952	88810650 *	NADPTyrAc	283	RDFT----R
	Thermochromatium tepidum	Ttep	NA	NA	NADPTyrAc	262	PHSL----R
α                       TyrCG-6	Hahella chejuensis	Hche	fig|349521.5.peg.4370	83647660 *	NADTyrAc●AroF	281	RDFT----R
upper-Gamma_5proteobacteria (2 Orders)	Marinobacter aquaeolei	Maqu	NA	77952716 *	NADTyrAc●AroF	260	RDFT----R
16S rRNA - congruent	Oceanospirillum sp.	OCEA	NA	89094102	NADTyrAc●AroF	282	RDFT----R
α                       TyrCG-7	Burkholderia cenocepacia	Bcen_1	fig|216591.1.peg.4051	NA	NAD(P)TyrAc	290	RDTF----R
Beta_1proteobacteria (Burkholderiaceae Family)	Burkholderia cepacia	Bcep	fig|269483.3.peg.5254	46316716 *	NAD(P)TyrAc	290	RDTF----R
16S rRNA - congruent	Burkholderia mallei	Bmal	fig|243160.4.peg.907	52428212 *	NAD(P)TyrAc●AroF	290	RDTF----R
	Burkholderia pseudomallei	Bpse_6	fig|272560.3.peg.4863	53720127 *	NAD(P)TyrAc●AroF	290	RDTF----R
	Burkholderia sp.	BURK	NA	78065629 *	NAD(P)TyrAc	290	RDTF----R
	Burkholderia thailandensis	Btha	NA	83721591 *	NAD(P)TyrAc●aroF	290	RDTF----R
	Burkholderia vietnamiensis	Bvie	fig|60552.1.peg.3874	67546805 *	NAD(P)TyrAc	290	RDTF----R
	Burkholderia xenovorans (B. fungorum)	Bxen	fig|36873.1.peg.4890	91784814 *	NAD(P)TyrAc	290	RDTF----R
	Ralstonia eutropha	Reut	fig|264198.3.peg.3327	73542258 *	NAD(P)TyrAc	282	RDTF----R
	Ralstonia metallidurans	Rmet	fig|119219.1.peg.2049	94309663 *	NAD(P)TyrAc	282	RDTF----R
	Ralstonia solanacearum	Rsol	fig|267608.1.peg.906	17427918 *	NAD(P)TyrAc	282	RDTF----R
α                       TyrCG-8	Bordetella avium	Bavi	fig|521.1.peg.518	NA	NAD(P)TyrAc	282	RDTF----R
Beta_2proteobacteria (Alcaligenaceae Family)	Bordetella bronchiseptica	Bbro	fig|257310.1.peg.3450	33602443 *	NAD(P)TyrAc	282	RDTF----R
16S rRNA - congruent	Bordetella parapertussis	Bpar	fig|257311.1.peg.2940	33597663 *	NAD(P)TyrAc	282	RDTF----R
	Bordetella pertussis	Bper_1	fig|257313.1.peg.827	33592104 *	NAD(P)TyrAc	282	RDFT----R
α                       TyrCG-9	Neisseria gonorrhoeae	Ngon	fig|242231.4.peg.1532	59801853 *	NADTyrAc	284	RDFT----R
Beta_3proteobacteria (Neisseriaceae Family)	Neisseria lactamica	Nlac	fig|486.1.peg.642	NA	NADTyrAc	284	RDFT----R
16S rRNA - congruent	Neisseria meningitides	Nmen	fig|122586.1.peg.422	15676352 *	NADTyrAc	284	RDFT----R
α                       TyrCG-10	Acidovorax avenae	Aave	NA	120611939	NAD(P)TyrAc	283	RDFT----R
Beta_4proteobacteria (Comamonadaceae Family)	Acidovorax sp.	ACID_2	NA	110592958	NAD(P)TyrAc	283	RDFT----R
16S rRNA - congruent	Polaromonas sp.	POLA	fig|296591.1.peg.2815	91787673 *	NAD(P)TyrAc	283	RDFT----R
	Rhodoferax ferrireducens	Rfer_1	fig|338969.3.peg.3314	89900360 *	NAD(P)TyrAc	283	RDFT----R
	Rubrivivax gelantinosus (M. petroleiphilum)	Rgel_1	fig|279263.3.peg.1701	47575153	NAD(P)TyrAc	283	RDFT----R
α                       TyrCG-11	Nitrosomonas europaea	Neur	fig|228410.1.peg.323	30248354 *	NADPTyrAa	289	NDMT----R
Beta_5proteobacteria (Nitrosomonadaceae Family)	Nitrosomonas eutropha	Neut	fig|335283.3.peg.1872	114331555 *	NADPTyrAa	289	NGMT----R
16S rRNA - congruent	Nitrosospira multiformis	Nmul_1	NA	82411378 *	NADPTyrAa	290	RDST----R
α                       TyrCG-12	Agrobacterium tumefaciens	Atum	fig|176299.4.peg.3832	15159711 *	NADPTyrAc	280	RDFT----R
Alpha_1proteobacteria (Most Orders)	Bartonella henselae	Bhen	fig|283166.1.peg.1442	49476273 *	NADPTyrAc	282	RDFT----R
16S rRNA - congruent	Bartonella quintana	Bqui	fig|283165.1.peg.1102	49240294 *	NADPTyrAc	282	RDFT----R
	Bradyrhizobium japonicum	Bjap_1	fig|224911.1.peg.1396	27376507 *	NADPTyrAc	282	RDFT----R
	Brucella abortus	Babo	fig|262698.3.peg.1913	62290836 *	NADPTyrAc	282	RDFT----R
	Brucella melitensis	Bmel	fig|224914.1.peg.79	17981952 *	NADPTyrAc	282	RDFT----R
	Brucella suis	Bsui_1	fig|204722.1.peg.1920	23348861 *	NADPTyrAc	282	RDFT----R
	Caulobacter crescentus	Ccre	fig|190650.1.peg.2207	16126463 *	NADPTyrAc	285	RDFT----R
	Erythrobacter litoralis	Elit	fig|314225.3.peg.737	85375111 *	NADTyrAc	280	RDFT----R
	Erythrobacter sp.	ERYT	fig|237727.3.peg.3049	85710209 *	NADTyrAc	281	RDFT----R
	Gluconobacter oxydans	Goxy	fig|290633.1.peg.2186	58040677 *	NADPTyrAp	278	RDFT----R
	Loktanella vestfoldensis	Lves_1	fig|314232.3.peg.2934	84514473 *	NADPTyrAc	282	RDFT----R
	Magnetospirillum magnetotacticum	Mmag_1	fig|188.1.peg.9423	23016193 *	NADTyrAc	282	RDFT----R
	Mesorhizobium loti	Mlot	fig|266835.1.peg.2723	13473052 *	NADPTyrAc	282	RDFT----R
	Mesorhizobium sp.	MESO	fig|266779.1.peg.199	110635414 *	NADPTyrAc	282	RDFT----R
	Nitrobacter hamburgensis	Nham	fig|323097.3.peg.298	92116292 *	xTyrAc	282	RDFT----R
	Nitrobacter sp.	NITR	fig|314253.3.peg.167	85713573 *	NADPTyrAc	282	RDFT----R
	Nitrobacter winogradskyi	Nwin	fig|323098.3.peg.226	75674780 *	NADPTyrAc	282	RDFT----R
	Novosphingobium aromaticivorans	Naro	fig|48935.1.peg.1935	87198720 *	NADTyrAc	281	RDFT----R
	Oceanicola batsensis	Obat	fig|252305.3.peg.283	84500113 *	NADPTyrAc	282	RDFT----R
	Oceanicola granulosus	Ogra_1	NA	89070716	NADPTyrAc	282	RDFT----R
	Parvularcula bermudensis	Pber_1	fig|314260.3.peg.961	84702226 *	NADTyrAc	282	RDFT----R
	Rhizobium etli	Retl	NA	86359392 *	NADPTyrAc	282	RDFT----R
	Rhizobium leguminosarum	Rleg	fig|216596.1.peg.4473	NA	NADPTyrAc	282	RDFT----R
	Rhodobacter capsulatus	Rcap	NA	NA	NADPTyrAc	282	RDFT----R
	Rhodobacter sphaeroides	Rsph	fig|272943.3.peg.1478	77462837 *	NADPTyrAc	282	RDFT----R
	Rhodobacterales (unidentified species)	RHOD	fig|314271.3.peg.844	84686190 *	NADPTyrAc	282	RDFT----R
	Rhodopseudomonas palustris	Rpal	fig|258594.1.peg.4419	39937500 *	NADPTyrAc	282	RDFT----R
	Rhodospirillum rubrum	1Rrub_1	fig|1085.1.peg.904	83594593 *	NADTyrAc	282	RDFT----R
	Roseobacter sp.	ROSE	fig|314262.3.peg.2107	86136450 *	NADPTyrAc	282	RDFT----R
	Roseovarius nubinhibens	Rnub	fig|89187.3.peg.541	83949929 *	NADPTyrAc	282	RDFT----R
	Roseovarius sp.	ROSE_1	fig|314264.3.peg.2308	85704144 *	NADPTyrAc	282	RDFT----R
	Silicibacter pomeroyi	1Spom_1	fig|246200.3.peg.3549	56679745 *	NADPTyrAc	282	RDFT----R
	Silicibacter sp.	SILI	fig|292414.1.peg.467	69301685 *	NADPTyrAc	282	RDFT----R
	Sinorhizobium meliloti	Smel_2	fig|266834.1.peg.3955	15075685 *	NADPTyrAc	282	RDFT----R
	Sphingopyxis alaskensis	Sala_2	fig|317655.9.peg.2749	103488365 *	NADTyrAc	281	RDFT----R
	Sulfitobacter sp.	SULF	fig|52598.3.peg.2337	83941368 *	NADPTyrAc	282	RDFT----R
	Zymomonas mobilis	Zmob	fig|264203.3.peg.916	56551316 *	NADTyrAc	281	RDAT----R
α                       TyrCG-13	Campylobacter coli	Ccol	fig|306254.1.peg.1062	57168699 *	NADTyrAx	274	KGMS----R
Epsilonproteobacteria Class	Campylobacter jejuni	Cjej	fig|192222.1.peg.119	15791518 *	NADTyrAx	274	KGMS----R
16S rRNA - congruent	Campylobacter lari	Clar	fig|306263.1.peg.477	57240749 *	NADTyrAx	274	KDMC----R
	Campylobacter upsaliensis	Cups	fig|306264.1.peg.1263	57505600 *	NADTyrAx	274	KGMC----R
	Helicobacter hepaticus	Hhep	fig|235279.1.peg.993	32262543 *	NADTyrAx	281	RSMS----R
	Helicobacter mustelae	Hmus	fig|217.1.peg.608	NA	NADTyrAx	274	RDMS----R
	Helicobacter pylori	Hpyl	fig|85963.1.peg.1290	15612359 *	NADTyrAx	274	RDMS----R
	Thiomicrospira denitrificans	Tden_2	fig|326298.3.peg.2020	78776858 *	NADTyrAx	274	RSMS----R
	Wolinella succinogenes	Wsuc	fig|273121.1.peg.325	34482497 *	NADTyrAx	274	RDMS----R
-------------------------	--------------------------------	-----------	-----------------	------------	------------	-----------	-----------
Xenolog Intruders	Cellulophaga sp.	CELL_1	fig|313590.3.peg.343	86131676 *	NADTyrAx	279	ASTV----R
Flavobacteria Class	Flavobacteriales bacterium	Fbac	fig|313603.3.peg.816	88713205 *	NADTyrAx	278	ESTV----R
	Flavobacterium johnsoniae	Fjoh	NA	90591593	NADTyrAx	279	ESTV----R
	Flavobacterium sp.	FLAV	fig|313593.3.peg.860	NA	NADTyrAx	279	ASTV----R
	Polaribacter filamentus	Pfil	NA	NA	NADTyrAx	279	ESTV----R
	Polaribacter irgensii	Pirg	fig|313594.3.peg.497	88801515	NADTyrAx	279	ASTV----R
	Psychroflexus torquis	Ptor	NA	91216681	NADTyrAx	281	ASTV----R
	Robiginitalea biformata	Rbif	NA	88806861 *	NADTyrAx	279	ESTV----R
	Tenacibaculum sp.	TENA	fig|313598.3.peg.1203	86134253 *	NADTyrAx	279	ESTV----R
α                       TyrCG-14	Desulfuromonas acetoxidans	1Dace_5	fig|891.1.peg.2292	NA	NADPTyrAx	282	RDFT----R
Delta_1proteobacteria (Desulfuromonadales Order)	Desulfuromonas acetoxidans	2Dace_5	fig|891.1.peg.100	68179840 *	NADTyrAx	281	RDFT----R
16S rRNA - congruent	Geobacter metallireducens	Gmet	fig|269799.3.peg.938	78222083 *	NADPTyrAx	281	RDFT----R
	Geobacter sp.	GEOB	NA	110601840	NADPTyrAx	281	RDFT----R
	Geobacter sulfurreducens	Gsul	fig|243231.1.peg.2590	39997701 *	NADTyrAx	281	RDFT----R
	Geobacter uraniumreducens	Gura	fig|351605.3.peg.1757	88936215 *	NADPTyrAx	281	RDFT----R
	Pelobacter carbinolicus	Pcar_1	fig|338963.3.peg.816	77919482 *	NADPTyrAx	281	RDFT----R
	Pelobacter propionicus	Ppro	NA	71836770	NADPTyrAx	281	RDFT----R
β                       TyrCG-15
Delta_2proteobacteria (Desulfovibrionales Order)	Desulfovibrio desulfuricans	Ddes	fig|207559.3.peg.3693	78358524 *	NADTyrAx	255	RRRLDAA-R
16S rRNA - congruent	Desulfovibrio vulgaris	Dvul	fig|882.1.peg.463	46578880 *	NADTyrAx	253	RRRLDAA-R
α                       TyrCG-16	Anabaena variabilis	Avar	fig|240292.3.peg.4775	75910594 *	NADPTyrAa	276	RDTS----R
Cyanobacteria Phylum	Crocosphaera watsonii	Cwat	fig|165597.1.peg.2861	67922127	NADPTyrAa	276	RDTS----R
16S rRNA - congruent	Gloeobacter violaceus	Gvio	fig|251221.1.peg.406	37519975 *	NADPTyrAa	271	FDTT----R
	Nostoc punctiforme	1Npun_1	fig|63737.1.peg.6205	53686866 *	NADPTyrAa	273	RDTS----R
	Nostoc sp.	1NOST_1	fig|103690.1.peg.1451	17130487 *	NADPTyrAa	276	RDTS----R
	Prochlorococcus marinus str. MIT 9313	Pmar_10	fig|74547.1.peg.1718	33635575 *	xTyrAa	276	ADTT----R
	Prochlorococcus marinus str. CCMP 1375	Pmar_16	fig|167539.1.peg.1716	33241168 *	xTyrAa	276	EDTT----R
	Prochlorococcus marinus ssp. pastoris	Pmar_17	fig|59919.1.peg.1561	33862121 *	xTyrAa	275	ADTT----R
	Synechococcus elongatus	Selo	fig|1140.3.peg.870	81299471	NADPTyrAa	276	CDTS----R
	Synechococcus sp. pcc7002	SYNE	NA	NA	NADPTyrAa	276	RDTS----R
	Synechococcus sp. WH 8102	SYNE_1	fig|84588.1.peg.2051	33633368 *	xTyrAa	276	ADTS----R
	Synechococcus sp. CC9902	SYNE_4	fig|316279.3.peg.1511	78185511 *	xTyrAa	276	ADTT----R
	Synechococcus sp. CC9605	SYNE_5	fig|110662.3.peg.1551	78211937 *	xTyrAa	276	ADTS----R
	Synechocystis sp. PCC6803	SYNE_3	fig|1148.1.peg.1391	16330562 *	NADPTyrAa	276	RDTS----R
	Thermosynechococcus elongatus	Telo	fig|197221.1.peg.2434	22299978 *	NADPTyrAa	276	RDTS----R
	Trichodesmium erythraeum	Tery	fig|203124.1.peg.1189	71674828 *	NADPTyrAa	276	HDTS----R
α                       TyrCG-17	Actinomyces naeslundii	Anae	NA	NA	NADTyrAa●ACT	271	RDVT----R
Actinobacteridae Subclass	Actinoplanes teichomyceticus	Atei	NA	45580876	NADTyrAa●ACT	270	RDVT----R
16S rRNA - congruent	Amycolatopsis balhimycina	Abal	NA	46275288	NADTyrAa	268	RDVT----R
	Amycolatopsis orientalis	Aori	NA	5051821	NADTyrAa●ACT	268	RDTT----R
	Bifidobacterium longum	Blon_1	fig|206672.1.peg.1314	23465944 *	NAD(P)TyrAa	283	RDMT----R
	Brevibacterium linens	Blin	fig|321955.3.peg.1676	62424885	NADTyrAa●ACT	273	RDVT----R
	Clavibacter michiganensis	Cmic	fig|31964.1.peg.6	NA	NADTyrAa●ACT	270	RDTT----R
	Corynebacterium diphtheriae	Cdip	fig|257309.1.peg.226	38232868 *	NAD(P)TyrAa	283	RDST----R
	Corynebacterium efficiens	Ceff	fig|196164.1.peg.195	25026751 *	NAD(P)TyrAa	282	RDVT----R
	Corynebacterium glutamicum	Cglu_1	fig|196627.4.peg.262	19551477 *	NAD(P)TyrAa	286	RDST----R
	Corynebacterium jeikeium	Cjei	fig|306537.3.peg.792	68537120 *	NAD(P)TyrAa	321	RDGT----R
	Janibacter sp.	JANI	fig|313589.3.peg.1373	84496364 *	NADTyrAa●ACT	270	RDVT----R
	Kineococcus radiotolerans	Krad	fig|266940.1.peg.4186	46365046 *	NADTyrAa●ACT	270	RDVT----R
	Leifsonia xyli	Lxyl	fig|281090.3.peg.1564	50954354 *	NADTyrAa●ACT	270	RDVT----R
	Mycobacterium avium	Mavi	fig|262316.1.peg.277	41406375 *	NAD(P)TyrAa	276	RDGT----R
	Mycobacterium bovis	Mbov_3	fig|233413.1.peg.3747	31794924	NAD(P)TyrAa	274	RDAT----R
	Mycobacterium leprae	Mlep	fig|272631.1.peg.1472	15828337 *	NAD(P)TyrAa	276	RDAT----R
	Mycobacterium marinum	Mmar_4	fig|216594.1.peg.258	NA	NAD(P)TyrAa	276	RDAT----R
	Mycobacterium microti	Mmic_1	fig|1806.1.peg.3235	NA	NAD(P)TyrAa	276	RDAT----R
	Mycobacterium smegmatis	Msme	fig|246196.1.peg.6289	NA	NAD(P)TyrAa	274	RDGT----R
	Mycobacterium sp.	MYCO_1	fig|164756.6.peg.4730	92913346 *	NAD(P)TyrAa	276	RDGT----R
	Mycobacterium tuberculosis	Mtub	fig|83331.1.peg.4002	15843374 *	NAD(P)TyrAa	276	RDAT----R
	Nocardia farcinica	Nfar	fig|247156.1.peg.306	54022200 *	NAD(P)TyrAa	277	RDVT----R
	Nonomuraea sp.	NONO	NA	32487233	NADTyrAa●ACT	268	RDVT----R
	Propionibacterium acnes	Pacn	fig|267747.1.peg.1192	50842688 *	NADTyrAa●ACT	276	RDVT----R
	Streptomyces avermitilis	Save	fig|227882.1.peg.6523	29610185 *	NADTyrAa●ACT	272	RDVT----R
	Streptomyces caeruleus	Scae_2	NA	7688712	NADTyrAa●ACT	270	SEIP----Q
	Streptomyces coelicolor	Scoe_1	fig|100226.1.peg.1728	31340546 *	NADTyrAa●ACT	270	RDVT----R
	Streptomyces lavendulae	Slav	NA	15029332	NADTyrAa●ACT	269	RDAT----R
	Streptomyces roseochomogenes	Sros	NA	24940594	NADTyrAa●ACT	270	SEIP----Q
	Streptomyces toyocaensis	Stoy	NA	21911427	NADTyrAa●ACT	270	RDVT----R
	Thermobifida fusca	Tfus	fig|269800.4.peg.764	72161612 *	NADTyrAa●ACT	271	RDMT----R
	Tropheryma whipplei	Twhi	fig|218496.1.peg.55	28572230 *	NADTyrAa●ACT	300	KDMT----R
α                       TyrCG-18	Bacillus anthracis	Bant	fig|198094.1.peg.2717	30262912 *	NADTyrAp●ACT	280	KDIT----R
Bacilli Class	Bacillus cereus	Bcer	fig|226900.1.peg.2798	30021055 *	NADTyrAp●ACT	280	KDIT----R
16S rRNA - congruent	Bacillus clausii	Bcla_1	fig|66692.3.peg.1946	56963667 *	NADTyrAp●ACT	279	RDIT----R
	Bacillus halodurans	Bhal_2	fig|272558.1.peg.1666	15614229 *	NADTyrAp●ACT	280	RDIT----R
	Bacillus licheniformis	Blic	fig|279010.5.peg.246	52003980 *	NADTyrAp●ACT	281	RDIT----R
	Bacillus subtilis	Bsub	fig|224308.1.peg.2265	16079318 *	NADTyrAp●ACT	281	RDIT----R
	Bacillus thuringiensis	Bthu	fig|281309.1.peg.2659	49479572 *	NADTyrAp●ACT	280	RDIT----R
	Enterococcus faecalis	Efae	fig|226185.1.peg.1467	29376128 *	NADTyrAp●ACT	278	RDIT----R
	Enterococcus faecium	Efae_1	fig|1352.1.peg.2808	68194610	NADTyrAp●ACT	277	RDIT----R
	Geobacillus kaustophilus	Gkau	fig|235909.3.peg.1007	56420732 *	NADTyrAp●ACT	282	RDIT----R
	Geobacillus stearothermophilus	Gste	fig|272567.1.peg.1853	NA	NADTyrAp●ACT	280	RDIT----R
	Lactobacillus plantarum	Lpla	fig|220668.1.peg.1693	28271503 *	NADTyrAp●ACT	280	KSIT----R
	Lactococcus lactis	Llac_1	fig|272623.1.peg.1789	15673727 *	NADTyrAp●ACT	273	RDLT----R
	Listeria innocua	Linn	fig|272626.1.peg.2025	16801104 *	NADTyrAp●ACT	281	RDIT----R
	Listeria monocytogenes	Lmon	fig|169963.1.peg.1915	16803963 *	NADTyrAp●ACT	281	RDIT----R
	Oceanobacillus iheyensis	Oihe	fig|221109.1.peg.1782	23099236 *	NADTyrAp●ACT	280	RDIT----R
	Staphylococcus aureus	Saur_2	fig|93062.4.peg.1582	49244651 *	NADTyrAp●ACT	281	RDIT----R
	Staphylococcus epidermidis	Sepi	fig|176280.1.peg.1047	27467965 *	NADTyrAp●ACT	281	RDIT----R
	Staphylococcus haemolyticus	Shae	fig|279808.3.peg.2461	70726545 *	NADTyrAp●ACT	281	RDIT----R
	Staphylococcus saprophyticus	Ssap	fig|342451.4.peg.734	73662696 *	NADTyrAp●ACT	281	RDIT----R
	Streptococcus gordonii	Sgor	NA	NA	NAD(P)TyrAp●ACT	281	RDMT----R
	Streptococcus mitis	Smit	fig|246201.1.peg.707	NA	NAD(P)TyrAp●ACT	282	RDMT----R
	Streptococcus mutans	Smut_1	fig|210007.1.peg.708	24379240 *	NAD(P)TyrAp●ACT	282	RDMT----R
	Streptococcus pneumoniae	Spne	fig|171101.1.peg.1230	15903274 *	NAD(P)TyrAp●ACT	282	RDMT----R
	Streptococcus sobrinus	Ssob	NA	NA	NAD(P)TyrAp●ACT	282	RDMT----R
	Streptococcus suis	Ssui	fig|1307.2.peg.1363	50591601	NADTyrAp●ACT	282	RDMT----R
	Streptococcus thermophilus	Sthe_5	fig|299768.3.peg.345	55738597 *	NAD(P)TyrAp●ACT	282	RDMT----R
α                       TyrCG-19	Clostridium acetobutylicum	Cace_2	fig|272562.1.peg.1058	15023791 *	NADTyrAx	276	RDAT----R
Clostridia_1 (Clostridiales Order)	Clostridium difficile	Cdif	fig|1496.1.peg.2965	115250885 *	NADTyrAx	275	RDLT----R
16S rRNA - congruent	Ruminococcus albus	Ralb	NA	NA	NADTyrAx	273	KDMT----R
α                       TyrCG-20	Carboxydothermus hydrogenoformans	Chyd_4	fig|246194.3.peg.918	78043672 *	NADTyrAp●ACT	243	RDLT----R
Clostridia_2 (2 Orders)	Clostridium thermocellum	Cthe_5	fig|203119.1.peg.2939	67874921 *	NADTyrAp●ACT	278	KDIT----R
16S rRNA - congruent	Thermoanaerobacter tengcongensis	Tten	fig|273068.3.peg.479	20807494 *	NADTyrAx	275	KDTT----R
α                       TyrCG-21
Clostridia_3 (2 Orders)	Heliobacillus mobilis	Hmob	NA	NA	NADTyrAp●ACT	280	RDTT----R
16S rRNA - congruent	Moorella thermoacetica	Mthe_3	fig|264732.1.peg.2464	83590180 *	NADTyrAp●ACT	279	RDTT----R
α                       TyrCG-22	Deinococcus geothermalis	Dgeo	fig|68909.1.peg.516	66781145 *	NADTyrAx●ACT	273	RDLT----R
Deinococci (Class)	Deinococcus radiodurans	Drad	fig|243230.1.peg.1305	6458858 *	NADTyrAx●ACT	273	RDLT----R
16S rRNA - congruent	Thermus thermophilus	Tthe_2	fig|300852.3.peg.856	55980768 *	NADTyrAx●ACT	276	RDLT----R
--------------------------	-------------------------------------	-----------	----------------------	----------	-------------------	-----------	-----------
Xenolog Intruder
Actinobacteria	Rubrobacter xylanophilus	Rxyl	fig|266117.1.peg.2540	45546179 *	NADTyrAx●ACT	266	RDLT----R
β                       TyrCG-23	Bacteroides fragilis	Bfra	fig|295405.3.peg.3998	53715229 *	NADTyrAx	256	KKHMAIA-K
Bacteroidetes Class	Bacteroides thetaiotaomicron	Bthe_9	fig|226186.1.peg.3931	29341249 *	NADTyrAx	256	KKHMAIA-K
16S rRNA - congruent	Prevotella ruminicola	Prum	NA	NA	NADTyrAx	263	KRHMRIA-K
	Tannerella forsythensis	Tfor_2	NA	NA	NADTyrAx	259	RRHMKIA-K
α                       TyrCG-24	Chlorobium chlorochromatii (uncultured Chlorobi)	Cchl	fig|156405.1.peg.554	78170201 *	NADTyrAx	276	ATLT----R
Chlorobia Class	Chlorobium ferrooxidans	Cfer_8	NA	110597282	NADTyrAx	277	ATLA----R
16S rRNA - congruent	Chlorobium limicola	Clim	NA	67918022	NADTyrAx	281	ATLA----R
	Chlorobium phaeobacteroides	Cpha_1	NA	67936884	NADTyrAx	281	ATLA----R
	Chlorobium tepidum	Ctep	fig|194439.1.peg.84	21672925 *	NADTyrAx	276	ASMA----R
	Chlorochromiumaggregatum sp.	CHLO_4	fig|888888.1.peg.969	NA	NADTyrAx	278	ATLT----R
	Pelodictyon luteolum	Plut	fig|319225.3.peg.2029	78167793 *	NADTyrAx	277	ASLT----R
	Pelodictyon phaeoclathratiforme	Ppha	NA	68549324	NADTyrAx	273	ATLA----R
	Prosthecochloris aestuarii	Paes	NA	68552198	NADTyrAx	281	ATLT----R
	Prosthecochloris vibrioformis	Pvib_1	NA	71481353	NADTyrAx	281	LSMA----R
--------------------------	-------------------------------------	-----------	----------------------	------------	-------------------	-----------	-----------
Xenolog Intruders	Acidobacterium capsulatum	Acap	NA	NA	NADTyrAx	282	REMT----R
Acidobacteria	Solibacter usitatus	Susi	fig|234267.9.peg.7488	67928654	xTyrAx	276	EDMT----R
α                       TyrCG-25
Unresolved phylogenetic mixture
Dictyoglomi	Dictyoglomus thermophilum	Dthe_6	NA	NA	NADTyrAx	279	KDTT----R
Thermotogae	Petrotoga miotherma	Pmio	NA	NA	NADTyrAx	276	KDTT----R
β                       TyrCG-26
Unresolved phylogenetic mixture
Bacteroidetes	Cytophaga hutchinsonii	Chut	fig|985.1.peg.1111	48855133 *	NADTyrAx	243	LDIK----R
upper-Gammaproteobacteria	Coxiella burnetii	Cbur	fig|227377.1.peg.935	29654299 *	NADTyrAx	251	VMAQTCNDK
Alphaproteobacteria	Jannaschia sp.	JANN	NA	89056034 *	NADTyrAx	243	RMTT----R
α                       TyrCG-27
Unresolved phylogenetic mixture
Deltaproteobacteria	Anaeromyxobacter dehalogenans	Adeh	NA	86156612 *	NADTyrAx	274	KDAT----R
Planctomycetaceae	Rhodopirellula baltica (Pirellula sp.)	Rbal	fig|243090.1.peg.3009	32473675	NADPTyrAx	272	LDTT----R
Verrucomicrobia	Verrucomicrobium spinosum	Vspi	NA	NA	NADPTyrAx	281	RDTT----R
α                       TyrCG-28
Unresolved phylogenetic mixture
Fibrobacteres	Fibrobacter succinogenes	Fsuc	NA	NA	NADPTyrAx	288	RDMT----R
Spirochaetes	Leptospira interrogans	Lint_1	fig|267671.1.peg.2379	45658293 *	NADPTyrAx	287	RDMT----R
β                       TyrCG-29
Chloroflexi (Dehalococcoidetes Class)	Dehalococcoides ethenogenes	Deth	fig|243164.3.peg.722	57234714 *	NAD(P)TyrAx	279	RLLDTLT-K
16S rRNA - congruent	Dehalococcoides sp.	DEHA	fig|255470.3.peg.868	73748302 *	NAD(P)TyrAx	269	RLLDTLT-K
β                       TyrCG-30	Maricaulis maris	Mmar	NA	110609330 *	NADTyrAx	235	TRSYDLL-K
Alpha_2proteobacteria (2 Orders)	Rhodospirillum rubrum	2Rrub_1	fig|1085.1.peg.3401	83592308 *	NADTyrAx	282	RDSEALF-R
16S rRNA – congruent	Silicibacter pomeroyi	2Spom_1	fig|246200.3.peg.1790	56678001 *	NADTyrAx	242	TASFDLL-K
--------------------------	-------------------------------------	----------	---------------------	----------	-------------------	----------	----------
Xenolog Intruder
Deltaproteobacteria	Myxococcus xanthus	Mxan	NA	108759735 *	NADTyrAx●AroH	262	PPSFQPVAR
α                       TyrCG-31
Planctomyceteceae Family	Blastopirellula marina	Bmar_4	fig|314230.3.peg.3748	87311378	NADPTyrAx	275	ADTT----R
16S rRNA - congruent	Gemmata obscuriglobus	Gobs	NA	NA	NADTyrAx	276	RDVT----R
TyrCG Orphans
α upper-Gammaproteobacteria	Acidithiobacillus ferrooxidans	Afer_4	NA	NA	NADTyrAc	278	RDFS----R
αi Aquificae	Aquifex aeolicus	Aaeo	fig|224324.1.peg.1217	15606822 *	NADTyrAc	279	KDFT----R
α Betaproteobacteria	Azoarcus sp.	AZOA	fig|76114.4.peg.1423	56475924 *	NAD(P)TyrAc	279	RDFT----R
α Betaproteobacteria	Chromobacterium violaceum	Cvio	fig|243365.1.peg.3407	34498862 *	NAD(P)TyrAc	279	RDFT----R
α Betaproteobacteria	Dechloromonas aromatica	Daro	fig|159087.4.peg.933	71906873 *	NAD(P)TyrAc	281	RDFT----R
α Clostridia	Desulfitobacterium hafniense	Dhaf	fig|49338.1.peg.2227	89334457 *	NADTyrAx	273	REIT----R
α unclassified proteobacteria	Magnetococcus sp.	MAGN_1	fig|156889.1.peg.1669	NA	NADTyrAx	260	RDFT----R
α Betaproteobacteria	Methylobacillus flagellatus	Mfla_5	fig|265072.1.peg.206	91775427 *	NAD(P)TyrAc	280	RDFT----R
α upper-Gammaproteobacteria	Methylococcus capsulatus	Mcap_1	fig|243233.4.peg.782	53804254 *	NADTyrAc	284	RDFT----R
α upper-Gammaproteobacteria	Microbulbifer degradans (Saccharophagus d.)	Mdeg	fig|203122.1.peg.1111	90021791 *	NADPTyrAc●AroF	283	RDFT----R
α upper-Gammaproteobacteria	Nitrosococcus oceani	Noce_1	fig|323261.3.peg.7	77163714 *	NADTyrAc	281	RDFS----R
α Alphaproteobacteria	Pelagibacter ubiqueh	Pubi	fig|335992.3.peg.1115	71082920 *	NADTyrAc	281	RDFS----R
α Firmicutes	Symbiobacterium thermophilum	Sthe	fig|292459.1.peg.1361	51856245 *	NAD(P)TyrAa	309	RDAT----R
β Deltaproteobacteria	Syntrophobacter fumaroxidans	Sfum_1	fig|335543.6.peg.3883	71548230	NADTyrAx	254	RVELSQVGR
α Clostridia	Syntrophomonas wolfei	Swol_1	NA	114566874 *	NADTyrAp	274	RDTT----R
β Thermodesulfobacteria	Thermodesulfobacterium commune	Tcom	NA	NA	NADTyrAx	251	KQLEILQ-R
α Thermotogae	Thermotoga maritima	Tmar	fig|243274.1.peg.339	15643112 *	NADTyrAx	252	LSNT----R
α Betaproteobacteria	Thiobacillus denitrificans	Tden	fig|292415.3.peg.543	74316971 *	NAD(P)TyrAc	278	RDFT----R
Cohesion group & lineagea	Source of TyrA sequence: Archaea	Acronymb	SEED: fig & peg number	gi numberc	TyrA specificitiesd & fusionse	Core size (aa)	276-Rxxx----R-284f
β                       TyrCG-80	Methanococcoides burtonii	Mbur	fig|259564.1.peg.2246	91773934 *	NAD(P)TyrAx●REG	269	EIMVDFVGR
Euryarchaea Phylum	Methanococcus maripaludis	Mmar_5	fig|267377.1.peg.1514	45359077 *	NADTyrAx●REG	272	ELMINIIAR
16S rRNA - congruent	Methanocoldococcus jannaschii	Mjan	fig|243232.1.peg.633	15668793 *	NADTyrAx●REG	273	ELMISIIGR
	Methanopyrus kandleri	Mkan_1	fig|190192.1.peg.795	20094235 *	NAD(P)TyrAx●REG	270	RLLMDVVGR
	Methanosarcina acetivorans	Mace	fig|188937.1.peg.4480	20093379 *	NAD(P)TyrAx●REG	269	SIMLDFVGR
	Methanosarcina barkeri	Mbar	fig|269797.3.peg.484	73668462 *	NAD(P)TyrAx●REG	269	AIMLDFVGR
	Methanosarcina mazei	Mmaz	fig|192952.1.peg.1275	21227377 *	NAD(P)TyrAx●REG	269	SIMLDFVGR
	Methanothermobacter thermautotrophicus	Mthe_7	fig|187420.1.peg.1607	2622768 *	NADTyrAx●REG	269	NLMIDTIAR
β                       TyrCG-81	Haloarcula marismortui	Hmar_2	fig|272569.1.peg.498	55377389 *	NADTyrAx	243	AGLFDLVEQ
Euryarchaea (Halobacteria Class)	Halobacterium sp.	HALO_6	fig|64091.1.peg.1136	15790293 *	NADTyrAx	244	RLAD----R
16S rRNA - congruent	Haloferax volcanii	Hvol_1	NA	NA	NADTyrAx	251	AALDELVAS
	Natronomonas pharaonis	Npha_1	fig|348780.3.peg.1741	76558182 *	NADTyrAx	242	EPLEALVDD
β                       TyrCG-82	Ferroplasma acidarmanus	Faci_1	fig|97393.1.peg.324	68141176 *	NADTyrAx	210	KFLEIEKIK
Euryarchaea (Thermoplasmata Class)	Picrophilus torridus	Ptor_1	fig|263820.1.peg.836	48477908 *	NADTyrAx	210	KLLEVSEIK
16S rRNA - congruent	Thermoplasma acidophilum	Taci_3	fig|273075.1.peg.248	16082503 *	NADTyrAx	194	HTRSFDMAR
	Thermoplasma volcanium	Tvol_2	fig|273116.1.peg.1350	13542181 *	NADTyrAx	195	RTKSFDTFK
β                       TyrCG-83
Euryarchaea (Methanomicobia Class)	Methanoculleus marisnigri	Mmar_6	NA	110604808	xTyrAx	271	RIEMGIAGR
16S rRNA - congruent	Methanospirillum hungatei	Mhun	fig|323259.5.peg.1087	88602324 *	xTyrAx	255	RIETGIAGR
β                       TyrCG-84	Sulfolobus acidocaldarius	Saci_4	fig|330779.3.peg.447	70606024 *	AroHI●NADTyrAx	249	REISKILDR
Crenarchaeota (Sulfolobales Order)	Sulfolobus solfataricus	Ssol	fig|273057.1.peg.273	15897245 *	AroHI●NADTyrAx	253	RELNKIIER
16S rRNA - congruent	Sulfolobus tokodaii	Stok	fig|273063.1.peg.2438	15922601 *	AroHI●NAD(P)TyrAx	248	RELNKILKR
β                       TyrCG-85
Unresolved phylogenetic mixture
Crenarchaeota	Aeropyrum pernix	Aper_1	fig|272557.1.peg.437	118431108 *	NADTyrAx	265	SPLPSTTYR
Crenarchaeota	Pyrobaculum aerophilum	Paer_2	fig|178306.1.peg.1339	18312982 *	NADTyrAx	244	KY-GGTSFK
Euryarchaea	Pyrococcus furiosus	Pfur	fig|186497.1.peg.1751	18978075 *	xTyrAx	255	RF-LTIYGK
Euryarchaea	Thermococcus kodakaraensis	Tkod	fig|69014.3.peg.6	57158518 *	NADTyrAx	255	AF-LETYGK
β                       TyrCG-86
Unresolved phylogenetic mixture
Euryarchaea	Archaeoglobus fulgidus	Aful_1	fig|224325.1.peg.224	11497843 *	NADTyrAx●AroH●PheAIp●ACT	242	KLAS----R
Nanoarchaeota	Nanoarchaeum equitans	Nequ	fig|228908.1.peg.192	41614988 *	NADPTyrAx●AroH●PheAIp●ACT	255	RLSE----R
Cohesion group & lineagea	Source of TyrA sequence: Eukaryota	Acronymb	SEED: fig & peg number	gi numberc	TyrA specificitiesd & fusionse	Core size (aa)	276-Rxxx----R-284f
β                       TyrCG-95	Arabidopsis thaliana	1Atha	fig|3702.1.peg.1877	15218283 *	NADPTyrAa	273	ETLLDLVEN
Viridiplantae Kingdom	Arabidopsis thaliana	2Athak	fig|3702.1.peg.25198	15242898 *	NADPTyrAa●NADPTyrAa	312, 275	ETLLD/RLVEN
	Lotus corniculatus	1Lcor_3	NA	NA	NADPTyrAa	273	ESLLNLVEN
	Lotus corniculatus	2Lcor_3	NA	NA	NADPTyrAa	273	ETLLSLVEN
	Lycopersicon esculentum	Lesc	NA	NA	NADPTyrAa	261	ESLLNLMEN
	Medicago truncatula	Mtrul	NA	92884247	NADPTyrAa●NADPTyrAa	273, 274	ES/TLLN/SLVEN
	Oryza sativa	1Osat	NA	53792620 *	NADPTyrAa	273	ETLLRLVDN
	Oryza sativa	2Osat	NA	53792618 *	NADPTyrAa	276	ETLLRLVDN
β                       TyrCG-98	Ashbya gossypii	Agos	NA	44986169 *	NADTyrAx	277	KMNISL--R
Fungi Kingdom	Aspergillus fumigatus	Afum	NA	71001394 *	NADTyrAx	274	KINITL--R
	Aspergillus oryzae	Aory	NA	83774947 *	NADTyrAx	274	KINITL--R
	Candida albicans	Calb_2	NA	68466097 *	NADTyrAx	274	KINISL--R
	Candida dubliniensis	Cdub	NA	NA	NADTyrAx	274	KINISL--R
	Candida glabrata	Cgla	NA	49528922 *	NADTyrAx	279	KVNISL--R
	Coccidioides immitis	Cimm	NA	90303694	NADTyrAx	276	KINITL--R
	Cryptococcus neoformans	Cneo_2	NA	57229998	NADTyrAx	270	KVNITL--R
	Debaryomyces hansenii	Dhan	NA	49658011	NADTyrAx	274	KMNISL--R
	Kluyveromyces lactis	Klac	NA	49644201	NADTyrAx	277	KVNISL--R
	Saccharomyces cerevisiae	Scer	fig|4932.3.peg.431	6319643 *	NADTyrAx	277	KVNISL--R
	Schizosaccharomyces pombe	Spom	fig|4896.1.peg.867	3184059 *	NADTyrAx	274	KMNLSM--R
	Ustilago maydis	Umay	NA	71020197 *	NADTyrAx	275	KINICL--R
	Yarrowia lipolytica	Ylip	NA	50556274 *	NADTyrAx	275	KMNISL--R
α designates cohesion groups that belong to the TyrAα sub-homology group as shown in the Tyr CG tree. TyrA CG tree
β designates cohesion groups that belong to the TyrAβ sub-homology group as shown in the TyrA CG tree. TyrA CG tree
aAn attempt is made to describe each cohesion group at the hierarchical level at which all organisms having the sequence occupy the same taxon. NCBIÕs taxonomy page is used as a resource for this. Typically, cohesion groups gather at about the level of Class, but wide deviations occur in either direction (see text). In our treatment, Gammaproteobacteria are clearly divided into two groups, with lower-Gammaproteobacteria and upper-Gammaproteobacteria being the equivalent of "Superorder" taxon designations. Thus, for example, the Betaproteobacteria (a formal class) partition into five cohesion groups which do not correspond to formal taxon subdivisions. The organism names and gi numbers are hyper-linked to the Taxonomy Browser at NCBI, the fig/peg numbers are hyperlinked to Protein Pages at the SEED.
bOrganism acronyms consist of four letters: the first letter of the genus name followed by the first three letters of the Species name. If underscore-number designations follow the acronym proper, these are used to distinguish potential ambiguities, multiple TyrA species in a single organism are distinguished by numbers preceding the acronym. (as implemented at AroPath).
cGene identification number. A red asterisk indicates that sequencing of the genome is essentially complete.
dSpecificities that have been experimentally demonstrated or which are considered certain for other reasons are shown in black. Specificities which can be predicted with a fair degree of confidence are shown in grey. Subscripts appended to the right of TyrA (TyrAa, TyrAp, TyrAc, and TyrAx) denote specificities for the cyclohexadiencyl substrate (arogenate, prephenate, both substrates, and substrate unknown), respectively.
eFusions are denoted by the convention of a bullet between the named domains.
fMotif numbering is based on the master alignment of the 58 cohesion-group representatives, where the motif RxxxR is shown as Rxxx----R to accommodate comparison of sequences that have an insertion in this region.
gNA, fig number (at SEED) or gi number is not available.
hIn some databases ÒCandidatusÓ (refers to an organism that cannot be maintained in a culture collection) precedes the genus/species designation.
iSee TyrCG-1 for additional TyrA xenologs present in these two organisms.
jGreen lettering indicates that the domain indicated is a pseudogene.
kArabidopsis thaliana has two tyrA genes, one of them being a fusion of two non-identical but similar domains. All three domains were included in the initial alignment
lMedicato truncatula possesses a tyrA gene that consists of fused non-identical, but similar, domains. Both domains were included in the initial alignment.